Consumo de suplementos vitamínicos em jovens do ensino superior público do Distrito de Bragança

O actual ritmo de vida acelerado e a má alimentação das pessoas, em especial dos estudantes, obriga, muitas vezes, ao uso irracional de suplementos vitamínicos. O presente artigo pretende descrever e analisar os hábitos de consumo de Suplementos Vitamínicos (SV) e os factores que influenciam este consumo, numa amostra de 460 alunos das várias escolas do IPB, extraída de uma população total de 7064 alunos, utilizando um estudo descritivo, transversal, de natureza quantitativa. Os dados foram obtidos através da aplicação de um questionário de auto-preenchimento, anónimo e voluntário, sendo sujeitos a tratamento estatístico através do programa SPSS 17.0 para Windows. A partir dos resultados foi possível concluir que 47,6% dos alunos questionados consome ou já consumiu SV, sendo os mais consumidos Centrum (40,2%), Cerebrum (27,4%) e Magnesium (20,6%), e os menos consumidos Amundsen, Bioelectra, CerealG, Cergumil, Panvitol, Tonosol e Vittol, não assinalados por nenhum dos inquiridos. Relativamente às variáveis em estudo (Género; Idade; Meio de onde provém; Escola; Grau Académico; Curso e Ano em que se encontra), nenhuma delas demostrou ter relação com o consumo de SV

Theoretical Study of the Thermolysis Reaction and Chemiexcitation of Coelenterazine Dioxetanes

Coelenterazine and other imidazopyrazinones are important bioluminescent substrates widespread in marine species and can be found in eight phyla of luminescent organisms. Light emission from these systems is caused by the formation and subsequent thermolysis of a dioxetanone intermediate, whose decomposition allows for efficient chemiexcitation to singlet excited states. Interestingly, some studies have also reported the involvement of unexpected dioxetane intermediates in the chemiand bioluminescent reactions of Coelenterazine, albeit with little information on the underlying mechanisms of these new species. Herein, we have employed a theoretical approach based on density functional theory to study for the first time the thermolysis reaction and chemiexcitation profile of two Coelenterazine dioxetanes. We have found that the thermolysis reactions of these species are feasible but with relevant energetic differences. More importantly, we found that the singlet chemiexcitation profiles of these dioxetanes are significantly less efficient than the corresponding dioxetanones. Furthermore, we identified triplet chemiexcitation pathways for the Coelenterazine dioxetanes. Given this, the chemiexcitation of these dioxetanes should lead only to minimal luminescence. Thus, our theoretical investigation of these systems indicates that the thermolysis of these dioxetanes should only provide dark pathways for the formation of nonluminescent degradation products of the chemi- and bioluminescent reactions of Coelenterazine and other imidazopyrazinones

Assessing the molecular divergence between Anopheles (Kerteszia) cruzii populations from Brazil using the timeless gene: further evidence of a species complex

Submitted by Sandra Infurna ([email protected]) on 2019-01-15T13:43:46Z No. of bitstreams: 1 luisaDp_rona_etal_IOC_2009.pdf: 651215 bytes, checksum: 4fc0bfe6cd7738120844230e1013d041 (MD5)Approved for entry into archive by Sandra Infurna ([email protected]) on 2019-01-15T13:52:05Z (GMT) No. of bitstreams: 1 luisaDp_rona_etal_IOC_2009.pdf: 651215 bytes, checksum: 4fc0bfe6cd7738120844230e1013d041 (MD5)Made available in DSpace on 2019-01-15T13:52:05Z (GMT). No. of bitstreams: 1 luisaDp_rona_etal_IOC_2009.pdf: 651215 bytes, checksum: 4fc0bfe6cd7738120844230e1013d041 (MD5) Previous issue date: 2009Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia Molecular de Insetos. Rio de Janeiro, RJ. Brasil.Universidade Federal de Santa Catarina. Departamento de Microbiologia, Imunologia e Parasitologia. Florianópolis, SC, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia Molecular de Insetos. Rio de Janeiro, RJ. Brasil / Queen Mary University of London. School of Biological and Chemical Sciences. London, UK.Universidade Federal de Santa Catarina. Departamento de Microbiologia, Imunologia e Parasitologia. Florianópolis, SC, Brasil.Fundação Oswaldo Cruz. Instituto Oswaldo Cruz. Laboratório de Biologia Molecular de Insetos. Rio de Janeiro, RJ. Brasil.Background: Anopheles (Kerteszia) cruzii was the most important vector of human malaria in southern Brazil between 1930–1960. Nowadays it is still considered an important Plasmodium spp. vector in southern and south-eastern Brazil, incriminated for oligosymptomatic malaria. Previous studies based on the analysis of X chromosome banding patterns and inversion frequencies in An. cruzii populations from these areas have suggested the occurrence of three sibling species. In contrast, two genetically distinct groups among An. cruzii populations from south/south-east and north-east Brazil have been revealed by isoenzyme analysis. Therefore, An. cruzii remains unclear

Efficient Methods for Scheduling Jobs in a Simulation Model Using a Multicore Multicluster Architecture

Over the past decade, the fast advance of network technologies, hardware and middleware, as well as software resource sophistication has contributed to the emergence of new computational models. Consequently, there was a capacity increasing for efficient and effective use of resources distributed aiming to integrate them, in order to provide a widely distributed environment, which computational capacity could be used to solve complex computer problems. The two most challenging aspects of distributed systems are resource management and task scheduling. This work contributes to minimize such problems by i) aiming to reduce this problem through the use of migration techniques; ii) implementing a multicluster simulation environment with mechanisms for load balancing; iii) plus, the gang scheduling implementation algorithms will be analyzed through the use of metrics, in order to measure the schedulers performance in different situations. Thus, the results showed a better use of resources, implying operating costs reduction

Juncus fernandez-carvajaliae

This species is endemic to central Spain, where it is currently only known from two sites in the Guadiana River basin located in the western half of Ciudad Real Province. Suitable habitat is frequent around both known sites, and the potential distribution area of this new species could be much larger. However, very little data are available at present regarding its population size, trends or threats and therefore it is assessed as Data Deficient; further research is required

An Analysis of the Mechanisms Influencing Health, Sleep, Life Satisfaction, and Emotional Well-Being

Ferreira, M. B., de Almeida, F., Soro, J. C., Herter, M. M., Pinto, D. C., & Silva, C. S. (2021). On the Relation Between Over-Indebtedness and Well-Being: An Analysis of the Mechanisms Influencing Health, Sleep, Life Satisfaction, and Emotional Well-Being. Frontiers in Psychology, 12, 1-14. [591875]. https://doi.org/10.3389/fpsyg.2021.591875This paper aims to explore the association between over-indebtedness and two facets of well-being – life satisfaction and emotional well-being. Although prior research has associated over-indebtedness with lower life satisfaction, this study contributes to the extant literature by revealing its effects on emotional well-being, which is a crucial component of well-being that has received less attention. Besides subjective well-being (SWB), reported health, and sleep quality were also assessed. The findings suggest that over-indebted (compared to non-over-indebted) consumers have lower life satisfaction and emotional well-being, as well as poorer (reported) health and sleep quality. Furthermore, over-indebtedness impacts life satisfaction and emotional well-being through different mechanisms. Consumers decreased perceived control accounts for the impact of over-indebtedness on both facets of well-being (as well as on reported health and sleep). Financial well-being (a specific component of life satisfaction), partly mediates the impact of indebtedness status on overall life satisfaction. The current study contributes to research focusing on the relationship between indebtedness, well-being, health, and sleep quality, and provides relevant theoretical and practical implications.publishersversionpublishe

Nanocomposite polymer electrolytes of sodium alginate and montmorillonite clay

Nanocomposite polymer electrolytes (NPEs) were synthesized using sodium alginate (Alg) and either sodium (SCa-3-Na+)- or lithium (SCa-3-Li+)-modified montmorillonite clays. The samples were characterized by structural, optical, and electrical properties. SCa-3-Na+ and SCa-3-Li+ clays’ X-ray structural analyses revealed peaks at 2θ = 7.2° and 6.7° that corresponded to the interlamellar distances of 12.3 and 12.8 Å, respectively. Alg-based NPEs X-ray diffractograms showed exfoliated structures for samples with low clay percentages. The increase of clay content promoted the formation of intercalated structures. Electrochemical Impedance Spectroscopy revealed that Alg-based NPEs with 5 wt% of SCa-3-Na+ clay presented the highest conductivity of 1.96 × 10−2 S/cm2, and Alg with 10 wt% of SCa-3-Li+ showed conductivity of 1.30 × 10−2 S/cm2, both measured at 70 °C. From UV-Vis spectroscopy, it was possible to infer that increasing concentration of clay promoted a decrease of the samples’ transmittance and, consequently, an increase of their reflectance.This research was partially founded by the Coordenação de Aperfeiçoamento de Pessoal de Nível Superior—Brasil (CAPES)—Finance Code 001 (proc. PNPD20131739-33002045017P6, F. Sentanin fellowship no. 1573926)

Inhibition of CD73 improves B cell-mediated anti-tumor immunity in a mouse model of melanoma.

CD73 is a cell surface enzyme that suppresses T cell-mediated immune responses by producing extracellular adenosine. Growing evidence suggests that targeting CD73 in cancer may be useful for an effective therapeutic outcome. In this study, we demonstrate that administration of a specific CD73 inhibitor, adenosine 5'-(α,β-methylene)diphosphate (APCP), to melanoma-bearing mice induced a significant tumor regression by promoting the release of Th1- and Th17-associated cytokines in the tumor microenvironment. CD8+ T cells were increased in melanoma tissue of APCP-treated mice. Accordingly, in nude mice APCP failed to reduce tumor growth. Importantly, we observed that after APCP administration, the presence of B cells in the melanoma tissue was greater than that observed in control mice. This was associated with production of IgG2b within the melanoma. Depletion of CD20+ B cells partially blocked the anti-tumor effect of APCP and significantly reduced the production of IgG2b induced by APCP, implying a critical role for B cells in the anti-tumor activity of APCP. Our results also suggest that APCP could influence B cell activity to produce IgG through IL-17A, which significantly increased in the tumor tissue of APCP-treated mice. In support of this, we found that in melanoma-bearing mice receiving anti-IL-17A mAb, the anti-tumor effect of APCP was ablated. This correlated with a reduced capacity of APCP-treated mice to mount an effective immune response against melanoma, as neutralization of this cytokine significantly affected both the CD8+ T cell- and B cell-mediated responses. In conclusion, we demonstrate that both T cells and B cells play a pivotal role in the APCP-induced anti-tumor immune response