Pectin a multifaceted biopolymer in the management of cancer : a review

The authors declare the following financial interests/personal relationships which may be considered as potential competing interests: Carene Picot-Allain reports financial support was provided by Carnegie Corporation of New York through the Early Career Research Leader Fellowship Program at Future Africa, University of Pretoria. Carene PicotAllain reports financial support was provided by Capacity building competitive grant Training the Next Generation of Scientists for Africa provided by Carnegie Corporation of New York through the Regional Universities Forum for Capacity Building in Agriculture (RUFORUM).ACKNOWLEDGEMENT : We acknowledge the support provided by the Carnegie Corporation of New York through the Early Career Research Leader Fellowship Program at Future Africa, University of Pretoria. Support for this research was made possible through a capacity building competitive grant Training the Next Generation of Scientists for Africa provided by Carnegie Corporation of New York through the Regional Universities Forum for Capacity Building in Agriculture (RUFORUM).This review article focuses on the multifaceted roles of pectin in cancer management, namely as an oncotherapeutic delivery vehicle and a pharmacological agent. Over the past decades, the potential of pectin as a novel therapeutical agent for the prevention and/or management of cancer has gained increasing interest. Pectin has been found to modulate different mechanisms involved in the onset and progression of carcinogenesis, such as galectin-3 inhibition, caspase-3- induced apoptosis, and autophagy. Elucidating the structure-activity relationship provides insight into the relationship between the structure of pectin and different mechanism/s. The bioactivity of pectin, with respect to its structure, was critically discussed to give a better insight of the relationship between the structure of the extracted pectin and the observed bioactive effects. The rhamnogalacturonan I part of the pectin chain was found to bind to galectin-3, associated with several cancer hallmarks. The anti-inflammatory and antioxidant potential of pectin were also described. The roles of pectin as a treatment enhancer and a drug delivery vehicle for oncotherapeutics were critically defined. The scientific findings presented in this paper are expected to highlight the potential and role of pectin recovered from various plant sources in preventing and managing cancer.FUNDING : This research was funded by the Carnegie Corporation of New York through the Early Career Research Leader Fellowship Program at Future Africa, University of Pretoria, G 17-55192 and the Carnegie Corporation of New York through the Regional Universities Forum for Capacity Building in Agriculture (RUFORUM), grant ID RU/ 2022/ RI/ 08.www.cell.com/heliyonam2024Consumer ScienceNon

An Integrated NMR, LC-DAD-MS, LC-QTOF Metabolomic Characterization of Sartoria hedysaroides: Correlation of Antioxidant and Enzyme Inhibitory Activity with Chemical Composition by Multivariate Data Analysis

Sartoria hedysaroides Boiss and Heldr. (Fabaceae) is an endemic plant of Turkey that has received little scientific consideration so far. In the present study, the chemical profiles of extracts from the aerial part and roots of S. hedysaroides obtained using solvents with different polarities were analyzed combining integrated NMR, LC-DAD-MSn, and LC-QTOF methods. In vitro antioxidant and enzyme inhibitory activities were evaluated, and the results were combined with chemical data using multivariate approaches. Phenolic acids, flavonoids, ellagitannins, and coumarins were identified and quantified in the extracts of aerial part and roots. Methanolic extract of S. hedysaroides aerial part showed the highest phenolic content and the highest antioxidant activity and cupric ion reducing antioxidant capacity. Dichloromethane extract of S. hedysaroides roots showed the highest inhibition of butyryl cholinesterase, while methanolic extract of S. hedysaroides aerial part was the most active tyrosinase inhibitor. Multivariate data analysis allowed us to observe a good correlation between phenolic compounds, especially caffeoylquinic derivatives and flavonoids and the antioxidant activity of extracts. Acetylcholinesterase inhibition was correlated with the presence of caffeoylquinic acids and coumarins. Overall, the present study appraised the biological potential of understudied S. hedysaroides, and provided a comprehensive approach combining metabolomic characterization of plant material and multivariate data analysis for the correlation of chemical data with results from multi-target biological assays

Supplementary data for the article: Zengin, G.; Cvetanović, A.; Gašić, U.; Tešić, Ž.; Stupar, A.; Bulut, G.; Sinan, K. I.; Uysal, S.; Picot-Allain, M. C. N.; Mahomoodally, M. F. A Comparative Exploration of the Phytochemical Profiles and Bio-Pharmaceutical Potential of Helichrysum Stoechas Subsp. Barrelieri Extracts Obtained via Five Extraction Techniques. Process Biochemistry 2020, 91, 113–125. https://doi.org/10.1016/j.procbio.2019.12.002

Supplementary material for: [https://doi.org/10.1016/j.procbio.2019.12.002]Related to published version: [http://cherry.chem.bg.ac.rs/handle/123456789/3963]Related to accepted version: [http://cherry.chem.bg.ac.rs/handle/123456789/3964

Chemical profiling and biological evaluation of Nepeta baytopii extracts and essential oil: An endemic plant from Turkey

Nepeta baytopii is a poorly studied, endemic Nepeta species (Lamiaceae) of Turkey. For the first time, the biological activities (antioxidant, enzyme inhibition, and cytotoxicity properties) of the hexane, ethyl acetate, methanol, water/methanol, and water extracts and essential oil prepared from N. baytopii aerial parts were assessed. Hydro-methanol (41.25 mg gallic acid equivalent (GAE)/g) and water extracts (50.30 mg GAE/g), respectively showed the highest radical scavenging (94.40 and 129.22 mg Trolox equivalent (TE)/g, for 2,2-diphenyl-1-picrylhydrazyl radical and 2,2-azinobis (3-ethylbenzothiazoline-6-sulfonic acid radical scavenging assays) and reducing (229.37 and 129.55 mg TE/g, for ferric-reducing antioxidant power and cupric-reducing antioxidant capacity assays) capacities in vitro. An interestingly high inhibition was observed for ethyl acetate extract against butyrylcholinesterase (10.85 mg galantamine equivalent/g). The methanol extract showed high cytotoxicity (31.7%) against HepG2 cells. Caryophyllene oxide was identified in high concentrations in the essential oil (39.3%). Luteolin and apigenin and their derivatives were identified from the methanol and water extracts. The results obtained from this study highlighted that the abundance of highly bioactive compounds from Nepeta baytopii ensures the multiple biological activities of the tested extracts, and this suggests a potential use in the pharmaceutical and nutraceutical fields, and therefore should be investigated further.info:eu-repo/semantics/publishedVersio

FIG. 9 in New data on the theropod diversity from the Middle to Late Jurassic of the Vaches Noires cliffs (Normandy, France)

FIG. 9. — Allosauroidea indet., left maxilla and dentary (A1). Tentative positioning of A1 specimen in an "allosauroid like" skull (A); maxillary in dorsal view (A) and interpretative drawing (C). Abbreviations: amp, anteromedial process; man, maxillary antrum; pmf, promaxillary fossa; pmr, promaxillary recess; poas, postantral strut; pras, preantral strut. Scale bar: 5 cm.Published as part of <i>Monvoisin, Evariste, Allain, Ronan, Buffetaut, Eric & Picot, Laurent, 2022, New data on the theropod diversity from the Middle to Late Jurassic of the Vaches Noires cliffs (Normandy, France), pp. 385-415 in Geodiversitas 44 (12)</i> on page 398, DOI: 10.5252/geodiversitas2022v44a12, <a href="http://zenodo.org/record/6391240">http://zenodo.org/record/6391240</a&gt

FIG. 13. — Specimen MPV 2020.1.9 in New data on the theropod diversity from the Middle to Late Jurassic of the Vaches Noires cliffs (Normandy, France)

FIG. 13. — Specimen MPV 2020.1.9, first or second dorsal vertebra of an indeterminate Allosauroidea from Oxfordian marls, in anterior (A), posterior (B) and left lateral (C) views. Abbreviations: cpof, centropostzygapophyseal fossa; acdl, anterior centrodiapophyseal lamina; cpol, centrodiapophyseal lamina; cpof, centropostzygapophyseal fossa; cprl, centroprezygapophyseal lamina; dp, diapophysis; ls, ligament scar; ns, neural spine; pcdl, posterior centrodiapophyseal lamina; plr, pleurocoel; po, postzygapophysis; pocdf, postzygapophyseal centrodiapophyseal fossa; pp, parapophysis; pr, prezygapophysis; prcdf, prezygapophyseal centrodiapophyseal fossa; prdl, prezygodiapophyseal lamina; spof, spinopostzygodiapophyseal fossa. Scale bar: 5 cm.Published as part of <i>Monvoisin, Evariste, Allain, Ronan, Buffetaut, Eric & Picot, Laurent, 2022, New data on the theropod diversity from the Middle to Late Jurassic of the Vaches Noires cliffs (Normandy, France), pp. 385-415 in Geodiversitas 44 (12)</i> on page 402, DOI: 10.5252/geodiversitas2022v44a12, <a href="http://zenodo.org/record/6391240">http://zenodo.org/record/6391240</a&gt

FIG. 10 in New data on the theropod diversity from the Middle to Late Jurassic of the Vaches Noires cliffs (Normandy, France)

FIG. 10. — Allosauroidea indet., right maxilla (MPV 2020.1.1), in lateral (A), medial (B) and dorsal (C) views. Details of mesial denticles from a replacement tooth of the second alveoli in lingual view (D). Abbreviations: aof, antorbital fossa; aor, antorbital ridge; amp, anteromedial process; pmr, promaxillary recess. Scale bar: A-C, 5 cm; D, 1 mm.Published as part of <i>Monvoisin, Evariste, Allain, Ronan, Buffetaut, Eric & Picot, Laurent, 2022, New data on the theropod diversity from the Middle to Late Jurassic of the Vaches Noires cliffs (Normandy, France), pp. 385-415 in Geodiversitas 44 (12)</i> on page 399, DOI: 10.5252/geodiversitas2022v44a12, <a href="http://zenodo.org/record/6391240">http://zenodo.org/record/6391240</a&gt

FIG. 8 in New data on the theropod diversity from the Middle to Late Jurassic of the Vaches Noires cliffs (Normandy, France)

FIG. 8. — Allosauroidea indet., left maxilla and dentary in occlusion (A1), lower Oxfordian Marnes de Villers, in lateral (A) and medial (B) views; mesial denticles of the fourth maxillary tooth in lateral view (C); mesial denticles of the second dentary tooth in lingual view (D); apex of the third dentary replacement tooth in lingual view (E). Abbreviations: aof, antorbital fossa; aor, antorbital ridge; amp, anteromedial process; dt, dentary tooth; mg, Meckelian groove; mt, maxillary tooth. Scale bars: A, B, 5 cm; C-E, 1 mm.Published as part of <i>Monvoisin, Evariste, Allain, Ronan, Buffetaut, Eric & Picot, Laurent, 2022, New data on the theropod diversity from the Middle to Late Jurassic of the Vaches Noires cliffs (Normandy, France), pp. 385-415 in Geodiversitas 44 (12)</i> on page 397, DOI: 10.5252/geodiversitas2022v44a12, <a href="http://zenodo.org/record/6391240">http://zenodo.org/record/6391240</a&gt

New data on the theropod diversity from the Middle to Late Jurassic of the Vaches Noires cliffs (Normandy, France)

Monvoisin, Evariste, Allain, Ronan, Buffetaut, Eric, Picot, Laurent (2022): New data on the theropod diversity from the Middle to Late Jurassic of the Vaches Noires cliffs (Normandy, France). Geodiversitas 44 (12): 385-415, DOI: 10.5252/geodiversitas2022v44a1

FIG. 19 in New data on the theropod diversity from the Middle to Late Jurassic of the Vaches Noires cliffs (Normandy, France)

FIG. 19. — Representation of the supposed three theropods taxon of the Vaches Noires cliffs with anatomic referred specimen positioning. Indeterminate Allosauroidea (A). Streptospondylus altdorfensis with the probable individual from Oolithes Ferrugineuse de Villers (B). Indeterminate Megalosauroidea distinct from Streptospondylus altdorfensis (C). Scale bars: 1 m.Published as part of <i>Monvoisin, Evariste, Allain, Ronan, Buffetaut, Eric & Picot, Laurent, 2022, New data on the theropod diversity from the Middle to Late Jurassic of the Vaches Noires cliffs (Normandy, France), pp. 385-415 in Geodiversitas 44 (12)</i> on page 409, DOI: 10.5252/geodiversitas2022v44a12, <a href="http://zenodo.org/record/6391240">http://zenodo.org/record/6391240</a&gt