ASSESSMENT OF ILLEGAL CAPITAL FLOWS IN THE REPUBLIC OF MOLDOVA

This paper analyses the existent methodologies used in international practice to estimate illegalcapital outflows. Also, authors carried out an assessment of the illegal capital outflows in the Republic ofMoldova on the basis of two models: the general method based on the balance of payments and the WorldBank’s "residual" model. The paper reflects the exceptional situation of the financial system of theRepublic of Moldova and trends in evolution of capital flows. The analysis of illegal flows should be partof the monitoring system of the country’s financial stability, which will allow identifying in time negativetrends that threaten Moldova's financial security. The main research methods were systemic analysis andlogic synthesis; data analysis and interpretation; statistical methods, etc. The main conclusionsobtained within the research of this topic are: for more reliable estimates for analytical purposes, it isnecessary to develop an adequate methodological base that would help to measure and analyze shadowcross-border flows; for the assessment of the financial security of the Republic of Moldova, as a transitioneconomy, it is important to monitor, analyze and forecast a broader list of financial indicators, as well astheir critical values

Screeningul mamografic al cancerului mamar în Republica Moldova (Prima experienţă)

Institutul Oncologic din Moldova, Centrul de Diagnostic German, USMF N. TestemiţanuBreast cancer is still increasing. Morbidity is also high due to the late diagnostics and, respectively, the large number of advanced cases. The role of mammography in early detection of breast cancer is crucial. Making screening programs, allows to reduce mortality by 35%. Target screening (50- 69 years) of 6675 women data is presented. Accumulated experience demonstrates that the effi cacy requires the following conditions: digital mammography, specialists in imagistics, mammalogists, close collaboration with general practitioners, informed population, unique analysis of the obtained results

Vascular Endothelial Growth Factor C Promotes Ovarian Carcinoma Progression through Paracrine and Autocrine Mechanisms

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Long-term efficacy and safety of eslicarbazepine acetate monotherapy for adults with newly diagnosed focal epilepsy: An open-label extension study

Objective: To assess the efficacy, safety, and tolerability of eslicarbazepine acetate (ESL) monotherapy during long-term treatment. Methods: An open-label extension (OLE) study was conducted in adults completing a phase 3, randomized, double-blind, noninferiority trial, during which they had received monotherapy with either once-daily ESL or twice-daily controlled-release carbamazepine (CBZ-CR) for newly diagnosed focal epilepsy. In the OLE study, all patients received ESL (800-1600 mg/d) for 2 years. Primary efficacy outcome was retention time (from baseline of the OLE study). Secondary efficacy assessments included seizure freedom rate (no seizures during the OLE study) and responder rate (≥50% seizure frequency reduction from baseline of double-blind trial). Safety assessments included evaluation of treatment-emergent adverse events (TEAEs). Results: Of 206 randomized patients, 96 who received ESL in the double-blind trial (ESL/ESL) and 88 who received CBZ-CR in the double-blind trial (CBZ-CR/ESL) were treated with ESL monotherapy (89.3% overall). Treatment retention time was similar between groups, with low probability of ESL withdrawal overall (80% in both groups throughout the study. Incidence of serious TEAEs was similar between groups (7.3% vs 5.7%; 0% vs 1.1% possibly related), as were the incidences of TEAEs considered at least possibly related to treatment (17.7% vs 18.2%) and TEAEs leading to discontinuation (3.1% vs 4.5%). The types of TEAEs were generally consistent with the known safety profile of ESL. Significance: ESL monotherapy was efficacious and generally well tolerated over the long term, including in patients who transitioned from CBZ-CR monotherapy. No new safety concerns emerged