By the work experience of the innovative platform «Applied music»

The aim of the investigation is to open the content of innovativeapproach to a solution of the problem of formation of the valuable attitude towards health and readiness for activities for health preservation and promotion by means of applied music with subjects of educational process. Methods. Separate components of the declared readiness and the valuable attitude towards health as complete personal education are designed on the basis of problem-oriented interdisciplinary approach using the evaluative, project educational technologies, technologies of applied music. Empirical methods involve. Results. Experience of an experimental platform is described: fundamental principles of the psychology and pedagogical concept of health creation are realized by means of applied music. The technology of personal growth of pupils which application creates favorable conditions for development of their potential is presented. Approbation of the health creating innovation offered by the author showed its efficiency and steady positive dynamics in acquisition of some competences in the area of attitude towards health and its preservations by students. Scientific novelty. The author introduces a new didactic unit into educational process – the «Applied Music» component which allows each participant of educational process to form an active position concerning the health and to project an individual strategy of a healthy lifestyle. Practical significance. Research materials can serve as a basis for optimization of the content of education structure – for the creation of a new throughline of training providing formation of readiness for health preservation and promotion activities with means of applied music. The necessity of this throughline is connected with a health state deterioration tendency of the students and insufficiently developed technologies of health protectionЦель работы – показать одно из возможных инновационных решений проблемы формирования у субъектов образовательного процесса ценностного отношения к здоровью и готовности к деятельности по сохранению и укреплению здоровья средствами прикладной музыки. Методы и методики. На основе проблемно-ориентированного междисциплинарного подхода с использованием развивающих, проектных образовательных технологий, технологий прикладной музыки у субъектов образовательного процесса были сформированы отдельные компоненты заявленной готовности и ценностное отношение к здоровью как целостное личностное образование. Результаты исследования. Описан опыт экспериментальной площадки, на базе которой были реализованы основные положения психолого-педагогической концепции здоровьесозидания средствами прикладной музыки. Представлена технология личностного роста учащихся, применение которой создает благоприятные условия для развития их потенциала. Апробация предлагаемой автором здоровьесозидающей инновации продемонстрировала ее эффективность и устойчивую позитивную динамику в обретении школьниками компетенций в области отношения к здоровью и его сохранения. Научная новизна работы заключается во введении в содержание образования новой дидактической единицы – компонента «Прикладная музыка», который помогает каждому участнику образовательного процесса обрести активную позицию в отношении своего здоровья и спроектировать индивидуальную стратегию здорового образа жизни. Практическое значение. Материалы публикации могут служить основой для оптимизации структуры содержания образования – создания новой сквозной линии обучения, обеспечивающей формирование готовности к деятельности по сохранению и укреплению здоровья посредством прикладной музыки. Необходимость такой сквозной линии связана с тенденцией ухудшения состояния здоровья учащихся и недостаточно разработанными технологиями здоровьесбережени

The use of yoga practice as a means of increasing emotional self-regulation of women

Received: 24.11.2022. Accepted: 18.12.2022.Рукопись поступила в редакцию: 24.11.2022. Принята к публикации: 18.12.2022.The article presents an analysis of the use of yoga as a method of improving people’s mental health, which has significantly decreased as a result of the pandemic and in the process of developing uncertainty and transformation of public life. The purpose of the study was to study the influence of yoga on the emotional self-regulation of women. The study involved 28 women, at the average age of 37.4, with different experience in yoga. To assess the development of emotional self-regulation, the method «Emotional Intelligence» (Lyusin D. V.) was used. The results of the study revealed significant differences between the development of indicators of emotional intelligence, such as understanding emotions, emotion management and expression control, depending on the duration of yoga classes. Increasing the emotional self-regulation of people who are engaged in yoga and who are under the influence of yoga requires further research. The research may be related to the role of yoga classes in improving the quality of life of those engaged.В статье представлены данные по использованию йоги как средства повышения психического здоровья людей, которое значительно снизилось в результате пандемии и в процессе развития неопределенности и трансформации общественной жизни. Цель исследования заключалась в изучении влияния йоги на развитие саморегуляции у женщин. В исследовании приняли участие 28 женщин, средний возраст 37,4, имеющий разный опыт занятий йогой. Для оценки развития эмоциональной саморегуляции использовалась методика «Эмоциональный интеллект» (Люсин Д. В.). Результаты исследования выявили достоверные различия между развитием показателей эмоционального интеллекта, такими как понимание эмоций, управление эмоциями и контроль экспрессии в зависимости от длительности занятий йогой. Повышение эмоциональной саморегуляции занимающихся под влиянием занятий йогой требует дальнейших исследований, которые могут быть связаны с ролью занятий йогой на повышение качества жизни занимающихся

АМИНОКИСЛОТНЫЙ СОСТАВ И БИОЛОГИЧЕСКАЯ ЦЕННОСТЬ БЕЛКОВ МЯСА СВИНЕЙ РАЗЛИЧНЫХ ГЕНОТИПОВ

It was established that the meat of young of Belarusian black-motley breed has the highest content of threonine, leucine, and arginine and all other essential amino acids has no significant drawbacks. For the tryptophan, isoleucine, methionine, valine, phenylalanine and histidine content, the Yorkshire breed animals have an advantage, but they are significantly limited (SCOR – 71.7 %) for the leucine content, indicating the imbalance of amino acid composition. Landrace animals have a small amount of methionine (SCOR – 94.4 %), the Belarusian large white – threonine (SCOR – 94.5 %). Belarusian meat breed and Duroc have a balanced amino acid composition. The protein quality indicator is set in the range 7.5–9.6.Установлено, что наивысшим содержанием треонина, лейцина и аргинина обладает мясо молодняка белорусской черно-пестрой породы и по всем остальным незаменимым аминокислотам не испытывает серьезного недостатка. По содержанию триптофана, изолейцина, метионина, валина, фенилаланина и гистидина преимущество имеют животные породы йоркшир, однако они значительно лимитированы (скор – 71,7 %) по содержанию лейцина, что свидетельствует о несбалансированости аминокислотного состава. Животные породы ландрас испытывают небольшую недостачу метионина (скор – 94,4 %), белорусская крупная белая – треонина (скор – 94,5 %). Белорусская мясная порода и дюрок имеют сбалансированный аминокислотный состав. Белково-качественный показатель установлен в пределах 7,5–9,6

Nonbacterial and bacterial osteomyelitis in children: a case–control retrospective study

PurposeOsteomyelitis is a group of bone infectious (bacterial osteomyeilitis—BO) and noninfectious inflammatory diseases (nonbacterial osteomyelitis—NBO) with similar clinical, radiology, and laboratory features. Many patients with NBO are misdiagnosed as BO and receive unnecessary antibiotics and surgery. Our study aimed to compare clinical and laboratory features of NBO and BO in children, to define key discriminative criteria, and to create an NBO diagnostic score (NBODS).MethodsThe retrospective multicenter cohort study included clinical, laboratory, and instrumental information about histologically confirmed NBO (n = 91) and BO (n = 31). The variables allowed us to differentiate both conditions used to construct and validate the NBO DS.ResultsThe main differences between NBO and BO are as follows: onset age—7.3 (2.5; 10.6) vs. 10.5 (6.5; 12.7) years (p = 0.03), frequency of fever (34.1% vs. 90.6%, p = 0.0000001), symptomatic arthritis (67% vs. 28.1%, p = 0.0001), monofocal involvement (28.6% vs. 100%, p = 0.0000001), spine (32% vs. 6%, p = 0.004), femur (41% vs. 13%, p = 0.004), foot bones (40% vs. 13%, p = 0.005), clavicula (11% vs. 0%, p = 0.05), and sternum (11% vs. 0%, p = 0.039) involvement. The following four criteria are included in the NBO DS: CRP ≤ 55 mg/l (56 points), multifocal involvement (27 points), femur involvement (17 points), and neutrophil bands ≤ 220 cell/μl (15 points). The sum > 17 points allowed to differentiate NBO from BO with a sensitivity of 89.0% and a specificity of 96.9%.ConclusionThe diagnostic criteria may help discriminate NBO and BO and avoid excessive antibacterial treatment and surgery

Studying the content of phenolic compounds of Bupleurum scorzonerifolium Willd., growing in the Baikal region with HPLC

Phenolic compounds of plants have a wide spectrum of pharmacological action. A number of effective herbal medicines and biologically active additives have been developed on the basis of raw materials and natural polyphenols. The sources of phenolic compounds are plants of the genus Bupleurum L. In Russia Bupleurum scorzonerifolium used in folk medicine. Infusions and decoctions were taken for diseases of the liver, gall bladder, topically as an anti-inflammatory agent. The composition of phenolic compounds in the above-ground organs of the B. scorzonerifolium studied by HPLC on the device "GILSTON". Samples of raw materials (above-ground organs) were collected in the southern areas of the Irkutsk region. For the analysis of the herb B. scorzonerifolium 70% extract ethyl alcohol was used. Separation was performed on substances Kromasil C18 column (4,6 x 250 mm, 5 micron). Detection was carried out using a UV detector "GILSTON" UV/VIS model 151, at a wavelength of 254 nm. In comparison with standard samples we identified 8 flavonoids (prevailing - izoquercetin, hyperoside, izoramnetin-3-glucoside), 5 aromatic acids (predominantly acid - cinnamic, gallic, chicory). The study established the content of epicatechin, catechin, epigallocatechingallate, coumarin. For the first time the content of acids - coffee, chlorogenic, gallic, chicory, cinnamon; flavonoids - vitsenin, lyuteolin-7-glucoside, isoramnetin-3-glucoside, apigenin; epicatechin, catechin, epigallocatechingallate; coumarin -was established in B. scorzonerifolium

Cloning and sequence analysis of cDNA for a human homolog of eubacterial ATP-dependent Lon proteases

AbstractOverlapping cDNA clones containing mRNA for a putative Lon protease (LonHS) were isolated from cDNA libraries prepared from human brain poly(A)+ RNA. The determined nucleotide sequence contains a 2814-bp open reading frame with two potential initiation codons (positions 62–64 and 338–340). The 5'-terminal 337-nucleotide fragment of LonHS mRNA is highly enriched with G and C nucleotides and could direct synthesis of the LonHS N-terminal domain. More likely this region promotes initiation of protein synthesis from the second AUG codon in a cap-independent manner. The amino acid sequence initiated at the second AUG codon includes 845 residues, over 30% of which are identical to those of eubacterial Lon proteases. Residues of the ‘A’ and ‘B’ motifs of NTP-binding pattern and a plausible catalytic serine residue are conserved in LonHS. Northern blot analysis revealed LonHS mRNA in lung, duodenum, liver and heart, but not in thymus cells

Accumulation of phenolic compounds in the aerial organs of Bupleurum scorzonerifolium Willd., growing in the Baikal region

A plant of the genus Bupleurum L. is being introduced into medical practice and being used in traditional medicine as an anti-inflammatory agent in diseases of the gastrointestinal tract, treatment of diseases of the liver and gall bladder. In folk medicine, infusionfrom the herb Bupleurum scorzonerifolium Willd. is used externally for inflammatory diseases of the eyes and skin diseases. B. scorzonerifolium is widespread and abundantly grows in the area of Ural Mountains, Altai, Tuva, in the Krasnoyarsk region, Baikal region, and Buryatia. Detection of phenolic compounds in B. scorzonerifolium was performed using qualitative analytical reactions. Studying the composition of flavonoids and phenol carbonic acids was carried out by paper chromatography. We established that the leaves of B. scorzonerifolium contain quercetin, kaempferol, rutin, hyperoside and isorhamnetin, stems - quercetin, kaempferol, rutin and isorhamnetin, flowers - quercetin, hyperoside and rutin. The leaves, flowers and stems found to contain caffeic, chlorogenic and ferulic acids. The quantitative content of tannins was determined by permanganometry method, flavonoids and phenol carbonic acids -by spectrophotometric method. The maximum quantity of phenolic compounds is detected in leaves and flowers. Thus, as a medicinal plant, the grass B. scorzonerifolium can be recommended for harvesting during the flowering period

Susceptibility testing and reporting of new antibiotics with a focus on tedizolid: an international working group report

Inappropriate use and overuse of antibiotics are among the most important factors in resistance development, and effective antibiotic stewardship measures are needed to optimize outcomes. Selection of appropriate antimicrobials relies on accurate and timely antimicrobial susceptibility testing. However, the availability of clinical breakpoints and in vitro susceptibility testing often lags behind regulatory approval by several years for new antimicrobials. A Working Group of clinical/medical microbiologists from Brazil, Canada, Mexico, Saudi Arabia, Russia and the UK recently examined issues surrounding antimicrobial susceptibility testing for novel antibiotics. While commercially available tests are being developed, potential surrogate antibiotics may be used as marker of susceptibility. Using tedizolid as an example of a new antibiotic, this special report makes recommendations to optimize routine susceptibility reporting

Genome-wide meta-analysis in alopecia areata resolves HLA associations and reveals two new susceptibility loci

Alopecia areata (AA) is a prevalent autoimmune disease with 10 known susceptibility loci. Here we perform the first meta-analysis of research on AA by combining data from two genome-wide association studies (GWAS), and replication with supplemented ImmunoChip data for a total of 3,253 cases and 7,543 controls. The strongest region of association is the major histocompatibility complex, where we fine-map four independent effects, all implicating human leukocyte antigen-DR as a key aetiologic driver. Outside the major histocompatibility complex, we identify two novel loci that exceed the threshold of statistical significance, containing ACOXL/BCL2L11(BIM) (2q13); GARP (LRRC32) (11q13.5), as well as a third nominally significant region SH2B3(LNK)/ATXN2 (12q24.12). Candidate susceptibility gene expression analysis in these regions demonstrates expression in relevant immune cells and the hair follicle. We integrate our results with data from seven other autoimmune diseases and provide insight into the alignment of AA within these disorders. Our findings uncover new molecular pathways disrupted in AA, including autophagy/apoptosis, transforming growth factor beta/Tregs and JAK kinase signalling, and support the causal role of aberrant immune processes in AA