CORDIC-Based Multi-Gb/s Digital Outphasing Modulator for Highly Efficient Millimeter-Wave Transmitters

This paper describes a high-speed CORDIC-based digital outphasing modulator. Fixed-point Matlab model of the outphasing modulator is developed to evaluate the system performance and define the circuit design parameters. Design issues such as signal quantization error, delay mismatch, and phase overflowing are addressed to enable hardware implementation. The complete outphasing modulator is fully custom designed in 40 nm CMOS, which can be integrated in a millimeter-wave outphasing transmitter to enhance the system average efficiency. Tested with 10.56 Gb/s 64-QAM, this work achieves an EVM of 3.2% and fulfils the IEEE 802.11ad spectral mask requirements

Entanglement dynamics for static two-level atoms in cosmic string spacetime

We study the entanglement dynamics of two static atoms coupled with a bath of fluctuating scalar fields in vacuum in the cosmic string spacetime. Three different alignments of atoms, i.e. parallel, vertical, and symmetric alignments with respect to the cosmic string are considered. We focus on how entanglement degradation and generation are influenced by the cosmic string, and find that they are crucially dependent on the atom-string distance r, the interatomic separation L, and the parameter $$\nu$$ that characterizes the nontrivial topology of the cosmic string. For two atoms initially in a maximally entangled state, the destroyed entanglement can be revived when the atoms are aligned vertically to the string, which cannot happen in the Minkowski spacetime. When the symmetrically aligned two-atom system is initially in the antisymmetric state, the lifetime of entanglement can be significantly enhanced as $$\nu$$ increases. For two atoms which are initially in the excited state, when the interatomic separation is large compared to the transition wavelength, entanglement generation cannot happen in the Minkowski spacetime, while it can be achieved in the cosmic string spacetime when the position of the two atoms is appropriate with respect to the cosmic string and $$\nu$$ is large enough

Effect of Folic Acid Supplementation on Renal Phenotype and Epigenotype in Early Weanling Intrauterine Growth Retarded Rats

Background/Aims: The objective of this study was to examine the responses of p53 promoter methylation involved in kidney structure and function of early weaning intrauterine growth retarded (IUGR) rats to dietary folic acid supplementation. Method: Sprague-Dawley rats were fed isocaloric diets containing either 21% protein diet (normal feed) or 10% protein diet throughout pregnancy and normal feed during lactation. After weaning, Offspring were then fed onto normal feed and normal feed supplemented with 5 mg folic acid/kg feed for a month, this produced 4 dietary groups (maternal diet/ weanling diet): Con, Folic, IUGR and IUGR+Folic. Renal function, renal structure, p53 promoter methylation and protein expression of offspring rats were measured at postnatal 2 months and 3 months. Results: Glomerular volume, blood urea nitrogen, 24 hours urine protein were significantly elevated in IUGR rats compared with Con rats but were decreased by dietary folic acid supplementation. p53 protein expression in IUGR rats were significantly higher than that in Con rats, and p53 promoter methylation status in IUGR rats was reduced significantly compared with Con rats. However, the changes in p53 gene expression and DNA methylation status of IUGR rats were reversed by dietary folic acid supplementation. Conclusions: Our study showed for the first time that folic acid supplementation during early period of life could reverse the abnormality in renal p53 methylation status and protein expression, glomerular volume and renal function of IUGR rats offspring

Release of Positive Transcription Elongation Factor b (P-TEFb) from 7SK Small Nuclear Ribonucleoprotein (snRNP) Activates Hexamethylene Bisacetamide-inducible Protein (HEXIM1) Transcription

By phosphorylating negative elongation factors and the C-terminal domain of RNA polymerase II (RNAPII), positive transcription elongation factor b (P-TEFb), which is composed of CycT1 or CycT2 and CDK9, activates eukaryotic transcription elongation. In growing cells, it is found in active and inactive forms. In the former, free P-TEFb is a potent transcriptional coactivator. In the latter, it is inhibited by HEXIM1 or HEXIM2 in the 7SK small nuclear ribonucleoprotein (snRNP), which contains, additionally, 7SK snRNA, methyl phosphate-capping enzyme (MePCE), and La-related protein 7 (LARP7). This P-TEFb equilibrium determines the state of growth and proliferation of the cell. In this study, the release of P-TEFb from the 7SK snRNP led to increased synthesis of HEXIM1 but not HEXIM2 in HeLa cells, and this occurred only from an unannotated, proximal promoter. ChIP with sequencing revealed P-TEFb-sensitive poised RNA polymerase II at this proximal but not the previously annotated distal HEXIM1 promoter. Its immediate upstream sequences were fused to luciferase reporters and were found to be responsive to many P-TEFb-releasing compounds. The superelongation complex subunits AF4/FMR2 family member 4 (AFF4) and elongation factor RNA polymerase II 2 (ELL2) were recruited to this proximal promoter after P-TEFb release and were required for its transcriptional effects. Thus, P-TEFb regulates its own equilibrium in cells, most likely to maintain optimal cellular homeostasis