Effects of attention on a relative mislocalization with successively presented stimuli

Previous studies yielded evidence that the precision, with which stimuli are localized in the visual periphery, is improved under conditions of focused attention. The present study examined whether focused attention is able to correct a mislocalization recently observed with successively presented stimuli: when observers are asked to localize the peripheral position of a briefly presented target with respect to a previously presented comparison stimulus, they tended to judge the target as being more towards the fovea than was its actual position. In three experiments the mislocalization was tested under conditions with focused and distributed attention. Results revealed that the mislocalization increased with distributed attention and disappeared when stimuli appeared consistently at predictable positions and thus under conditions of focused attention. However, when a procedure with a trial-by-trial cueing was applied the mislocalization was only reduced, but not wiped out completely. In a recently developed dynamic field model consisting of interacting excitatory and inhibitory neuronal cell populations the results were explained as an attentional modulation of spontaneous (baseline) levels of neural activity.Fundação para a Ciência e a Tecnologia (FCT)Deutsche Forschungsgemeinschaft - DFG MU 1298/

Vocational and training behaviours of German corporations in Japan, India and China - German models or local procedures?

For many years the possible introduction of the German dual vocational education programme into other countries has been discussed. The transferability of the German vocational education and training system into other countries has been controversially discussed in the work of development assistance and in international comparative vocational education research for a long time, even though the empirical basis is quite narrow. The present study focuses on the vocational and training behaviours of German corporations in their subsidiaries in Japan, China and India. Even though all three nations are important countries for the German corporations the culture, the vocational education and employment systems are very different. Based upon the theory of the EPRG model in international management, this study analyses the vocational education and training activities and in terms of the EPRG model by interviews with experts. The findings indicate that a polycentric approach is used exclusively in India and to a significant extent in China. In Japan, in addition to the prevalent polycentric approach, there is also a strong influence of geocentric training styles. The similarities can be partly explained by the stronger focus on theoretical training institutions and a more academic attitude in society as a whole, which means that purely vocational training plays a marginal role with low esteem. In this context, it would be difficult to implement the German style of vocational education and training

Incidence of Lyme Borreliosis in Germany: A retrospective observational healthcare claims study

Lyme borreliosis (LB) is the most common tick–borne disease in Germany. Although the incidence of LB in Germany has been assessed in several studies, those studies either used data from statutory surveillance, which frequently underreport cases, or data from health claims databases, which may overestimate cases due to non–specific LB case definitions. Here, using a more specific case definition, we describe the incidence of medically–attended LB by disease manifestation, age group, and federal state for the period 2015–2019. Both inpatient and outpatient cases were analyzed from a claims database. To be eligible for inclusion, patients were required to have an LB specific ICD–10 GM diagnosis code plus an antibiotic prescription, and for disseminated manifestations, a laboratory test order additionally. LB cases were classified as erythema migrans (EM), or disseminated disease including Lyme arthritis (LA), Lyme neuroborreliosis (LNB), and all other disease manifestations (OTH). Between 2015 and 2019, the incidence of medically–attended LB cases ranged from 195.7/100,000 population per year (95% confidence interval [CI], 191.0 – 200.5) to 254.5/100,000 population per year (95% CI, 249.0 – 260.0) per year. The majority of cases (92.2%) were EM, while 2.8% presented as LA, 3.8% as LNB, and 1.2% as OTH. For both EM and disseminated disease, the incidence peaked in children aged 5–9 years and in older adults. By federal state, the incidence of medically–attended EM ranged from 74.4/100,000 population per year (95% CI, 71.9 – 77.0) per year in Hamburg, to 394.1/100,000 population per year (95% CI, 370.7 – 417.6) per year in Saxony, whereas for medically–attended disseminated disease, the highest incidence was in Thuringia, Saxony, and Bavaria (range: 22.0 [95% CI, 19.9 – 24.0] to 35.7 [95% CI, 34.7 – 36.7] per 100,000 population per year). This study comprehensively estimated the incidence of all manifestations of medically–attended LB and showed a high incidence of LB throughout Germany. Results from the study support performing epidemiological studies in all federal states to measure the burden of LB and to invest in public health interventions for prevention

Daily Supplementation with 4000 IU Vitamin D3 for Three Years Does Not Modify Cardiovascular Risk Markers in Patients with Advanced Heart Failure: The Effect of Vitamin D on Mortality in Heart Failure Trial

Background/Aims: We aimed to investigate the effect of a moderately high vitamin D dose on lipid parameters and biochemical markers of vascular calcification (VC) in patients with established cardiovascular disease. Methods: We included in this pre-specified secondary analysis of a randomized controlled trial 161 patients with advanced heart failure and 25-hydroxyvitamin D (25OHD) concentrations <75 nmol/L (vitamin D group: n = 80; placebo group: n = 81), who received a daily vitamin D-3 supplement of 4,000 IU for 3 years. We assessed between-group differences of the lipid parameters total-cholesterol, high-density lipoprotein-cholesterol, low-density lipoprotein-cholesterol, and triglycerides, and the VC markers fetuin-A and non-phosphorylated undercarboxylated matrix gla protein (MGP) at study termination, with adjustment for baseline values. Results: Lipid parameters, the percentage of patients with dyslipoproteinemia, and VC markers did not differ significantly between groups at study termination (p values: 0.395-0.939). Like-wise, vitamin D achieved no significant treatment effect on these markers in subgroup analyses in patients with 25OHD concentrations <30 nmol/L, nonusers of lipid-lowering drugs, or diabetic patients (p values: 0.245-0.998). Conclusion: Our data indicate that vitamin D does not improve the lipid profile and does not influence the calcification inhibitors fetuin-A and non-phosphorylated undercarboxylated MGP in patients with advanced heart failure. (C) 2018 S. Karger AG, Base

Vitamin D supplementation does not prevent the testosterone decline in males with advanced heart failure: the EVITA trial

PurposeObservational studies indicate a positive association between circulating 25-hydroxyvitamin D (25OHD) and testosterone (T) concentrations. Because low 25OHD concentrations and T deficiency are considered to be a generalized phenomenon in patients with advanced heart failure (HF), we aimed to investigate whether vitamin D supplementation has beneficial effects on T indices in these patients.MethodsIn a pre-specified secondary analysis of the EVITA (effect of vitamin D on mortality in heart failure) randomized controlled trial, we analyzed in male subjects with 25OHD concentrations<75nmol/L the effect of a daily vitamin D-3 supplement of 4000IU for 3years (n=71) vs. placebo (n=62) on total T (TT), sex hormone-binding globulin (SHBG), free T (fT), and bioactive T (BAT). We assessed changes from baseline until study termination and between-group differences at study termination.Results25OHD increased in the placebo group from 36.6nmol/L by 9.2nmol/L (95% CI 3.2-15.1nmol/L; P=0.003) and in the vitamin D group from 36.5nmol/L by 63.9nmol/L (95% CI 52.6-75.3nmol/L; P<0.001), with a significant between-group difference at study termination (P<0.001). TT and SHBG concentrations did not change significantly, neither in the placebo group nor in the vitamin D group (P=0.845-0.082), but concentrations of fT and BAT declined significantly in both groups (P=0.025-0.008). At study termination, there were no between-group differences in TT (P=0.612), SHBG (P=0.393), fT (P=0.861), or BAT (P=0.960).ConclusionsIn male patients with advanced HF and low 25OHD concentrations, a daily vitamin D-3 supplement of 4000IU for 3years did not prevent the decline in testosterone indices

Effects of Vitamin D Supplementation on Renin and Aldosterone Concentrations in Patients with Advanced Heart Failure: The EVITA Trial

Objective. 1,25-Dihydroxyvitamin D (1,25([OH](2)D) is considered to be a negative endogenous regulator of the renin-angiotensinaldosterone system (RAAS), but the effect of vitamin D supplementation on the RAAS is inconclusive. Design. In this prespecified secondary analysis of a randomized controlled trial, we assessed in 165 patients with heart failure (vitamin D group: n = 83; placebo group: n = 82) the effect of three years of vitamin D supplementation with 4000 IU daily on parameters of the RAAS (renin and aldosterone) and on circulating 1,25(OH)(2)D, plasma phosphate, and fibroblast growth factor (FGF)-23. We assessed age- and baseline-adjusted between-group differences at study termination. Results. Almost all patients were under treatment with beta-blockers, inhibitors of the RAAS, and diuretics. Initially, the frequency of concentrations above the laboratory-specific reference range (renin: >23.9 mIU/L; aldosterone: >232 ng/L) in the vitamin D and placebo group was 87.7% and 92.7%, respectively (renin), and 24.1% and 32.5%, respectively (aldosterone). Vitamin D increased adjusted 1,25(OH)(2)D concentrations significantly (mean treatment effect and 95% CI: 18.3 pmol/L,7.3 to 29.3 pmol/L; P < 0.001) but had no significant effects on phosphate (0.18 mmol/L, -0.00 to 0.35 mmol/L; P = 0.051), FGF-23 (685 RU/mL, -213 to 1585 RU/mL; P = 0.134), renin (312 mIU/L, -279 to 902 ng/L; P = 0.298), or aldosterone (-0.19 ng/L, -5.09 to 4.70 ng/L; P = 0.938). Vitamin D supplementation was, however, associated with an increase in renin concentrations in the subgroup with baseline 25-hydroxyvitamin D below 30 nmol/L (n = 67; 1365 mIU/, 343 to 2386 mIU/L; P = 0.010). Conclusions. In patients with advanced heart failure treated according to evidence-based guidelines, vitamin D supplementation did not significantly influence parameters of the RAAS in the entire study cohort but was associated with an increase in plasma renin concentrations in the subgroup with low baseline 25-hydroxyvitamin D concentrations