Possible Vertical Transmission of Bartonella bacilliformis in Peru

A 22-day-old male was admitted with a 2-day history of irritability, dyspnea, jaundice, fever, and gastrointestinal bleeding. A thin blood smear was performed, which showed the presence of intraerythrocyte bacteria identified as Bartonella bacilliformis, and subsequently, the child was diagnosed with Carrion's disease. The diagnosis was confirmed by specific polymerase chain reaction. The child was born in a non-endemic B. bacilliformis area and had not traveled to such an area before hospitalization. However, the mother was from an endemic B. bacilliformis area, and posterior physical examination showed the presence of a wart compatible with B. bacilliformis in semi-immune subjects. These data support vertical transmission of B. bacilliformis

Identfication of viral and bacterial etiologic agents of the pertussis-like syndrome in children under 5 years old hospitalized

Background: Acute respiratory infections (ARIs) represent an important cause of morbidity and mortality in children, remaining a major public health concern, especially affecting children under 5 years old from low-income countries. Unfortunately, information regarding their epidemiology is still limited in Peru. Methods: A secondary data analysis was performed from a previous cross-sectional study conducted in children with a probable diagnosis of Pertussis from January 2010 to July 2012. All samples were analyzed via Polymerase Chain Reaction (PCR) for the following etiologies: Influenza-A, Influenza-B, RSV-A, RSV-B, Adenovirus, Parainfluenza 1 virus, Parainfluenza 2 virus, Parainfluenza 3 virus, Mycoplasma pneumoniae and Chlamydia pneumoniae. Results: A total of 288 patients were included. The most common pathogen isolated was Adenovirus (49%), followed by Bordetella pertussis (41%) from our previous investigation, the most prevelant microorganisms were Mycoplasma pneumonia (26%) and Influenza-B (19.8%). Coinfections were reported in 58% of samples and the most common association was found between B. pertussis and Adenovirus (12.2%). Conclusions: There was a high prevalence of Adenovirus, Mycoplasma pneumoniae and other etiologies in patients with a probable diagnosis of pertussis. Despite the presence of persistent cough lasting at least two weeks and other clinical characteristics highly suspicious of pertussis, secondary etiologies should be considered in children under 5 years-old in order to give a proper treatment.Revisión por pare

Detection of Bordetella pertussis using a PCR test in infants younger 3 than one year old hospitalized with whooping cough in five 4 Peruvian hospitals

Objectives To report the incidence, epidemiology, and clinical features of Bordetella pertussis in Peruvian infants under 1 year old. Patients and methods A prospective cross-sectional study was conducted in five hospitals in Peru from January 2010 to July 2012. A total of 392 infants under 1 year old were admitted with a clinical diagnosis of whooping cough and tested for B. pertussis by PCR. Results The pertussis toxin and IS481 genes were detected in 39.54% (155/392) of the cases. Infants aged less than 3 months were the most affected, with a prevalence of 73.55% (114/155). The most common household contact was the mother, identified in 20% (31/155) of cases. Paroxysm of coughing (89.03%, 138/155), cyanosis (68.39%, 106/155), respiratory distress (67.09%, 104/155), and breastfeeding difficulties (39.35%, 61/155) were the most frequent symptoms reported. Conclusion An increase in pertussis cases has been reported in recent years in Peru, despite national immunization efforts. Surveillance with PCR for B. pertussis is essential, especially in infants less than 1 year old, in whom a higher rate of disease-related complications and higher mortality have been reported

Possible Vertical Transmission of Bartonella bacilliformis in Peru

A 22-day-old male was admitted with a 2-day history of irritability, dyspnea, jaundice, fever, and gastrointestinal bleeding. A thin blood smear was performed, which showed the presence of intraerythrocyte bacteria identified as Bartonella bacilliformis, and subsequently, the child was diagnosed with Carrion's disease. The diagnosis was confirmed by specific polymerase chain reaction. The child was born in a non-endemic B. bacilliformis area and had not traveled to such an area before hospitalization. However, the mother was from an endemic B. bacilliformis area, and posterior physical examination showed the presence of a wart compatible with B. bacilliformis in semi-immune subjects. These data support vertical transmission of B. bacilliformis

Dataset 29-2018

<p><b>High prevalence of respiratory virus and atypical bacterium among children with a probable diagnosis of pertussis</b></p> <p> </p> <p>Jorge Valverde^1<b>†</b>, Stephanie Saiki^2<b>†</b>, Angela Cornejo-Tapia^1<b>*</b>, Fernando Vásquez-Achaya¹, Maria Esther Castillo³, Verónica Petrozzi-Helasvuo¹, Wilmer Silva-caso¹, Miguel Angel Aguilar-Luis^1,2,4, Olguita del Aguila⁵, Carlos Bada⁶, Erico Cieza-Mora⁷, Juana del Valle-Mendoza^1,2<b>*</b></p><p>^<b><br></b></p><p>^<b><br></b></p><p></p><p><b>ABSTRACT</b></p> <p><b>Background: </b>Acute respiratory infections (ARIs) represent an important cause of morbidity and mortality in children, remaining a major public health concern, especially affecting children under 5 years old from low-income countries. Unfortunately, information regarding their epidemiology is still limited in Peru</p> <p><b>Methods:</b> A secondary data analysis was performed from a previous cross-sectional study conducted in children with a probable diagnosis of Pertussis from January 2010 to July 2012. All samples were analyzed via Polymerase Chain Reaction (PCR) for the following etiologies: Influenza-A, Influenza-B, RSV-A, RSV-B, Adenovirus, Parainfluenza 1 virus, Parainfluenza 2 virus, Parainfluenza 3 virus, <i>Mycoplasma pneumoniae</i> and <i>Chlamydia pneumoniae</i>.</p> <p><b>Results:</b> A total of 288 patients were included. The most common pathogen isolated was Adenovirus (49%), followed by <i>Bordetella pertussis</i> (41%) from our previous investigation, the most prevelant microorganisms were <i>Mycoplasma pneumonia</i> (26%) and Influenza-B (19.8%). Coinfections were reported in 53.5% of samples and the most common association was found between <i>M. pneumoniae</i> and Adenovirus (9%). <b>Conclusions:</b> There was a high prevalence of Adenovirus, <i>Mycoplasma pneumoniae</i> and other etiologies in patients with a probable diagnosis of pertussis. Despite the presence of persistent cough lasting at least two weeks and other clinical characteristics highly suspicious of pertussis, secondary etiologies should be considered in children under 5 years-old in order to give a proper treatment.</p>^<b></b><p></p

Dataset 2018

High prevalence of respiratory virus and atypical bacterium among children with a probable diagnosis of pertussis<div> <p> </p> <p>Jorge Valverde^1<b>†</b>, Stephanie Saiki^2<b>†</b>, Angela Cornejo-Tapia^1<b>*</b>, Fernando Vásquez-Achaya¹, Maria Esther Castillo³, Verónica Petrozzi-Helasvuo¹, Wilmer Silva-caso¹, Miguel Angel Aguilar-Luis^1,2,4, Olguita del Aguila⁵, Carlos Bada⁶, Erico Cieza-Mora⁷, Juana del Valle-Mendoza^1,2<b>*</b></p><div><br></div><div><p><b>Background: </b>Acute respiratory infections (ARIs) represent an important cause of morbidity and mortality in children, remaining a major public health concern, especially affecting children under 5 years old from low-income countries. Unfortunately, information regarding their epidemiology is still limited in Peru</p> <p><b>Methods:</b> A secondary data analysis was performed from a previous cross-sectional study conducted in children with a probable diagnosis of Pertussis from January 2010 to July 2012. All samples were analyzed via Polymerase Chain Reaction (PCR) for the following etiologies: Influenza-A, Influenza-B, RSV-A, RSV-B, Adenovirus, Parainfluenza 1 virus, Parainfluenza 2 virus, Parainfluenza 3 virus, <i>Mycoplasma pneumoniae</i> and <i>Chlamydia pneumoniae</i>.</p> <p><b>Results:</b> A total of 288 patients were included. The most common pathogen isolated was Adenovirus (49%), followed by <i>Bordetella pertussis</i> (41%) from our previous investigation, the most prevelant microorganisms were <i>Mycoplasma pneumonia</i> (26%) and Influenza-B (19.8%). Coinfections were reported in 53.5% of samples and the most common association was found between <i>M. pneumoniae</i> and Adenovirus (9%). <b>Conclusions:</b> There was a high prevalence of Adenovirus, <i>Mycoplasma pneumoniae</i> and other etiologies in patients with a probable diagnosis of pertussis. Despite the presence of persistent cough lasting at least two weeks and other clinical characteristics highly suspicious of pertussis, secondary etiologies should be considered in children under 5 years-old in order to give a proper treatment.</p><br></div></div