“Is This Enough?” Digitizing Liz Lerman Dance Exchange Archives Media

Special Collections in Performing Arts (SCPA) at University of Maryland Libraries collects performing arts materials that preserve performance practice, instruction, and scholarship, including the full scope of audiovisual (AV) formats. The Liz Lerman Dance Exchange Archives at SCPA contains, among common print archival materials, a significant number of AV materials. This collection is examplar of the numerous challenges facing AV digitization and preservation projects in university libraries and archives, including determining metadata standards and best practices, describing at the appropriate level, handling technical and personnel issues, and working with vendors. In this article we outline the decisions made for this project, our ultimate workflow, lessons learned, and future plans

Digital Conversion and Media Reformatting: Management and Production of Digital Collections

The Digital Conversion and Media Reformatting plan was written in 2012 and revised 2013-2014, as a five-year plan for the newly established department at the University of Maryland Libraries under the Digital Systems and Stewardship Division. The plan focuses on increasing digitization production, both in-house and through vendors, and creates a model for the management of this production

Scaling Up Video Digitization at the University of Maryland Libraries: A Case Study

In 2015, a team at the University of Maryland Libraries collaborated on a pilot project to digitize 100 VHS tapes from the Liz Lerman Dance Exchange collection and, in doing so, established organizational workflows for video digitization and access. After completing the pilot phase of the project, staff who worked on the project published a case study in this journal that articulated a question echoed throughout that process: “Is this enough?” Enough descriptive metadata? Enough technical metadata? Enough storage space? This article will reflect on the pilot project, detail how the digitization specifications and workflows established during the pilot project have changed over the intervening years, and how they were scaled-up to digitize and make accessible the remaining videos 1,125 videos in the collection under the auspices of a 2018 National Endowment for the Humanities grant

Using Chronicling America: Genealogy

This brochure can be printed freely.This brochure is to be distributed by institutions, and to be used to assist genealogists in using Chronicling America, the Library of Congress database that hosts newspapers. This brochure was created by the Co-Principal Investigators of the Historic Maryland Newspapers Project, so it has a focus on Maryland newspapers

Audiovisual Alacrity: Managing Timely Access to Audiovisual Collections

Joint presentation given at the Society of American Archivists Conference on August 16, 2014; session 707

Digitization Initiatives Committee Charter

This is the charter of the Digitization Initiatives Committee (DIC) of the University of Maryland Libraries. The committee was established “to collect and document proposed outsourced digitization projects across the UMD Libraries, match these projects with available or proposed fiscal resources, and prioritize the projects...based on available fiscal resources, Libraries strategic initiatives, division priorities, and available staff resources for the specific projects.

University of Maryland Libraries: Digital Preservation Policy

The University of Maryland (UMD) Libraries, in keeping with its mission “To enable the intellectual inquiry and learning required to meet the education, research and community outreach mission of the university,” serves as a trusted caretaker of the UMD Libraries’ collections, including those in digital format. The Digital Preservation Policy supports this mission and is the highest-level digital preservation policy document in the UMD Libraries. The Policy makes explicit the UMD Libraries’ commitment to preserving content selected for retention by collection managers. It defines a comprehensive digital preservation program for both born-analog and born-digital collections. The audience for this policy includes UMD Libraries employees, digital content contributors, donors, and users

The structural basis of lipid scrambling and inactivation in the endoplasmic reticulum scramblase TMEM16K

Membranes in cells have defined distributions of lipids in each leaflet, controlled by lipid scramblases and flip/floppases. However, for some intracellular membranes such as the endoplasmic reticulum (ER) the scramblases have not been identified. Members of the TMEM16 family have either lipid scramblase or chloride channel activity. Although TMEM16K is widely distributed and associated with the neurological disorder autosomal recessive spinocerebellar ataxia type 10 (SCAR10), its location in cells, function and structure are largely uncharacterised. Here we show that TMEM16K is an ER-resident lipid scramblase with a requirement for short chain lipids and calcium for robust activity. Crystal structures of TMEM16K show a scramblase fold, with an open lipid transporting groove. Additional cryo-EM structures reveal extensive conformational changes from the cytoplasmic to the ER side of the membrane, giving a state with a closed lipid permeation pathway. Molecular dynamics simulations showed that the open-groove conformation is necessary for scramblase activity

Dose response of the 16p11.2 distal copy number variant on intracranial volume and basal ganglia.

Carriers of large recurrent copy number variants (CNVs) have a higher risk of developing neurodevelopmental disorders. The 16p11.2 distal CNV predisposes carriers to e.g., autism spectrum disorder and schizophrenia. We compared subcortical brain volumes of 12 16p11.2 distal deletion and 12 duplication carriers to 6882 non-carriers from the large-scale brain Magnetic Resonance Imaging collaboration, ENIGMA-CNV. After stringent CNV calling procedures, and standardized FreeSurfer image analysis, we found negative dose-response associations with copy number on intracranial volume and on regional caudate, pallidum and putamen volumes (β = -0.71 to -1.37; P < 0.0005). In an independent sample, consistent results were obtained, with significant effects in the pallidum (β = -0.95, P = 0.0042). The two data sets combined showed significant negative dose-response for the accumbens, caudate, pallidum, putamen and ICV (P = 0.0032, 8.9 × 10-6, 1.7 × 10-9, 3.5 × 10-12 and 1.0 × 10-4, respectively). Full scale IQ was lower in both deletion and duplication carriers compared to non-carriers. This is the first brain MRI study of the impact of the 16p11.2 distal CNV, and we demonstrate a specific effect on subcortical brain structures, suggesting a neuropathological pattern underlying the neurodevelopmental syndromes

Genetic correlations and genome-wide associations of cortical structure in general population samples of 22824 adults

Cortical thickness, surface area and volumes vary with age and cognitive function, and in neurological and psychiatric diseases. Here we report heritability, genetic correlations and genome-wide associations of these cortical measures across the whole cortex, and in 34 anatomically predefined regions. Our discovery sample comprises 22,824 individuals from 20 cohorts within the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) consortium and the UK Biobank. We identify genetic heterogeneity between cortical measures and brain regions, and 160 genome-wide significant associations pointing to wnt/β-catenin, TGF-β and sonic hedgehog pathways. There is enrichment for genes involved in anthropometric traits, hindbrain development, vascular and neurodegenerative disease and psychiatric conditions. These data are a rich resource for studies of the biological mechanisms behind cortical development and aging