A comparison study between electrospun polycaprolactone and piezoelectric poly(3-hydroxybutyrate-co-3-hydroxyvalerate) scaffolds for bone tissue engineering

This study was supported by the Federal Target Program #14.587.21.0013 (a unique application number 2015-14-588-0002-5599)

Novel Feature for Catalytic Protein Residues Reflecting Interactions with Other Residues

Owing to their potential for systematic analysis, complex networks have been widely used in proteomics. Representing a protein structure as a topology network provides novel insight into understanding protein folding mechanisms, stability and function. Here, we develop a new feature to reveal correlations between residues using a protein structure network. In an original attempt to quantify the effects of several key residues on catalytic residues, a power function was used to model interactions between residues. The results indicate that focusing on a few residues is a feasible approach to identifying catalytic residues. The spatial environment surrounding a catalytic residue was analyzed in a layered manner. We present evidence that correlation between residues is related to their distance apart most environmental parameters of the outer layer make a smaller contribution to prediction and ii catalytic residues tend to be located near key positions in enzyme folds. Feature analysis revealed satisfactory performance for our features, which were combined with several conventional features in a prediction model for catalytic residues using a comprehensive data set from the Catalytic Site Atlas. Values of 88.6 for sensitivity and 88.4 for specificity were obtained by 10fold crossvalidation. These results suggest that these features reveal the mutual dependence of residues and are promising for further study of structurefunction relationship

Cardiac lymphatics in health and disease

The lymphatic vasculature, which accompanies the blood vasculature in most organs, is indispensable in the maintenance of tissue fluid homeostasis, immune cell trafficking, and nutritional lipid uptake and transport, as well as in reverse cholesterol transport. In this Review, we discuss the physiological role of the lymphatic system in the heart in the maintenance of cardiac health and describe alterations in lymphatic structure and function that occur in cardiovascular pathology, including atherosclerosis and myocardial infarction. We also briefly discuss the role that immune cells might have in the regulation of lymphatic growth (lymphangiogenesis) and function. Finally, we provide examples of how the cardiac lymphatics can be targeted therapeutically to restore lymphatic drainage in the heart to limit myocardial oedema and chronic inflammation.Peer reviewe

A922 Sequential measurement of 1 hour creatinine clearance (1-CRCL) in critically ill patients at risk of acute kidney injury (AKI)

Meeting abstrac

Plasticity of Blood- and Lymphatic Endothelial Cells and Marker Identification

Peer reviewe

Civil society in Central and Eastern Europe: The ambivalent legacy of accession

Civil society organisations in Central and Eastern Europe (CEE) have remained weak players compared to their counterparts in established democracies. Given the particular incentives that the EU offered for the empowerment of non-state actors during pre-accession, it has often been assumed that EU intervention improved this situation. We argue that, instead, the EU's impact was highly ambivalent. Although the EU aid and EU-induced policy reform levelled the way for established actors' involvement in multilevel politics, it reinforced some of the barriers to development that the civil society organisations face in CEE. In particular, EU measures have failed to address the lack of sustainable income, of formalised interactions with the state and of grassroot support. Drawing on the experiences of trade unions and environmental groups, we show that this ambivalent 'legacy of accession' is due to an unfortunate interrelation between various, often implicit mechanisms of the EU's enlargement regime on one hand, and particular problems inherited from state socialism and transition on the other. Acta Politica (2010) 45, 41-69. doi: 10.1057/ap.2009.1