18 research outputs found
Common variants in Alzheimer’s disease and risk stratification by polygenic risk scores
- Author
- Aarsland Dag
- Abdelnour Carla
- Alarcón-Martín Emilio
- Alcolea Daniel
- Alegret Montserrat
- Alvarez Ignacio
- Anastasiou Anna
- Anastasiou Costas
- Andrade Victor
- Antonell Anna
- Antúnez Carmen
- Appollonio Ildebrando
- Arcaro Marina
- Archetti Silvana
- Arias Pastor Alfonso
- Armstrong Nicola J.
- Arosio Beatrice
- Bailly Henri
- Banaj Nerisa
- Baquero Miquel
- Belezhanska Diyana
- Bellenguez Céline
- Benaque Alba
- Benussi Alberto
- Benussi Luisa
- Bernal Sánchez-Arjona María
- Besse Céline
- Bessi Valentina
- Binetti Giuliano
- Bis Joshua C.
- Bizzarro Alessandra
- Blesa Rafael
- Boerwinkle Eric
- Boland Anne
- Borroni Barbara
- Boschi Silvia
- Bossù Paola
- Botne Sando Sigrid
- Buerger Katharina
- Buiza-Rueda Dolores
- Caffarra Paolo
- Calero Miguel
- Castaño Eduardo M.
- Cecchetti Roberta
- Cervera-Carles Laura
- Charbonnier Camille
- Chillotti Caterina
- Chipi Elena
- Chêne Geneviève
- Ciccone Simona
- Clark Christopher
- Conti Elisa
- contributors EADB
- Corbatón-Anchuelo Arturo
- Corma-Gómez Anaïs
- Costantini Emanuele
- Craig David
- Cuesta Carolina
- Custodero Carlo
- Daian Delphine
- Dalmasso Maria Carolina
- Daniele Antonio
- Dardiotis Efthimios
- de Mendonça Alexandre
- De Roeck Ellen
- de Rojas Itziar
- Deckert Jürgen
- del Ser Teodoro
- Deniz-Naranjo M. Candida
- Deramecourt Vincent
- DeStefano Anita L.
- Dichgans Martin
- Diehl-Schmid Janine
- Diez-Fairen Mónica
- Dionigi Rossi Paolo
- Djurovic Srdjan
- Dufouil Carole
- Duron Emmanuelle
- Düzel Emrah
- Engelborghs Sebastiaan
- Escott-Price Valentina
- Esiri Margaret
- Espinosa Ana
- Ewers Michael
- Farotti Lucia
- Farrer Lindsay A.
- Fenoglio Chiara
- Fernández-Fuertes Marta
- Ferrarese Carlo
- Ferrari Camilla
- Ferreira Catarina B.
- Ferri Evelyn
- Fin Bertrand
- Fischer Peter
- Fließbach Klaus
- Fornage Myriam
- Fortea Juan
- Fostinelli Silvia
- Franco-Macías Emilio
- Frank-García Ana
- Frikke-Schmidt Ruth
- Froelich Lutz
- Galimberti Daniela
- García-González Pablo
- García-Madrona Sebastián
- Gelpi Ellen
- Ghidoni Roberta
- Giaccone Giorgio
- Giedraitis Vilmantas
- Giegling Ina
- Gil Silvia
- Goldhardt Oliver
- González-Perez Antonio
- Graff Caroline
- Grande Giulia
- Greco Antonio
- Grenier-Boley Benjamin
- Grimmer Timo
- Grünblatt Edna
- Haapasalo Annakaisa
- Hadjigeorgiou Georgios
- Haines Jonathan L.
- Hampel Harald
- Hanon Oliver
- Hartmann Annette M.
- Hausner Lucrezia
- Heilmann-Heimbach Stefanie
- Helisalmi Seppo
- Heneka Michael T.
- Hernández Isabel
- Herrmann Martin J.
- Hiltunen Mikko
- Hoffmann Per
- Holmans Peter A.
- Holmes Clive
- Hort Jakub
- Huerto Vilas Raquel
- Hulsman Marc
- Hägg Sara
- Ikram M. Arfan
- Ingelsson Martin
- Ingino Carlos
- Janowitz Daniel
- Jansen Iris E.
- Jessen Frank
- Jian Xueqiu
- Joachim Catharine
- Johansson Charlotte
- Jürgen Deckert
- Kalaria Rajesh N.
- Karlsson Ida K.
- Kern Silke
- Kilander Lena
- Kinhult Ståhlbom Anne
- Kivipelto Miia
- Kleineidam Luca
- Kohler Eduardo
- Koivisto Anne
- Kok Almar A. L.
- Kornhuber Johannes
- Kosmidis Mary H.
- Koutsouraki Effrosyni
- Kunkle Brian W.
- Kuulasmaa Teemu
- Küçükali Fahri
- Lage Carmen
- Laske Christoph
- Lauria Alessandra
- Lebouvier Thibaud
- Lehtisalo Jenni
- Lemstra Afina W.
- Lerch Ondrej
- Löwenmark Malin
- MacLeod Catherine
- Macías Juan
- Maier Wolfgang
- Mangialasche Francesca
- Mangone Carlos
- Mann David M.
- Marianthi Arnaoutoglou
- Marshall Rachel
- Martín Montes Angel
- Martínez Rodríguez Carmen
- Martínez Carmen
- Martínez-Larrad María Teresa
- Masullo Carlo
- Mayeux Richard
- McGuinness Bernadette
- Mead Simon
- Meggy Alun
- Mendoza Silvia
- Menéndez-González Manuel
- Molina-Porcel Laura
- Montrreal Laura
- Moreno Fermin
- Moreno-Grau Sonia
- Morgan Kevin
- Muchnik Carolina
- Muñoz-Fernandez Carmen
- Nacmias Benedetta
- Naj Adam C.
- Neary David
- Ngandu Tiia
- Nicolas Gaël
- Nordestgaard Børge G.
- Nöthen Markus M.
- Ortega Gemma
- Ortiz Cecilia
- Padovani Alessandro
- Palacio Dana Lis
- Papenberg Goran
- Parnetti Lucilla
- Pasquier Florence
- Pastor Ana Belén
- Pedersen Nancy L.
- Pericak-Vance Margaret A.
- Peters Oliver
- Pijnenburg Yolande A. L.
- Pineda Juan A.
- Pisanu Claudia
- Polak Thomas
- Politis Daniel G.
- Popp Julius
- Pérez-Cordón Alba
- Quenez Olivier
- Quintela Inés
- Rainero Innocenzo
- Reyes Toso Carlos
- Reynolds Chandra A.
- Richardson Anna
- Riedel-Heller Steffi
- Riederer Peter
- Roberto Natalia
- Rodriguez-Rodriguez Eloy
- Rongve Arvid
- Rosas Allende Irene
- Rosende-Roca Maitée
- Rossi Giacomina
- Royo Jose Luís
- Rubino Elisa
- Rujescu Dan
- Rábano Alberto
- Saenz Aldo
- Sakka Paraskevi
- Saltvedt Ingvild
- Sanabria Ángela
- Sanchez-Garcia Florentino
- Satizabal Claudia L.
- Scamosci Michela
- Scarmeas Nikolaos
- Scarpini Elio
- Scherbaum Norbert
- Scherer Martin
- Schmid Matthias
- Schneider Anja
- Seidu Nazib M.
- Selbæk Geir
- Seripa Davide
- Sims Rebecca
- Skoog Ingmar
- Skrobot Olivia Anna
- Sleegers Kristel
- Smith A. David
- Soininen Hilkka
- Solomon Alina
- Sorbi Sandro
- Sotolongo-Grau Oscar
- Spallazzi Marco
- Spalletta Gianfranco
- Spottke Annika
- Squassina Alessio
- Stringa Najada
- Tagliavini Fabrizio
- Tankard Rick M.
- Tesi Niccolo
- Thomassen Jesper Qvist
- Tremolizzo Lucio
- Tsolaki Magda
- Tybjærg-Hansen Anne
- Ullgren Abbe
- Vacca Alessandro
- Valero Sergi
- Van Broeckhoven Christine
- Van Dongen Jasper
- van Schoor Natasja M.
- Vandenberghe Rik
- Vardy Emma R. L. C.
- Vidal Jean-Sebastien
- Vogelgsang Jonathan
- Vyhnalek Martin
- Wagner Michael
- Wallon David
- Wang Li-San
- Weinhold Leonie
- Wiltfang Jens
- Windle Gill
- Woods Bob
- Yang Qiong
- Yannakoulia Mary
- Zetterberg Henrik
- Zettergren Anna
- Zoia Chiara Paola
- Zulaica Miren
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2021
- Field of study
Funder: Funder: Fundación bancaria ‘La Caixa’ Number: LCF/PR/PR16/51110003 Funder: Grifols SA Number: LCF/PR/PR16/51110003 Funder: European Union/EFPIA Innovative Medicines Initiative Joint Number: 115975 Funder: JPco-fuND FP-829-029 Number: 733051061Genetic discoveries of Alzheimer's disease are the drivers of our understanding, and together with polygenetic risk stratification can contribute towards planning of feasible and efficient preventive and curative clinical trials. We first perform a large genetic association study by merging all available case-control datasets and by-proxy study results (discovery n = 409,435 and validation size n = 58,190). Here, we add six variants associated with Alzheimer's disease risk (near APP, CHRNE, PRKD3/NDUFAF7, PLCG2 and two exonic variants in the SHARPIN gene). Assessment of the polygenic risk score and stratifying by APOE reveal a 4 to 5.5 years difference in median age at onset of Alzheimer's disease patients in APOE ɛ4 carriers. Because of this study, the underlying mechanisms of APP can be studied to refine the amyloid cascade and the polygenic risk score provides a tool to select individuals at high risk of Alzheimer's disease
New insights into the genetic etiology of Alzheimer's disease and related dementias
- Author
- Aarsland Dag
- Abdelnour Carla
- ADGC .
- Ahmad Shahzad
- Alarcón-Martín Emilio
- Alcolea Daniel
- Alegret Montserrat
- Allende Irene Rosas
- Alvarez Ignacio
- Amin Najaf
- Amouyel Philippe
- Andrade Victor
- Andreassen Ole A
- Antúnez Carmen
- Appollonio Ildebrando
- Arcaro Marina
- Archetti Silvana
- Armstrong Nicola J
- Arosio Beatrice
- Athanasiu Lavinia
- Bailly Henri
- Banaj Nerisa
- Baquero Miquel
- Barral Sandra
- Beiser Alexa
- Bellenguez Céline
- Below Jennifer E
- Benchek Penelope
- Benussi Luisa
- Berr Claudine
- Besse Céline
- Bessi Valentina
- Biessels Geert Jan
- Binetti Giuliano
- Bis Joshua C
- Bizarro Alessandra
- Blesa Rafael
- Boada Mercè
- Boerwinkle Eric
- Boland Anne
- Borroni Barbara
- Boschi Silvia
- Bossù Paola
- Bresner Catherine
- Bressler Jan
- Brodaty Henry
- Broeckhoven Christine Van
- Brookes Keeley J
- Brusco Luis Ignacio
- Bråthen Geir
- Buiza-Rueda Dolores
- Bullido María J
- Burholt Vanessa
- Bush William S
- Bûrger Katharina
- Calero Miguel
- Campos-Martin Rafael
- Cantwell Laura B
- Carracedo Ángel
- Cecchetti Roberta
- Cervera-Carles Laura
- Chapuis Julien
- Charbonnier Camille
- CHARGE .
- Chen Hung-Hsin
- Chene Geneviève
- Chillotti Caterina
- Chung Jaeyoon
- Ciccone Simona
- Claassen Jurgen AHR
- Clarimon Jordi
- Clark Christopher
- Conti Elisa
- Corma-Gómez Anaïs
- Costa Marcos R
- Costantini Emanuele
- Cuccaro Michael L
- Custodero Carlo
- Daian Delphine
- Dalmasso Maria Carolina
- Damotte Vincent
- Daniele Antonio
- Dardiotis Efthimios
- Dartigues Jean-François
- de Deyn Peter Paul
- de Mendonça Alexandre
- de Munain Adolfo Lopez
- de Paiva Lopes Katia
- de Rojas Itziar
- de Witte Lot D
- Debette Stéphanie
- Deckert Jürgen
- DEGESCO .
- Del Ser Teodoro
- Deleuze Jean-François
- Demgene .
- Denning Nicola
- DeStefano Anita
- Dichgans Martin
- Diehl-Schmid Janine
- Diez-Fairen Mónica
- Djurovic Srdjan
- Dongen Jasper Van
- Dufouil Carole
- Duron Emmanuelle
- Düzel Emrah
- EADB .
- EADI .
- Eiriksdottir Gudny
- Engelborghs Sebastiaan
- Escott-Price Valentina
- Espinosa Ana
- Ewers Michael
- Faber Kelley M
- Fabrizio Tagliavini
- Fardo David W
- Farotti Lucia
- Farrer Lindsay A
- Fenoglio Chiara
- Fernández-Fuertes Marta
- Ferrari Raffaele
- Ferreira Catarina B
- Ferri Evelyn
- Fin Bertrand
- FinnGen .
- Fischer Peter
- Fladby Tormod
- Fließbach Klaus
- Fongang Bernard
- Fornage Myriam
- Foroud Tatiana M
- Fortea Juan
- Fostinelli Silvia
- Fox Nick C
- Franco-Macías Emlio
- Frank-García Ana
- Frikke-Schmidt Ruth
- Froelich Lutz
- Fulton-Howard Brian
- Galimberti Daniela
- Garcia-Gonzalez Pablo
- Garcia-Madrona Sebastian
- Garcia-Ribas Guillermo
- García-Alberca Jose Maria
- García-González Pablo
- GERAD .
- Ghanbari Mohsen
- Ghidoni Roberta
- Giedraitis Vilmantas
- Giegling Ina
- Giorgio Giaccone
- Goate Alison M
- Goldhardt Oliver
- Gomez-Fonseca Duber
- González-Pérez Antonio
- GR@ACE .
- Graff Caroline
- Grande Giulia
- Green Emma
- Grenier-Boley Benjamin
- Grimmer Timo
- Grunin Michelle
- Grünblatt Edna
- Gudnason Vilmundur
- Guetta-Baranes Tamar
- Haapasalo Annakaisa
- Hadjigeorgiou Georgios
- Haines Jonathan L
- Hamilton-Nelson Kara L
- Hampel Harald
- Hanon Olivier
- Hardy John
- Hartmann Annette M
- Harwood Janet
- Hausner Lucrezia
- Heilmann-Heimbach Stefanie
- Helisalmi Seppo
- Heneka Michael T
- Hernández Isabel
- Herrmann Martin J
- Hiltunen Mikko
- Hoffmann Per
- Holmans Peter A
- Holmes Clive
- Holstege Henne
- Hort Jakub
- Hulsman Marc
- Humphrey Jack
- Ikram M Arfan
- Ingelsson Martin
- Jansen Iris E
- Jessen Frank
- Jian Xueqiu
- Johansson Charlotte
- Juan Pascual Sánchez
- Jun Gyungah R
- Kastumata Yuriko
- Kauwe John
- Kehoe Patrick G
- Kilander Lena
- Kivipelto Miia
- Kleineidam Luca
- Koivisto Anne
- Kornhuber Johannes
- Kosmidis Mary H
- Kuksa Pavel P
- Kukull Walter A
- Kunkle Brian W
- Kuulasmaa Teemu
- Kuzma Amanda B
- Küçükali Fahri
- Lage Carmen
- Lambert Jean-Charles
- Laukka Erika J
- Launer Lenore
- Lauria Alessandra
- Lee Chien-Yueh
- Lehtisalo Jenni
- Lerch Ondrej
- Lleó Alberto
- Longstreth William
- Lopez Oscar
- Love Seth
- Luckcuck Lauren
- Lunetta Kathryn L
- Löwemark Malin
- Ma Yiyi
- MacLeod Catherine A
- Macías Juan
- Maier Wolfgang
- Mangialasche Francesca
- Marquié Marta
- Marshall Rachel
- Martin Eden R
- Masullo Carlo
- Mather Karen
- Mayeux Richard
- Mead Simon
- Mecocci Patrizia
- Medina Miguel
- Meggy Alun
- Mehrabian Shima
- Mendoza Silvia
- Menéndez-González Manuel
- Mir Pablo
- Moebus Susanne
- Mol Merel
- Molina-Porcel Laura
- Montes Angel Martín
- Montrreal Laura
- Morelli Laura
- Moreno Fermin
- Moreno-Grau Sonia
- Morgan Kevin
- Mosley Thomas
- Muchnik Carolina
- Mukherjee Shubhabrata
- Nacmias Benedetta
- Naj Adam C
- Ngandu Tiia
- Nicolas Gael
- Nielsen Sune Fallgaard
- Nordestgaard Børge G
- Nöthen Markus M
- Olaso Robert
- Orellana Adelina
- Orsini Michela
- Ortega Gemma
- Padovani Alessandro
- Paolo Caffarra
- Papenberg Goran
- Parnetti Lucilla
- Pasquier Florence
- Pastor Alfonso Arias
- Pastor Ana Belén
- Pastor Pau
- Peloso Gina
- Pericak-Vance Margaret A
- Pericard Pierre
- Peters Oliver
- Pijnenburg Yolande AL
- Pineda Juan A
- Pisanu Claudia
- Piñol-Ripoll Gerard
- Polak Thomas
- Popp Julius
- Posthuma Danielle
- Priller Josef
- Prokic Ivana
- Psaty Bruce M
- Puerta Raquel
- Pérez-Cordón Alba
- Pérez-Tur Jordi
- Quenez Olivier
- Quintela Inés
- Rainero Innocenzo
- Raj Towfique
- Rajabli Farid
- Ramakers Inez
- Ramirez Alfredo
- Real Luis M
- Reinders Marcel JT
- Reitz Christiane
- Reyes-Dumeyer Dolly
- Ridge Perry
- Riedel-Heller Steffi
- Riederer Peter
- Roberto Natalia
- Rodriguez-Rodriguez Eloy
- Rodríguez Carmen Martínez
- Rongve Arvid
- Rosende-Roca Maitée
- Rossi Giacomina
- Rossi Paolo Dionigi
- Royo Jose Luis
- Rubino Elisa
- Ruiz Agustín
- Rujescu Dan
- Rábano Alberto
- Sachdev Perminder
- Sakka Paraskevi
- Saltvedt Ingvild
- Sanabria Ángela
- Sanchez-Garcia Florentino
- Sando Sigrid B
- Sarnowski Chloé
- Satizabal Claudia L
- Scamosci Michela
- Scarmeas Nikolaos
- Scarpini Elio
- Schellenberg Gerard D
- Scheltens Philip
- Scherbaum Norbert
- Scherer Martin
- Schmid Matthias
- Schneider Anja
- Schott Jonathan M
- Selbæk Geir
- Seripa Davide
- Serrano Manuel
- Seshadri Sudha
- Sha Jin
- Shadrin Alexey A
- Sims Rebecca
- Skrobot Olivia
- Sleegers Kristel
- Slifer Susan
- Snijders Gijsje JL
- Soininen Hilkka
- Solfrizzi Vincenzo
- Solomon Alina
- Song Yeunjoo
- Sorbi Sandro
- Sotolongo-Grau Oscar
- Spallazzi Marco
- Spalletta Gianfranco
- Spottke Annika
- Squassina Alessio
- Stordal Eystein
- Ståhlbom Anne Kinhult
- Sáez María Eugenia
- Sánchez-Arjona María Bernal
- Sánchez-Valle Raquel
- Tartan Juan Pablo
- Tesí Niccolo
- Thalamuthu Anbupalam
- Thomas Tegos
- Thomassen Jesper Qvist
- Tosto Giuseppe
- Traykov Latchezar
- Tremolizzo Lucio
- Tsolaki Anthoula
- Tsolaki Magda
- Tybjærg-Hansen Anne
- Tárraga Lluís
- Uitterlinden Andre
- Ullgren Abbe
- Ulstein Ingun
- Valero Sergi
- Valladares Otto
- van der Flier Wiesje M
- van der Lee Sven J
- van der Lugt Aad
- van Duijn Cornelia M
- van Rooij Jeroen
- van Swieten John
- Vance Jeffery
- Vandenberghe Rik
- Vardarajan Badri N
- Verhey Frans
- Vidal Jean-Sébastien
- Vilas Raquel Huerto
- Vogelgsang Jonathan
- Vyhnalek Martin
- Wagner Michael
- Wallon David
- Wang Li-San
- Wang Ruiqi
- Weinhold Leonie
- Williams Julie
- Wiltfang Jens
- Windle Gill
- Woods Bob
- Yang Qiong
- Yannakoulia Mary
- Yaqub Amber
- Zare Habil
- Zhang Xiaoling
- Zhao Yi
- Zhu Congcong
- Zulaica Miren
- Álvarez Victoria
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/04/2022
- Field of study
Characterization of the genetic landscape of Alzheimer's disease (AD) and related dementias (ADD) provides a unique opportunity for a better understanding of the associated pathophysiological processes. We performed a two-stage genome-wide association study totaling 111,326 clinically diagnosed/'proxy' AD cases and 677,663 controls. We found 75 risk loci, of which 42 were new at the time of analysis. Pathway enrichment analyses confirmed the involvement of amyloid/tau pathways and highlighted microglia implication. Gene prioritization in the new loci identified 31 genes that were suggestive of new genetically associated processes, including the tumor necrosis factor alpha pathway through the linear ubiquitin chain assembly complex. We also built a new genetic risk score associated with the risk of future AD/dementia or progression from mild cognitive impairment to AD/dementia. The improvement in prediction led to a 1.6- to 1.9-fold increase in AD risk from the lowest to the highest decile, in addition to effects of age and the APOE ε4 allele
Common variants in Alzheimer's disease and risk stratification by polygenic risk scores.
- Author
- Aarsland Dag
- Abdelnour C.
- Abdelnour Carla
- Adarmes-Gomez A.D.
- Alarcon-Martin Emilio
- Alcolea Daniel
- Alegret Montserrat
- Alvarez Ignacio
- Alvarez Victoria
- Amouyel Philippe
- Andrade Victor
- Andreassen Ole A.
- Antonell Anna
- Antunez Carmen
- Appollonio Ildebrando
- Arcaro Marina
- Archetti Silvana
- Arias Pastor Alfonso
- Armstrong Nicola J.
- Arosio Beatrice
- Bailly Henri
- Banaj Nerisa
- Baquero Miquel
- Belen Pastor Ana
- Bellenguez Celine
- Benaque Alba
- Benussi Alberto
- Benussi Luisa
- Bernal Sanchez-Arjona Maria
- Bessi Valentina
- Binetti Giuliano
- Bis Joshua C.
- Blennow Kaj
- Blesa Rafael
- Boada Merce
- Boerwinkle Eric
- Borroni Barbara
- Boschi Silvia
- Bossu Paola
- Buerger Katharina
- Buiza-Rueda Dolores
- Bullido Maria J.
- Caffarra Paolo
- Calero Miguel
- Carolina Dalmasso Maria
- Carracedo Angel
- Cecchetti Roberta
- Cervera-Carles Laura
- Charbonnier Camille
- Chene Genevieve
- Chillotti Caterina
- Ciccone Simona
- Clarimon Jordi
- Clark Christopher
- Conti Elisa
- Corbaton-Anchuelo Arturo
- Corma-Gomez Anais
- Dardiotis Efthimios
- de Mendonca Alexandre
- de Rojas Itziar
- Deckert Juergen
- Deckert Jurgen
- del Ser Teodoro
- Deniz-Naranjo M. Candida
- Deramecourt Vincent
- DeStefano Anita L.
- Dichgans Martin
- Diehl-Schmid Janine
- Diez-Fairen Monica
- Djurovic Srdjan
- Duezel Emrah
- Dufouil Carole
- Duron Emmanuelle
- Duzel Emrah
- Engelborghs Sebastiaan
- Escott-Price Valentina
- Esiri Margaret
- Espinosa Ana
- Ewers Michael
- Farotti Lucia
- Farrer Lindsay A.
- Fenoglio Chiara
- Fernandez-Fuertes Marta
- Ferreira Catarina B.
- Ferri Evelyn
- Fischer Peter
- Fliessbach Klaus
- Fornage Myriam
- Fortea Juan
- Fostinelli Silvia
- Franco-Macias Emilio
- Frank-Garcia Ana
- Frikke-Schmidt Ruth
- Froelich Lutz
- Galimberti Daniela
- Garcia-Gonzalez Pablo
- Garcia-Madrona Sebastian
- Garcia-Ribas Guillermo
- Gelpi Ellen
- Ghidoni Roberta
- Giaccone Giorgio
- Giedraitis Vilmantas
- Giegling Ina
- Gil Silvia
- Goldhardt Oliver
- Gonzalez-Perez Antonio
- Graff Caroline
- Grande Giulia
- Grenier-Boley Benjamin
- Grimmer Timo
- Gruenblatt Edna
- Grunblatt Edna
- Haapasalo Annakaisa
- Hadjigeorgiou Georgios
- Haegg Sara
- Hagg Sara
- Haines Jonathan L.
- Hampel Harald
- Hanon Oliver
- Hartmann Annette M.
- Hausner Lucrezia
- Heilmann-Heimbach Stefanie
- Helisalmi Seppo
- Heneka Michael T.
- Hernandez Isabel
- Herrmann Martin J.
- Hiltunen Mikko
- Hoffmann Per
- Holmans Peter A.
- Holmes Clive
- Holstege Henne
- Hort Jakub
- Huerto Vilas Raquel
- Huisman Martijn
- Hulsman Marc
- Ikram M. Arfan
- Ingelsson Martin
- Jansen Iris E.
- Jessen Frank
- Jian Xueqiu
- K\ufc\ue7\ufckali Fahri
- Kalaria Rajesh N.
- Karlsson Ida K.
- Kehoe Patrick Gavin
- Kern Silke
- Kilander Lena
- Kivipelto Miia
- Kleineidam Luca
- Kok Almar A.L.
- Kornhuber Johannes
- Kosmidis Mary H.
- Kunkle Brian W.
- Kuulasmaa Teemu
- Lage Carmen
- Lambert Jean-Charles
- Lebouvier Thibaud
- Lehtisalo Jenni
- Lemstra Afina W.
- Lerch Ondrej
- Lleo Alberto
- Loewenmark Malin
- Lopez de Munain Adolfo
- Lowenmark Malin
- Macias Juan
- Macleod C.
- Maier Wolfgang
- Mangialasche Francesca
- Maria Garcia-Alberca Jose
- Marquie Marta
- Marshall Rachel
- Martin Montes Angel
- Martinez Rodriguez Carmen
- Masullo Carlo
- Mather Karen A.
- Mayeux Richard
- Mead Simon
- Medina Miguel
- Meggy Alun
- Mendoza Silvia
- Menendez-Gonzalez Manuel
- Mir Pablo
- Molina-Porcel Laura
- Montrreal Laura
- Moreno Fermin
- Moreno-Grau Sonia
- Morgan Kevin
- Munoz-Fernandez Carmen
- Nacmias Benedetta
- Naj Adam C.
- Ngandu Tiia
- Nicolas Gael
- Noethen Markus M.
- Nordestgaard Borge G.
- Nothen Markus M.
- Orellana Adelina
- Ortega Gemma
- Padovani Alessandro
- Papenberg Goran
- Parnetti Lucilla
- Pasquier Florence
- Pastor Pau
- Pedersen Nancy L.
- Perez-Cordon Alba
- Perez-Tur Jordi
- Pericak-Vance Margaret A.
- Peters Oliver
- Pijnenburg Yolande A. L.
- Pineda Juan A.
- Pinol-Ripoll Gerard
- Pisanu Claudia
- Polak Thomas
- Popp Julius
- Posthuma Danielle
- Quenez Olivier
- Quintela Ines
- Rabano Alberto
- Rainero Innocenzo
- Ramirez Alfredo
- Real Luis M.
- Reynolds Chandra A.
- Riedel-Heller Steffi
- Riederer Peter
- Roberto Natalia
- Rodriguez-Rodriguez Eloy
- Rongve Arvid
- Rosas Allende Irene
- Rosende-Roca Maitee
- Rossi Giacomina
- Rossi Paolo Dionigi
- Royo Jose Luis
- Rubino Elisa
- Ruiz Agustin
- Rujescu Dan
- Saez Maria Eugenia
- Sakka Paraskevi
- Saltvedt Ingvild
- Sanabria Angela
- Sanchez-Garcia Florentino
- Sanchez-Juan Pascual
- Sanchez-Valle Raquel
- Sando Sigrid Botne
- Satizabal Claudia L.
- Scamosci Michela
- Scarmeas Nikolaos
- Scarpini Elio
- Schellenberg Gerard D.
- Scheltens Philip
- Scherbaum Norbert
- Scherer Martin
- Schmid Matthias
- Schneider Anja
- Seidu Nazib M.
- Selbaek Geir
- Seripa Davide
- Serrano-Rios Manuel
- Seshadri Sudha
- Sims Rebecca
- Skoog Ingmar
- Skrobot Olivia Anna
- Sleegers Kristel
- Smith A. David
- Soininen Hilkka
- Sorbi Sandro
- Sotolongo-Grau Oscar
- Spallazzi Marco
- Spalletta Gianfranco
- Spottke Annika
- Squassina Alessio
- Stahlbom Anne Kinhult
- Stringa Najada
- Tagliavini Fabrizio
- Tankard Rick M.
- Tarraga Lluis
- Teresa Martinez-Larrad Maria
- Tesi Niccolo
- Thomassen Jesper Qvist
- Tremolizzo Lucio
- Tsolaki Magda
- Tybjaerg-Hansen Anne
- Tybjorg-Hansen Anne
- Ullgren Abbe
- Valero Sergi
- Van Broeckhoven Christine
- van der Flier Wiesje M.
- van der Lee Sven J.
- Van Dongen Jasper
- van Duijn Cornelia M.
- van Schoor Natasja M.
- Vandenberghe Rik
- Vidal Jean-Sebastien
- Vogelgsang Jonathan
- Vyhnalek Martin
- Wagner Michael
- Wallon David
- Wang Li-San
- Weinhold Leonie
- Williams Julie
- Wiltfang Jens
- Yang Qiong
- Yannakoulia Mary
- Zetterberg Henrik
- Zettergren Anna
- Zulaica Miren
- Publication venue
- Nat Commun
- Publication date
- 01/01/2021
- Field of study
Funder: Funder: Fundación bancaria ‘La Caixa’ Number: LCF/PR/PR16/51110003 Funder: Grifols SA Number: LCF/PR/PR16/51110003 Funder: European Union/EFPIA Innovative Medicines Initiative Joint Number: 115975 Funder: JPco-fuND FP-829-029 Number: 733051061Genetic discoveries of Alzheimer's disease are the drivers of our understanding, and together with polygenetic risk stratification can contribute towards planning of feasible and efficient preventive and curative clinical trials. We first perform a large genetic association study by merging all available case-control datasets and by-proxy study results (discovery n = 409,435 and validation size n = 58,190). Here, we add six variants associated with Alzheimer's disease risk (near APP, CHRNE, PRKD3/NDUFAF7, PLCG2 and two exonic variants in the SHARPIN gene). Assessment of the polygenic risk score and stratifying by APOE reveal a 4 to 5.5 years difference in median age at onset of Alzheimer's disease patients in APOE ɛ4 carriers. Because of this study, the underlying mechanisms of APP can be studied to refine the amyloid cascade and the polygenic risk score provides a tool to select individuals at high risk of Alzheimer's disease
Multiancestry analysis of the HLA locus in Alzheimer’s and Parkinson’s diseases uncovers a shared adaptive immune response mediated by HLA-DRB1*04 subtypes
- Author
- Aarsland Dag
- Aarsland Dag
- Abdelnour Carla
- Abraham Richard
- Abraham Richard
- Adarmes-Gómez A.D.
- Adarmes-Gómez Ad
- Aguilera N.
- Aguilera Nuria
- Ahmad Shahzad
- Al-Chalabi Ammar
- Al-Chalabi Ammar
- Alarcon E.
- Alarcón-Martín E.
- Alarcón-Martín Emilio
- Alcolea Daniel
- Alegret M.
- Alegret Montserrat
- Alonso M.D.
- Alvarez Ignacio
- Alvarez Victoria
- Ambati Aditya
- Amer-Ferrer G.
- Amin Najaf
- Amouyel Philippe
- Amouyel Philippe
- Amouyel Phillippe
- Anastasiou Anna
- Anastasiou Costas
- Andrade Victor
- Andreassen Ole A.
- Andreassen Ole A.
- Andreassen Ole A.
- Andreoni Simona
- Annuar Azlina Ahmad
- Antequera M.
- Anthoula Tsolaki
- Antikainen Riitta
- Antonell Anna
- Antúnez C.
- Appollonio Ildebrando
- Arcaro Marina
- Archetti Silvana
- Arfan Ikram M.
- Arias Pastor Alfonso
- Ariel Prestia Federico
- Armstrong Nicola J.
- Arosio Beatrice
- Arosio Beatrice
- Assogna Francesca
- Athanasiu Lavinia
- Athanasiu Lavinia
- Au Wing-Lok
- Bahrami Shahram
- Bailly Henri
- Banaj Nerisa
- Baquero M.
- Baquero Miquel
- Bass Nicholas J.
- Bass Nick
- Bastiani Patrizia
- Bayer Anthony
- Becker Tim
- Belezhanska Diyana
- Bellenguez Céline
- Bellenguez Céline
- Bellenguez Céline
- Belloy Michael E.
- Belén Pastor Ana
- Ben-Shlomo Yoav
- Benussi Alberto
- Benussi Luisa
- Benussi Luisa
- Bergh Sverre
- Bernal M.
- Bernardo-Harrington Mateus
- Berr Claudine
- Berr Claudine
- Besse Céline
- Bessi Valentina
- Binetti Giuliano
- Bizarro Alessandra
- Bjerke Maria
- Blennow Kaj
- Blesa R.
- Blesa Rafael
- Boada M.
- Boada M.
- Boada Mercè
- Boada Mercè
- Boecker Henning
- Boland Anne
- Boland Anne
- Borroni Barbara
- Borroni Barbara
- Boschi Silvia
- Bosnes Ingunn
- Bossù Paola
- Brayne Carol
- Brayne Carol
- Bresner Catherine
- Brice Alexis
- Brodaty Henry
- Brookes Keeley J.
- Brown Kristelle
- Brown Kristelle S.
- Bråthen Geir
- Bråthen Geir
- Buendia M.
- Buendia Mar
- Buiza-Rueda D.
- Buiza-Rueda Dolores
- Bullido M.J.
- Bullido María J.
- Bullido María J.
- Burguera J.A.
- Burholt Vanessa
- BÛrger Katharina
- Caffarra Paolo
- Calero M.
- Calero Miguel
- campion Dominique
- Campos-Martin Rafael
- Cano A.
- Carracedo A.
- Carracedo Ángel
- Carrillo F.
- Carrillo F.
- Carrion-Claro M.
- Carrión-Claro M.
- Casajeros M.J.
- Castaño Eduardo M.
- Castillo Morales Atahualpa
- Cañabate P.
- Cañabate Pilar
- Cecchetti Roberta
- Cervera-Carles Laura
- Chan Anne Y.Y.
- Chao Yinxia
- Chapuis Julien
- Charbonnier Camille
- Chen Ling
- Chen Yongping
- Chene Geneviève
- Chew Elaine Guo Yan
- Chillotti Caterina
- Chipi Elena
- Chung Sun Ju
- Ciccone Simona
- Ciullo Valentina
- Claassen Jurgen A.H.R.
- Clarimon Jordi
- Clarimon Jordi
- Clarimon Jordi
- Clarimón J.
- Clark Christopher
- Clarke Robert
- Collinge John
- Collinge John
- Conti Elisa
- Corbatón-Anchuelo A.
- Cores Valeria
- Corma-Gómez Anaïs
- Costa Marcos R
- Costantini Emanuele
- Craig David
- Craig David
- Cruz-Gamero J.M.
- Cuesta Carolina
- Custodero Carlo
- Daian Delphine
- Dalmasso Maria Carolina
- Damotte Vincent
- Damotte Vincent
- Daniele Antonio
- Daniele Antonio
- Dardiotis Efthimios
- Darling Daniel
- Dartigues Jean-Francois
- Dartigues Jean-François
- David Smith A.
- David Smith A.
- Davies Chloe
- de Deyn Peter Paul
- de Mendonça Alexandre
- de Mendonça Alexandre
- de Munain Adolfo Lopez
- de Pancorbo M.M.
- De Roeck Ellen
- de Rojas I.
- de Rojas I.
- de Rojas Itziar
- de Rojas Itziar
- Debette Stéphanie
- Debette Stéphanie
- Deckert Jürgen
- del Ser T.
- del Ser Teodoro
- Del Zompo Maria
- Deleuze Jean-François
- Deleuze Jean-François
- Deloukas Panagiotis
- Deloukas Pangiotis
- den Bussche Hendrik
- Denning Nicola
- Denning Nicola
- Deramecourt Vincent
- Dermecourt Vincent
- Dichgans Martin
- Dichgans Martin
- Dichgans Martin
- Diego S.
- Diego Susana
- Diehl-Schmid Janine
- Diez-Fairen M.
- Diez-Fairen Mónica
- Dionigi Rossi Paolo
- Djurovic Srdjan
- Djurovic Srdjan
- Dolores Alonso María
- Dowzell Kimberley
- Drichel Dmitriy
- Dubois Bruno
- Dufouil Carole
- Dufouil Carole
- Dufouil Carole
- During Emmanuel
- Duron Emmanuelle
- Düzel Emrah
- Düzel Emrah
- Engelborghs Sebastiaan
- Epelbaum Jacques
- Escott-Price Valentina
- Escott-Price Valentina
- Escuela R.
- Escuela R.
- Espinosa A.
- Espinosa Ana
- Etchepareborda Ignacio
- Eugenia Sáez María
- Ewers Michael
- Fabrizio Tagliavini
- Fallgaard Nielsen Sune
- Farotti Lucia
- Fenoglio Chiara
- Fernández-Fuertes Marta
- Ferrarese Carlo
- Ferreira Catarina B
- Ferri Evelyn
- Feulner Thomas
- Fievet Nathalie
- Fievet Nathalie
- Fin Bertrand
- Fischer Peter
- Fisher Elizabeth
- Fladby Tormod
- Fladby Tormod
- Fließbach Klaus
- Foo Jia Nee
- Foo Jia Nee
- Forsell Charlotte
- Fortea J.
- Fortea Juan
- Fostinelli Silvia
- Fox Nick
- Fox Nick C.
- Fox Nick C.
- Franco E.
- Franco-Macías Emlio
- Frank-García A.
- Frank-García Ana
- Frikke-Schmidt Ruth
- Frikke-Schmidt Ruth
- Froelich Lutz
- Frölich Lutz
- Gailhajenet A.
- Gailhajenet Anna
- Galeano Pablo
- Galimberti Daniela
- Galimberti Daniela
- Gan-Or Ziv
- Garcia Madrona S.
- Garcia-Gonzalez Pablo
- Garcia-Madrona Sebastian
- Garcia-Ribas G.
- Garcia-Ribas Guillermo
- Garcia-Ribas Guillermo
- García-Alberca J.M.
- García-Alberca José María
- García-González P.
- García-González Pablo
- García-González Pablo
- Garrote-Espina L.
- Garrote-Espina L.
- Germani Sandra
- Gerrish Amy
- Gerrish Amy
- Ghanbari Mohsen
- Ghidoni Roberta
- Giedraitis Vilmantas
- Giedraitis Vilmantas
- Giegling Ina
- Giegling Ina
- Gill Michael
- Gill Michael
- Gill Michael
- Gim Jungsoo
- Giorgio Giaccone
- Goldhardt Oliver
- Goldhardt Oliver
- González-Péerez A.
- González-Pérez Antonio
- Graff Caroline
- Graff Caroline
- Grande Giulia
- Green Emma
- Greicius Michael D.
- Grenier-Boley Benjamin
- Grenier-Boley Benjamin
- Grenier-Boley Benjamin
- Grimmer Timo
- Grünblatt Edna
- Grünblatt Edna
- Gu Wei
- Guerreiro Rita
- Guetta-Baranes Tamar
- Guitart M.
- Guitart Marina
- Gurling Hugh
- Gwilliam Rhian
- Gwilliam Rhian
- Gómez-Garre P.
- Gómez-Garre P.
- Haapasalo Annakaisa
- Hadjigeorgiou Georgios
- Hampel Harald
- Hampel Harald
- Hannequin Didier
- Hanon Olivier
- Hanon Olivier
- Hanon Olivier
- Hardy John
- Hardy John
- Hardy John
- Harold Denise
- Harold Denise
- Hartmann Annette M.
- Hartmann Annette M.
- Harwood Janet
- Hausner Lucrezia
- Hausner Lucrezia
- He Zihuai
- Heilmann-Heimbach Stefanie
- Heilmann-Heimbach Stefanie
- Helisalmi Seppo
- Heneka Michael T.
- Hernández Isabel
- Herold Christine
- Herrmann Martin J.
- Heun Reinhard
- Heuser Isabella
- Hevilla S.
- Hiltunen Mikko
- Hiltunen Mikko
- Hodges Angela
- Hoffmann Per
- Hoffmann Per
- Hollingworth Paul
- Hollingworth Paul
- Holmans Peter
- Holmans Peter A.
- Holmes Clive
- Holmes Clive
- Holstege Henne
- Holstege Henne
- Hooper Nigel M.
- Hort Jakub
- Hort Jakub
- Huerto Vilas Raquel
- Hulsman Marc
- Hüll Michael
- Ibarria M.
- Ibarria Marta
- Ignacio Bacha Juan
- Ignacio Brusco Luis
- Ikeuchi Takeshi
- Ingelsson Martin
- Ingelsson Martin
- Ingino Carlos
- Jan Biessels Geert
- Janowitz Daniel
- Jansen Iris
- Jansen Iris
- Jeon Beom S.
- Jessen Frank
- Jessen Frank
- Jessen Frank
- Jesús S.
- Jesús S.
- Jiang Lulu
- Johansson Charlotte
- Johnston Janet A.
- Johnston Jarret A.
- Jones Lesley
- Jones Lesley
- Jung Yoo Jin
- Jöckel Karl-Heinz
- Jürgen Deckert
- Kauwe John
- Kehoe Patrick
- Kehoe Patrick G.
- Kehoe Patrick G.
- Kern Silke
- Khor Chiea Chuen
- Kilander Lena
- Kinhult Ståhlbom Anne
- Kivipelto Miia
- Kleineidam Luca
- Klopp Norman
- Kochen Silvia
- Koh Woon-Puay
- Kohler Eduardo
- Kohler Matias
- Koivisto Anne
- Kornhuber Johannes
- Kornhuber Johannes
- Kosmidis Mary H.
- Kuulasmaa Teemu
- Kuulasmaa Teemu
- Kölsch Heike
- Küçükali Fahri
- Küçükali Fahri
- Laatikainen Tiina
- Labrador Espinosa M.A.
- Labrador Ma
- Lacidogna Giordano
- Lacour ndré
- Laczo Jan
- Lafuente A.
- Lafuente Asunción
- Lage C.
- Lage Carmen
- Lage Carmen
- Lambert Jean-Charles
- Lambert Jean-Charles
- Lambert Jean-Charles
- Laske Christoph
- Laukka Erika J
- Lauria Alessandra
- Lawlor Brian
- Lawlor Brian
- Le Guen Yann
- Lee Kun Ho
- Legaz A.
- Lehtisalo Jenni
- Lerch Ondrej
- Lian Michelle M.
- Lian Michelle Mulan
- Lim Jia Lun
- Lim Shen-Yang
- Lin Juei-Jueng
- Lin Ling
- Lindström Jaana
- Lis Palacio Dana
- Lisso Julieta
- Liu Chunfeng
- Liu Jianjun
- Livingston Gill
- Livingston Gill
- Lleó Alberto
- Lleóo A.
- Lord Jenny
- Love Seth
- Love Seth
- Lovestone Simon
- Lovestone Simon
- Luckcuck Lauren
- Luckcuck Lauren
- Luis Royo Jose
- Luo Guo
- Lupton Michelle
- Lupton Michelle
- Luís Royo Jose
- Lynch Aoibhinn
- Lynch Aoibhinn
- Lóopez de Munáin A.
- López-García S.
- López-García Sara
- Löwemark Malin
- Macias J.
- Macias-García D.
- Macias-García D.
- MacLeod Catherine A.
- Macías Juan
- Magda Tsolaki
- Maier Wolfgang
- Maier Wolfgang
- Malik Rainer
- Mangialasche Francesca
- Mangone Carlos
- Mann David
- Mann David
- Manzanares S.
- Mao Chengjie
- Marco Spallazzi
- Maria García-Alberca Jose
- Maroñas O.
- Marquié M.
- Marquié M.
- Marquié Marta
- Marshall Rachel
- Marshall Rachel
- Martín Montes A.
- Martín Montes Angel
- Martín E.
- Martín Elvira
- Martínez Rodríguez Carmen
- Martínez B.
- Martínez C.
- Martínez M.T.
- Martínez V.
- Martínez-Lage Álvarez A.
- Marín M.
- Marín M.
- Marín T.
- Marín-Muñoz J.
- Masullo Carlo
- Masullo Carlo
- Mata Ignacio
- Mather Karen
- Matoska Vaclav
- Mauleón Ana
- Mayhaus Manuel
- Mayo Kevin
- McGuinness Bernadette
- McGuinness Bernadette
- McQuillin Andrew
- McQuillin Andrew
- Mead Simon
- Mead Simon
- Meah Wee-Yang
- Mecocci Patrizia
- Mecocci Patrizia
- Medel Nancy
- Medina M.
- Medina Miguel
- Meggy Alun
- Meggy Alun
- Mehrabian Shima
- Mehrabian Shima
- Mendioroz Iriarte M.
- Mendoza Silvia
- Menéndez-González M.
- Menéndez-González Manuel
- Mignot Emmanuel
- Mir P.
- Mir Pablo
- Mir Pablo
- Miyashita Akinori
- Moebus Susanne
- Moebus Susanne
- Moebus Susanne
- Mok Shi Qi
- Mok Vincent
- Mol Merel
- Molina-Porcel Laura
- Montrreal L.
- Montrreal L.
- Montrreal Laura
- Morelli Laura
- Moreno Fermin
- Moreno Fermin
- Moreno M.
- Moreno Mariona
- Moreno-Grau S.
- Moreno-Grau Sonia
- Morgan Kevin
- Morgan Kevin
- Morizono Takashi
- Morris John
- Muchnik Carolina
- Mummery Catherine
- Möthen Markus M
- Nacmias Benedetta
- Nacmias Benedetta
- Naito Tatsuhiko
- Nash William
- Natunen Teemu
- Ng Ebonne Y.
- Ngandu Tiia
- Nicolas Aude
- Nicolas Gael
- Nicolas Gael
- Niida Shumpei
- Nordestgaard Børge G.
- Nordestgaard Børge G.
- Novack Gisela
- Nuñez-Llaves R.
- Nöthen Markus M.
- O'Donovan Michael
- O'Donovan Michael C.
- Okada Yukinori
- Olaso Robert
- Olivar Natividad
- Olivé C.
- Orellana A.
- Orellana A.
- Orellana Adelina
- Orsini Michela
- Ortega G.
- Ortega Gemma
- Ortiz Cecilia
- Owen Michael
- Owen Michael J.
- Ozaki Kouichi
- Pablo Tartan Juan
- Padovani Alessandro
- Pancho A.
- Pancho Ana
- Paola Zoia Chiara
- Paolo Caffarra
- Papenberg Goran
- Papenberg Goran
- Papma Janne
- Park Hyeonseul
- Parnetti Lucilla
- Parnetti Lucilla
- Parveen Kayenat
- Parveen Kayenat
- Pasquier Florence
- Pasquier Florence
- Pasquier Florence
- Passmore Peter
- Passmore Peter
- Pastor P.
- Pastor Pau
- Pastor Pau
- Patel Yogen
- Pei Zhong
- Peixoto Leal Thiago
- Pelejà E.
- Pelejà Esther
- Peltonen Markku
- Peng Rong
- Pericard Pierre
- Periñán Mt
- Periñán-Tocino T.
- Perneczky Robert
- Peters Oliver
- Peters Oliver
- Pickering-Brown Stuart
- Pijnenburg Yolande A. L.
- Pijnenburg Yolande A.L.
- Pinchler Sabrina
- Pineda J.A.
- Pineda Juan A.
- Pineda-Sánchez R.
- Pineda-Sánchez R.
- Piras Fabrizio
- Piras Federica
- Pisanu Claudia
- Piñol Ripoll G.
- Piñol-Ripoll Gerard
- Piñol-Ripoll Gerard
- Polak Thomas
- Politis Daniel G.
- Popp Julius
- Popp Julius
- Porcel Laura Molina
- Posthuma Danielle
- Powell John
- Powell John F.
- Prakash Kumar-M.
- Preckler S.
- Preckler Silvia
- Priller Josef
- Proitsi Petra
- Proitsi Petra
- Prokic Ivana
- Puerta R.
- Puerta Raquel
- Puerta Raquel
- Péerez Tur J.
- Pérez-Cordon A.
- Pérez-Cordón Alba
- Pérez-Tur Jordi
- Pérez-Tur Jordi
- Quenez Olivier
- Quintela I.
- Quintela Inés
- Qvist Thomassen Jesper
- Rainero Innocenzo
- Rainero Innocenzo
- Ramakers Inez
- Ramakers Inez
- Ramirez Alfredo
- Ramirez Alfredo
- Ramirez Alfredo
- Real de Asúa D.
- Real L.M.
- Real Luis M.
- Real Luis M.
- Reinders Marcel J.T.
- Reyes Toso Carlos
- Riedel-Heller Steffi
- Riedel-Heller Steffi
- Riedel-Heller Steffi
- Riederer Peter
- Riemenschneider Matthias
- Rios Mario
- Ritchie Karen
- Roberto Natalia
- Rodrigo S.
- Rodrigo-Herrero Silvia
- Rodriguez-Rodriguez Eloy
- Rodriguez-Rodriguez Eloy
- Rodríguez-Rodríguez E.
- Rojo Matias
- Rong Zhang Bao
- Rongve Arvid
- Rongve Arvid
- Rosas Allende Irene
- Rosende-Roca M.
- Rosende-Roca Maitée
- Ross Owen A.
- Rossi Giacomina
- Rossi Giacomina
- Rossor Martin
- Rossor Martin
- Roveta Fausto
- Royo J.L.
- Rubino Elisa
- Rubinsztein David C.
- Rubinsztein David C.
- Ruiz A.
- Ruiz A.
- Ruiz Agustín
- Ruiz Agustín
- Rujescu Dan
- Rujescu Dan
- Rujescu Dan
- Ryan Natalie S.
- Ryan Nathalie
- Ráabano A.
- Rábano Alberto
- Sachdev Perminder
- Saenz Aldo
- Sakka Paraskevi
- Sala Gessica
- Saltvedt Ingvild
- Saltvedt Ingvild
- Salvadori Nicola
- Sanabria A.
- Sanabria Ángela
- Sanchez Abalos Mariana
- Sanchez del Valle Díaz R.
- Sanchez-Garcia Florentino
- Sando Sigrid B.
- Sando Sigrid B.
- Sastre Merlín Isabel
- Sastre I.
- Satake Wataru
- Scamosci Michela
- Scarmeas Nikolaos
- Scarmeas Nikolaos
- Scarpini Elio
- Scheltens Philip
- Scheltens Philip
- Scherbaum Norbert
- Scherbaum Norbert
- Scherer Martin
- Scherer Martin
- Schmid Matthias
- Schneider Anja
- Schneider Anja
- Schott Jonathan M.
- Schott Jonathan M.
- Schürmann Britta
- Selbæk Geir
- Selbæk Geir
- Selnes Per
- Sempere Vicente
- Seripa Davide
- Seripa Davide
- Serpente Maria
- Serrano-Rios M.
- Sevillano Zulma
- Shadrin Alexey A.
- Shadrin Alexey A.
- Shang Hui-Fang
- Shaw Christopher E.
- Shaw Christopher E.
- Shi Chang-He
- Shofany Jacob
- Sims Rebecca
- Sims Rebecca
- Sims Rebecca
- Singleton Andrew B.
- Skoog Ingmar
- Skrobot Olivia
- Sleegers Kristel
- Sleegers Kristel
- Soininen Hilkka
- Solfrizzi Vincenzo
- Solfrizzi Vincenzo
- Solis Patricia
- Solomon Alina
- Song Kyuyoung
- Sorbi Sandro
- Sotolongo-Grau O.
- Sotolongo-Grau O.
- Sotolongo-Grau Oscar
- Spalletta Gianfranco
- Spalletta Gianfranco
- Spottke Annika
- Squassina Alessio
- Squassina Alessio
- Stordal Eystein
- Stordal Eystein
- Strandberg Timo
- Sussams Rebecca
- Sáez M.E.
- Sánchez Juan Pascual
- Sánchez-Arjona María Bernal
- Sánchez-Juan P.
- Sánchez-Juan Pascual
- Sánchez-Valle Raquel
- Sánchez-Valle Raquel
- Takalo Mari
- Talyansky Seth D.
- Tan Ai Huey
- Tan Eng-King
- Tan Eng-King
- Tan Louis C.S.
- Tandiono Moses
- Tegos Thomas
- Teipel Stefan
- Teresa Martínez-Larrad María
- Tesí Niccolo
- Teunissen Charlotte
- Thalamuthu Anbupalam
- Thomas Charlene
- Thomas Tegos
- Thomassen Jesper Qvist
- Thonberg Håkan
- Toda Tatsushi
- Todd Stephen
- Todd Stephen
- Traykov Latchezar
- Tremolizzo Lucio
- Tremolizzo Lucio
- Tsolaki Magda
- Tsolaki Magda
- Tuomilehto Jaakko
- Turton James
- Tybjærg-Hansen Anne
- Tzourio Christophe
- Táarraga L.
- Tárraga Lluís
- Uitterlinden Andre
- Ullgren Abbe
- Ulstein Ingun
- Ulstein Ingun
- Uphill James
- Vacca Alessandro
- Valero S.
- Valero S.
- Valero Sergi
- Van Broeckhoven Christine
- van der Flier Wiesje
- van der Flier Wiesje M.
- van der Lee Sven J.
- van der Lugt Aad
- Van Dongen Jasper
- van Duijn Cornelia M.
- Van Duin Cornelia
- van Rooij Jeroen
- van Swieten John
- van Swieten John
- Vandenberghe Rik
- Vardy Emma
- Vargas L.
- Vargas Liliana
- Verhey Frans
- Verhey Frans
- Vicente M.P.
- Vidal Jean-Sébastien
- Vigo-Ortega R.
- Vigo-Ortega R.
- Vivancos L.
- Vogelgsang Jonathan
- Vyhnalek Martin
- Vyhnalek Martin
- Waern Margda
- Wagner Michael
- Wallon David
- Wallon David
- Warden Donald
- Warner Nick
- Warren Jason D.
- Weber Heike
- Weinhold Leonie
- Wichmann H-Erich
- Wilcock Gordon
- Williams Amy
- Williams Julie
- Williams Julie
- Williams Julie
- Wiltfang Jens
- Wiltfang Jens
- Wiltfang Jens
- Windle Gill
- Woods Bob
- Wu Yih-Ru
- Xu Renshi
- Xu Yu-ming
- Yan Yaping
- Yang Jing
- Yannakoulia Mary
- Yaqub Amber
- Yogeshwar Selina Maria
- Yonkova Mihova Kalina
- Yu Eric
- Zetterberg Henrik
- Zettergren Anna
- Zhang Jing
- Zulaica Miren
- Álvarez I.
- Álvarez V.
- Álvarez Victoria
- Publication venue
- National Academy of Sciences
- Publication date
- 29/08/2023
- Field of study
Across multiancestry groups, we analyzed Human Leukocyte Antigen (HLA) associations in over 176,000 individuals with Parkinson’s disease (PD) and Alzheimer’s disease (AD) versus controls. We demonstrate that the two diseases share the same protective association at the HLA locus. HLA-specific fine-mapping showed that hierarchical protective effects of HLA-DRB1*04 subtypes best accounted for the association, strongest with HLA-DRB1*04:04 and HLA-DRB1*04:07, and intermediary with HLA-DRB1*04:01 and HLA-DRB1*04:03. The same signal was associated with decreased neurofibrillary tangles in postmortem brains and was associated with reduced tau levels in cerebrospinal fluid and to a lower extent with increased Aβ42. Protective HLA-DRB1*04 subtypes strongly bound the aggregation-prone tau PHF6 sequence, however only when acetylated at a lysine (K311), a common posttranslational modification central to tau aggregation. An HLA-DRB1*04-mediated adaptive immune response decreases PD and AD risks, potentially by acting against tau, offering the possibility of therapeutic avenues
Surgical treatment of acromioclavicular dislocation associated with midshaft fracture of the ipsilateral clavicle
- Author
- Publication venue
- Universa BV
- Publication date
- 17/02/2019
- Field of study
Acromioclavicular dislocation combined with a midshaft clavicle fracture is a rare traumatic shoulder problem. Various treatment options have been described in literature. We describe a new technique using a hook plate and coracoclavicular sling to replace the ruptured coracoclavicular ligaments in combination with plate osteosynthesis of the clavicle fracture. Furthermore, we provide a short overview of the few cases described in literature and their treatment options.
Differences in structural covariance brain networks between behavioral variant frontotemporal dementia and Alzheimer's disease
- Author
- Agosta
- Andersson
- Anne Hafkemeijer
- Annette A. van den Berg-Huysmans
- Ashburner
- Balthazar
- Beckmann
- Beckmann
- Borroni
- Broe
- Buckner
- Christiane Möller
- Cole
- Damoiseaux
- Douaud
- Dubois
- Elise G. P. Dopper
- Evans
- Farb
- Filippi
- Filippini
- Folstein
- Fornito
- Frederik Barkhof
- Good
- Greicius
- Griffanti
- Hafkemeijer
- Hafkemeijer
- Hafkemeijer
- He
- Hugo Vrenken
- Jafri
- Jenkinson
- Jeroen van der Grond
- John C. van Swieten
- Krueger
- Lize C. Jiskoot
- McKhann
- Montembeault
- Nichols
- Philip Scheltens
- Rabinovici
- Rascovsky
- Ratnavalli
- Reid
- Rombouts
- Rosen
- Rytty
- Seeley
- Seeley
- Segall
- Serge A. R. B. Rombouts
- Smith
- Smith
- Smith
- Smith
- Spreng
- Tijms
- Wiesje M. van der Flier
- Yolande A. L. Pijnenburg
- Zhang
- Zhou
- Zielinski
- Publication venue
- 'Wiley'
- Publication date
- 01/01/2016
- Field of study
Disease‐specific patterns of gray matter atrophy in Alzheimer's disease (AD) and behavioral variant frontotemporal dementia (bvFTD) overlap with distinct structural covariance networks (SCNs) in cognitively healthy controls. This suggests that both types of dementia target specific structural networks. Here, we study SCNs in AD and bvFTD. We used structural magnetic resonance imaging data of 31 AD patients, 24 bvFTD patients, and 30 controls from two centers specialized in dementia. Ten SCNs were defined based on structural covariance of gray matter density using independent component analysis. We studied group differences in SCNs using F‐tests, with Bonferroni corrected t‐tests, adjusted for age, gender, and study center. Associations with cognitive performance were studied using linear regression analyses. Cross‐sectional group differences were found in three SCNs (all P < 0.0025). In bvFTD, we observed decreased anterior cingulate network integrity compared with AD and controls. Patients with AD showed decreased precuneal network integrity compared with bvFTD and controls, and decreased hippocampal network and anterior cingulate network integrity compared with controls. In AD, we found an association between precuneal network integrity and global cognitive performance (P = 0.0043). Our findings show that AD and bvFTD target different SCNs. The comparison of both types of dementia showed decreased precuneal (i.e., default mode) network integrity in AD and decreased anterior cingulate (i.e., salience) network integrity in bvFTD. This confirms the hypothesis that AD and bvFTD have distinct anatomical networks of degeneration and shows that structural covariance gives valuable insights in the understanding of network pathology in dementia
Common variants in Alzheimer’s disease and risk stratification by polygenic risk scores
- Author
- Aarsland Dag
- Abdelnour C.
- Abdelnour Carla
- Adarmes-Gómez A. D.
- Aguilera N.
- Alarcon E.
- Alarcón-Martín E.
- Alarcón-Martín Emilio
- Alcolea Daniel
- Alegret M.
- Alegret Montserrat
- Alonso M. D.
- Alvarez Ignacio
- Amer-Ferrer G.
- Amouyel Philippe
- Anastasiou Anna
- Anastasiou Costas
- Andrade Victor
- Andreassen Ole A.
- Andreoni Simona
- Antequera M.
- Antikainen Riitta
- Antonell Anna
- Antúnez C.
- Antúnez Carmen
- Appollonio Ildebrando
- Arcaro Marina
- Archetti Silvana
- Arias Pastor Alfonso
- Armstrong Nicola J.
- Arosio Beatrice
- Assogna Francesca
- Bacha Juan Ignacio
- Bagnoli Silvia
- Bailly Henri
- Banaj Nerisa
- Baquero M.
- Baquero Miquel
- Bastiani Patrizia
- Belezhanska Diyana
- Bellenguez Céline
- Bellou Eftychia
- Benaque A.
- Benaque Alba
- Bennett K.
- Benussi Alberto
- Benussi Luisa
- Bernal Sánchez-Arjona María
- Bernal M.
- Besse Céline
- Bessi Valentina
- Binetti Giuliano
- Bis Joshua C.
- Bizzarro Alessandra
- Bjerke Maria
- Blennow Kaj
- Blesa R.
- Blesa Rafael
- Boada M.
- Boada M.
- Boada Mercè
- Boecker Henning
- Boerwinkle Eric
- Boland Anne
- Borroni Barbara
- Boschi Silvia
- Bossù Paola
- Botne Sando Sigrid
- Brayne Carol
- Bresner Catherine
- Brusco Luis Ignacio
- Buendia M.
- Buerger Katharina
- Buiza-Rueda D.
- Buiza-Rueda D.
- Bullido M. J.
- Bullido María J.
- Burguera J. A.
- Burholt Vanessa
- Caffarra Paolo
- Calero M.
- Calero Miguel
- Carracedo A.
- Carracedo Ángel
- Carrillo F.
- Carrión-Claro M.
- Casajeros M. J.
- Castaño Eduardo M.
- Cañabate P.
- Cecchetti Roberta
- Cervera-Carles Laura
- Charbonnier Camille
- Chillotti Caterina
- Chipi Elena
- Chêne Geneviève
- Ciccone Simona
- Ciullo Valentina
- Clare Linda
- Clarimón Jordi
- Clarimón Jordi
- Clark Christopher
- Conti Elisa
- Corbatón-Anchuelo A.
- Corbatón-Anchuelo Arturo
- Cores Valeria
- Corma-Gómez Anaïs
- Costantini Emanuele
- Craig David
- Cruz-Gamero J. M.
- Cuesta Carolina
- Custodero Carlo
- Daian Delphine
- Dalmasso Maria Carolina
- Daniele Antonio
- Dardiotis Efthimios
- de Mendonça Alexandre
- de Pancorbo M. M.
- De Roeck Ellen
- de Rojas I.
- de Rojas I.
- de Rojas Itziar
- Deckert Jürgen
- del Ser T.
- del Ser Teodoro
- Del Zompo Maria
- Deleuze Jean François
- Deniz-Naranjo M. Candida
- Deramecourt Vincent
- DeStefano Anita L.
- Dichgans Martin
- Diego S.
- Diehl-Schmid Janine
- Diez-Fairen M.
- Diez-Fairen Mónica
- Dionigi Rossi Paolo
- Djurovic Srdjan
- Dufouil Carole
- Duron Emmanuelle
- Düzel Emrah
- Engelborghs Sebastiaan
- Escott-Price Valentina
- Escuela R.
- Esiri Margaret
- Espinosa A.
- Espinosa Ana
- Etchepareborda Ignacio
- Ewers Michael
- Farotti Lucia
- Farrer Lindsay A.
- Fenoglio Chiara
- Fernández-Fuertes Marta
- Ferrarese Carlo
- Ferrari Camilla
- Ferreira Catarina B.
- Ferri Evelyn
- Fin Bertrand
- Fischer Peter
- Fließbach Klaus
- Fornage Myriam
- Fortea J.
- Fortea Juan
- Fostinelli Silvia
- Fox Nick C.
- Franco-Macías E.
- Franco-Macías Emilio
- Frank-García A.
- Frank-García A.
- Frikke-Schmidt Ruth
- Froelich Lutz
- Gailhajenet A.
- Galeano Pablo
- Galimberti Daniela
- Garcia Madrona S.
- Garcia-Ribas Guillermo
- Garcia-Ribas Guillermo
- García-Alberca J. M.
- García-Alberca Jose María
- García-González P.
- García-González Pablo
- García-Madrona Sebastián
- Garrote-Espina L.
- Gelpi Ellen
- Germani Sandra
- Ghidoni Roberta
- Giaccone Giorgio
- Giedraitis Vilmantas
- Giegling Ina
- Gil S.
- Gil Silvia
- Goldhardt Oliver
- González-Perez Antonio
- González-Pérez A.
- Graff Caroline
- Grande Giulia
- Greco Antonio
- Grenier-Boley Benjamin
- Grimmer Timo
- Grozeva Detelina
- Grünblatt Edna
- Guitart M.
- Gómez-Garre P.
- Haapasalo Annakaisa
- Hadjigeorgiou Georgios
- Haines Jonathan L.
- Hampel Harald
- Hanon Oliver
- Harris Jenny
- Hartmann Annette M.
- Harwood Janet
- Hausner Lucrezia
- Heilmann-Heimbach Stefanie
- Helisalmi Seppo
- Heneka Michael T.
- Hernández I.
- Hernández I.
- Hernández I.
- Herrman Martin J.
- Herrmann Martin J.
- Heun Reinhard
- Hevilla S.
- Hiltunen Mikko
- Hoffmann Per
- Holmans Peter A.
- Holmes Clive
- Holstege Henne
- Hooper Nigel M.
- Hort Jakub
- Huerto Vilas Raquel
- Huisman Martijn
- Hulsman Marc
- Hägg Sara
- Ibarria M.
- Ikram M. Arfan
- Ingelsson Martin
- Ingino Carlos
- Janowitz Daniel
- Jansen Iris E.
- Jansen Iris E.
- Jessen Frank
- Jesús S.
- Jian Xueqiu
- Joachim Catharine
- Johansson Charlotte
- Johnston Janet
- Jones Matthew
- Jürgen Deckert
- Kalaria Rajesh N.
- Karlsson Ida K.
- Kehoe Patrick Gavin
- Kern Silke
- Kilander Lena
- Kinhult Ståhlbom Anne
- Kivipelto Miia
- Kleineidam Luca
- Kochen Silvia
- Kohler Eduardo
- Kohler Matias
- Koivisto Anne
- Kok Almar A.L.
- Kornhuber Johannes
- Kosmidis Mary H.
- Kosmidis Mary H.
- Koutsouraki Effrosyni
- Kunkle Brian W.
- Kuulasmaa Teemu
- Kölsch Heike
- Küçükali Fahri
- Laatikainen Tiina
- Labrador Espinosa M. A.
- Lacidogna Giordano
- Laczo Jan
- Lafuente A.
- Lage C.
- Lage Carmen
- Lambert Jean Charles
- Laske Christoph
- Lauria Alessandra
- Lebouvier Thibaud
- Legaz A.
- Lehtisalo Jenni
- Lemstra Afina W.
- Leonenko Ganna
- Lerch Ondrej
- Lindström Jaana
- Lisetti Viviana
- Lisso Julieta
- Lleó A.
- Lleó Alberto
- Lopez de Munain A.
- Lopez de Munain Adolfo
- Love Seth
- Luckuck Lauren
- López-García S.
- López-García Sara
- Löwenmark Malin
- Macias J.
- Macias-García D.
- Macleod C.
- Macías Juan
- Maier Wolfgang
- Mangialasche Francesca
- Mangone Carlos
- Mann David M.
- Manzanares S.
- Marianthi Arnaoutoglou
- Maroñas O.
- Marquié M.
- Marquié M.
- Marquié Marta
- Marshall Rachel
- Martín Montes A.
- Martín Montes Angel
- Martín E.
- Martínez Rodríguez Carmen
- Martínez B.
- Martínez C.
- Martínez Carmen
- Martínez M. T.
- Martínez V.
- Martínez-Lage Álvarez P.
- Martínez-Larrad María Teresa
- Marín M.
- Marín T.
- Marín-Muñoz J.
- Masullo Carlo
- Mather Karen A.
- Matoska Vaclav
- Matthews F.
- Mauleón A.
- Mayeux Richard
- McCracken C.
- McGuinness Bernadette
- Mead Simon
- Mecocci Patrizia
- Medel Nancy
- Medina M.
- Medina Miguel
- Meggy Alun
- Mehrabian Shima
- Mendioroz Iriarte M.
- Mendoza Silvia
- Menzies Georgina
- Menéndez-González M.
- Menéndez-González M.
- Mihova Kalina Yonkova
- Mir P.
- Mir Pablo
- Molina-Porcel Laura
- Molinuevo J. L.
- Montrreal L.
- Montrreal Laura
- Morelli Laura
- Moreno Fermin
- Moreno M.
- Moreno-Grau S.
- Moreno-Grau S.
- Morgan Kevin
- Muchnik Carolina
- Muñoz-Fernandez Carmen
- Nacmias Benedetta
- Naj Adam C.
- Natunen Teemu
- Neary David
- Ngandu Tiia
- Nicolas Gaël
- Nordestgaard Børge G.
- Novack Gisela
- Nöthen Markus M.
- Olaso Robert
- Olivar Natividad
- Orellana A.
- Orellana Adelina
- Orsini Michela
- Ortega G.
- Ortega Gemma
- Ortiz Cecilia
- Padovani Alessandro
- Palacio Dana Lis
- Pancho A.
- Papenberg Goran
- Parnetti Lucilla
- Pasquier Florence
- Passmore Peter
- Pastor Ana Belén
- Pastor P.
- Pastor Pau
- Pedersen Nancy L.
- Pelejá E.
- Peltonen Markku
- Pericak-Vance Margaret A.
- Periñán-Tocino T.
- Perneczky Robert
- Peters Oliver
- Phillips Judith
- Piaceri Irene
- Pickering-Brown Stuart
- Pijnenburg Yolande A.L.
- Pineda J. A.
- Pineda Juan A.
- Pineda-Sanchez R.
- Piras Fabrizio
- Piras Federica
- Pisanu Claudia
- Piñol-Ripoll G.
- Piñol-Ripoll Gerard
- Polak Thomas
- Politis Daniel G.
- Polvikoski Tuomo M.
- Popp Julius
- Posthuma Danielle
- Preckler S.
- Prestia Federico Ariel
- Priller Josef
- Pérez Tur J.
- Pérez-Cordon A.
- Pérez-Cordón Alba
- Pérez-Tur Jordi
- Quenez Olivier
- Quintela I.
- Quintela I.
- Rainer Malik
- Rainero Innocenzo
- Ramirez Alfredo
- Real de Asúa D.
- Real Luis M.
- Real Luis M.
- Reyes Toso Carlos
- Reynolds Chandra A.
- Richardson Anna
- Riedel-Heller Steffi
- Riederer Peter
- Rios Mario
- Roberto Natalia
- Rodrigo S.
- Rodriguez-Rodriguez Eloy
- Rodríguez-Rodríguez E.
- Rojo Matias
- Rongve Arvid
- Rongve Arvid
- Rosas Allende Irene
- Rosende-Roca M.
- Rosende-Roca Maitée
- Rossi Giacomina
- Roveta Fausto
- Royo J. L.
- Royo Jose Luís
- Rubino Elisa
- Ruiz A.
- Ruiz A.
- Ruiz Agustín
- Rujescu Dan
- Rábano A.
- Rábano A.
- Saad Salha
- Saenz Aldo
- Sakka Paraskevi
- Sala Gessica
- Salani Francesca
- Saltvedt Ingvild
- Salvadori Nicola
- Sanabria A.
- Sanabria Ángela
- Sanchez Abalos Mariana
- Sanchez del Valle Díaz R.
- Sanchez-Garcia Florentino
- Sastre I.
- Satizabal Claudia L.
- Scamosci Michela
- Scarmeas Nikolaos
- Scarpini Elio
- Schellenberg Gerard D.
- Scheltens Philip
- Scherbaum Norbert
- Scherer Martin
- Schmid Matthias
- Schneider Anja
- Schott Jonathan M.
- Seidu Nazib M.
- Selbæk Geir
- Seripa Davide
- Serpente Maria
- Serrano-Rios M.
- Serrano-Ríos Manuel
- Seshadri Sudha
- Sevillano Zulma
- Sims Rebecca
- Skoog Ingmar
- Skrobot Olivia Anna
- Sleegers Kristel
- Smith A. David
- Snowden Julie
- Soininen Hilkka
- Solfrizzi Vincenzo
- Solis Patricia
- Solomon Alina
- Sommerville Ewen W.
- Sorbi Sandro
- Sotolongo-Grau O.
- Sotolongo-Grau Oscar
- Spallazzi Marco
- Spalletta Gianfranco
- Spottke Annika
- Squassina Alessio
- Strandberg Timo
- Stringa Najada
- Sáez M. E.
- Sáez María Eugenia
- Sánchez-Juan P.
- Sánchez-Juan Pascual
- Sánchez-Valle Raquel
- Tagliavini Fabrizio
- Takalo Mari
- Tankard Rick M.
- Tegos Thomas
- Teipel Stefan
- Tesi Niccolo
- Thomassen Jesper Qvist
- Thonberg Håkan
- Todd Stephen
- Traykov Latchezar
- Tremolizzo Lucio
- Tsolaki Magda
- Tuomilehto Jaakko
- Tybjærg-Hansen Anne
- Tárraga L.
- Tárraga Lluís
- Ullgren Abbe
- Vacca Alessandro
- Valero S.
- Valero S.
- Valero Sergi
- Van Broeckhoven Christine
- van der Flier Wiesje M.
- van der Lee Sven J.
- Van Dongen Jasper
- van Duijn Cornelia M.
- van Schoor Natasja M.
- Vandenberghe Rik
- Vardy Emma R.L.C.
- Vargas L.
- Vicente M. P.
- Vidal Jean Sebastien
- Vigo-Ortega R.
- Vivancos L.
- Vogelgsang Jonathan
- Vyhnalek Martin
- Wagner Michael
- Wallon David
- Wang Li San
- Weber Heike
- Weinhold Leonie
- Wilcock Gordon
- Williams Julie
- Wiltfang Jens
- Windle Gill
- Woods Robert
- Yang Qiong
- Yannakoulia Mary
- Zetterberg Henrik
- Zettergren Anna
- Zoia Chiara Paola
- Zulaica Miren
- Álvarez I.
- Álvarez V.
- Álvarez Victoria
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 07/06/2021
- Field of study
Genetic discoveries of Alzheimer’s disease are the drivers of our understanding, and together with polygenetic risk stratification can contribute towards planning of feasible and efficient preventive and curative clinical trials. We first perform a large genetic association study by merging all available case-control datasets and by-proxy study results (discovery n = 409,435 and validation size n = 58,190). Here, we add six variants associated with Alzheimer’s disease risk (near APP, CHRNE, PRKD3/NDUFAF7, PLCG2 and two exonic variants in the SHARPIN gene). Assessment of the polygenic risk score and stratifying by APOE reveal a 4 to 5.5 years difference in median age at onset of Alzheimer’s disease patients in APOE ɛ4 carriers. Because of this study, the underlying mechanisms of APP can be studied to refine the amyloid cascade and the polygenic risk score provides a tool to select individuals at high risk of Alzheimer’s disease
New insights into the genetic etiology of Alzheimer’s disease and related dementias
- Author
- A David Smith
- Aaltonen L.
- Aaltonen V.
- Aarno Palotie
- Aarsland D.
- Aavikko M.
- Abalos M. S.
- Abdelnour C.
- Abner E.
- Abraham R.
- Ad Adarmes-Gómez
- Adam Boxer
- Adam Ziemann
- Adams H.
- Adams P. M.
- Adarmes-Gómez A.
- Adarmes-Gómez A. D.
- Adriana Gamboa
- Adrienne L Cupples
- Adrienne Tin
- Aguilera N.
- Aguilera N.
- Aguirre A.
- Agustina Legaz
- Ahmad S.
- Aimee Pierce
- Aino Salminen
- Airi Jussila
- Aisha Khaleeq
- Aki Havulinna
- Akinyemi R. O.
- Al-Chalabi A.
- Alan B Stevens
- Alan Lerner
- Alarcón-Martín E.
- Albert M. S.
- Alberto Benussi
- Albin R. L.
- Alcolea D.
- Aldo Saenz
- Alegret M.
- Alessandra Chesi
- Alessandro Vacca
- Alexander Teumer
- Alexis Brice
- Ali M.
- Alisa Manning
- Alison E Fohner
- Allan I Levey
- Allen M.
- Allende I. R.
- Alonso M. D.
- Alonso M. D.
- Alvarez I.
- Alvarez L.
- Alvin Thomas
- Alyssa Aguirre
- Amanda Cano
- Amanda Elliott
- Amanda G Smith
- Amanda J Myers
- Amer-Ferrer G.
- Amin N.
- Ammar Al-Chalabi
- Amouyel P.
- Amy Gerrish
- Amy Williams
- Ana Mauleón
- Ana Pancho
- Anastasia Shcherban
- Anastasiou A.
- Anastasiou C.
- Anders Malarstig
- Andrade V.
- Andrea Ganna
- Andreassen O. A.
- Andreoni S.
- Andrew J Saykin
- Andrew McQuillin
- Andrew N McDavid
- Andrew P Lieberman
- Andrew Peterson
- Andrey Loboda
- André Lacour
- Angela Hodges
- Aniket Mishra
- Ann C McKee
- Anna Anastasiou
- Anna Antonell
- Anna Gailhajenet
- Anna M Karydas
- Anna Podgornaia
- Anne Lehtonen
- Anne Pitkäranta
- Anne Remes
- Annette Fitzpatrick
- Annika Auranen
- Antequera M.
- Anthony Bayer
- Anthony Muslin
- Antikainen R.
- Antonell A.
- Antti Karlsson
- Antti Palomäki
- Anttonen V.
- Antúnez C.
- Anu Jalanko
- Anu Loukola
- Aoibhinn Lynch
- Aparicio H. J.
- Aparna Chhibber
- Apinya Lertratanakul
- Apostolova L. G.
- Appollonio I.
- Arcaro M.
- Archetti S.
- Arjun Masurkar
- Armstrong N.
- Armstrong N. J.
- Arnold S. E.
- Arosio B.
- Arto Lehisto
- Arto Lehistö
- Arto Mannermaa
- Arvas M.
- Ashok Raj
- Assogna F.
- Asthana S.
- Astrid D Adarmes-Gómez
- Asunción Lafuente
- Atahualpa Castillo Morales
- Athanasiu L.
- Athena Matakidou
- Atwood C. S.
- Audrey Chu
- Auge F.
- Auranen A.
- Auvinen P.
- Awaisa G.
- Ayres G.
- Bacha J. I.
- Bahadori M.
- Bahrami S.
- Bailly H.
- Baldwin C. T.
- Banaj N.
- Baquero M.
- Barbara Davis
- Barber R. C.
- Barnes L. L.
- Barral S.
- Barral S.
- Barry Reisberg
- Bass N.
- Bass N. J.
- Bastiani P.
- Bayer A.
- Beach T. G.
- Becker J. T.
- Becker J. T.
- Becker T.
- Beecham G. W.
- Beekly D.
- Begoña Martínez
- Behrens T.
- Beiser A.
- Belezhanska D.
- Bellenguez C.
- Below J. E.
- Below J. E.
- Ben Challis
- Ben-Shlomo Y.
- Benchek P.
- Benitez B. A.
- Benjamin Williams
- Bennett D.
- Benussi A.
- Benussi L.
- Bergh S.
- Bernadette McGuinness
- Bernard Mazoyer
- Bernardino Ghetti
- Bernardo-Harrington M.
- Berr C.
- Bertelson J.
- Beryl Cummings
- Besse C.
- Bessi V.
- Beth A Dombroski
- Betts J.
- Bhangale T.
- Biessels G. J.
- Binetti G.
- Bing N.
- Bird T. D.
- Bis J. C.
- Biswas S.
- Bizarro A.
- Bjerke M.
- Blacker D.
- Blesa R.
- Blomster T.
- Boada M.
- Bob Georgantas
- Boecker H.
- Boerwinkle E.
- Boeve B. F.
- Boland A.
- Borroni B.
- Boschi S.
- Bosnes I.
- Bossù P.
- Bowen J. D.
- Bowers N.
- Boxer A.
- Bradley F Boeve
- Bradley T Hyman
- Brauer M.
- Brayne C.
- Brein G.
- Bresner C.
- Bressler J.
- Breteler M.
- Brewer J.
- Brian Fulton-Howard
- Brian Lawlor
- Brice A.
- Bridget Riley-Gillis
- Britta Schürmann
- Brodaty H.
- Broeckhoven C. V.
- Bronson P.
- Brookes K. J.
- Brown K.
- Brown K. S.
- Bruce L Miller
- Bruno A Benitez
- Bruno Dubois
- Brusco L. I.
- Bråthen G.
- Buendia M.
- Buiza-Rueda D.
- Bullido M. J.
- Burguera J. A.
- Burholt V.
- Burke J. R.
- Burns J. M.
- Bush W. S.
- Bush W. S.
- Buxbaum J. D.
- Bûrger K.
- C Dirk Keene
- Cairns N. J.
- Calero M.
- Caliskan M.
- Call K.
- Call K.
- campion D.
- Campos-Martin R.
- Cano A.
- Cantwell L. B.
- Cao C.
- Carlo Ferrarese
- Carlos Cruchaga
- Carlos Ingino
- Carlos Mangone
- Carlos Reyes Toso
- Carlson C. S.
- Carlsson C. M.
- Carmen Lage
- Carney R. M.
- Carol A Miller
- Carol Brayne
- Carolina Cuesta
- Caroline Fox
- Carpén O.
- Carracedo Á.
- Carrasquillo M. M.
- Carrillo F.
- Carrillo F.
- Carrion-Claro M.
- Casajeros M. J.
- Castaño E. M.
- Catherine Marshall
- Catherine Mummery
- Cañabate P.
- Cecchetti R.
- Cecilia Ortiz
- Cervera-Carles L.
- Challis B.
- Chang D.
- Chang-En Yu
- Chapuis J.
- Charbonnier C.
- Charlene Thomas
- Charles DeCarli
- Charles S DeCarli
- Charlotte Forsell
- Chasman D.
- Chasse S.
- Chatelain C.
- Chauhan G.
- Chen C. -Y.
- Chen H.
- Chen H.
- Chen H. -H.
- Chen X.
- Chene G.
- Chesi A.
- Chesselet M. -F.
- Chhibber A.
- Chia-Yen Chen
- Chiara Paola Zoia
- Chien-Yueh Lee
- Chillotti C.
- Chin N. A.
- Chipi E.
- Chloe Davies
- Choy D.
- Christine Herold
- Christine M Hulette
- Christoph Laske
- Christophe Tzourio
- Christopher E Shaw
- Christopher S Carlson
- Christopher Whelan
- Chu A.
- Chuang-Kuo Wu
- Chuanhai Cao
- Chui H. C.
- Chung J.
- Chung J.
- Ciccone S.
- Ciullo V.
- Claassen J. A. H. R.
- Clarence Wang
- Clarimon J.
- Clark C.
- Clarke R.
- Clement Chatelain
- Clinton B Wright
- Clinton T Baldwin
- Close D.
- Clàudia Olivé
- Collinge J.
- Comic H.
- Constantine G Lyketsos
- Conti E.
- Cores V.
- Corma-Gómez A.
- Costa M. R.
- Costantini E.
- Costas Anastasiou
- Cox S.
- Craft S.
- Craig D.
- Craig S Atwood
- Crane P. K.
- Cribbs D. H.
- Crocco E. A.
- Crohns M.
- Cruchaga C.
- Csilla Sipeky
- Cuccaro M. L.
- Cuesta C.
- Cullum M.
- Cummings B.
- Cupples A. L.
- Custodero C.
- Cynthia M Carlsson
- D Macias-García
- Daian D.
- Dalmasso M. C.
- Daly M.
- Damotte V.
- Dan Liu
- Dana Lis Palacio
- Daniel C Marson
- Daniel Chasman
- Daniel G Politis
- Daniel H Geschwind
- Daniel Janowitz
- Daniel Macias-García
- Daniele A.
- Danjuma Quarless
- Danny Oh
- Darby E.
- Dardiotis E.
- Dartigues J. -F.
- David Bennett
- David C Rubinsztein
- David Choy
- David Close
- David Craig
- David H Cribbs
- David Mann
- David Paydarfar
- David Pulford
- David Rice
- David Sultzer
- Davies C.
- Davies G.
- Davis B.
- Davis J. W.
- Dawn Waterworth
- de Deyn P. P.
- De Jager P. L.
- de Mendonça A.
- de Munain A. L.
- de Paiva Lopes K.
- de Rojas I.
- de Witte L. D.
- Debby W Tsuang
- Debette S.
- Debora Melo van Lent
- Deborah Blacker
- Deborah C Mash
- DeCarli C.
- DeCarli C. S.
- Deckert J.
- Deepak Rajpal
- del Ser T.
- Deleuze J. -F.
- della Briotta Parola P.
- della Briotta Parolo P.
- Deloukas P.
- Deloukas P.
- Denis A Evans
- Denise Harold
- Denning N.
- Dennis W Dickson
- Deramecourt V.
- Deramerourt V.
- DeStefano A.
- DeToledo J.
- Dhanaprakash Jambulingam
- Diana Chang
- Dichgans M.
- Dick M.
- Dickson D. W.
- Didier Hannequin
- Diego Real de Asúa
- Diego S.
- Diehl-Schmid J.
- Diez-Fairen M.
- Dina Vojinovic
- Diogo D.
- Diptee Kulkarni
- Diyana Belezhanska
- Djurovic S.
- Dmitriy Drichel
- Dombroski B. A.
- Dominique Campion
- Donald R Royall
- Donald Warden
- Dongen J. V.
- Dongyu Liu
- Donner K.
- Doody R. S.
- Dorothee Diogo
- Douglas Mains
- Douglas R Galasko
- Dowzell K.
- Drichel D.
- Duane Beekly
- Duara R.
- Dubois B.
- Dufouil C.
- Duperron M. -G.
- Dupuis J.
- Duron E.
- Dylan Williams
- Düzel E.
- Eaton S.
- Edith Hofer
- Edmond Teng
- Eduardo Kohler
- Eduardo M Castaño
- Edward B Lee
- Edwin S Monuki
- Eeva Kangasniemi
- Eeva Sliz
- Ehm M.
- Eicher J.
- Eija Laakkonen
- Eiriksdottir G.
- Ekaterina Rogaeva
- Eklund K.
- Elaine Peskind
- Elena Chipi
- Elenius K.
- Eleonor Wigmore
- Elhaj Mohammed
- Eliezer Masliah
- Elina Järvensivu
- Elina Kilpeläinen
- Elizabeth A Crocco
- Elizabeth Fisher
- Elizabeth Head
- Elizabeth Litkowski
- Ellen De Roeck
- Ellen M Wijsman
- Ellen Tsai
- Elliot Hong
- Elliot Tucker-Drob
- Elliott A.
- Elmutaz Shaikho
- Elvira Martín
- Emily Holzinger
- Emma Vardy
- Engelborghs S.
- Epelbaum J.
- Eric B Larson
- Eric M Reiman
- Erich Strauss
- Erik D Roberson
- Erika Kvikstad
- Erin Abner
- Ertekin-Taner N.
- Escott-Price V.
- Escuela R.
- Esmaeeli S.
- Espinosa A.
- Espinosa M. A. L.
- Essi Kaiharju
- Ester Pelejá
- Esther Pelejà
- Etchepareborda I.
- Ethan Xu
- Evans D. A.
- Evans T.
- Eveleen Darby
- Ewers M.
- F Carrillo
- Faber K. M.
- Fabrizio Piras
- Fabrizio T.
- Fairchild T. J.
- Fallon K. B.
- Fan F.
- Fanli Xu
- Fardo D. W.
- Farlow M. R.
- Farotti L.
- Farrell J. J.
- Farrer L. A.
- Fausto Roveta
- Federica Piras
- Federico Ariel Prestia
- Fedik Rahimov
- Fenoglio C.
- Fernandez-Hernandez V.
- Fernández-Fuertes M.
- Ferrarese C.
- Ferrari R.
- Ferreira C. B.
- Ferri E.
- Ferris S.
- Feulner T.
- Fievet N.
- Fin B.
- Fischer P.
- Fisher E.
- Fitzpatrick A.
- Fladby T.
- Flanagan E Margaret
- Fließbach K.
- Fohner A. E.
- Fongang B.
- Fornage M.
- Foroud T. M.
- Forsell C.
- Fortea J.
- Fostinelli S.
- Fox C.
- Fox N.
- Fox N. C.
- Francesca Assogna
- Franck Auge
- Franco-Macías E.
- Frank Fan
- Frank M LaFerla
- Frank Martiniuk
- Frank-García A.
- Frikke-Schmidt R.
- Froelich L.
- Frosch M. P.
- Frölich L.
- Fulton-Howard B.
- Fátima Carrillo
- Färkkilä M.
- Gail Davies
- Gail P Jarvik
- Gailhajenet A.
- Galasko D. R.
- Galeano P.
- Galimberti D.
- Galit Weinstein
- Gamboa A.
- Ganesh Chauhan
- Ganguli M.
- Ganna A.
- Garcia-Gonzalez P.
- Garcia-Madrona S.
- Garcia-Ribas G.
- Garcia-Tabuenca J.
- García-Alberca J. M.
- García-González P.
- Garrote-Espina L.
- Gary W Beecham
- Gayle Ayres
- Gearing M.
- Geerlings M.
- Gena Roshchupkin
- Geoff Kerchner
- Georg Brein
- Georgantas B.
- George-Hyslop P. S.
- Germani S.
- Gerrish A.
- Geschwind D. H.
- Gessica Sala
- Ghanbari M.
- Ghazal Awaisa
- Ghetti B.
- Ghidoni R.
- Ghosh S.
- Giedraitis V.
- Giegling I.
- Gilbert J. R.
- Gill Livingston
- Gill M.
- Giordano Lacidogna
- Giorgio G.
- Gisela Novack
- Glatt S. J.
- Goate A. M.
- Goldhardt O.
- Gomez-Fonseca D.
- Gonzalez H. M.
- González-Pérez A.
- Gordillo J. E.
- Gordon Wilcock
- Gormley P.
- Goss M.
- Gossel M.
- Grabe H.
- Grabowski T. J.
- Gracia-Tabuenca J.
- Graff C.
- Graff-Radford N. R.
- Graham Heap
- Graham R.
- Grand Q. L.
- Grande G.
- Grant S. F. A.
- Green E.
- Green R. C.
- Greenberg S.
- Grenier-Boley B.
- Grimmer T.
- Growdon J. H.
- Grunin M.
- Grünblatt E.
- Gu W.
- Gudnason V.
- Guerreiro R.
- Guetta-Baranes T.
- Guillermo Amer-Ferrer
- Guitart M.
- Gurling H.
- Gursoy U.
- Gwilliam R.
- Gómez-Garre P.
- Gómez-Garre P.
- H-Erich Wichmann
- Haapasalo A.
- Habes M.
- Hadjigeorgiou G.
- Haines J. L.
- Haines J. L.
- Hakon Hakonarson
- Hakonarson H.
- Hall J.
- Hamilton R. L.
- Hamilton-Nelson K. L.
- Hampel H.
- Hannele Laivuori
- Hannele Mattsson
- Hannele Uusitalo-Järvinen
- Hannequin D.
- Hannu Kankaanranta
- Hannu Uusitalo
- Hannula-Jouppi K.
- Hanon O.
- Hans Grabe
- Hao Chen
- Hao Mei
- Harari O.
- Hardy J.
- Harju J.
- Harju T.
- Harold D.
- Harrell L. E.
- Harri Siirtola
- Harry V Vinters
- Hartmann A. M.
- Harvima I.
- Harwood J.
- Hata Comic
- Hausner L.
- Haut J.
- Hautala N.
- Havulinna A.
- Head E.
- Heap G.
- Heckbert S. R.
- Hector M Gonzalez
- Hedman Å.
- Heike Kölsch
- Heike Weber
- Heikki Joensuu
- Heikkinen S.
- Heiko Runz
- Heilmann-Heimbach S.
- Helena C Chui
- Helena Schmidt
- Heli Lehtonen
- Helisalmi S.
- Hema Sekhar
- Henderson V. W.
- Hendolin M.
- Hendrik van den Bussche
- Heneka M. T.
- Henning Boecker
- Henrik Wilms
- Henrike Heyne
- Henry L Paulson
- Hernandez M.
- Hernández I.
- Herold C.
- Heron S.
- Herrmann M. J.
- Heun R.
- Heuser I.
- Hevilla S.
- Heyne H.
- Hieab Adams
- Hiekkalinna T.
- Hiltunen M.
- Hinttala R.
- Hochfeld M.
- Hodges A.
- Hofer E.
- Hoffman J.
- Hoffmann P.
- Hohman T.
- Hollingworth P.
- Holmans P. A.
- Holmes C.
- Holstege H.
- Holzinger E.
- Hong E.
- Honig L. S.
- Hooper N. M.
- Hort J.
- Howard J Rosen
- Howard Jacob
- Hu X.
- Huang Y.
- Hubert Chen
- Huebinger R. M.
- Huentelman M. J.
- Hugh Gurling
- Hughes T.
- Hugo J Aparicio
- Huhtakangas J.
- Huilaja L.
- Hulette C. M.
- Hulsman M.
- Humphrey J.
- Hunkapiller J.
- Huntington Potter
- Hyman B. T.
- Hynan L. S.
- Hyvärinen K.
- Håkan Thonberg
- Hüll M.
- Ibanez L.
- Ibarria M.
- Ignacio Etchepareborda
- Ikram M. A.
- Ilkka Harvima
- Ingelsson M.
- Ingino C.
- Ingunn Bosnes
- Iriarte M. M.
- Isabel Sastre
- Isabel Sastre Merlín
- Isabella Heuser
- Isomäki P.
- Jaakko Kaprio
- Jaakko Parkkinen
- Jaakko Tuomilehto
- Jaana Lindström
- Jacob H.
- Jacob Haut
- Jacob Shofany
- Jacques Epelbaum
- Jaeyoon Chung
- Jalanko A.
- Jambulingam D.
- James B Leverenz
- James Brewer
- James D Bowen
- James Hall
- James J Lah
- James R Burke
- James T Becker
- James T Becker
- James Turton
- James Uphill
- Jan Laczo
- Janet A Johnston
- Janet P Smith
- Janet van Adelsberg
- Janice Knebl
- Janowitz D.
- Jansen I. E.
- Jari Lahti
- Jari Laukkanen
- Jarmo Harju
- Jarmo Ritari
- Jarret A Johnston
- Jarvik G. P.
- Jason D Warren
- Javier Garcia-Tabuenca
- Javier Gracia-Tabuenca
- Jayadev S.
- Jean Shin
- Jean-Paul Vonsattel
- Jeannette Simino
- Jeff Waring
- Jeffrey A Kaye
- Jeffrey L Tilson
- Jeffrey M Burns
- Jeffrey O'Connell
- Jeffrey Waring
- Jennifer E Below
- Jennifer E Phillips-Cremins
- Jennifer Schutzman
- Jennifer Smith
- Jennifer Williamson
- Jenny Lord
- Jerome Rotter
- Jesse Mez
- Jessen F.
- Jesús S.
- Jesús S.
- Jian X.
- Jimmy Liu
- Jiménez M. G.
- Jin L. -W.
- Jiwoo Lee
- Jo Betts
- Joan S Reisch
- Joel H Kramer
- Joensuu H.
- Johanna Huhtakangas
- Johanna Mattson
- Johanna Mäkelä
- Johanna Schleutker
- Johannes Kettunen
- Johansson C.
- John Bertelson
- John C Morris
- John Collinge
- John DeToledo
- John Eicher
- John F Powell
- John H Growdon
- John J Farrell
- John M Olichney
- John M Ringman
- John Malamon
- John Michon
- John Powell
- John Q Trojanowski
- John R Gilbert
- John S.
- Johnson K.
- Johnson L.
- Johnston J. A.
- Johnston J. A.
- Jonathan L Haines
- Jones L.
- Joni A Turunen
- Jorge Esparza Gordillo
- Jose Romero
- Joseph D Buxbaum
- Joseph E Parisi
- Joseph F Quinn
- Joseph Maranville
- Joshua A Sonnen
- Joshua Hoffman
- Joshua M Shulman
- Joshua W Miller
- Josée Dupuis
- Jr
- Juan Andrés Burguera
- Juan C Troncoso
- Juan Ignacio Bacha
- Juan Macias
- Juan Marín-Muñoz
- Juan P. S.
- Juha Karjalainen
- Juha Rinne
- Juha Sinisalo
- Juhani Junttila
- Jukka Partanen
- Jukka Peltola
- Julie A Schneider
- Julie Hunkapiller
- Julieta Lisso
- Julkunen V.
- Jun G. R.
- Junttila J.
- Juonala M.
- Jussi Pihlajamäki
- Jussila A.
- Justin Wade Davis
- Järvensivu E.
- Jöckel K. -H.
- Kaarniranta K.
- Kaarteenaho R.
- Kai Kaarniranta
- Kaiharju E.
- Kaipiainen-Seppänen O.
- Kaisa Tasanen
- Kaj Metsärinne
- Kajanne R.
- Kalaoja M.
- Kalina Yonkova Mihova
- Kalle Pärn
- Kalpala K.
- Kamboh M. I.
- Kanai M.
- Kangasniemi E.
- Kankaanranta H.
- Kaprio J.
- Karen S King
- Kari Eklund
- Kari Linden
- Kari Pulkki
- Karihtala P.
- Karjalainen J.
- Karjalainen M.
- Karl-Heinz Jöckel
- Karlsson A.
- Karydas A. M.
- Kastumata Y.
- Katariina Hannula-Jouppi
- Katharina Wittfeld
- Katherine Call
- Kathleen A Welsh-Bohmer
- Kathy Call
- Kathy Klinger
- Kati Donner
- Kati Hyvärinen
- Kati Kristiansson
- Katri Pylkäs
- Katri Raikkonen-Talvitie
- Katz M. J.
- Kaunisto M.
- Kauppi P.
- Kauppila S.
- Kautz T. F.
- Kauwe J.
- Kaye J. A.
- Kayenat Parveen
- Keene C. D.
- Kehoe P. G.
- Keith Usiskin
- Kenneth B Fallon
- Kerchner G.
- Kettunen J.
- Khaleeq A.
- Kiiskinen T.
- Kilander L.
- Kilpeläinen E.
- Kilpi T.
- Kim Johnson
- Kim R.
- Kimberley Dowzell
- Kimmo Palin
- King K. S.
- Kirk C Wilhelmsen
- Kirsi Kalpala
- Kirsi Sipilä
- Kiviniemi M.
- Kivipelto M.
- Klaus Elenius
- Kleineidam L.
- Klinger K.
- Klopp N.
- Knebl J.
- Knol M.
- Kochen S.
- Kohler E.
- Kohler M.
- Koivisto A.
- Kornhuber J.
- Koskinen M.
- Kosma V. -M.
- Kosmidis M. H.
- Koulu L.
- Kowall N. W.
- Kramer J. H.
- Kremen W.
- Kristelle Brown
- Kristelle S Brown
- Kristiansson K.
- Kristin Tsuo
- Kujala U.
- Kuksa P. P.
- Kukull W. A.
- Kulkarni D.
- Kunkle B. W.
- Kurki M.
- Kuulasmaa T.
- Kuzma A. B.
- Kvikstad E.
- Kähönen M.
- Kälviäinen R.
- Kölsch H.
- Küçükali F.
- L Garrote-Espina
- Laakkonen E.
- Laakso M.
- Laatikainen T.
- Labrador M.
- Lacaze P.
- Lacidogna G.
- Lacour A.
- Laczo J.
- LaFerla F. M.
- Lafuente A.
- Lage C.
- Lage C.
- Lah J. J.
- Lahdenperä S.
- Lahti J.
- Laiho P.
- Laitinen T.
- Laivuori H.
- Lambert J. -C
- Larson E. B.
- Laske C.
- Laukka E. J.
- Laukkanen J.
- Laukkanen M.
- Launer L.
- Laura Huilaja
- Laura Ibanez
- Laura Pirilä
- Lauri Aaltonen
- Lauria A.
- Lawlor B.
- Lawrence S Honig
- Lee C. -Y.
- Lee C. -Y.
- Lee E. B.
- Lee J.
- Lee-Way Jin
- Leena Koulu
- Legaz A.
- Lehisto A.
- Lehtisalo J.
- Lehtonen A.
- Lehtonen H.
- Lei Yu
- Leigh Johnson
- Lemmelä S.
- Lerch O.
- Lerner A.
- Lertratanakul A.
- Lesley Jones
- Leung Y. Y.
- Leverenz J. B.
- Levey A. I.
- Li M.
- Li S.
- Liana G Apostolova
- Lieberman A. P.
- Liisa Suominen
- Liliana Vargas
- Liliana Vivancos
- Liming Qu
- Linda J van Eldik
- Linda McCarthy
- Linda S Hynan
- Linden K.
- Lindström J.
- Lindy E Harrell
- Lipton R. B.
- Lisa Alvarez
- Lisa L Barnes
- Lisa Yanek
- Lisso J.
- Litkowski E.
- Liu D.
- Liu D.
- Liu J.
- Liu X.
- Livingston G.
- Lleó A.
- Llorens V.
- Loboda A.
- Loerch P.
- Logue M.
- Loitfelder M.
- Lon S Schneider
- Longstreth W.
- Loomis S.
- Lopez O.
- Lord J.
- Lorena Garrote-Espina
- Lotta Männikkö
- Loukola A.
- Love S.
- Lovestone S.
- Lu T.
- Luckcuck L.
- Lunetta K. L.
- Luodonpää M.
- Lupton M.
- Lutz Frölich
- Lyketsos C. G.
- Lynch A.
- Lähteenmäki S.
- López-García S.
- López-García S.
- Löwemark M.
- M Carrion-Claro
- M Ilyas Kamboh
- M Marín
- Ma Labrador
- Ma Y.
- Macias J.
- Macias-García D.
- MacLeod C. A.
- Macías J.
- Maier W.
- Maillard P.
- Mains D.
- Maite Mendioroz Iriarte
- Malamon J.
- Malarstig A.
- Malcolm Dick
- Malik R.
- Mangialasche F.
- Mangone C.
- Mann D.
- Mannermaa A.
- Manning A.
- Mantere T.
- Manuel González Jiménez
- Manuel Mayhaus
- Manuel Rivas
- Manzanares S.
- Mar Buendia
- Maranville J.
- Marcia Ory
- Margaret F. E.
- Margit Pelkonen
- Mari E Niemi
- Mari Kaunisto
- Mari Takalo
- Maria Bjerke
- Maria Del Zompo
- Maria Knol
- Maria Pilar Vicente
- Maria Serpente
- Maria Siponen
- Marian Martinez de Pancorbo
- Mariana Sanchez Abalos
- Marie-Francoise Chesselet
- Marie-Gabrielle Duperron
- Mariet Allen
- Marika Crohns
- Marilyn S Albert
- Marina Guitart
- Mario Carrión-Claro
- Mario Rios
- Mariona Moreno
- Marioni R.
- Marisa Loitfelder
- Marita Kalaoja
- Marja Luodonpää
- Marja-Riitta Taskinen
- Mark A Sager
- Mark Daly
- Mark Logue
- Mark McCarthy
- Markku Laakso
- Markku Laukkanen
- Markku Peltonen
- Markku Voutilainen
- Markus Juonala
- Markus Perola
- Marla Gearing
- Marla Hochfeld
- Maroñas O.
- Marquié M.
- Mars N.
- Marsel Mesulam
- Marsha Polk
- Marshall C.
- Marshall R.
- Marson D. C.
- Marta Ibarria
- Marta Marín
- Martin E. R.
- Martin R Farlow
- Martin Rossor
- Martin Rossor
- Martin Woon
- Martinez de Pancorbo M.
- Martiniuk F.
- Martirio Antequera
- Martti Färkkilä
- Martín E.
- Martínez B.
- Martínez V.
- Martínez-Lage Álvarez P.
- Martínez-Larrad M. T.
- Mary Ganguli
- Mary Pat Reeve
- Mary Quiceno
- Mary Sano
- Maryam Bahadori
- María Dolores Alonso
- María Dolores Alonso
- María José Casajeros
- María Teresa Martínez-Larrad
- María Teresa Periñán-Tocino
- Marín M.
- Marín M.
- Marín T.
- Marín-Muñoz J.
- Masahiro Kanai
- Mash D. C.
- Masliah E.
- Massman P.
- Masullo C.
- Masurkar A.
- Matakidou A.
- Mateus Bernardo-Harrington
- Mather K.
- Matias Kohler
- Matias Rojo
- Matoska V.
- Matt Brauer
- Matthew J Huentelman
- Matthew P Frosch
- Matthias Gossel
- Matthias Riemenschneider
- Mattson J.
- Mattsson H.
- Mauleón A.
- Mayeux R.
- Mayhaus M.
- Mazoyer B.
- McCarthy L.
- McCarthy M.
- McCormick W. C.
- McCurry S. M.
- McDavid A. N.
- McDonough S.
- McDonough S.
- McGuinness B.
- McKee A. C.
- McQuillin A.
- Mead S.
- Mecocci P.
- Medel N.
- Medina M.
- Meg Ehm
- Meggy A.
- Mehrabian S.
- Mehta V.
- Mei H.
- Melissa Miller
- Mendoza S.
- Menéndez-González M.
- Meretoja T.
- Merlín I. S.
- Mervi Aavikko
- Mesulam M.
- Metsärinne K.
- Mez J.
- Michael C O'Donovan
- Michael Gill
- Michael Hüll
- Michael J Owen
- Michael L Cuccaro
- Michael O'Donovan
- Michael Owen
- Michelle Hernandez
- Michelle Lupton
- Michon J.
- Miguel Angel Labrador Espinosa
- Mihova K. Y.
- Miia Turpeinen
- Miika Koskinen
- Mika Kähönen
- Mikko Arvas
- Mikko Kiviniemi
- Miller B. L.
- Miller C. A.
- Miller J. W.
- Miller M.
- Minal Caliskan
- Mindy J Katz
- Minerva M Carrasquillo
- Mingyao Li
- Minna Hendolin
- Minna Karjalainen
- Mir P.
- Mirjam Geerlings
- Mishra A.
- Mitja Kurki
- Moebus S.
- Moeen Riaz
- Mohamad Habes
- Mohammed E.
- Mol M.
- Molina-Porcel L.
- Monica Goss
- Monica Rodriguear
- Monique Breteler
- Montes A. M.
- Montine T. J.
- Montrreal L.
- Monuki E. S.
- Morales A. C.
- Morelli L.
- Moreno F.
- Moreno M.
- Moreno-Grau S.
- Morgan K.
- Morris J. C.
- Mosley T.
- Mt Periñán
- Muchnik C.
- Muhammad Ali
- Mukherjee S.
- Mummery C.
- Munro Cullum
- Murali Sargurupremraj
- Murray Raskind
- Muslin A.
- Myers A. J.
- Mäkelä J.
- Mäkelä T.
- Männikkö L.
- Mäntylä P.
- Nacmias B.
- Naj A. C.
- Nan Bing
- Nancy Medel
- Nash W.
- Natalie Bowers
- Natalie S Ryan
- Nathalie Fievet
- Nathalie Ryan
- Nathaniel A Chin
- Natividad Olivar
- Natunen T.
- Neil W Kowall
- Neill R Graff-Radford
- Ngandu T.
- Nguyen T.
- Nicholas J Bass
- Nick Bass
- Nick Fox
- Nick Warner
- Nicola Armstrong
- Nicola Salvadori
- Nicolas G.
- Nielsen S. F.
- Niemi M. E.
- Nieminen P.
- Nigel J Cairns
- Nigel M Hooper
- Niiranen T.
- Nilüfer Ertekin-Taner
- Nina Hautala
- Nina Mars
- Nizar Smaoui
- Nordestgaard B. G.
- Norman Klopp
- Novack G.
- Nuria Aguilera
- Nuria Aguilera
- Nuñez-Llaves R.
- Nyquist P.
- Nöthen M. M.
- Oh D.
- Oili Kaipiainen-Seppänen
- Olalla Maroñas
- Olaso R.
- Olichney J. M.
- Olivar N.
- Olivé C.
- Olli Carpén
- Ollila T.
- Orellana A.
- Orsini M.
- Ortega G.
- Ortiz C.
- Ory M.
- Oscar Harari
- Otto Valladares
- Outi Tuovila
- Owen M.
- Owen M. J.
- O’Bryant S.
- O’Connell J.
- O’Donovan M.
- O’Donovan M. C.
- P Gómez-Garre
- Paajanen T.
- Pablo Galeano
- Pablo Martínez-Lage Álvarez
- Padhraig Gormley
- Padovani A.
- Pakkanen R.
- Palacio D. L.
- Palin K.
- Palmer R.
- Palomäki A.
- Palotie A.
- Palotie U.
- Palta P.
- Panagiotis Deloukas
- Pancho A.
- Pangiotis Deloukas
- Paola Bronson
- Paolo C.
- Papenberg G.
- Parisi J. E.
- Parkkinen J.
- Parnetti L.
- Partanen J.
- Parveen K.
- Pasquier F.
- Passmore P.
- Passmore P.
- Pastor A. A.
- Pastor A. B.
- Pastor P.
- Patel Y.
- Patel Y.
- Patrice L Whitehead
- Patricia Solis
- Patrick Loerch
- Patrizia Bastiani
- Paul Hollingworth
- Paul K Crane
- Paul Lacaze
- Paul Massman
- Paul Nyquist
- Paula Kauppi
- Pauline Maillard
- Paulson H. L.
- Paus T.
- Pausova Z.
- Pavel P Kuksa
- Pavlik V.
- Paydarfar D.
- Peeter Karihtala
- Pekka Nieminen
- Pelejà E.
- Pelkonen M.
- Peloso G.
- Peltola J.
- Peltonen M.
- Peltonen S.
- Pendergrass S.
- Penelope Benchek
- Pentti Tienari
- Per Selnes
- Perez V.
- Pericak-Vance M. A.
- Pericard P.
- Periñán M.
- Periñán-Tocino M. T.
- Perneczky R.
- Perola M.
- Perrie M Adams
- Peskind E.
- Peter Passmore
- Peter Passmore
- Peter St George-Hyslop
- Peters O.
- Petersen R. C.
- Peterson A.
- Petra Proitsi
- Petri Virolainen
- Petrovski S.
- Philip L De Jager
- Phillips-Cremins J. E.
- Pia Isomäki
- Pickering-Brown S.
- Pierce A.
- Pietro Della Briotta Parola
- Pietro Della Briotta Parolo
- Pihlajamäki J.
- Pijnenburg Y. A. L.
- Pikkarainen S.
- Pilar Cañabate
- Pilar Cañabate
- Pilar Gómez-Garre
- Pinchler S.
- Pineda J. A.
- Pineda-Sánchez R.
- Piras F.
- Piras F.
- Pirilä L.
- Pirkko Pussinen
- Pisanu C.
- Pitkäranta A.
- Piñol-Ripoll G.
- Plenge R.
- Podgornaia A.
- Polak T.
- Politis D. G.
- Polk M.
- Poon W. W.
- Popovic R.
- Popp J.
- Posthuma D.
- Potter H.
- Powell J.
- Powell J. F.
- Preckler S.
- Prestia F. A.
- Priit Palta
- Priller J.
- Proitsi P.
- Prokic I.
- Psaty B. M.
- Puerta R.
- Pulford D.
- Pulkki K.
- Pussinen P.
- Pylkäs K.
- Päivi Auvinen
- Päivi Laiho
- Päivi Mäntylä
- Pärn K.
- Pérez-Cordón A.
- Pérez-Tur J.
- Qu L.
- Quarless D.
- Quenez O.
- Quentin Le Grand
- Quiceno M.
- Quinn J. F.
- Quintela I.
- R Escuela
- R Pineda-Sánchez
- R Vigo-Ortega
- Rachelle S Doody
- Rahimov F.
- Raikkonen-Talvitie K.
- Raimo Pakkanen
- Rainer Malik
- Rainero I.
- Raisa Serpi
- Raj A.
- Raj T.
- Rajabli F.
- Rajpal D.
- Rajula R.
- Ramakers I.
- Ramirez A.
- Randall L Woltjer
- Ranjan Duara
- Raskind M.
- Rathinakannan V. S.
- Raymond Palmer
- Raúl Nuñez-Llaves
- Real de Asúa D.
- Real L. M.
- Rebecca Sussams
- Reddy Rajula
- Reetta Hinttala
- Reetta Kälviäinen
- Reeve M. P.
- Regina M Carney
- Regis Wong
- Reiman E. M.
- Reinders M. J. T.
- Reinhard Heun
- Reinhold Schmidt
- Reisberg B.
- Reisch J. S.
- Reitz C.
- Relja Popovic
- Remes A.
- Reyes-Dumeyer D.
- Rhian Gwilliam
- Riaz M.
- Riccardo Marioni
- Rice D.
- Rich S.
- Richard Abraham
- Richard B Lipton
- Ridge P.
- Riedel-Heller S.
- Riederer P.
- Riemenschneider M.
- Riitta Antikainen
- Riitta Kaarteenaho
- Riley-Gillis B.
- Ringman J. M.
- Rinne J.
- Rios M.
- Ripatti S.
- Risto Kajanne
- Rita Guerreiro
- Ritari J.
- Rivas M.
- Roberson E. D.
- Robert A Stern
- Robert C Barber
- Robert C Green
- Robert Clarke
- Robert Graham
- Robert Perneczky
- Robert Plenge
- Robert Vassar
- Roberto N.
- Rocío Escuela
- Rocío Pineda-Sánchez
- Rodrigo S.
- Rodrigo-Herrero S.
- Rodriguear M.
- Rodriguez-Rodriguez E.
- Rodríguez C. M.
- Roeck E. D.
- Rogaeva E.
- Roger L Albin
- Roger N Rosenberg
- Rojo M.
- Romero J.
- Ronald C Petersen
- Ronald Kim
- Ronald L Hamilton
- Rongve A.
- Rosario Vigo-Ortega
- Rosen H. J.
- Rosenberg R. N.
- Rosende-Roca M.
- Roshchupkin G.
- Rossi G.
- Rossi P. D.
- Rossor M.
- Rossor M.
- Rotter J.
- Roveta F.
- Royall D. R.
- Royo J. L.
- Rubino E.
- Rubinsztein D. C.
- Rudolph E Tanzi
- Rufus O Akinyemi
- Ruiz A.
- Rujescu D.
- Runz H.
- Russell H Swerdlow
- Ryan M Huebinger
- Ryan N.
- Ryan N. S.
- Rábano A.
- Rüeger S.
- S Jesús
- Saba Y.
- Sabrina Pinchler
- Sachdev P.
- Saenz A.
- Sager M. A.
- Sahar Esmaeeli
- Saila Kauppila
- Sakka P.
- Sala G.
- Sally John
- Salmi T.
- Salminen A.
- Salo T.
- Salomaa V.
- Saltvedt I.
- Salvadora Manzanares
- Salvadori N.
- Salvatore Spina
- Sami Heikkinen
- Samir Wadhawan
- Sampsa Pikkarainen
- Samuel Heron
- Samuli Ripatti
- Sanabria Á.
- Sanchez-Garcia F.
- Sando S. B.
- Sandra Barral
- Sandra Germani
- Sandra Weintraub
- Sanjay Asthana
- Sanna Seitsonen
- Sanni Lahdenperä
- Sano M.
- Sara López-García
- Sara López-García
- Sarah Pendergrass
- Saray Hevilla
- Sargurupremraj M.
- Sarnowski C.
- Sastre I.
- Satizabal C. L.
- Saykin A. J.
- Scamosci M.
- Scarmeas N.
- Scarpini E.
- Schellenberg G. D.
- Scheltens P.
- Scherbaum N.
- Scherer M.
- Schleutker J.
- Schmid M.
- Schmidt H.
- Schmidt R.
- Schneider A.
- Schneider J. A.
- Schneider L. S.
- Schott J. M.
- Schutzman J.
- Schürmann B.
- Scott Chasse
- Scott Small
- Seeley W. W.
- Seitsonen S.
- Sekhar H.
- Selbæk G.
- Selnes P.
- Seppo Vainio
- Seripa D.
- Serpente M.
- Serpi R.
- Serrano M.
- Seshadri S.
- Sevillano Z.
- Sha J.
- Shadrin A. A.
- Shahram Bahrami
- Shaikho E.
- Shameek Biswas
- Shaw C. E.
- Shcherban A.
- Shin J.
- Shofany J.
- Shulman J. M.
- Shuo Li
- Sid O'Bryant
- Siirtola H.
- Silvia Jesús
- Silvia Kochen
- Silvia Preckler
- Silvia Rodrigo
- Silvia Rodrigo-Herrero
- Simino J.
- Simon Cox
- Simon Lovestone
- Simona Andreoni
- Sims R.
- Sina Rüeger
- Sini Lähteenmäki
- Sinisalo J.
- Sipeky C.
- Sipilä K.
- Sipilä T. P.
- Siponen M.
- Sirkku Peltonen
- Sistonen T.
- Skrobot O.
- Slavé Petrovski
- Sleegers K.
- Slifer S.
- Sliz E.
- Small S.
- Smaoui N.
- Smith A. D.
- Smith A. G.
- Smith J.
- Smith J. P.
- Snijders G. J. L.
- Soininen H.
- Solfrizzi V.
- Solis P.
- Solomon A.
- Song Y. E.
- Sonnen J. A.
- Sorbi S.
- Sotolongo-Grau O.
- Soumitra Ghosh
- Spallazzi M.
- Spalletta G.
- Spina S.
- Spottke A.
- Squassina A.
- Stefan McDonough
- Stefan McDonough
- Stefan Teipel
- Stephanie Loomis
- Stephen J Glatt
- Stephen M Strittmatter
- Stephen Rich
- Stephen Todd
- Stern R. A.
- Steven E Arnold
- Steven Ferris
- Steven G Younkin
- Steven Greenberg
- Stevens A. B.
- Stordal E.
- Strandberg T.
- Strauss E.
- Strittmatter S. M.
- Struan F A Grant
- Stuart Pickering-Brown
- Ståhlbom A. K.
- Sultzer D.
- Suman Jayadev
- Suominen L.
- Susan Eaton
- Susan H Slifer
- Susan M McCurry
- Susan R Heckbert
- Susana Diego
- Susanna Lemmelä
- Sussams R.
- Suzanne Craft
- Sverre Bergh
- Swerdlow R. H.
- Sáez M. E.
- Sánchez-Arjona M. B.
- Sánchez-Valle R.
- Tai-He Xia
- Takalo M.
- Tamara Marín
- Tanzi R. E.
- Tarja Laitinen
- Tartan J. P.
- Taru Tukiainen
- Tasanen K.
- Taskinen M. -R.
- Tavia Evans
- Teea Salmi
- Teemu Natunen
- Teemu Niiranen
- Teemu Paajanen
- Teipel S.
- Teng E.
- Terhi Kilpi
- Terhi Ollila
- Tero Hiekkalinna
- Terttu Harju
- Tesí N.
- Teumer A.
- Thalamuthu A.
- Thomas A.
- Thomas C.
- Thomas D Bird
- Thomas Feulner
- Thomas G Beach
- Thomas J Fairchild
- Thomas J Grabowski
- Thomas J Montine
- Thomas S Wingo
- Thomas T.
- Thomas Wisniewski
- Thomassen J. Q.
- Thonberg H.
- Tienari P.
- Tiffany F Kautz
- Tiina Laatikainen
- Tiinamaija Tuomi
- Tilson J. L.
- Tim Becker
- Tim Behrens
- Tim Lu
- Timo Blomster
- Timo P Sipilä
- Timo Strandberg
- Timothy Hohman
- Timothy Hughes
- Tin A.
- Todd S.
- Tomas Paus
- Tomi Mäkelä
- Toso C. R.
- Tosto G.
- Traykov L.
- Tremolizzo L.
- Trojanowski J. Q.
- Troncoso J. C.
- Trung Nguyen
- Tsai E.
- Tsolaki A.
- Tsolaki M.
- Tsuang D. W.
- Tsuo K.
- Tucker-Drob E.
- Tukiainen T.
- Tuomi T.
- Tuomilehto J.
- Tuomo Kiiskinen
- Tuomo Mantere
- Tuomo Meretoja
- Tuovila O.
- Turpeinen M.
- Turton J.
- Turunen J. A.
- Tushar Bhangale
- Tuula Salo
- Tuuli Sistonen
- Tybjærg-Hansen A.
- Tzourio C.
- Tárraga L.
- Uitterlinden A.
- Ulla Palotie
- Ullgren A.
- Ulstein I.
- Ulvi Gursoy
- Uphill J.
- Urho Kujala
- Usiskin K.
- Uusitalo H.
- Uusitalo-Järvinen H.
- Vacca A.
- Vaclav Matoska
- Vainio S.
- Valentina Ciullo
- Valeria Cores
- Valero S.
- Valladares O.
- Valladares O.
- Valory Pavlik
- Valtteri Julkunen
- van Adelsberg J.
- Van Deerlin V. M.
- van den Bussche H.
- van der Flier W. M.
- van der Lee S. J.
- van der Lugt A.
- van Duijn C. M.
- van Eldik L. J.
- van Lent D. M.
- van Rooij J.
- van Swieten J.
- Vance J.
- Vandenberghe R.
- Vardarajan B. N.
- Vardy E.
- Vargas L.
- Vassar R.
- Veikko Salomaa
- Veli-Matti Kosma
- Venkat Subramaniam Rathinakannan
- Verhey F.
- Vesa Aaltonen
- Vicente M. P.
- Victor W Henderson
- Victoria Fernandez-Hernandez
- Victoria Perez
- Victoriana Martínez
- Vidal J. -S.
- Vigo-Ortega R.
- Vilas R. H.
- Vinay Mehta
- Vincent Deramecourt
- Vincent Deramerourt
- Vincent Llorens
- Vinters H. V.
- Virolainen P.
- Vivancos L.
- Vivianna M Van Deerlin
- Vogelgsang J.
- Vojinovic D.
- Vonsattel J. -P.
- Voutilainen M.
- Vuokko Anttonen
- Vyhnalek M.
- Wadhawan S.
- Wagner M.
- Wallon D.
- Wang C.
- Wang L. -S.
- Wang R.
- Wang Y.
- Warden D.
- Waring J.
- Waring J.
- Warner N.
- Warren J. D.
- Waterworth D.
- Wayne C McCormick
- Wayne W Poon
- Weber H.
- Wei Gu
- Wei Zhou
- Weinhold L.
- Weinstein G.
- Weintraub S.
- Welsh-Bohmer K. A.
- Whelan C.
- Whitehead P. L.
- Wichmann H. -E.
- Wigmore E.
- Wijsman E. M.
- Wilcock G.
- Wilhelmsen K. C.
- Will S Bush
- William Kremen
- William Nash
- William W Seeley
- Williams A.
- Williams B.
- Williams D.
- Williams J.
- Williamson J.
- Wilms H.
- Wiltfang J.
- Windle G.
- Wingo T. S.
- Wisniewski T.
- Wittfeld K.
- Woltjer R. L.
- Wong R.
- Woods B.
- Woon M.
- Wright C. B.
- Wu C. -K.
- Wu Y.
- Xia T. -H.
- Xing Chen
- Xinli Hu
- Xiongwei Zhu
- Xu E.
- Xu F.
- Xuan Liu
- Yanbing Wang
- Yanek L.
- Yang Q.
- Yang Y.
- Yannakoulia M.
- Yaqub A.
- Yasaman Saba
- Yash Patel
- Yeunjoo E Song
- Yi Zhao
- Ying Wu
- Yoav Ben-Shlomo
- Yogen Patel
- Younkin S. G.
- Yu C. -E.
- Yu L.
- Yuanchao Zhang
- Yuk Yee Leung
- Yunfeng Huang
- Yunju Yang
- Zare H.
- Zdenka Pausova
- Zhang X.
- Zhang Y.
- Zhao Y.
- Zhao Y.
- Zhou W.
- Zhu C.
- Zhu X.
- Ziemann A.
- Zoia C. P.
- Zompo M. D.
- Zulaica M.
- Zulma Sevillano
- Álvarez V.
- Åsa Hedman
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2022
- Field of study
Characterization of the genetic landscape of Alzheimer’s disease (AD) and related dementias (ADD) provides a unique opportunity for a better understanding of the associated pathophysiological processes. We performed a two-stage genome-wide association study totaling 111,326 clinically diagnosed/‘proxy’ AD cases and 677,663 controls. We found 75 risk loci, of which 42 were new at the time of analysis. Pathway enrichment analyses confirmed the involvement of amyloid/tau pathways and highlighted microglia implication. Gene prioritization in the new loci identified 31 genes that were suggestive of new genetically associated processes, including the tumor necrosis factor alpha pathway through the linear ubiquitin chain assembly complex. We also built a new genetic risk score associated with the risk of future AD/dementia or progression from mild cognitive impairment to AD/dementia. The improvement in prediction led to a 1.6- to 1.9-fold increase in AD risk from the lowest to the highest decile, in addition to effects of age and the APOE ε4 allele
Common variants in Alzheimer's disease and risk stratification by polygenic risk scores
- Author
- Aarsland Dag
- Abdelnour C.
- Abdelnour Carla
- Adarmes-Gomez A.D.
- Alarcon-Martin Emilio
- Alcolea Daniel
- Alegret Montserrat
- Alvarez Ignacio
- Alvarez Victoria
- Amouyel Philippe
- Andrade Victor
- Andreassen Ole A.
- Antonell Anna
- Antunez Carmen
- Appollonio Ildebrando
- Arcaro Marina
- Archetti Silvana
- Arias Pastor Alfonso
- Armstrong Nicola J.
- Arosio Beatrice
- Bailly Henri
- Banaj Nerisa
- Baquero Miquel
- Belen Pastor Ana
- Bellenguez Celine
- Benaque Alba
- Benussi Alberto
- Benussi Luisa
- Bernal Sanchez-Arjona Maria
- Bessi Valentina
- Binetti Giuliano
- Bis Joshua C.
- Blennow Kaj
- Blesa Rafael
- Boada Merce
- Boerwinkle Eric
- Borroni Barbara
- Boschi Silvia
- Bossu Paola
- Buerger Katharina
- Buiza-Rueda Dolores
- Bullido Maria J.
- Caffarra Paolo
- Calero Miguel
- Carolina Dalmasso Maria
- Carracedo Angel
- Cecchetti Roberta
- Cervera-Carles Laura
- Charbonnier Camille
- Chene Genevieve
- Chillotti Caterina
- Ciccone Simona
- Clarimon Jordi
- Clark Christopher
- Conti Elisa
- Corbaton-Anchuelo Arturo
- Corma-Gomez Anais
- Dardiotis Efthimios
- de Mendonca Alexandre
- de Rojas Itziar
- Deckert Juergen
- Deckert Jurgen
- del Ser Teodoro
- Deniz-Naranjo M. Candida
- Deramecourt Vincent
- DeStefano Anita L.
- Dichgans Martin
- Diehl-Schmid Janine
- Diez-Fairen Monica
- Djurovic Srdjan
- Duezel Emrah
- Dufouil Carole
- Duron Emmanuelle
- Duzel Emrah
- Engelborghs Sebastiaan
- Escott-Price Valentina
- Esiri Margaret
- Espinosa Ana
- Ewers Michael
- Farotti Lucia
- Farrer Lindsay A.
- Fenoglio Chiara
- Fernandez-Fuertes Marta
- Ferreira Catarina B.
- Ferri Evelyn
- Fischer Peter
- Fliessbach Klaus
- Fornage Myriam
- Fortea Juan
- Fostinelli Silvia
- Franco-Macias Emilio
- Frank-Garcia Ana
- Frikke-Schmidt Ruth
- Froelich Lutz
- Galimberti Daniela
- Garcia-Gonzalez Pablo
- Garcia-Madrona Sebastian
- Garcia-Ribas Guillermo
- Gelpi Ellen
- Ghidoni Roberta
- Giaccone Giorgio
- Giedraitis Vilmantas
- Giegling Ina
- Gil Silvia
- Goldhardt Oliver
- Gonzalez-Perez Antonio
- Graff Caroline
- Grande Giulia
- Grenier-Boley Benjamin
- Grimmer Timo
- Gruenblatt Edna
- Grunblatt Edna
- Haapasalo Annakaisa
- Hadjigeorgiou Georgios
- Haegg Sara
- Hagg Sara
- Haines Jonathan L.
- Hampel Harald
- Hanon Oliver
- Hartmann Annette M.
- Hausner Lucrezia
- Heilmann-Heimbach Stefanie
- Helisalmi Seppo
- Heneka Michael T.
- Hernandez Isabel
- Herrmann Martin J.
- Hiltunen Mikko
- Hoffmann Per
- Holmans Peter A.
- Holmes Clive
- Holstege Henne
- Hort Jakub
- Huerto Vilas Raquel
- Huisman Martijn
- Hulsman Marc
- Ikram M. Arfan
- Ingelsson Martin
- Jansen Iris E.
- Jessen Frank
- Jian Xueqiu
- K\ufc\ue7\ufckali Fahri
- Kalaria Rajesh N.
- Karlsson Ida K.
- Kehoe Patrick Gavin
- Kern Silke
- Kilander Lena
- Kivipelto Miia
- Kleineidam Luca
- Kok Almar A.L.
- Kornhuber Johannes
- Kosmidis Mary H.
- Kunkle Brian W.
- Kuulasmaa Teemu
- Lage Carmen
- Lambert Jean-Charles
- Lebouvier Thibaud
- Lehtisalo Jenni
- Lemstra Afina W.
- Lerch Ondrej
- Lleo Alberto
- Loewenmark Malin
- Lopez de Munain Adolfo
- Lowenmark Malin
- Macias Juan
- Macleod C.
- Maier Wolfgang
- Mangialasche Francesca
- Maria Garcia-Alberca Jose
- Marquie Marta
- Marshall Rachel
- Martin Montes Angel
- Martinez Rodriguez Carmen
- Masullo Carlo
- Mather Karen A.
- Mayeux Richard
- Mead Simon
- Medina Miguel
- Meggy Alun
- Mendoza Silvia
- Menendez-Gonzalez Manuel
- Mir Pablo
- Molina-Porcel Laura
- Montrreal Laura
- Moreno Fermin
- Moreno-Grau Sonia
- Morgan Kevin
- Munoz-Fernandez Carmen
- Nacmias Benedetta
- Naj Adam C.
- Ngandu Tiia
- Nicolas Gael
- Noethen Markus M.
- Nordestgaard Borge G.
- Nothen Markus M.
- Orellana Adelina
- Ortega Gemma
- Padovani Alessandro
- Papenberg Goran
- Parnetti Lucilla
- Pasquier Florence
- Pastor Pau
- Pedersen Nancy L.
- Perez-Cordon Alba
- Perez-Tur Jordi
- Pericak-Vance Margaret A.
- Peters Oliver
- Pijnenburg Yolande A. L.
- Pineda Juan A.
- Pinol-Ripoll Gerard
- Pisanu Claudia
- Polak Thomas
- Popp Julius
- Posthuma Danielle
- Quenez Olivier
- Quintela Ines
- Rabano Alberto
- Rainero Innocenzo
- Ramirez Alfredo
- Real Luis M.
- Reynolds Chandra A.
- Riedel-Heller Steffi
- Riederer Peter
- Roberto Natalia
- Rodriguez-Rodriguez Eloy
- Rongve Arvid
- Rosas Allende Irene
- Rosende-Roca Maitee
- Rossi Giacomina
- Rossi Paolo Dionigi
- Royo Jose Luis
- Rubino Elisa
- Ruiz Agustin
- Rujescu Dan
- Saez Maria Eugenia
- Sakka Paraskevi
- Saltvedt Ingvild
- Sanabria Angela
- Sanchez-Garcia Florentino
- Sanchez-Juan Pascual
- Sanchez-Valle Raquel
- Sando Sigrid Botne
- Satizabal Claudia L.
- Scamosci Michela
- Scarmeas Nikolaos
- Scarpini Elio
- Schellenberg Gerard D.
- Scheltens Philip
- Scherbaum Norbert
- Scherer Martin
- Schmid Matthias
- Schneider Anja
- Seidu Nazib M.
- Selbaek Geir
- Seripa Davide
- Serrano-Rios Manuel
- Seshadri Sudha
- Sims Rebecca
- Skoog Ingmar
- Skrobot Olivia Anna
- Sleegers Kristel
- Smith A. David
- Soininen Hilkka
- Sorbi Sandro
- Sotolongo-Grau Oscar
- Spallazzi Marco
- Spalletta Gianfranco
- Spottke Annika
- Squassina Alessio
- Stahlbom Anne Kinhult
- Stringa Najada
- Tagliavini Fabrizio
- Tankard Rick M.
- Tarraga Lluis
- Teresa Martinez-Larrad Maria
- Tesi Niccolo
- Thomassen Jesper Qvist
- Tremolizzo Lucio
- Tsolaki Magda
- Tybjaerg-Hansen Anne
- Tybjorg-Hansen Anne
- Ullgren Abbe
- Valero Sergi
- Van Broeckhoven Christine
- van der Flier Wiesje M.
- van der Lee Sven J.
- Van Dongen Jasper
- van Duijn Cornelia M.
- van Schoor Natasja M.
- Vandenberghe Rik
- Vidal Jean-Sebastien
- Vogelgsang Jonathan
- Vyhnalek Martin
- Wagner Michael
- Wallon David
- Wang Li-San
- Weinhold Leonie
- Williams Julie
- Wiltfang Jens
- Yang Qiong
- Yannakoulia Mary
- Zetterberg Henrik
- Zettergren Anna
- Zulaica Miren
- Publication venue
- Publication date
- 01/01/2021
- Field of study
Recommended from our members
Nat Commun
- Author
- Aarsland Dag
- Abdelnour Carla
- Alarcón-Martín Emilio
- Alcolea Daniel
- Alegret Montserrat
- Alvarez Ignacio
- Amouyel Philippe
- Andrade Victor
- Andreassen Ole A.
- Antonell Anna
- Antúnez Carmen
- Appollonio Ildebrando
- Arcaro Marina
- Archetti Silvana
- Arias Pastor Alfonso
- Armstrong Nicola J.
- Arosio Beatrice
- Bailly Henri
- Banaj Nerisa
- Baquero Miquel
- Bellenguez Céline
- Benaque Alba
- Benussi Alberto
- Benussi Luisa
- Bernal Sánchez-Arjona María
- Bessi Valentina
- Binetti Giuliano
- Bis Joshua C
- Blennow Kaj
- Blesa Rafael
- Boada Mercè
- Boerwinkle Eric
- Borroni Barbara
- Boschi Silvia
- Bossù Paola
- Botne Sando Sigrid
- Buerger Katharina
- Buiza-Rueda Dolores
- Bullido María J
- Caffarra Paolo
- Calero Miguel
- Carracedo Ángel
- Cecchetti Roberta
- Cervera Carles Laura
- Charbonnier Camille
- Chillotti Caterina
- Chêne Geneviève
- Ciccone Simona
- Clarimón Jordi
- Clark Christopher
- Conti Elisa
- Corbatón-Anchuelo Arturo
- Corma-Gómez Anaïs
- Dalmasso Maria Carolina
- Dardiotis Efthimios
- de Mendonça Alexandre
- De Rojas Itziar
- Deckert Jürgen
- del Ser Teodoro
- Deniz-Naranjo M. Candida
- Deramecourt Vincent
- DeStefano Anita L.
- Dichgans Martin
- Diehl-Schmid Janine
- Diez-Fairen Monica
- Dionigi Rossi Paolo
- Djurovic Srdjan
- Dufouil Carole
- Duron Emmanuelle
- Düzel Emrah
- Engelborghs Sebastiaan
- Escott-Price Valentina
- Esiri Margaret
- Espinosa Ana
- Ewers Michael
- Farotti Lucia
- Farrer Lindsay A.
- Fenoglio Chiara
- Fernández-Fuertes Marta
- Ferreira Catarina B.
- Ferri Evelyn
- Fischer Peter
- Fließbach Klaus
- Fornage Myriam
- Fortea Juan
- Fostinelli Silvia
- Franco-Macías Emilio
- Frank-García Ana
- Frikke-Schmidt Ruth
- Froelich Lutz
- Galimberti Daniela
- García-Alberca Jose María
- García-González Pablo
- García-Madrona Sebastián
- García-Ribas Guillermo
- Gelpi Ellen
- Ghidoni Roberta
- Giaccone Giorgio
- Giedraitis Vilmantas
- Giegling Ina
- Gil Silvia
- Goldhardt Oliver
- González-Perez Antonio
- Graff Caroline
- Grande Giulia
- Grenier-Boley Benjamin
- Grimmer Timo
- Grünblatt Edna
- Haapasalo Annakaisa
- Hadjigeorgiou Georgios
- Haines Jonathan L.
- Hampel Harald
- Hanon Olivier
- Hartmann Annette M.
- Hausner Lucrezia
- Heilmann-Heimbach Stefanie
- Helisalmi Seppo
- Heneka Michael T.
- Hernández Isabel
- Herrmann Martin J.
- Hiltunen Mikko
- Hoffmann Per
- Holmans Peter
- Holmes Clive
- Holstege Henne
- Hort Jakub
- Huerto Vilas Raquel
- Huisman Martijn A
- Hulsman Marc
- Hägg Sara
- Ikram M. Arfan
- Ingelsson Martin
- Jansen Iris E.
- Jessen Frank
- Jian Xueqiu
- Kalaria Rajesh N.
- Karlsson Ida K.
- Kehoe Patrick Gavin
- Kern Silke
- Kilander Lena
- Kinhult Ståhlbom Anne
- Kivipelto Miia
- Kleineidam Luca
- Kok Almar A. L.
- Kornhuber Johannes
- Kosmidis Mary H.
- Kunkle Brian W.
- Kuulasmaa Teemu
- Küçükali Fahri
- Lage Carmen
- Lambert Jean-Charles
- Lebouvier Thibaud
- Lehtisalo Jenni
- Lemstra Afina W.
- Lerch Ondrej
- Lleó Alberto
- Lopez de Munain Adolfo
- Löwenmark Malin
- Macías Juan
- Maier Wolfgang
- Mangialasche Francesca
- Marquié Marta
- Marshall Rachel
- Martín Montes Angel
- Martínez Rodríguez Carmen
- Martínez-Larrad María Teresa
- Masullo Carlo
- Mather Karen A
- Mayeux Richard
- Mead Simon
- Mecocci Patrizia
- Medina Miguel
- Meggy Alun
- Mendoza Silvia
- Menéndez-González Manuel
- Mir Pablo
- Molina-Porcel Laura
- Montrreal Laura
- Moreno Fermin
- Moreno-Grau Sonia
- Morgan Kevin
- Muñoz-Fernandez Carmen
- Nacmias Benedetta
- Naj Adam C.
- Ngandu Tiia
- Nicolas Gaël
- Nordestgaard Børge G.
- Nöthen Markus M.
- Orellana Adelina
- Ortega Gemma
- Padovani Alessandro
- Papenberg Goran
- Parnetti Lucilla
- Pasquier Florence
- Pastor Ana Belén
- Pastor Pau
- Pedersen Nancy L.
- Pericak-Vance Margaret A
- Peters Oliver
- Pijnenburg Yolande A. L.
- Pineda Juan A.
- Pisanu Claudia
- Piñol-Ripoll Gerard
- Polak Thomas
- Popp Julius
- Posthuma Danielle
- Pérez-Cordón Alba
- Pérez-Tur Jordi
- Quenez Olivier
- Quintela Inés
- Rainero Innocenzo
- Ramirez Alfredo
- Real Luis M.
- Reynolds Chandra A.
- Riedel-Heller Steffi
- Riederer Peter
- Roberto Natalia
- Rodríguez-Rodríguez Eloy
- Rongve Arvid
- Rosas Allende Irene
- Rosende-Roca Maitée
- Rossi Giacomina
- Royo Jose Luís
- Rubino Elisa
- Ruiz Agustín
- Rujescu Dan
- Rábano Alberto
- Sakka Paraskevi
- Saltvedt Ingvild
- Sanabria Ángela
- Sanchez-Garcia Florentino
- Sanchez-Valle Raquel
- Satizabal Claudia L.
- Scamosci Michela
- Scarmeas Nikolaos
- Scarpini Elio
- Schellenberg Gerard D.
- Scheltens Philip
- Scherbaum Norbert
- Scherer Martin
- Schmid Matthias
- Schneider Anja
- Seidu Nazib M.
- Selbæk Geir
- Seripa Davide
- Serrano-Ríos Manuel
- Seshadri Sudha
- Sims Rebecca
- Skoog Ingmar
- Skrobot Olivia Anna
- Sleegers Kristel
- Soininen Hilkka
- Sorbi Sandro
- Sotolongo Grau Oscar
- Spallazzi Marco
- Spalletta Gianfranco
- Spottke Annika
- Squassina Alessio
- Stringa Najada
- Sáez María Eugenia
- Sánchez-Juan Pascual
- Tagliavini Fabrizio
- Tankard Rick M.
- Tesi Niccolo
- Thomassen Jesper Qvist
- Tremolizzo Lucio
- Tsolaki Magda
- Tybjærg-Hansen Anne
- Tárraga Lluís
- Ullgren Abbe
- Universitat Autònoma de Barcelona
- Valero Sergi
- Van Broeckhoven Christine
- van der Flier Wiesje M
- van der Lee Sven J.
- Van Dongen Jasper
- van Duijn Cornelia M.
- van Schoor Natasja M.
- Vandenberghe Rik
- Vidal Jean-Sébastien
- Vogelgsang Jonathan
- Vyhnalek Martin
- Wagner Michael
- Wallon David
- Wang Li-San
- Weinhold Leonie
- Williams Julie
- Wiltfang Jens
- Yang Qiong
- Yannakoulia Mary
- Zetterberg Henrik
- Zettergren Anna
- Zulaica Miren
- Álvarez Victoria
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2023
- Field of study
Genetic discoveries of Alzheimer's disease are the drivers of our understanding, and together with polygenetic risk stratification can contribute towards planning of feasible and efficient preventive and curative clinical trials. We first perform a large genetic association study by merging all available case-control datasets and by-proxy study results (discovery n = 409,435 and validation size n = 58,190). Here, we add six variants associated with Alzheimer's disease risk (near APP, CHRNE, PRKD3/NDUFAF7, PLCG2 and two exonic variants in the SHARPIN gene). Assessment of the polygenic risk score and stratifying by APOE reveal a 4 to 5.5 years difference in median age at onset of Alzheimer's disease patients in APOE ɛ4 carriers. Because of this study, the underlying mechanisms of APP can be studied to refine the amyloid cascade and the polygenic risk score provides a tool to select individuals at high risk of Alzheimer's disease