Updated constraints on spatial variations of the fine-structure constant

Recent work by Webb {\it et al.} has provided indications of spatial variations of the fine-structure constant, $\alpha$, at a level of a few parts per million. Using a dataset of 293 archival measurements, they further show that a dipole provides a statistically good fit to the data, a result subsequently confirmed by other authors. Here we show that a more recent dataset of dedicated measurements further constrains these variations: although there are only 10 such measurements, their uncertainties are considerably smaller. We find that a dipolar variation is still a good fit to the combined dataset, but the amplitude of such a dipole must be somewhat smaller: $8.1\pm1.7$ ppm for the full dataset, versus $9.4\pm2.2$ ppm for the Webb {\it et al.} data alone, both at the $68.3\%$ confidence level. Constraints on the direction on the sky of such a dipole are also significantly improved. On the other hand the data can't yet discriminate between a pure spatial dipole and one with an additional redshift dependence.Comment: 10 pages, 4 figure

Constraining spatial variations of the fine-structure constant in symmetron models

We introduce a methodology to test models with spatial variations of the fine-structure constant $\alpha$, based on the calculation of the angular power spectrum of these measurements. This methodology enables comparisons of observations and theoretical models through their predictions on the statistics of the $\alpha$ variation. Here we apply it to the case of symmetron models. We find no indications of deviations from the standard behavior, with current data providing an upper limit to the strength of the symmetron coupling to gravity ($\log{\beta^2}<-0.9$) when this is the only free parameter, and not able to constrain the model when also the symmetry breaking scale factor $a_{SSB}$ is free to vary.Comment: Phys. Lett. B (in press

Axon diversity of lamina I local-circuit neurons in the lumbar spinal cord

Spinal lamina I is a key area for relaying and integrating information from nociceptive primary afferents with various other sources of inputs. Although lamina I projection neurons have been intensively studied, much less attention has been given to local-circuit neurons (LCNs), which form the majority of the lamina I neuronal population. In this work the infrared light-emitting diode oblique illumination technique was used to visualize and label LCNs, allowing reconstruction and analysis of their dendritic and extensive axonal trees. We show that the majority of lamina I neurons with locally branching axons fall into the multipolar (with ventrally protruding dendrites) and flattened (dendrites limited to lamina I) somatodendritic categories. Analysis of their axons revealed that the initial myelinated part gives rise to several unmyelinated small-diameter branches that have a high number of densely packed, large varicosities and an extensive rostrocaudal (two or three segments), mediolateral, and dorsoventral (reaching laminae III–IV) distribution. The extent of the axon and the occasional presence of long, solitary branches suggest that LCNs may also form short and long propriospinal connections. We also found that the distribution of axon varicosities and terminal field locations show substantial heterogeneity and that a substantial portion of LCNs is inhibitory. Our observations indicate that LCNs of lamina I form intersegmental as well as interlaminar connections and may govern large numbers of neurons, providing anatomical substrate for rostrocaudal “processing units” in the dorsal horn

Frontal lobe epilepsy

About one-quarter of patients with refractory focal epilepsies have frontal lobe epilepsy (FLE). The typical seizure semiology for FLE includes unilateral clonic, tonic asymmetric or hypermotor seizures. Interictal electroencephalograms (EEG) usually reveal interictal epileptiform discharges and rhythmical midline theta, which has localizing value. The usefulness of ictal EEG recordings is limited by frequent muscle artifacts in motor seizures and because a large portion of the frontal lobe cortex is "hidden" to scalp electrodes. Ictal single photon emission CT and positron emission tomography are able to localize FLE in about one-third of patients only. A pre-surgical evaluation should include, whenever possible, a subclassification of FLE as dorsolateral frontal, mesial frontal or basal frontal lobe epilepsy to allow a minimal cortical resection. A review of the typical findings of seizure semiology, interictal and ictal EEG regarding the different FLE subtypes is given. Etiology, medical treatment and surgery are also discussed