23 research outputs found
Atypical sympathetic arousal in children with autism spectrum disorder and its association with anxiety symptomatology
- Author
- A Kushki
- A Kushki
- A Kylliäinen
- A Lanatà
- A Schwerdtfeger
- A Siegel
- BE Hubert
- C Daluwatte
- C Lord
- C Lord
- CJ Anderson
- CJ Anderson
- D Jezova
- D Mathersul
- D Mathersul
- DC Fowles
- DM Riby
- DR Bach
- E Anagnostou
- E Bal
- E Neuhaus
- F Beissner
- FJ Steensel van
- H Snoek
- I Smeekens
- J Coull
- J Naveteur
- JA Brian
- JA Wilken
- JR Stroop
- L Pina-Camacho
- LM Jansen
- LMC Jansen
- M Benedek
- M Franz
- M South
- MA Patriquin
- MC Chang
- ME Dawson
- MH Hollocks
- RC Philip
- S Baron-Cohen
- SC Herpertz
- SN Garfinkel
- SW Porges
- SW Porges
- T Eilam-Stock
- T McAuley
- TP Levine
- TW Benevides
- W Hirstein
- X Ming
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Implicating genes, pleiotropy, and sexual dimorphism at blood lipid loci through multi-ancestry meta-analysis
- Author
- Aadahl Mette
- Abbas Shahid
- Abecasis Goncalo
- Adair Linda S.
- Adams Hieab H. H.
- Adeyemo Adebowale A.
- Aguilar-Salinas Carlos A.
- Akiyama Masato
- Al-Mulla Fahd
- Arbeeva Liubov
- Arnett Donna K.
- Asselbergs Folkert W.
- Assimes Themistocles
- Attia John
- Banas Bernhard
- Bandinelli Stefania
- Baras Aris
- Bayyana Swati
- Bechayda Sonny Augustin
- Benjamins Jan W.
- Bennett David A.
- Bentley Amy R.
- Beulens Joline W. J.
- Bharadwaj Dwaipayan
- Bhatti Konain Fatima
- Bielak Lawrence F.
- Biino Ginevra
- Bis Joshua C
- Bjerregaard Anne A.
- Black Corri
- Boehnke Michael
- Bollepalli Sailalitha
- Boomsma Dorret I.
- Bork-Jensen Jette
- Bouchard Claude
- Bradfield Jonathan P.
- Bradford Yuki
- Brandslund Ivan
- Braund Peter S.
- Brody Jennifer A.
- Brown Christopher D.
- Brown Michael R.
- Brown Morris
- Brumpton Ben M.
- Buring Julie E.
- Burtt Noël P.
- Böger Carsten A.
- Cade Brian E.
- Cai Qiuyin
- Campbell Archie
- Campbell Harry
- Caulfield Mark J.
- Cañadas-Garre Marisa
- Chai Jin Fang
- Chambers John C.
- Chandak Giriraj R.
- Chang Kyong-Mi
- Chasman Daniel I.
- Chaturvedi Nish
- Chen Shufeng
- Chen YEugene
- Chen Yii-Der Ida
- Chen Zhengming
- Cheng Ching-Yu
- Chitrala Kumaraswamy Naidu
- Cho Kelly
- Cho Yoon Shin
- Choi Hyeok Sun
- Choudhury Ananyo
- Christensen Henry
- Christensen Kaare
- Christofidou Paraskevi
- Chuang Lee-Ming
- Ciullo Marina
- Clarke Shoa L.
- Concas Maria Pina
- Correa Adolfo
- Costanzo Maria C.
- Couture Christian
- Cruz Miguel
- Cuellar-Partida Gabriel
- Cupples LAdrienne
- Damrauer Scott M.
- Dantoft Thomas M.
- Daviglus Martha
- Daw EWarwick
- de Borst Gert J.
- de Graaf Jacqueline
- De Jager Philip L.
- de Kleijn Dominique
- de Silva H. Janaka
- de Vries Paul S.
- Dedoussis George
- Delgado Graciela E.
- Deloukas Panos
- Demirkan Ayşe
- Dorajoo Rajkumar
- Doumatey Ayo P.
- Elders Petra J. M.
- Engmann Jorgen
- Erdmann Jeanette
- Evans Michele K.
- Farmaki Aliki-Eleni
- Faul Jessica D.
- Feitosa Mary F.
- Feng QiPing
- Fernandez-Lopez Juan Carlos
- Forer Lukas
- Fornage Myriam
- Francesco Cucca
- Frank Mirjam
- Franke Andre
- Franks Paul W.
- Frayling Timothy M.
- Freitag-Wolf Sandra
- Fuchsberger Christian
- Galesloot Tessel E.
- Gao Zishan
- Gaziano John M.
- Ghanbari Mohsen
- Giannakopoulou Olga
- Giardoglou Tota
- Gieger Christian
- Girotto Giorgia
- Giulianini Franco
- Goel Anuj
- Golightly Yvonne M.
- Gordon-Larsen Penny
- Graff Mariaelisa
- Graham Sarah E.
- Grant Struan F. A.
- Grarup Niels
- Gu Dongfeng
- Gudbjartsson Daniel F.
- Gudnason Vilmundur
- Guo Xiuqing
- Gustafsson S
- Haessler Jeffrey
- Hakonarson Hakon
- Han Sohee
- Hansen Torben
- Hart Leen M.'t
- Hattersley Andrew T.
- Havulinna Aki S.
- Haworth Simon
- Hayes M. Geoffrey
- Hayward Caroline
- Hazelhurst Scott
- Hebbar Prashantha
- Heid Iris M.
- Helgadottir Anna
- Heng Chew-Kiat
- Hewitt Alex W.
- Hidalgo Bertha
- Hilliard Austin T.
- Hindy George
- Hirschhorn Joel N.
- Hishigaki Haretsugu
- Ho Yuk-Lam
- Hoefer Imo E.
- Hofer Edith
- Hollander Anneke Iden
- Holm Hilma
- Holmes Michael V.
- Homuth Georg
- Hottenga Jouke Jan
- Huang Hongyan
- Huang Jianfeng
- Huang Wei
- Huerta-Chagoya Alicia
- Hui Qin
- Hung Yi-Jen
- Hunt Karen A.
- Hunt Steven C.
- Huo Shaofeng
- Hutri-Kähönen Nina
- Hveem Kristian
- Hwang Mi Yeong
- Hwu Chii-Min
- Ichihara Sahoko
- Iha Hiroyuki
- Ikeda Daisuke D.
- Ikram M. Arfan
- Ingelsson Erik
- Irvin Marguerite R.
- Jackson Rebecca D.
- Jang Dongkeun
- Jang Hye-Mi
- Jarvelin Marjo-Riitta
- Jarvik Gail P.
- Ji Yingji
- Jin Zi-Bing
- Jonas Jost B.
- Joshi Peter K.
- Jousilahti Pekka
- Jukema J. Wouter
- Jung Bettina
- Justice Anne E.
- Jäger Susanne
- Jöckel Karl-Heinz
- Kamatani Yoichiro
- Kanai Masahiro
- Kanoni Stavroula
- Kaprio Jaakko
- Kardia Sharon L. R.
- Karpe Fredrik
- Kathiresan Sekar
- Kato Norihiro
- Katsuya Tomohiro
- Kawaguchi Takahisa
- Kee Frank
- Kentistou Katherine A.
- Khera Amit V.
- Khor Chiea Chuen
- Kiemeney Lambertus A. L. M.
- Kim Bong-Jo
- Kim Eung Kweon
- Kim Han-Na
- Kim Hyung-Lae
- Kim Young Jin
- Kivimaki Mika
- Klarin Derek
- Kleber Marcus E.
- Koh Woon-Puay
- Koistinen Heikki A.
- Kolcic Ivana
- Kooner Jaspal S.
- Kooperberg Charles
- Kovacs Peter
- Kraaijeveld Adriaan O.
- Kraft Peter
- Krauss Ronald M.
- Kronenberg Florian
- Kubo Michiaki
- Kullo Iftikhar J.
- Kumari Meena
- Kurbasic Azra
- Kutalik Zoltan
- Kuusisto Johanna
- Kähönen Mika
- Kårhus Line L.
- Laakso Markku
- Lamina Claudia
- Lange Leslie A.
- Langenberg Claudia
- Launer Lenore J.
- Le Phuong
- Lee Hyejin
- Lee Jong Young
- Lehtimäki Terho
- Leonard Hampton L.
- Lettre Guillaume
- Li Hengtong
- Li Huaixing
- Li Liming
- Li Xiaohui
- Li Xiaoyin
- Liang Jingjing
- Lieb Wolfgang
- Lin Kuang
- Lin Maoxuan
- Lin Shih-Yi
- Lin Xu
- Lind Lars
- Lingren Todd
- Linneberg Allan
- Liu Fangchao
- Liu Jun
- Liu Junfeng
- Lo Ken Sin
- Locke Adam E.
- Loeffler Markus
- Long Jirong
- Loos Ruth J. F.
- Lorés-Motta Laura
- Loukola Anu
- Lu Xiangfeng
- Luan Jian'an
- Lynch Julie A.
- Lyssenko Valeriya
- Lyytikäinen Leo-Pekka
- Magnusson Patrik K. E.
- Mahajan Anubha
- Mamakou Vasiliki
- Mangino Massimo
- Manichaikul Ani
- Marouli Eirini
- Marques-Vidal Pedro
- Marten Jonathan
- Martin Hilary C.
- Martin Lisa Warsinger
- Martin Nicholas G.
- Matsuda Fumihiko
- Matteo Floris
- Mauro Pala
- McCarthy Mark I.
- McDaid Aaron F.
- McKnight Amy Jayne
- Medina-Gomez Carolina
- Meidtner Karina
- Mellström Dan
- Mercader Josep M.
- Miller Jason E.
- Millwood Iona Y.
- Mitchell Jonathan S.
- Mitchell Paul
- Mitchell Ruth E.
- Mohlke Karen L.
- Mook-Kanamori Dennis O.
- Mori Trevor A.
- Morris Andrew P.
- Morrison Alanna C.
- Munroe Patricia B.
- Munz Matthias
- Murakami Yoshinori
- Männikkö Minna
- März Winfried
- Møllehave Line T.
- Nabika Toru
- Nakatochi Masahiro
- Nalls Mike A.
- Namjou Bahram
- Nardone Giuseppe Giovanni
- Narita Akira
- Natarajan Pradeep
- Nelson Amanda E.
- Nelson Christopher P.
- Nethander Maria
- Neville Matt J.
- Nielsen Aneta A.
- Niinikoski Harri
- Nikus Kjell
- Nongmaithem Suraj S.
- Noordam Raymond
- North Kari E.
- Ntalla Ioanna
- Nutile Teresa
- O'Donnell Christopher J.
- Obura Morgan O.
- Ohlsson Claes
- Okada Yukinori
- Olafsson Isleifur
- Oldehinkel Albertine J.
- Oldmeadow Christopher
- Orozco Lorena
- Pacheco Jennifer Allen
- Pahkala Katja
- Pajukanta Päivi
- Palmer Colin N. A.
- Pandit Anita
- Parra Esteban J.
- Pasterkamp Gerard
- Pauper Marc
- Pedersen Nancy L.
- Pedersen Oluf
- Peloso Gina M
- Pennell Craig E.
- Penninx Brenda
- Peters Annette
- Petersen Eva R. B.
- Peyser Patricia A.
- Pitkänen Niina
- Pitsillides Achilleas
- Polasek Ozren
- Poulter Neil
- Poveda Alaitz
- Pramstaller Peter P.
- Prasad Gauri
- Preuss Michael H.
- Province Michael A.
- Psaty Bruce M.
- Pérusse Louis
- Qu Jia
- Rader Daniel J.
- Raitakari Olli T.
- Rallidis Loukianos S.
- Ramdas Shweta
- Ramirez Julia
- Ramsay Michèle
- Rao D. C.
- Rasheed Asif
- Rasheed Humaira
- Rayner Nigel W.
- Redline Susan
- Reilly Dermot F.
- Reiner Alexander P.
- Rhee Sang Youl
- Ridker Paul M.
- Ripatti Samuli
- Ritchie Marylyn D.
- Rosenthal Elisabeth A.
- Rotimi Charles N.
- Rotter Jerome I.
- Ruggiero Daniela
- Ruotsalainen Sanni E.
- Ryu Seungho
- Sabanayagam Charumathi
- Sabater-Lleal Maria
- Sakaue Saori
- Saleheen Danish
- Salomaa Veikko
- Samani Nilesh J.
- Sattar Naveed
- Schmidt Börge
- Schmidt Ellen M.
- Schmidt Helena
- Schmidt Reinhold
- Scholz Markus
- Schulze Matthias B.
- Schunkert Heribert
- Scott Rodney J.
- Sengupta Dhriti
- Sever Peter
- Shin Jae Hun
- Shu Xiao-Ou
- Sim Xueling
- Simonsick Eleanor
- Slieker Roderick C.
- Smith Blair H.
- Smith Jennifer A.
- Smyth Laura J.
- Snieder Harold
- Southam Lorraine
- Spector Tim D.
- Spracklen Cassandra N.
- Stark Klaus J.
- Stefansson Kari
- Strachan David P.
- Stringham Heather M.
- Sun Yan V.
- Sung Yun Ju
- Surakka Ida
- Tabara Yasuharu
- Tai EShyong
- Takayama Jun
- Takeuchi Fumihiko
- Tamiya Gen
- Tang Hua
- Tardif Jean-Claude
- Terao Chikashi
- Terzikhan Natalie
- Thanaraj Thangavel Alphonse
- Theusch Elizabeth
- Thiery Joachim
- Thorleifsson Gudmar
- Thorsteinsdottir Unnur
- Timmers Paul R. H. J.
- Timpson Nicholas J.
- Trembath Richard C.
- Trivedi Bhavi
- Trompet Stella
- Tsao Noah L.
- Tsao Philip S.
- Turman Constance
- Tusié-Luna Teresa
- Tönjes Anke
- Universitat Autònoma de Barcelona
- Vaccargiu Simona
- van Dam Rob M.
- van der Harst Pim
- van der Laan Sander W
- van der Most Peter J.
- van Dijk Ko Willems
- van Duijn Cornelia M.
- van Heel David A.
- van Meurs Joyce B. J.
- van Setten Jessica
- Vazquez-Moreno Miguel
- Vedantam Sailaja
- Verma Anurag
- Verweij Niek
- Vestergaard Henrik
- Veturi Yogasudha
- Villalpando Clicerio Gonzalez
- Vitart Veronique
- Völzke Henry
- Walker Mark
- Walters Robin G.
- Wang Carol A.
- Wang Chaolong
- Wang Jun-Sing
- Wang Ya Xing
- Wang Yuxuan
- Wang Zeyuan
- Wang Zhe
- Wareham Nicholas J.
- Warner Sophie C.
- Warren Helen R.
- Watkins Hugh
- Wei Wei-Qi
- Wei Wen B.
- Weir David R.
- Weiss Stefan
- Whitfield John B.
- Wickremasinghe Ananda R.
- Widén Elisabeth
- Wielscher Matthias
- Wild Sarah H.
- Willemsen Allegonda H. M.
- Willer Cristen J.
- Wilson James F.
- Wilson James G.
- Wilson Peter W. F.
- Winkler Thomas W.
- Wojczynski Mary K.
- Wong Andrew
- Wong Tien-Yin
- Woo Jeong-Taek
- Wood Andrew R.
- Wu Jer-Yuarn
- Wu Kuan-Han H.
- Xia Rui
- Xue Chao
- Yamamoto Masayuki
- Yang Bin
- Yang Jian
- Yang Jingyun
- Yao Jie
- Yin Xianyong
- Yokota Mitsuhiro
- Yoon Kyungheon
- Yousri Noha A.
- Yu Ketian
- Yuan Jian-Min
- Zajac Greg J. M.
- Zeggini Eleftheria
- Zeng Lingyao
- Zhang Jifeng
- Zhang Weihua
- Zhao Jing-Hua
- Zhao Wei
- Zheng Wei
- Zhou Wei
- Zhu X
- Zhu Xiang
- Zilhao Nuno R.
- Zimmermann Martina E.
- Zmuda Joseph M.
- Zonderman Alan B.
- Åsvold Bjørn Olav
- Publication venue
- Publication date
- 01/01/2022
- Field of study
Publisher Copyright: © 2022, The Author(s).Background: Genetic variants within nearly 1000 loci are known to contribute to modulation of blood lipid levels. However, the biological pathways underlying these associations are frequently unknown, limiting understanding of these findings and hindering downstream translational efforts such as drug target discovery. Results: To expand our understanding of the underlying biological pathways and mechanisms controlling blood lipid levels, we leverage a large multi-ancestry meta-analysis (N = 1,654,960) of blood lipids to prioritize putative causal genes for 2286 lipid associations using six gene prediction approaches. Using phenome-wide association (PheWAS) scans, we identify relationships of genetically predicted lipid levels to other diseases and conditions. We confirm known pleiotropic associations with cardiovascular phenotypes and determine novel associations, notably with cholelithiasis risk. We perform sex-stratified GWAS meta-analysis of lipid levels and show that 3–5% of autosomal lipid-associated loci demonstrate sex-biased effects. Finally, we report 21 novel lipid loci identified on the X chromosome. Many of the sex-biased autosomal and X chromosome lipid loci show pleiotropic associations with sex hormones, emphasizing the role of hormone regulation in lipid metabolism. Conclusions: Taken together, our findings provide insights into the biological mechanisms through which associated variants lead to altered lipid levels and potentially cardiovascular disease risk.Peer reviewe
The impact of surgical delay on resectability of colorectal cancer: An international prospective cohort study
- Author
- Abadia M
- Abassy J
- Abate E
- Abbott Tom EF
- Abdelaal Samir A
- Abdeldayem H
- Abdelkabir M
- Abdelsamed A
- Abdulwahed E
- Abiyere H
- Abou Chaar MK
- Abukhalaf SA
- Abukhalaf Sadi
- Adamina Michel
- Ademuyiwa Adesoji
- Ademuyiwa Adesoji O
- Adeyeye A
- Adisa Adewale
- Afzal MF
- Agarwal Arnav
- Aggarwal M
- Agnes A
- Agostini C
- Agrawal A
- Agrawal N
- Agresta F
- Aguiar Junior S
- Ahmed A
- Ahmed K
- Ahmed Nafees R
- Ahmed Z
- Ahn JH
- Aime A
- Akhtar N
- Akkulak Murat
- Akrivou D
- Al Abdallah M
- Al Riyami S
- Al Sayed M
- Al-Masri M
- Al-Najjar H
- Al-Slaibi I
- Alaa S
- Alakaloko Felix
- Alameer Ehab
- Alamri Alex
- Alawneh F
- Albertsmeier M
- Albertsmeier Markus
- Alderson Derek
- Aldokali N
- Alemanno G
- Alfieri S
- Algallai M
- Ali AA
- Alkadiki Ghadah Z
- Almaadany Faraj S
- Almeida AC
- Almeida-Reis R
- Almezghwi H
- Almond Max
- Alrahawy M
- Alser Osaid
- Alshaar Muhammad
- Alshareea E
- Alshareef K
- Alshryda Sattar
- Alsoufi A
- Altamirano Riquoir C
- Altomare DF
- Altomi I
- Alurralde C
- Alvarez MR
- Alvi A
- Alwarfly S
- AlZAEDE S
- Alzeerelhouseini IAH
- Amaral MJ
- Amira G
- Amorim E
- Amrani L
- Anania G
- Anastasi A
- Andrade Kam da Silva A
- Andrade R
- Annessi V
- Annicchiarico A
- Antonakis P
- Antonopoulou M
- Aprile A
- Aremu M
- Arias-Amezquita F
- Aribi N
- Aribi S
- Arkadopoulos N
- Armao T
- Armatura G
- Arminio A
- Arnaud Alexis P
- Arora A
- Arslan K
- Ashoush F
- Athanasakis E
- Attia D
- Augestad Knut Magne
- Aversano A
- Avlund T
- Awada Barakat J
- Ayasra F
- Ayasra Faris
- Ayasra Y
- Ayub B
- Ayubi A
- Ayyaz M
- Azevedo C
- Azevedo J
- Azevedo Jose
- Azevedo P
- Azman Mohd ZA
- Azzam AY
- Babalola O
- Badra R
- Bagraith K
- Baili E
- Balabel M
- Balconi A
- Baldari L
- Baldi C
- Baldini E
- Bali K
- Ballabio M
- Ballouhey Q
- Baloyiannis I
- Bandovas JP
- Bankhead-Kendall Brittany K
- Banky B
- Banuelos Romero E
- Baptista VH
- Barker D
- Barlow Emma
- Barod Ravi
- Barone R
- Baronio G
- Barrat B
- Barros Vieira A
- Bartalucci B
- Bartolini I
- Bashir Y
- Bass G
- Batistotti P
- Batstone Martin
- Baxevanidou K
- Beard David
- Becker R
- Bekele K
- Belia F
- Belkhadir ZH
- Bellacci A
- Belli A
- Bellolio F
- Bellora P
- Belluco C
- Belvedere A
- Bendjemar L
- Benkabbou A
- Benson Ruth A
- Bergamini C
- Bergeat D
- Bernante P
- Berselli M
- Bertelli G
- Bertolani E
- Besser N
- Beyer K
- Beyrne C
- Bezerra Santos T
- Bhangu Aneel A
- Bhat GA
- Bhat MA
- Biala M
- Bianchini M
- Bianco F
- Biel Juan Rey
- Bigam D
- Biondi A
- Birolo SL
- Bisagni P
- Blanco-Colino Ruth
- Bodanese B
- Boeker C
- Bondurri A
- Bong C
- Boni L
- Bonilla A
- Bonnet S
- Bordoni P
- Borges Castro F
- Borges N
- Borghi F
- Bork U
- Borroni G
- Bouchagier K
- Bouche PA
- Bouliaris K
- Boutros M
- Bowman S
- Boyce R
- Brachini G
- Bradulskis S
- Braham H
- Brar Amanpreet
- Bravo Ana Minaya
- Breen Kerry A
- Bretherton Chris
- Bristow Rob
- Bromage Steve
- Brown C
- Brunelli Alessandro
- Bruscino A
- Buarque Igor Lima
- Buarque Lima
- Bucci Fares A
- Buerba GA
- Burgan D
- Burke Joshua
- Butt U
- Bywater Edward
- Caccetta M
- Calabro M
- Camacho C
- Camara P
- Camarneiro R
- Caminsky N
- Campagnaro T
- Canas-Martinez A
- Canonico G
- Capelli P
- Capezzuoli L
- Capolupo GT
- Capunge I
- Caram EL
- Carannante F
- Carbone F
- Carcoforo P
- Cardoso N
- Cardoso P
- Carissimi F
- Caruana Edward J
- Carvello MM
- Casati M
- Cassinotti E
- Catena F
- Cecire J
- Ceelen W
- Ceretti Pisani A
- Cervellera M
- Cetares C
- Chaar Mohammad
- Chakrabortee Sohini
- Chan E
- Charalabopoulos A
- Charre L
- Chaturvedi A
- Chaturvedi H
- Chatzikomnitsa P
- Chaudhry Daoud
- Chebaro A
- Chen S
- Chessa A
- Chiappini A
- Chiarugi M
- Chinda J
- Chiozza M
- Chisthi M
- Chiva Luis
- Choong E
- Chowdri N
- Christensen P
- Christensen Peter
- Christidis P
- Christou C
- Chrysos E
- Chumbinho B
- Cianflocca D
- Cicerchia PM
- Cirillo B
- Clarizia G
- Claro M
- Coccolini F
- Cocozza E
- Coelho Nunes M
- Coffey JC
- Cohen Paul
- Colletti G
- Colombo F
- Colquhoun Alexandra
- Confalonieri M
- Connelly T
- Conti L
- Contis I
- Coonar Aman S
- Corbellini C
- Cordera F
- Corless K
- Corrigan M
- Cosentino Marino L
- Cosimelli M
- Costa M
- Costa Matos P
- Costa MJMA
- Costanzi A
- Costeira B
- Cotoia A
- Cotte E
- Cox Daniel
- Cozza V
- Creavin B
- Cremonini C
- Crespo A
- Cuasquen Velasquez BG
- Cukier M
- Cukier Moises
- Cullivan O
- Cunha C
- Cunha MF
- Cunha Miguel F
- Cunha R
- Cunningham RM
- D'Aloisio G
- D'Ugo D
- D'Ugo S
- D'Urso A
- da Cruz Lima L
- da Silva Abreu A
- da Silva Lima C
- Dainius E
- Dajani K
- Daly A
- Danias N
- Davidson Giana H
- Dawson AC
- Dawson Brett E
- de Almeida Ramalho F
- de Barros Figueiredo
- De Lima RK
- De Lucia F
- De Nardi P
- De Palma G
- de Sa Correia T
- de Sampaio Regina L
- De Simone V
- De Sousa X
- De Toma G
- De Troia A
- De Vincenti R
- Deirino A
- Delinasios G
- Dell A
- Della Giustina E
- Dellaportas D
- Delrio P
- Demetriades Andreas K
- Demyttenaere S
- Denet C
- Depalma N
- Derksen T
- Desai Anant
- Desio M
- Desoouza A
- Deus AC
- Devarakonda S
- Devezas V
- Devine M
- Dhamija P
- Dharanipragada K
- Di Bella A
- Di Franco G
- Di Lauro K
- Di Martino C
- Di Marzo F
- Di Saverio Salomone
- Diamantis A
- Diaz P
- Dijan E
- Domingues J
- Donati D
- dos Santos Martins G
- Doudakmanis C
- Dowdy Sean
- Doyle A
- Drake Thomas M
- Drane A
- Droghetti M
- Duchalais E
- Dudi-Venkata NN
- Dumitra Sinziana
- Duran Sosa EE
- Earley H
- Eastmond A
- Ebbehoj AL
- Ebben L
- Economopoulou P
- Edwards John
- Edwards John G
- Efthimiou M
- Egoroff N
- El Ahmadi B
- El Amrani M
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- Zourntou S
- Publication venue
- 'Royal College of Obstetricians & Gynaecologists (RCOG)'
- Publication date
- 01/06/2022
- Field of study
AIM: The SARS-CoV-2 pandemic has provided a unique opportunity to explore the impact of surgical delays on cancer resectability. This study aimed to compare resectability for colorectal cancer patients undergoing delayed versus non-delayed surgery. METHODS: This was an international prospective cohort study of consecutive colorectal cancer patients with a decision for curative surgery (January-April 2020). Surgical delay was defined as an operation taking place more than 4 weeks after treatment decision, in a patient who did not receive neoadjuvant therapy. A subgroup analysis explored the effects of delay in elective patients only. The impact of longer delays was explored in a sensitivity analysis. The primary outcome was complete resection, defined as curative resection with an R0 margin. RESULTS: Overall, 5453 patients from 304 hospitals in 47 countries were included, of whom 6.6% (358/5453) did not receive their planned operation. Of the 4304 operated patients without neoadjuvant therapy, 40.5% (1744/4304) were delayed beyond 4 weeks. Delayed patients were more likely to be older, men, more comorbid, have higher body mass index and have rectal cancer and early stage disease. Delayed patients had higher unadjusted rates of complete resection (93.7% vs. 91.9%, P = 0.032) and lower rates of emergency surgery (4.5% vs. 22.5%, P < 0.001). After adjustment, delay was not associated with a lower rate of complete resection (OR 1.18, 95% CI 0.90-1.55, P = 0.224), which was consistent in elective patients only (OR 0.94, 95% CI 0.69-1.27, P = 0.672). Longer delays were not associated with poorer outcomes. CONCLUSION: One in 15 colorectal cancer patients did not receive their planned operation during the first wave of COVID-19. Surgical delay did not appear to compromise resectability, raising the hypothesis that any reduction in long-term survival attributable to delays is likely to be due to micro-metastatic disease
Ultralight vector dark matter search using data from the KAGRA O3GK run
- Author
- Abac A. G.
- Abbott R.
- Abe H.
- Abouelfettouh I.
- Acernese F.
- Ackley Kendall
- Adamcewicz Christian
- Adhicary S.
- Adhikari Naresh
- Adhikari Rana X.
- Adkins V. K.
- Adya V. B.
- Affeldt C.
- Afif Ismail M.
- Agarwal Deepali
- Agathos Michalis
- Aguiar Odylio D.
- Aguilar I.
- Aiello Lorenzo
- Ain Anirban
- Ajith Parameswaran
- Akseli Hannuksela Otto
- Akutsu Tomotada
- Al-Jodah Ammar
- Al-Shammari S.
- Albanesi S.
- Alberto Trani Alessandro
- Alfaidi Reem Atallah E
- Allocca Annalisa
- Alléné C.
- Altin Paul
- Alvarez-Lopez Sofia
- Amato Alex
- Amez-Droz L.
- Amorosi A.
- Amra C.
- Anand S.
- Ananyeva A.
- Anderson Stuart
- Anderson Warren G.
- Andia Manuel
- Ando M.
- Andrade T.
- Andrea Prodi Giovanni
- Andres Nicolas
- Andric Tomislav
- Andrés-Carcasona Marc
- Anglin J.
- Anne Bizouard Marie
- Ansoldi S.
- Antelis Javier M.
- Antier Sarah
- Antoni Ramis Vidal Felip
- Antonietta Palaia Maria
- Antonio Font Roda Jose
- Aoumi M.
- Appavuravther E. Z.
- Appert S.
- Apple S. K.
- Arai Koji
- Araya Akito
- Araya Melody
- Areeda Joseph
- Argianas L. Granda
- Arif Shaikh Md
- Aritomi Naoki
- Armato F.
- Arnaud Nicolas
- Arogeti Megan
- Aronson Scott
- Arun K. G.
- Ashton Gregory
- Aso Yoichi
- Assiduo M.
- Aston S. M.
- Astone Pia
- Aubin Florian
- AVALLONE Guerino
- Babak Stanislav
- Badaracco Francesca
- Badger C.
- Bae Sangwook
- Bagnasco Stefano
- Bagui E.
- Bai Y.
- Baier Jeremy
- Bajpai Rishabh
- Baka T.
- Ball M.
- Ballardin G.
- Ballmer S. W.
- Banagiri Sharan
- Banerjee Biswajit
- Bankar Deepak
- Baral Pratyusava
- Barayoga J. C.
- Barish B. C.
- Barker D.
- Barneo Pablo
- Barone Fabrizio
- Barr Bryan
- Barsotti Lisa
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- KARATHANASIS CHRISTOS.
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- Massaro L.
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- Michaloliakos Ioannis
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- MORALES ESTER. RUIZ.
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- Moraru D.
- Morawski F.
- More Anupreeta
- More Surhud
- Moreno Claudia
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- Nakano Hiroyuki
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- Yan S.
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- Yeh S. -W.
- Yelikar A. B.
- Yeung S. M. C.
- Yin X.
- Yokoyama Jun'ichi
- Yokozawa T.
- Yoo Jooheon
- Yu Hang
- Yuzurihara Hirotaka
- Zadrożny A.
- Zahoor Jan Aasim
- Zannelli A. J.
- Zanolin M.
- Zeeshan M.
- Zelenova T.
- Zendri J. -P.
- Zeoli M.
- Zerrad M.
- Zevin Michael
- Zhang A. C.
- Zhang Jue
- Zhang L.
- Zhang Rui
- Zhang T.
- Zhang Ya
- Zhao C.
- Zhao Yue
- Zhao Yuhang
- Zheng Yanyan
- Zhong Haowen
- Zhong S.
- Zhou R.
- Zhu Zong-Hong
- Zucker M. E.
- Zweizig John
- Árpád Gergely László
- 劉 國欽
- 曹周键
- 都丸 隆行
- Publication venue
- Publication date
- 01/03/2024
- Field of study
Among the various candidates for dark matter (DM), ultralight vector DM can be probed by laser interferometric gravitational wave detectors through the measurement of oscillating length changes in the arm cavities. In this context, KAGRA has a unique feature due to differing compositions of its mirrors, enhancing the signal of vector DM in the length change in the auxiliary channels. Here we present the result of a search for U(1)B−L gauge boson DM using the KAGRA data from auxiliary length channels during the first joint observation run together with GEO600. By applying our search pipeline, which takes into account the stochastic nature of ultralight DM, upper bounds on the coupling strength between the U(1)B−L gauge boson and ordinary matter are obtained for a range of DM masses. While our constraints are less stringent than those derived from previous experiments, this study demonstrates the applicability of our method to the lower-mass vector DM search, which is made difficult in this measurement by the short observation time compared to the auto-correlation time scale of DM
Search for gravitational-lensing signatures in the full third observing run of the LIGO-Virgo network
- Author
- Abbott R.
- Abe H.
- Acernese F.
- Ackley Kendall
- Adhicary S.
- Adhikari Naresh
- Adhikari Rana X.
- Adkins V. K.
- Adya V. B.
- Affeldt C.
- Agarwal D.
- Agathos Michalis
- Aguiar Odylio D.
- Aiello Lorenzo
- Ain A.
- Ajith Parameswaran
- Akutsu Tomotada
- Albanesi S.
- Alfaidi R. A.
- Allocca Annalisa
- Alléné C.
- Altin Paul
- Amato Alex
- Anand S.
- Ananyeva A.
- Anderson Stuart
- Anderson Warren G.
- Ando M.
- Andrade T.
- Andrea Prodi Giovanni
- Andres Nicolas
- Andric Tomislav
- Andrés-Carcasona Marc
- Anne Bizouard Marie
- Ansoldi S.
- Antelis Javier M.
- Antier Sarah
- Antonio Font Roda Jose
- Apostolatos T.
- Appavuravther E. Z.
- Appert S.
- Apple S. K.
- Arai Koji
- Araya Akito
- Araya Melody
- Areeda Joseph
- Arif Shaikh Md
- Aritomi Naoki
- Arnaud Nicolas
- Arogeti M.
- Aronson S. M.
- Arène M.
- Asada Hideki
- Ashton Gregory
- Aso Yoichi
- Assiduo M.
- Aston S. M.
- Astone Pia
- Aubin Florian
- Babak Stanislav
- Badaracco Francesca
- Badger C.
- Bae S.
- Bae Y.
- Bagnasco Stefano
- Bai Y.
- Baier J. G.
- Baird J.
- Bajpai Rishabh
- Baka T.
- Ball M.
- Ballardin G.
- Ballmer S. W.
- Baltus Grégory
- Banagiri Sharan
- Banerjee Biswajit
- Bankar Deepak
- Barayoga J. C.
- Barish B. C.
- Barker D.
- Barneo Pablo
- Barone Fabrizio
- Barr Bryan
- Barsotti Lisa
- Barsuglia Matteo
- Barta Dániel
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- Barton Mark Andrew
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- Basak S.
- Bassiri Riccardo
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- Bawaj Mateusz
- Bayley Joseph
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- Beatrice Cummings Rebecca
- Bedakihale V. M.
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- Bejger Michał
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- Benoit William
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- Bernuzzi Sebastiano
- Beroiz Martin
- Berry Christopher P. L.
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- Bertolini A.
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- Beveridge Damon
- Bhandare R.
- Bhandari A. V.
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- Brau James E.
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- Chalathadka Subrahmanya Shreevathsa
- Champion Elizabeth
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- Charlton Philip
- CHASSANDE-MOTTIN Eric
- Chatterjee Chayan
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- Chaturvedi M.
- Chaty Sylvain
- Chatziioannou Katerina
- Chen ChianShu
- Chen Dan
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- Coulon J. -P.
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- Couvares Peter
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- Coyne Dennis
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- Zhao Yue
- Zhao Yuhang
- Zheng Yanyan
- Zhou R.
- Zhu Xingjiang
- Zhu Zong-Hong
- Zimmerman Aaron
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- Árpád Gergely László
- 劉 國欽
- 曹周键
- 王谨
- 都丸 隆行
- Publication venue
- Publication date
- 01/04/2023
- Field of study
Gravitational lensing by massive objects along the line of sight to the source causes distortions of gravitational wave-signals; such distortions may reveal information about fundamental physics, cosmology and astrophysics. In this work, we have extended the search for lensing signatures to all binary black hole events from the third observing run of the LIGO--Virgo network. We search for repeated signals from strong lensing by 1) performing targeted searches for subthreshold signals, 2) calculating the degree of overlap amongst the intrinsic parameters and sky location of pairs of signals, 3) comparing the similarities of the spectrograms amongst pairs of signals, and 4) performing dual-signal Bayesian analysis that takes into account selection effects and astrophysical knowledge. We also search for distortions to the gravitational waveform caused by 1) frequency-independent phase shifts in strongly lensed images, and 2) frequency-dependent modulation of the amplitude and phase due to point masses. None of these searches yields significant evidence for lensing. Finally, we use the non-detection of gravitational-wave lensing to constrain the lensing rate based on the latest merger-rate estimates and the fraction of dark matter composed of compact objects
Observation of gravitational waves from the coalescence of a 2.5−4.5 M⊙ compact object and a neutron star
- Author
- Abac Adrian
- Abbott R.
- Abouelfettouh I.
- Acernese F.
- Ackley Kendall
- Adhicary S.
- Adhikari Naresh
- Adhikari Rana X.
- Adkins V. K.
- Afif Ismail M.
- Agarwal Deepali
- Agathos Michalis
- Aghaei Abchouyeh Maryam
- Aguiar Odylio D.
- Aguilar I.
- Aiello Lorenzo
- Ain Anirban
- Ajith Parameswaran
- Akcay Sarp
- Akseli Hannuksela Otto
- Akutsu Tomotada
- Al-Jodah Ammar
- Al-Shammari S.
- Albanesi Simone
- Alex iandolo Guido
- Alfaidi Reem Atallah E
- Allocca Annalisa
- Alléné C.
- Altin Paul
- Alvarez-Lopez Sofia
- Amato Alex
- Amez-Droz L.
- Amorosi A.
- Amra C.
- Ananyeva A.
- Anderson Stuart
- Anderson Warren G.
- Andia Manuel
- Ando M.
- Andrade T.
- Andrea Prodi Giovanni
- Andres Nicolas
- Andric Tomislav
- Andrés Vallejo Peña Sergio
- Andrés-Carcasona Marc
- Anglin J.
- Anne Bizouard Marie
- Ansoldi Stefano
- Antelis Javier M.
- Antier Sarah
- Antoni Ramis Vidal Felip
- Antonietta Palaia Maria
- Antonio Font Roda Jose
- Aoumi M.
- Appavuravther E. Z.
- Appert S.
- Apple S. K.
- Arai Koji
- Araya Akito
- Araya Melody
- Areeda Joseph
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- Arif Shaikh Md
- Aritomi N.
- Armato Federico
- Arnaud Nicolas
- Arogeti Megan
- Aronson Scott
- Arun K. G.
- Ashton Gregory
- Aso Yoichi
- Assiduo M.
- Aston S. M.
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- Attadio Francesca
- Aubin Florian
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- Virtuoso Andrea
- Vitale Salvatore
- Vives A.
- Vocca Helios
- Voigt Daniel
- von Reis E. R. G.
- von Wrangel J. S. A.
- Vyatchanin Sergey P.
- Wade L. E.
- Wade Madeline
- Wagner Katelyn
- Wajid A.
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- Wu Hsun-Chung
- Wuchner E.
- Wysocki Daniel
- Xu Victoria
- Xu Yumeng
- Yaala M. Ben
- Yadav Nikesh
- Yamamoto Hiroaki
- Yamamoto Kazuhiro
- Yamamoto Takahiro
- Yamamoto Takahiro S.
- Yamamura S.
- Yamazaki Ryo
- Yan S.
- Yan T.
- Yang F.
- Yang Fengwei
- Yang Kate Z.
- Yang Yi
- Yarbrough Zach
- Yasui H.
- Yeh S. -W.
- Yelikar A. B.
- Yin X.
- Yokoyama Jun'ichi
- Yokozawa T.
- Yoo Jooheon
- Yu Hang
- Yuan S.
- Yuzurihara Hirotaka
- Zadrożny A.
- Zanolin M.
- Zeeshan M.
- Zelenova T.
- Zendri J. -P.
- Zeoli M.
- Zerrad M.
- Zevin Michael
- Zhang A. C.
- Zhang L.
- Zhang Rui
- Zhang T.
- Zhang Ya
- Zhao C.
- Zhao Yue
- Zhao Yuhang
- Zheng Yanyan
- Zhong Haowen
- Zhou R.
- Zhu Xingjiang
- Zhu Zong-Hong
- Zimmerman Aaron
- Zucker M. E.
- Zweizig John
- Árpád Gergely László
- 劉 國欽
- 都丸 隆行
- Publication venue
- Publication date
- 23/04/2024
- Field of study
Search for eccentric black hole coalescences during the third observing run of LIGO and Virgo
- Author
- Abac A. G.
- Abbott R.
- Abe H.
- Acernese F.
- Ackley Kendall
- Adamcewicz C.
- Adhicary S.
- Adhikari Naresh
- Adhikari Rana X.
- Adkins V. K.
- Adya V. B.
- Affeldt C.
- Afif Ismail M.
- Agarwal D.
- Agathos Michalis
- Aguiar Odylio D.
- Aguilar I.
- Aiello Lorenzo
- Ain Anirban
- Ajith Parameswaran
- Akseli Hannuksela Otto
- Akutsu Tomotada
- Al-Jodah Ammar
- Albanesi S.
- Alberto Trani Alessandro
- Alfaidi Reem Atallah E
- Allocca Annalisa
- Alléné C.
- Almualla M.
- Altin Paul
- Amato Alex
- Amez-Droz L.
- Amorosi A.
- Anand S.
- Ananyeva A.
- Andersen R.
- Anderson Stuart
- Anderson Warren G.
- Andia Manuel
- Ando M.
- Andrade T.
- Andrea Prodi Giovanni
- Andres Nicolas
- Andric Tomislav
- Andrés-Carcasona Marc
- Anne Bizouard Marie
- Ansoldi S.
- Antelis Javier M.
- Antier Sarah
- Antonio Font Roda Jose
- Aoumi M.
- Apostolatos T.
- Appavuravther E. Z.
- Appert S.
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- Arai Koji
- Araya Akito
- Araya Melody
- Areeda Joseph
- Arif Shaikh Md
- Aritomi Naoki
- Armato F.
- Arnaud Nicolas
- Arogeti Megan
- Aronson Scott
- Arun K. G.
- Ashton Gregory
- Aso Yoichi
- Assiduo M.
- Aston S. M.
- Astone Pia
- Aubin Florian
- Babak Stanislav
- Badalyan A.
- Badaracco Francesca
- Badger C.
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- LIETO ALBERTO. DI.
- LIGO Collaboration
- Lin Chien-Yu
- Lin Chun-Yu
- Lin En-Tzu
- Lin F.
- Lin H.
- Lin Lupin C. C.
- Lin Y.
- Linde F.
- Linker S. D.
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- Littenberg T. B.
- Liu Anna
- Liu Jian
- Llamas F.
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- Losurdo Giovanni
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- mantovani maddalena
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- Marka Szabolcs
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- Markakis Charalampos
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- SINGH MUKESH. KUMAR.
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- Vallero S.
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- Vasuth Matyas
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- Veske Doğa
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- Vijaykumar Aditya
- Villa-Ortega Verónica
- Vincent Erin
- Vinet J. -Y.
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- VIRGO Collaboration
- Virtuoso Andrea
- Vitale Salvatore
- Vocca H.
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- Xiao Liting
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- Yaala M. Ben
- Yadav Nikesh
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- Yokoyama Jun'ichi
- Yokozawa T.
- Yoo Jooheon
- Yu Hang
- Yuzurihara Hirotaka
- Zadrożny A.
- Zahoor Jan Aasim
- Zannelli A. J.
- Zanolin M.
- Zeeshan M.
- Zelenova T.
- Zendri J. -P.
- Zevin Michael
- Zhang Jue
- Zhang L.
- Zhang Rui
- Zhang T.
- Zhang Ya
- Zhang Yanqi
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- Zhao Yue
- Zhao Yuhang
- Zheng Yanyan
- Zhong Haowen
- Zhou R.
- Zhu Zong-Hong
- Zimmerman Aaron
- Zucker M. E.
- Zweizig John
- Álvarez-López S.
- Árpád Gergely László
- 劉 國欽
- 曹周键
- 都丸 隆行
- Publication venue
- Publication date
- 01/08/2023
- Field of study
Despite the growing number of confident binary black hole coalescences observed through gravitational waves so far, the astrophysical origin of these binaries remains uncertain. Orbital eccentricity is one of the clearest tracers of binary formation channels. Identifying binary eccentricity, however, remains challenging due to the limited availability of gravitational waveforms that include effects of eccentricity. Here, we present observational results for a waveform-independent search sensitive to eccentric black hole coalescences, covering the third observing run (O3) of the LIGO and Virgo detectors. We identified no new high-significance candidates beyond those that were already identified with searches focusing on quasi-circular binaries. We determine the sensitivity of our search to high-mass (total mass M>70 M⊙) binaries covering eccentricities up to 0.3 at 15 Hz orbital frequency, and use this to compare model predictions to search results. Assuming all detections are indeed quasi-circular, for our fiducial population model, we place an upper limit for the merger rate density of high-mass binaries with eccentricities 0<e≤0.3 at 0.33 Gpc−3 yr−1 at 90\% confidence level
Prevalence of respiratory viruses among febrile children with or without acute respiratory symptoms in Tanzania
- Author
- Publication venue
- Publication date
- 01/01/2011
- Field of study
Background Respiratory viruses are the most frequent cause of febrile illnesses in infants and young children but few investigations have assessed their impact and epidemiology in Africa . We investigated their rate in febrile outpatient children attending in Tanzania. Methods Children aged 2 months -10 years with fever >38 _C were recruited prospectively between April and December 2008. Medical history and clinical examination were recorded in a standardized fashion and nasopharyngeal swabs analyzed for the presence of 12 viruses by real-time PCR (FLUAV, FLUBV, RSV, MPV, HPIV-1/3, four types of HCoV, HBoV, PIC and HAdV). Ct values were used to provide semi-quantitative viral loads.Results Of 1005 febrile children enrolled, 623 (62%) had respiratory symptoms (URTI in 66%, bronchiolitis in 7% and clinical pneumonia in 27%); 156 (16%) had febrile illness that remained of unspecified etiology and 226 (22%) had other infectious diseases and no ARI (62 malaria, 56 gastroenteritis, 36 urinary tract and 72 others). The proportions of patients with at least one respiratory virus were 70%, 61% and 47% (Pvalue < 0.001) in these three groups. When excluding picornavirus and adenovirus these proportions were 48%, 24% and 26% (P-value < 0.001). Apart from picornavirus and adenovirus, influenza A and B viruses were the most frequent followed by coronavirus and RSV. The proportion of children with presumably high viral titers (Ct < 25) was higher in the group with respiratory symptoms (31%) than in the two other groups (21% and 16%). Influenza genotyping revealed strains that were similar to the ones circulating elsewhere in the world.Conclusion In African children with febrile illness, the prevalence of respiratory viruses, especially influenza A and B, is high particularly in the presence of respiratory symptoms, but also, although less so, in those with unspecified etiology or other infectious diseases. This highlights that these viruses are commonly circulating in Tanzanian children
Recycling of Bioplastics: Routes and Benefits
- Author
- A Carné Sánchez
- A Elamri
- A López
- A López
- A Morschbacker
- A Morschbacker
- A Repo
- A Sangalang
- AA Shah
- AB Raheem
- AG Buekens
- AM Al-Sabagh
- AM Al-Sabagh
- AS Goje
- ATWM Hendriks
- AU Igamberdiev
- B Kunwar
- C Samorì
- C Zhang
- CC Chu
- CKS Pillai
- CM Mendieta
- CM Thomas
- CSK Reddy
- CSM Pereira
- CT Bowmer
- D Forni
- D Forni
- D Paszun
- D Zhao
- DAS Ravens
- DD Cornell
- DE Henton
- DMC López
- DS Achilias
- DS Achilias
- DY Kim
- E Bugnicourt
- European Bioplastics Association
- European Bioplastics Association
- F Awaja
- F Burat
- F Gao
- F Masmoudi
- F Wang
- F Welle
- FA Leibfarth
- FC de Paula
- FD Alsewailem
- G Odian
- G Schliecker
- GE Luckachan
- GP Karayannidis
- GP Karayannidis
- H Ariffin
- H Jin
- H Kopnick
- H Kurokawa
- H Saptoadi
- H Tsuji
- H Wang
- H Zou
- I Zembouai
- J Greene
- J Hopewell
- J Jambeck
- J Jamradloedluk
- J Lu
- J Payne
- J Scheirs
- J Schmidt
- J Siddiqui
- J Wang
- JD Stephen
- JH Song
- K Amulya
- K Hamad
- K Hamad
- K Lee
- K Lee
- K Madhavan Nampoothiri
- K Ute
- KD Cox
- KH Lee
- KP Lueft
- L Chen
- L Luo
- L Shen
- L Shen
- L Shen
- LA Román-Ramírez
- LA Román-Ramírez
- LF Rivas
- LS Diaz Silvarrey
- LS Dilkes-Hoffman
- LS Nair
- M Arnoult
- M Cole
- M Grigore
- M Jari
- M Kulawska
- M Niaounakis
- M Niaounakis
- M Niaounakis
- M Niaounakis
- M Rabnawaz
- M Zaverl
- MAH Alzuhairi
- MD Tabone
- MF Cosate de Andrade
- MF Cosate de Andrade
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- MI Ul Haq
- MJ Fabra
- N Gurieff
- N Jacquel
- N Malik
- N Miskolczi
- N Singh
- NK Barman
- P Straka
- PP Upare
- Q Wang
- QF Yue
- R Auras
- R De Clercq
- R De Clercq
- R Geyer
- R Miandad
- R Rai
- R Scaffaro
- R Shogren
- RA Hites
- RA Vasudeo
- REN De Castro
- RL Shogren
- S Chaudhary
- S Farah
- S Honus
- S Inkinen
- S Kumar
- S Mishra
- S Philip
- S Pina
- S Wang
- SK Mohan
- SM Al-Salem
- SM Al-Salem
- SY Ong
- T Artham
- T Defoirdt
- T Defoirdt
- T Freier
- T Yoshioka
- T Yoshioka
- TP Haider
- United Nations Enviroment Programme
- UR Vaidya
- V Piemonte
- V Piemonte
- V Piemonte
- V Pimpan
- V Sinha
- W Sikorska
- World Economic Forum
- X Qi
- X Song
- X Song
- XH Zong
- Y Aoyagi
- Y Ikada
- Y Lemmouchi
- Y Poirier
- Y Tokiwa
- Y Tokiwa
- Y Yang
- Y Zhu
- YH Seo
- Z Wang
- ZMR Roohi
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
The power of genetic diversity in genome-wide association studies of lipids
- Author
- Aadahl M. (Mette)
- Abbas S. (Shahid)
- Abecasis G. (Goncalo)
- Adair L. S. (Linda S.)
- Adams H. H. (Hieab H. H.)
- Aguilar-Salinas C. A. (Carlos A.)
- Ahmed M. (Meraj)
- Akiyama M. (Masato)
- Al-Mulla F. (Fahd)
- Arbeeva L. (Liubov)
- Arendt M. (Marina)
- Arnett D. K. (Donna K.)
- Asselbergs F. W. (Folkert W.)
- Assimes T. L. (Themistocles L.)
- Asvold B. O. (Bjorn Olav)
- Attia J. (John)
- Bandinelli S. (Stefania)
- Baras A. (Aris)
- Bechayda S. A. (Sonny Augustin)
- Benjamins J. W. (Jan W.)
- Bennett D. A. (David A.)
- Bentley A. R. (Amy R.)
- Beulens J. W. (Joline W. J.)
- Bharadwaj D. (Dwaipayan)
- Bhatti F. (Fatima)
- Bielak L. F. (Lawrence F.)
- Biino G. (Ginevra)
- Bis J. C. (Joshua C.)
- Black C. (Corri)
- Boehnke M. (Michael)
- Boger C. A. (Carsten A.)
- Bollepalli S. (Sailalitha)
- Boomsma D. I. (Dorret, I)
- Bork-Jensen J. (Jette)
- Bouchard C. (Claude)
- Bradfield J. P. (Jonathan P.)
- Bradford Y. (Yuki)
- Brandslund I. (Ivan)
- Braund P. S. (Peter S.)
- Brody J. A. (Jennifer A.)
- Brown C. D. (Christopher D.)
- Brown M. (Morris)
- Brown M. R. (Michael R.)
- Brumat M. (Marco)
- Brumpton B. M. (Ben M.)
- Buring J. E. (Julie E.)
- Cade B. E. (Brian E.)
- Cai Q. (Qiuyin)
- Campbell A. (Archie)
- Campbell H. (Harry)
- Canadas-Garre M. (Marisa)
- Caulfield M. J. (Mark J.)
- Chai J. F. (Jin Fang)
- Chai X. (Xiaoran)
- Chambers J. C. (John C.)
- Chandak G. R. (Giriraj R.)
- Chang K.-M. (Kyong-Mi)
- Chasman D. I. (Daniel, I)
- Chaturvedi N. (Nish)
- Chen S. (Shufeng)
- Chen Y. E. (Y. Eugene)
- Chen Y. I. (Yii-Der Ida)
- Chen Z. (Zhengming)
- Cheng C.-Y. (Ching-Yu)
- Chitrala K. N. (Kumaraswamy Naidu)
- Cho K. (Kelly)
- Cho Y. S. (Yoon Shin)
- Choi H. S. (Hyeok Sun)
- Choudhury A. (Ananyo)
- Christensen H. (Henry)
- Christensen K. (Kaare)
- Christofidou P. (Paraskevi)
- Ciullo M. (Marina)
- Clarke S. L. (Shoa L.)
- Concas M. P. (Maria Pina)
- Correa A. (Adolfo)
- Couture C. (Christian)
- Cruz M. (Miguel)
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- Huang H. (Hongyan)
- Huang J. (Jianfeng)
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- Jung B. (Bettina)
- Justice A. E. (Anne E.)
- Järvelin M.-R. (Marjo-Riitta)
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- Kim H.-L. (Hyung-Lae)
- Kim H.-N. (Han-Na)
- Kim Y. J. (Young Jin)
- Kivimaki M. (Mika)
- Klarin D. (Derek)
- Kleber M. E. (Marcus E.)
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- Kraaijeveld A. O. (Adriaan O.)
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- Lee H. (Hyejin)
- Lee J. (Jiwon)
- Lee J. Y. (Jong Young)
- Lehtimaki T. (Terho)
- Leonard H. L. (Hampton L.)
- Lettre G. (Guillaume)
- Li H. (Huaixing)
- Li L. (Liming)
- Li X. (Xiaohui)
- Li X. (Xiaoyin)
- Lieb W. (Wolfgang)
- Lin K. (Kuang)
- Lin M. (Maoxuan)
- Lin S.-Y. (Shih-Yi)
- Lin X. (Xu)
- Lind L. (Lars)
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- Liu F. (Fangchao)
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- Lyssenko V. (Valeriya)
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- Marques-Vidal P. (Pedro)
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- Mohlke K. L. (Karen L.)
- Mollehave L. T. (Line T.)
- Mook-Kanamori D. O. (Dennis O.)
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- Morrison A. C. (Alanna C.)
- Munroe P. B. (Patricia B.)
- Munz M. (Matthias)
- Murakami Y. (Yoshinori)
- Männikkö M. (Minna)
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- Neville M. J. (Matt J.)
- Niinikoski H. (Harri)
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- Surakka I. (Ida)
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- Takeuchi F. (Fumihiko)
- Tamiya G. (Gen)
- Tardif J.-C. (Jean-Claude)
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- Wojczynski M. K. (Mary K.)
- Wong A. (Andrew)
- Wong T.-Y. (Tien-Yin)
- Woo J.-T. (Jeong-Taek)
- Wood A. R. (Andrew R.)
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- Yin X. (Xianyong)
- Yokota M. (Mitsuhiro)
- Yoon K. (Kyungheon)
- Young K. L. (Kristin L.)
- Yu K. (Ketian)
- Yuan J.-M. (Jian-Min)
- Zajac G. J. (Greg J. M.)
- Zeggini E. (Eleftheria)
- Zeng L. (Lingyao)
- Zhang J. (Jifeng)
- Zhang W. (Weihua)
- Zhao J.-H. (Jing-Hua)
- Zhao W. (Wei)
- Zheng W. (Wei)
- Zhou W. (Wei)
- Zhu X. (Xiang)
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- Zimmermann M. E. (Martina E.)
- Zmuda J. M. (Joseph M.)
- Zonderman A. B. (Alan B.)
- Publication venue
- Springer Nature
- Publication date
- 01/01/2021
- Field of study
Abstract
Increased blood lipid levels are heritable risk factors of cardiovascular disease with varied prevalence worldwide owing to different dietary patterns and medication use1. Despite advances in prevention and treatment, in particular through reducing low-density lipoprotein cholesterol levels2, heart disease remains the leading cause of death worldwide3. Genome-wideassociation studies (GWAS) of blood lipid levels have led to important biological and clinical insights, as well as new drug targets, for cardiovascular disease. However, most previous GWAS4‐23 have been conducted in European ancestry populations and may have missed genetic variants that contribute to lipid-level variation in other ancestry groups. These include differences in allele frequencies, effect sizes and linkage-disequilibrium patterns24. Here we conduct a multi-ancestry, genome-wide genetic discovery meta-analysis of lipid levels in approximately 1.65 million individuals, including 350,000 of non-European ancestries. We quantify the gain in studying non-European ancestries and provide evidence to support the expansion of recruitment of additional ancestries, even with relatively small sample sizes. We find that increasing diversity rather than studying additional individuals of European ancestry results in substantial improvements in fine-mapping functional variants and portability of polygenic prediction (evaluated in approximately 295,000 individuals from 7 ancestry groupings). Modest gains in the number of discovered loci and ancestry-specific variants were also achieved. As GWAS expand emphasis beyond the identification of genes and fundamental biology towards the use of genetic variants for preventive and precision medicine25, we anticipate that increased diversity of participants will lead to more accurate and equitable26 application of polygenic scores in clinical practice