THE STRATEGIC PLANNING WITHIN THE ENTERPRISE PRODUCING ROAD VEHICLES

We can look at the planning as the first function of the management because it will take place before the other functions, the avoidance of errors, the economy of resources and the increase of the company activity performances may be achieved through the planning activity. The policy of the organization producing the road vehicles remains the same as long as the organization will carry out its activity or it may be changed when the managerial team will be also changed. As we said before, throughout the whole period of the application of the policy of the organization producing the road vehicles. The main objective of the strategic planning for the companies producing road vehicles is to establish the main objective of activity of the company and that of the organization of the activities in order to obtain the expected results and the achievement of the objectives. The strategic planning has as distinctive element the approach of the content elements of the management and strategic marketing as a process, made up of successive stages (phases), being in interdependent relations. The action carried out by cascade involves the passage of each phase step by step.marketing, strategic planning, road vehicles, management.

Dezvoltarea spaţială durabilă a fronturilor la apă din punctul de vedere al anvelopării spaţiale

The main goal of this paper is to illustrate through specific examples of European cities a few intervention actions for waterfront revitalization , in the current context of the sustainable spatialdevelopment. Multiple and varied approaches proves a real interest in these areas located along the water, areas that displays a great environmental and architectural potential for the city and its people.Restorating a valuable space without permanent interventions, generating and locating major objectives, implementating new principles based on diversity and flexibility or assigning radicalfunctiones, developing pedestrian areas, protecting traditional areas, resume and integrates some of the attitudes adopted by major cities in their present requeste for dialogue with nature, in this case represented by water, building a new identity with past items. Waterfronts, although located in a controversial area, may be the answer of the current issues raised by sustainable development, offering a new challenge and a real opportunity at the same time, for architects and for society

THE INFLUENCE OF THE NUMBER OF ACTIVE ENTERPRISES IN SERVICES ON EXPORTS. THE CASE OF 25 EU COUNTRIES IN 2007

Services are the most important contributor to the GDP and also the most important job generator. Countries development, usually, is based on the services sector. The present paper is aiming to highlight the influence of the number of active enterprises in services on exports. The paper is based on a model generated using data provided by Eurostat, for 25 EU countries and for 4 services categories. Generated in Eviews 4.1, the model is correctly specified, with a R-squared value of 0.65, and revealed a validated influence of the number of enterprises active in Wholesale and retail trade; repair of motor vehicles, motorcycles and personal and household goods and in Real estate, renting and business activities on exports.enterprise, services, exports, European Union

DESCRIPTIVE ANALYSIS OF THE INTERNATIONAL MIGRATION PHENOMENON IN ROMANIA BETWEEN 1991 AND 2008

Migration represented and represents a very important phenomenon at global level, taking into consideration besides its demographic implications, its extremely diverse implications such as socio-economic, socio-cultural, territorial, or environmental. This represents, probably, the main reason why the research on migration is interdisciplinary, having strong connections with sociology, political sciences, history, economics, geography, demography, psychology, or low, among others. All these disciplines target different aspects of population migration, and a proper comprehension of the phenomenon implies a contribution from the part of all of them. Although migration represents a phenomenon manifested since ancient times, it has never been such an universal or significant phenomenon from the socio-economical or political perspective, as it is in present times. International migration has both a negative and positive impact on both provider and receiving countries, in general playing a very important role in the structure and dimension of the population of a country. Romania is not an exception to the previously expressed statement; furthermore, after the fall of the communist regime, migration became for Romania one of the most important socio-economical phenomena. The present paper aims at analyzing in a descriptive manner the international migration phenomenon in Romania between 1991 and 2008, from quantitative perspective. Based on data identified in the \"Statistical Yearbook of Romania" - 2008 and 2009 editions - the analysis revealed the fact that both immigration and emigration flows registered oscillatory evolutions in the analysed period, but the general trend of immigration was of increasing, while the one of emigration was of decreasing. Immigration was dominated by the presence of males, of persons aged between 26 and 40 and of persons coming from the Republic of Moldova. On the other side, in the case of emigration the significant presence of females, of persons aged between 26 and 40, of persons of Romanian nationality and of those who preferred as main destination country Italy, was remarkable.international migration, immigration, emigration, Romania

Surgery in tumors of the lateral ventricles – last 8 years experience

Introduction: Tumors of the lateral ventricle are rare lesions including a large variety of benign or malignant tumors. These tumors could originate in the ventricular wall or arising and expanding within the lateral ventricle from the surrounding neural structures. The purpose of this study is to discuss postoperative results and factors that affected the preference for transcallosal or transcortical approach.Material and methods: We performed a retrospective study, lasted between 2005-2013, that comprised 26 consecutive patients who underwent operation for lateral ventricle tumors. The main clinical symptoms and signs were associated with the localization and size of the tumors. Cerebral computed tomography and magnetic resonance imaging were used to determine the location and expansion of each tumor. The transcortical approach was used in 17 patients and the transcallosal approach was used in 9 patients.Results: Total tumor resection was achieved in 73% of cases (19 patients). Most frequent histological tumor’s type was glioblastoma, choroid plexus papilloma, ependymoma and meningioma. Signs of increased intracranial pressure were most dominant. One patient died because of postoperative intraventricular hemorrhage. Additional neurological deficits were seen in 3 patients and postoperative seizure occurred in three patients. One patient with preoperative hydrocephalus required ventriculo-peritoneal shunting after tumor’s resection. Two patients developed postoperative epidural hematoma and one required reoperation. 15 of 26 patients received postoperative radiotherapy and 6 of them received adjuvant chemotherapy. The mean duration of postoperative evaluation was 24,32 (range 5-92). Excepting the cases with subtotal resection, two patients were reoperated for recurrences.Conclusions: The nature, size, location and vascularization of intraventricular tumors are the most important elements influencing the choice of surgical approach. Surgeons must evaluate all these factors and prefer the short and safe way to remove the tumor

Cyber-physical Threat Detection Platform Designed for Healthcare Systems

Hospitals are responsible for delivering healthcare services to patients in need. These services are large and complex and get affected by multiple interacting actors, such as doctors, nurses, patients, citizens, medical suppliers, health insurance providers. Lately, hospitals around the world are one of the main targets when it comes to terrorist attacks, the cyber realm being the principal source. The healthcare sector is particularly vulnerable due to heavy involvement in patient personal and health information, time constraints, and complex day-to-day operations. In addition to cyber-threats, physical threats are increasingly growing and even healthcare facilities are not immune to them. Malicious intended people created cyber threatening attacks with the purpose to systematically collect evidence against the healthcare system, to advocate for the end of such attacks, and to endanger people\u27s lives or to use the stolen personal data for bad intended actions. Henceforth it is necessary to build a platform that will get alerts and incidents at a fast pace in real-time to prevent any casualties at low cost. SAFECARE project aims to offer protection to hospitals and increase the compliance for the European regulations and security regarding ethics and privacy for health services. This paper presents a solution that will enhance security in hospitals. The primary platform will be built based on a BTMS (Building Threat Monitoring System) where events, incidents, and alerts will be transmitted by sensors from hospital rooms in real-time. Several scenarios were thought to simulate different types of attacks against hospitals and according to the scenarios, various prototypes will be built for assuring the security of the personal and patients from various hospitals.</p

Functional divergence in the role of N-linked glycosylation in smoothened signaling

The G protein-coupled receptor (GPCR) Smoothened (Smo) is the requisite signal transducer of the evolutionarily conserved Hedgehog (Hh) pathway. Although aspects of Smo signaling are conserved from Drosophila to vertebrates, significant differences have evolved. These include changes in its active sub-cellular localization, and the ability of vertebrate Smo to induce distinct G protein-dependent and independent signals in response to ligand. Whereas the canonical Smo signal to Gli transcriptional effectors occurs in a G protein-independent manner, its non-canonical signal employs Gαi. Whether vertebrate Smo can selectively bias its signal between these routes is not yet known. N-linked glycosylation is a post-translational modification that can influence GPCR trafficking, ligand responsiveness and signal output. Smo proteins in Drosophila and vertebrate systems harbor N-linked glycans, but their role in Smo signaling has not been established. Herein, we present a comprehensive analysis of Drosophila and murine Smo glycosylation that supports a functional divergence in the contribution of N-linked glycans to signaling. Of the seven predicted glycan acceptor sites in Drosophila Smo, one is essential. Loss of N-glycosylation at this site disrupted Smo trafficking and attenuated its signaling capability. In stark contrast, we found that all four predicted N-glycosylation sites on murine Smo were dispensable for proper trafficking, agonist binding and canonical signal induction. However, the under-glycosylated protein was compromised in its ability to induce a non-canonical signal through Gαi, providing for the first time evidence that Smo can bias its signal and that a post-translational modification can impact this process. As such, we postulate a profound shift in N-glycan function from affecting Smo ER exit in flies to influencing its signal output in mice

Socioeconomic differences in food habits among 6- to 9-year-old children from 23 countries-WHO European Childhood Obesity Surveillance Initiative (COSI 2015/2017)

Background: Socioeconomic differences in children's food habits are a key public health concern. In order to inform policy makers, cross-country surveillance studies of dietary patterns across socioeconomic groups are required. The purpose of this study was to examine associations between socioeconomic status (SES) and children's food habits. Methods: The study was based on nationally representative data from children aged 6-9 years (n = 129,164) in 23 countries in the World Health Organization (WHO) European Region. Multivariate multilevel analyses were used to explore associations between children's food habits (consumption of fruit, vegetables, and sugar-containing soft drinks) and parental education, perceived family wealth and parental employment status. Results: Overall, the present study suggests that unhealthy food habits are associated with lower SES, particularly as assessed by parental education and family perceived wealth, but not parental employment status. We found cross-national and regional variation in associations between SES and food habits and differences in the extent to which the respective indicators of SES were related to children's diet. Conclusion: Socioeconomic differences in children's food habits exist in the majority of European and Asian countries examined in this study. The results are of relevance when addressing strategies, policy actions, and interventions targeting social inequalities in children's diets.The authors gratefully acknowledge support from a grant from the Russian Government in the context of the WHO European Office for the Prevention and Control of NCDs. Data collection in the countries was made possible through funding from Albania: WHO through the Joint Programme on Children, Food Security and Nutrition “Reducing Malnutrition in Children,” funded by the Millennium Development Goals Achievement Fund, and the Institute of Public Health; Bulgaria: Ministry of Health, National Center of Public Health and Analyses, WHO Regional Office for Europe; Croatia: Ministry of Health, Croatian Institute of Public Health and WHO Regional Office for Europe; Czechia: Ministry of Health of the Czech Republic, grant nr. AZV MZČR 17-31670 A and MZČ–VO EÚ 00023761; Denmark: Danish Ministry of Health; Georgia: WHO; Ireland: Health Service Executive; Italy: Ministry of Health and Italian National Institute of Health; Kazakhstan: Ministry of Health of the Republic of Kazakhstan and WHO Country Office; Kyrgyzstan: World Health Organization; Latvia: Ministry of Health, Centre for Disease Prevention and Control; Lithuania: Science Foundation of Lithuanian University of Health Sciences and Lithuanian Science Council and WHO; Malta: Ministry of Health; Montenegro: WHO and Institute of Public Health of Montenegro; Norway: Ministry of Health and Norwegian Institute of Public Health; Poland: National Health Programme, Ministry of Health; Portugal: Ministry of Health Institutions, the National Institute of Health, Directorate General of Health, Regional Health Directorates and the kind technical support from the Center for Studies and Research on Social Dynamics and Health (CEIDSS); Romania: Ministry of Health; Russian Federation: WHO; San Marino: Health Ministry, Educational Ministry; Serbia: This study was supported by the World Health Organization (Ref. File 2015-540940); Spain: Spanish Agency for Food Safety and Nutrition (AESAN); Tajikistan: WHO Country Office in Tajikistan and Ministry of Health and Social Protection; Turkmenistan: WHO Country Office in Turkmenistan and Ministry of Health; Turkey: Turkish Ministry of Health and World Bank. The CO-CREATE project has received funding from the European Union's Horizon 2020 research and innovation program under grant agreement No. 774210.info:eu-repo/semantics/publishedVersio

International Asteroid Warning Network Timing Campaign : 2019 XS

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