Highly Ionized Potassium Lines in Solar X-ray Spectra and the Abundance of Potassium

The abundance of potassium is derived from X-ray lines observed during flares by the RESIK instrument on the solar mission CORONAS-F between 3.53 A and 3.57 A. The lines include those emitted by He-like K and Li-like K dielectronic satellites, which have been synthesized using the CHIANTI atomic code and newly calculated atomic data. There is good agreement of observed and synthesized spectra, and the theoretical behavior of the spectra with varying temperature estimated from the ratio of the two GOES channels is correctly predicted. The observed fluxes of the He-like K resonance line per unit emission measure gives log A(K) = 5.86 (on a scale log A(H) = 12), with a total range of a factor 2.9. This is higher than photospheric abundance estimates by a factor 5.5, a slightly greater enhancement than for other elements with first ionization potential (FIP) less than about 10 eV. There is, then, the possibility that enrichment of low-FIP elements in coronal plasmas depends weakly on the value of the FIP which for K is extremely low (4.34 eV). Our work also suggests that fractionation of elements to form the FIP effect occurs in the low chromosphere rather than higher up, as in some models.Comment: 14 pages, 3 figure

Restoration of the Red Wolf

WOLFERS IN NORTHEASTERN North Carolina were busy on February 5, 1768. Records from the Tyrrell County courthouse read: “Giles Long and Thomas Wllkinson awarded one pound for a certified wolf scalp; Jeremiah Norman awarded two pounds for certified wolf and wild-cat scalps; Davenport Smithwick awarded one pound for a certified wolf-scalp. Such was the nature of the war on the wolf: people killed them for money. The belief of the time held that the war was necessary because it was humankind\u27s manifest destiny to tame the wilderness. And for the wilderness to be tame, the wolf had to be exterminated. The wolf was resourceful and hardy, but the wolfers persisted with increasingly sophisticated methods of killing. The war lasted 200 years, and the wolf lost.

The Solar Flare Chlorine Abundance from RESIK X-ray Spectra

The abundance of chlorine is determined from X-ray spectra obtained with the RESIK instrument on {\em CORONAS-F} during solar flares between 2002 and 2003. Using weak lines of He-like Cl, \ion{Cl}{16}, between 4.44 and 4.50 \AA, and with temperatures and emission measures from {\em GOES} on an isothermal assumption, we obtained $A({\rm Cl}) = 5.75 \pm 0.26$ on a scale $A({\rm H}) = 12$. The uncertainty reflects an approximately factor 2 scatter in measured line fluxes. Nevertheless our value represents what is probably the best solar determination yet obtained. It is higher by factors of 1.8 and 2.7 than Cl abundance estimates from an infrared sunspot spectrum and nearby \ion{H}{2} regions. The constancy of the RESIK abundance values over a large range of flares ({\em GOES} class from below C1 to X1) argues for any fractionation that may be present in the low solar atmosphere to be independent of the degree of solar activity.Comment: 13 pages, 3 colour figures. To be published, Astrophysical Journa

Comparison of Commercial and Self-Initiated Weight Loss Programs in People With Prediabetes: A Randomized Control Trial

To determine if a widely available weight-management program (Weight Watchers) could achieve sufficient weight loss in persons with prediabetes compared with a Diabetes Prevention Program-based individual counseling program supported by National Diabetes Education Program materials. METHODS: We conducted an individual, randomized intervention trial in Indianapolis, Indiana, in 2013 to 2014, in 225 persons with prediabetes. We compared the Weight Watchers weight-management program (n = 112) with Your Game Plan to Prevent Type 2 Diabetes, a program developed by the National Diabetes Education Program. Outcomes were weight and metabolic markers measured at baseline, 6 months, and 12 months. RESULTS: Intervention participants lost significantly more weight than controls at 6 months (5.5% vs 0.8%) and 12 months (5.5% vs 0.2%; both P < .001). The intervention group also had significantly greater improvements in hemoglobin A1c and high-density lipoprotein cholesterol level than did controls. CONCLUSIONS: A large weight-management program is effective for achieving lifestyle changes associated with diabetes prevention. Such programs could significantly increase the availability of diabetes prevention programs worldwide making an immediate and significant public health impact

Dose Finding Study To Assess Safety, Pk And Efficacy Of Fimepinostat (Cudc‐907) With Venetoclax Or Rituximab Plus Bendamustine In Patients With Relapsed/Refractory Lymphoma

Peer Reviewedhttps://deepblue.lib.umich.edu/bitstream/2027.42/149554/1/hon9_2632.pd

Contribution of chromosomal polymorphisms to the G-matrix of Mimulus guttatus

This is the peer reviewed version of the following article: Scoville, A., Lee, Y. W., Willis, J. H., & Kelly, J. K. (2009). Contribution of chromosomal polymorphisms to the G-matrix of Mimulus guttatus. The New Phytologist, 183(3), 803–815. http://doi.org/10.1111/j.1469-8137.2009.02947.x, which has been published in final form at http://doi.org/10.1111/j.1469-8137.2009.02947.x. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Self-Archiving.Evolution of genetic (co)variances (the G-matrix) fundamentally influences multitrait divergence. Here, we isolated the contribution of two chromosomal quantitative trait loci (QTLs), a meiotic drive locus and a polymorphic inversion, to the overall G-matrix for a suite of floral, phenological and male fitness traits in a population of Mimulus guttatus. This allowed us to predict the evolution of trait means and genetic (co)variances as a function of allele frequencies, and to evaluate theories about the maintenance of genetic variation in fitness. Individuals generated using a replicated F2 breeding design were grown under common conditions, genotyped and measured for trait values. Significant additive genetic variance existed for all traits, and most genetic covariances were significantly nonzero. Both QTLs contribute to the additive genetic (co)variances of multiple traits. Pleiotropy was not generally consistent, either between QTLs or with the genetic background. Shifts in allele frequencies at either QTL are predicted to result in substantial changes in the G-matrix. Both QTLs contribute substantially to the genetic variation in pollen viability. The Drive QTL, and perhaps also the inversion, demonstrates the contribution of balancing selection to the maintenance of genetic variation in fitness

A Prospective Study of Lupus and Rheumatoid Arthritis in Relation to Deployment in Support of Iraq and Afghanistan: The Millennium Cohort Study

The objective of this study was to prospectively assess the association between deployment in support of the operations in Iraq and Afghanistan and newly reported lupus and rheumatoid arthritis while also considering the effects of demographic, behavioral, and occupational characteristics. A total of 77,047 (2001–2003) and 31,110 (2004–2006) participants completed the baseline Millennium Cohort questionnaire and were resurveyed approximately every 3 years. Longitudinal analyses were used to assess the adjusted association between deployment to Iraq and Afghanistan with and without combat exposures and newly reported disease. After adjusting, deployment was not significantly associated with newly reported lupus compared with nondeployers. However, compared with nondeployers, deployers with and without combat exposures were significantly less likely to newly report rheumatoid arthritis. Women, non-Hispanic black, and Hispanic participants had a significantly elevated risk for both diseases. Overall, deployment was not associated with an increased risk of newly reported lupus or rheumatoid arthritis

Anticancer properties of distinct antimalarial drug classes

We have tested five distinct classes of established and experimental antimalarial drugs for their anticancer potential, using a panel of 91 human cancer lines. Three classes of drugs: artemisinins, synthetic peroxides and DHFR (dihydrofolate reductase) inhibitors effected potent inhibition of proliferation with IC 50 s in the nM- low µM range, whereas a DHODH (dihydroorotate dehydrogenase) and a putative kinase inhibitor displayed no activity. Furthermore, significant synergies were identified with erlotinib, imatinib, cisplatin, dasatinib and vincristine. Cluster analysis of the antimalarials based on their differential inhibition of the various cancer lines clearly segregated the synthetic peroxides OZ277 and OZ439 from the artemisinin cluster that included artesunate, dihydroartemisinin and artemisone, and from the DHFR inhibitors pyrimethamine and P218 (a parasite DHFR inhibitor), emphasizing their shared mode of action. In order to further understand the basis of the selectivity of these compounds against different cancers, microarray-based gene expression data for 85 of the used cell lines were generated. For each compound, distinct sets of genes were identified whose expression significantly correlated with compound sensitivity. Several of the antimalarials tested in this study have well-established and excellent safety profiles with a plasma exposure, when conservatively used in malaria, that is well above the IC 50 s that we identified in this study. Given their unique mode of action and potential for unique synergies with established anticancer drugs, our results provide a strong basis to further explore the potential application of these compounds in cancer in pre-clinical or and clinical settings

Assessing connectivity between an overlying aquifer and a coal seam gas resource using methane isotopes, dissolved organic carbon and tritium

Coal seam gas (CSG) production can have an impact on groundwater quality and quantity in adjacent or overlying aquifers. To assess this impact we need to determine the background groundwater chemistry and to map geological pathways of hydraulic connectivity between aquifers. In south-east Queensland (Qld), Australia, a globally important CSG exploration and production province, we mapped hydraulic connectivity between the Walloon Coal Measures (WCM, the target formation for gas production) and the overlying Condamine River Alluvial Aquifer (CRAA), using groundwater methane (CH4) concentration and isotopic composition (δ13C-CH4), groundwater tritium (3H) and dissolved organic carbon (DOC) concentration. A continuous mobile CH4 survey adjacent to CSG developments was used to determine the source signature of CH4 derived from the WCM. Trends in groundwater δ13C-CH4 versus CH4 concentration, in association with DOC concentration and 3H analysis, identify locations where CH4 in the groundwater of the CRAA most likely originates from the WCM. The methodology is widely applicable in unconventional gas development regions worldwide for providing an early indicator of geological pathways of hydraulic connectivity

Impact of Scottish vocational qualifications on residential child care : have they fulfilled the promise?

This article will present findings from a doctoral study exploring the impact of 'SVQ Care: Promoting Independence (level III)' within children's homes. The study focuses on the extent to which SVQs enhance practice and their function within a 'learning society'. A total of 30 staff were selected from seven children's homes in two different local authority social work departments in Scotland. Each member of staff was interviewed on four separate occasions over a period of 9 months. Interviews were structured using a combination of repertory grids and questions. Particular focus was given to the assessment process, the extent to which SVQs enhance practice and the learning experiences of staff. The findings suggest that there are considerable deficiencies both in terms of the SVQ format and the way in which children's homes are structured for the assessment of competence. Rather than address the history of failure within residential care, it appears that SVQs have enabled the status quo to be maintained whilst creating an 'illusion' of change within a learning society