Treatment of grade III furcation lesion by tunneling in a smoker patient: Clinical Case Report

Objective: The aim of this study is to describe a case report of lower molar treatment with grade III furca- tion by the tunneling technique in a heavy smoker patient. Case presentation: In the present study, a 40-year- -old man, a heavy smoker (> 20 cigarettes / day) presented a grade III furcation injury on dental element 46 af- ter a clinical and radiographic examination. After non-surgical periodontal therapy, the patient was treated with the execution of the tunneling of the furcation of the tooth 46, which was effective in the control of the disea- se and in the maintenance of the dental element after 12 months of follow up. Final considerations: The tun- neling technique was effective in the control of periodontal disease in a heavy smoking patient, with a good standard of hygiene and motivation, and good clinical results were maintained after 12 months of follow-up

Comparing the analytical performances of Micro-NIR and FT-NIR spectrometers in the evaluation of acerola fruit quality, using PLS and SVM regression algorithms

The main goal of this study was to investigate the analytical performances of a state-of-the-art device, one of the smallest dispersion NIR spectrometers on the market (MicroNIR 1700), making a critical comparison with a benchtop FT-NIR spectrometer in the evaluation of the prediction accuracy. In particular, the aim of this study was to estimate in a non-destructive manner, titratable acidity and ascorbic acid content in acerola fruit during ripening, in a view of direct applicability in field of this new miniaturised handheld device. Acerola (Malpighia emarginata DC.) is a super-fruit characterised by a considerable amount of ascorbic acid, ranging from 1.0% to 4.5%. However, during ripening, acerola colour changes and the fruit may lose as much as half of its ascorbic acid content. Because the variability of chemical parameters followed a non-strictly linear profile, two different regression algorithms were compared: PLS and SVM. Regression models obtained with Micro-NIR spectra give better results using SVM algorithm, for both ascorbic acid and titratable acidity estimation. FT-NIR data give comparable results using both SVM and PLS algorithms, with lower errors for SVM regression. The prediction ability of the two instruments was statistically compared using the Passing-Bablok regression algorithm; the outcomes are critically discussed together with the regression models, showing the suitability of the portable Micro-NIR for in field monitoring of chemical parameters of interest in acerola fruits

Thermally and Dynamically Driven Atmospheric Circulations over Heterogeneous Atmospheric Boundary Layer: Support for Safety Protocols and Environment Management at Nuclear Central Areas

Ilha Grande Bay is located in Angra dos Reis, Rio de Janeiro State, Brazil. The area is characterized by different land cover, complex topography and proximity to the Atlantic Ocean. These aspects make it susceptible to thermally and dynamically induced atmospheric circulations such as those associated with valley/mountain and land/sea breeze systems, among others. The Almirante \uc1lvaro Alberto Nuclear Complex (CNAAA) is located in this region, with a total of two nuclear power plants (NPPs) in operation in the Brazilian territory, Angra I and Angra II. Therefore, knowledge of local atmospheric circulation has become a matter of national and international security. Considering the importance of the meteorological security tool as a support for licensing, installation, routine operation and nuclear accident mitigation, the main aim of this study is the development of combined strategies of environmental statistical modeling in the analysis of thermally and dynamically driven atmospheric circulations over mountainous and coastal environments. We identified and hierarchized the influence of the thermally and mechanically driven forcing on the wind regime and stability conditions in the coastal atmospheric boundary layer over the complex topography region. A meteorological network of ground-based instruments was used along with physiographic information for the observational characterization of the atmospheric patterns in the spatial and time\u2013frequency domain. The predominant wind directions and intensity are attributed to the combined action of multiscale weather systems, notably, the valley/mountain and continent/ocean breeze circulations, the forced channeling due to valley axis orientation, the influence of the synoptic scale systems and atmospheric thermal tide. The observational investigation of the combined influence of terrain effects and meteorological systems aimed to understand the local atmospheric circulation serves as support for safety protocols of the NPPs, contemplating operation and environmental management. The importance of the study for the adequacy and skill evaluation of computational modeling systems for atmospheric dispersion of pollutants such as radionuclide and conventional contaminants can be also highlighted, in order that such systems are used as tools for environmental planning and managing nuclear operations, particularly those located in regions over mountainous and coastal environments with a heterogeneous atmospheric boundary layer

Divergent clonal selection dominates medulloblastoma at recurrence

The development of targeted anti-cancer therapies through the study of cancer genomes is intended to increase survival rates and decrease treatment-related toxicity. We treated a transposon-driven, functional genomic mouse model of medulloblastoma with 'humanized' in vivo therapy (microneurosurgical tumour resection followed by multi-fractionated, image-guided radiotherapy). Genetic events in recurrent murine medulloblastoma exhibit a very poor overlap with those in matched murine diagnostic samples (<5%). Whole-genome sequencing of 33 pairs of human diagnostic and post-therapy medulloblastomas demonstrated substantial genetic divergence of the dominant clone after therapy (<12% diagnostic events were retained at recurrence). In both mice and humans, the dominant clone at recurrence arose through clonal selection of a pre-existing minor clone present at diagnosis. Targeted therapy is unlikely to be effective in the absence of the target, therefore our results offer a simple, proximal, and remediable explanation for the failure of prior clinical trials of targeted therapy

Risk factors for unfavourable postoperative outcome in patients with Crohn's disease undergoing right hemicolectomy or ileocaecal resection. An international audit by ESCP and S-ECCO

Aim: Patient- and disease-related factors, as well as operation technique, all have the potential to impact on postoperative outcome in Crohn's disease. The available evidence is based on small series and often displays conflicting results. The aim was to investigate the effect of preoperative and intra-operative risk factors on 30-day postoperative outcome in patients undergoing surgery for Crohn's disease. Method: This was an international prospective snapshot audit including consecutive patients undergoing right hemicolectomy or ileocaecal resection. The study analysed a subset of patients who underwent surgery for Crohn's disease. The primary outcome measure was the overall Clavien\u2013Dindo postoperative complication rate. The key secondary outcomes were anastomotic leak, reoperation, surgical site infection and length of stay in hospital. Multivariable binary logistic regression analyses were used to produce odds ratios and 95% confidence intervals. Results: In all, 375 resections in 375 patients were included. The median age was 37 and 57.1% were women. In multivariate analyses, postoperative complications were associated with preoperative parenteral nutrition (OR 2.36, 95% CI 1.10\u20134.97), urgent/expedited surgical intervention (OR 2.00, 95% CI 1.13\u20133.55) and unplanned intra-operative adverse events (OR 2.30, 95% CI 1.20\u20134.45). The postoperative length of stay in hospital was prolonged in patients who received preoperative parenteral nutrition (OR 31, 95% CI 1.08\u20131.61) and those who had urgent/expedited operations (OR 1.21, 95% CI 1.07\u20131.37). Conclusion: Preoperative parenteral nutritional support, urgent/expedited operation and unplanned intra-operative adverse events were associated with unfavourable postoperative outcome. Enhanced preoperative optimization and improved planning of operation pathways and timings may improve outcomes for patients