Plazma bogata trombocitima – revolucionarna ili samo obična terapija

Musculoskeletal injuries are the most frequent reason for athletes being away from sports competitions. Modern sport strives to return athletes to full competition rhythm after injury as soon as possible. Accordingly, new therapeutic discoveries have been found whose function is to accelerate the healing process with as high tissue quality as possible. The current musculoskeletal system injury management methods include protection, rest, ice, compression, elevation, NSAID, physiotherapy, hyperbaric oxygen therapy, prolotherapy injections and corticosteroid injections. The last resort is surgery. Nevertheless, conservative treatment is preferred because surgical treatment requires longer recovery and there is a possibility of developing complications. The new and still insufficiently investigated non-operative treatment is platelet rich plasma (PRP). PRP is a simple product that is derived from the patient’s venous anticoagulated blood and it possesses a concentration of platelets which is 4 to 6 time bigger. The growth factors released from granules of the platelets include the transforming growth factor (TGF-β), platelet-derived growth factors (PDGF-AB and PDGFBB), the insulin-like growth factor (IGF), vascular endothelial growth factors (VEGHs), epidermal growth factors (EGFs) and the fibroblast growth factor (FGF). PRP is used for the treatment of acute muscle injuries, tendon injuries, ligament injuries and chondral lesions. Although PRP is suggested as a safe and harmless product, its efficiency is still a matter of discussion, since there are not enough studies that could be evaluated and mutually compared; however, generally speaking, it is accepted that the PRP can accelerate the healing response and stimulate athletes’ recovery from some well indicated injuries.Ozljede mišićno-koštanog sustava najčešći su razlog udaljavanja sportaša sa sportskih borilišta. Moderni sport teži tome da se sportaše što prije nakon ozljede vrati u puni natjecateljski ritam. Tragom toga dolazi se do novih terapijskih otkrića kojima je glavna funkcija ubrzati procese cijeljenja sa što kvalitetnijim tkivom. Trenutno korištene metode zbrinjavanja ozljeda mišićno-koštanog sustava uključuju zaštitu, odmor, led, kompresiju, podizanje ozljeđenog uda, nesteroidne protuupalne lijekove, fizikalnu terapiju, hiperbaričnu terapiju kisikom, proloterapiju i injekcije kortikosteroida. Posljednje rješenje je kiruški zahvat. Unatoč svemu, teži se konzervativnom liječenju jer kiruško liječnje zahtijeva duži oporavak te postoji mogućnost komplikacija. Nova i još nedovoljno istražena nekiruška metoda jest plazma obogaćena trombocitima. Radi se o jednostavnom proizvodu koji se dobiva iz venske nekoagulirane krvi pacijenta i koji sadrži 4 do 6 puta veću koncentraciju trombocita. Čimbenici rasta koje otpuštaju granule trombocita su transformirajući čimbenik rasta (TGF-β), čimbenik rasta podrijetlom iz trombocita (PDGF-AB i PDGF-BB), inzulinu sličan čimbenik rasta (IGF), vaskularni endotelijalni čimbenik rasta (VEGHs), epidermalni čimbenik rasta (EGFs) i čimbenik rasta fibroblasta (FGF). Koristi se za liječenje akutnih ozljeda mišića, ozljeda tetiva, ozljeda ligamenata i hondralnih lezija. Iako se liječenje plazmom obogaćenom trombocitima preporuča kao siguran i bezopasan proizvod, njegova učinkovitost i dalje ostaje predmet rasprava, s obzirom da ne postoji dovoljno istraživanja koja bi se mogla evaluirati i međusobno usporediti. Međutim, općenito je prihvaćeno da plazma obogaćena trombocitima može ubrzati proces zacjeljivanja i stimulirati oporavak sportaša kod dobro indiciranih ozljeda

Open reduction and internal fixation of isolated 4th metacarpal shaft fracture in recreation athletes: single center results

Pozadina: Prijelomi metakarpala uobičajene su povrede koje se pojavljuju kod opće populacije, kao i kod sportaša. Cilj: Cilj ove retrospektivne studije je prikaz dvostruke serije prijeloma 4. izolirane metakarpalne kosti kod rekreativnih sportaša podvrgnutih kirurškom zahvatu i njihovom razdoblju oporavka primjenjujući mjere liječenja i postoperativnu njegu do povrata njihovim svakodnevnim aktivnostima. Plan studije: retrospektivna studija promatranja.Metode: Obavljena je jedna retrospektivna studija koja je uključila 49 bolesnika (37 muškaraca, 12 žena) prosječne dobi od 25,7 s izoliranim prijelomom 4. izolirane metakarpalne kosti koji se dogodio u dvogodišnjem razdoblju od siječnja 2010. do prosinca 2011. Kriteriji su: dislocirani prijelom 4. izolirane metakarpalne kosti, akutna ozljeda koja je nastupila ne dulje od 10 dana prije prijema u bolnici kod rekreativnih sportaša i učenika mlađih od 40 godina. Mehanizmi povreda bili su izravan kontakt ili udarac šakom (26), pad (14) i rotacijski pokret rukom (9). Obavljen je kirurški zahvat s unutarnjom fiksacijom pomoću pločica niskoga profila (20) ili 2 do 3 mini-vijka. Bolesnici su obavili protokol za jednodnevni kirurški zahvat, nakon čega je slijedila standardna rehabilitacija i rana mobilizacija. Rezultati: Prosječno praćenje bolesnika bilo je 12 mjeseci. Prosječna sveukupna vrijednost MSC fleksije bila je 54,7 stupnjeva te MCO ekstenzije 8,97 stupnjeva, a sveukupna vrijednost postrehabilitacijske MCP fleksije 88,97 stupnjeva i MCP ekstenzije 17,04 stupnjeva. Nisu primijećene nikakve komplikacije, svi su se prijelomi zaliječili bez znakova infekcije ili krivoga srastanja kostiju. Zaključak: Kirurško liječenje prijeloma 4. izolirane metakarpalne kosti s pločicama niskog profila i mini-vijcima je dobra tehnika koja predstavlja čvrstu fiksaciju i osigurava brzi oporavak do pokreta prije povreda. Povećava se kvaliteta življenje uslijed brzog oporavka i povrata normalnim dnevnim i sportskim aktivnostima. Takvo liječenje znači profitabilnost s jednodnevnim operativnim zahvatom, smanjujući troškove liječenja s rezultatima od velike koristi za pacijente.Background: Metacarpal fractures are common injuries, which appear in the general population, as well as in the population of athletes. Aim: The aim of this retrospective study was to show a twofold series of isolated 4th metacarpal shaft fractures exclusively in the population of recreation athletes, which were surgically treated and the time frame of their return to everyday activities according to applied measures of treatment and postoperative care. Study design: Retrospective observational study. Methods: A retrospective single center study was conducted, including 49 patients (37 male, 12 female), mean age 25.7, with isolated 4th metacarpal shaft fracture, which occurred during the two-year period from January 2010 to December 2011. Inclusion criteria were: isolated dislocated 4th metacarpal shaft fracture, acute injury with onset no longer than 10 days before being admitted to hospital, recreation athletes and participants younger than 40 years of age. Injury mechanisms were direct contact or punch (26), fall (14) and rotational motion of the hand (9). Patients were surgically treated with internal fixation with low profile plates (20) or with 2 or 3 (29) mini-screws. Patients followed protocol for one-day surgery and afterwards standard rehabilitation protocol with early mobilization. Results: The mean follow-up of the patients was 12 months. Average total value of postoperative MCP flexion was 54.7 degrees and MCP extension was 8.97 degrees and total value of postrehabilitational MCP flexion was 88.97 degrees and MCP extension 17.04 degrees. No complications were noted, all fractures healed, without any signs of infection or malunion. Conclusion: Surgical treatment of the 4th metacarpal shaft fracture with low profile plates and mini-screws is a good technique that represents rigid fixation and provides fast recovery to pre-injury range of movements. The quality of life is enhanced due to fast recovery and return to normal daily and sports activities. Such treatment indicates profitability, hence to a one-day surgery, decreasing treatment costs and resulting in high beneficial aspects for patients

UNDERESTIMATED FREQUENCY OF RESISTANT HYPERTENSION IN PREDIALYSIS NONDIABETIC PATIENTS

Prava prevalencija rezistentne hipertenzije (RH) nije poznata. Temeljem studija može se zaključiti da je prisutna u 10-15% pacijenata prethodno liječenih zbog hipertenzije, što je veliki broj bolesnika. RH se definira nemogućnošću postizanja vrijednosti krvnog tlaka (KT) koje su ispod ciljnih (za opću populaciju 140/90 mm Hg for the general population and >130/80 mm Hg for patients with diabetes or kidney disease. Prior to diagnosing a patient as having RH, it is important to document medication compliance and exclude white-coat hypertension, inaccurate BP measurement, and secondary causes. The role of aldosterone in RH has gained increasing recognition. There is strong evidence for the use of spironolactone as a highly effective antihypertensive agent. Aldosterone plays a signiicant role in RH pathogenesis, primarily due to its vasoconstrictive effects and the possibility of altering vascular compliance. In RH, there is a high prevalence of cardiac and extra-cardiac target organ damage. It is known that BP control in chronic kidney disease is the key factor for reducing cardiovascular risk and renal disease progression. The objective of the study was to evaluate the prevalence of RH in predialysis nondiabetic (CKD stage I-IV) patients

Ružička days : International conference 16th Ružička Days “Today Science – Tomorrow Industry” : Proceedings

Proceedings contains articles presented at Conference divided into sections: open lecture (1), chemical analysis and synthesis (3), chemical and biochemical engineering (8), food technology and biotechnology (8), medical chemistry and pharmacy (3), environmental protection (11) and meeting of young chemists (2)

The role of volunteering in developing managerial competencies

Svrha rada je analizirati ulogu volontiranja u unapređenju postojećih i razvoju novih kompetencija. U teorijskom dijelu rada pojmovno se definiraju znanje, vještine, sposobnosti i kompetencije, predstavljaju se najčešće klasifikacije ključnih menadžerskih vještina, te su prikazana istraživanja koja navode ključne vještine koje se volontiranjem mogu steći. U empirijskom dijelu rada provedeno je istraživanje na uzorku od 36 studenata Diplomskog sveučilišnog studija na Ekonomskom fakultetu u Zagrebu i 85 volontera u Republici Hrvatskoj o tome u kojoj mjeri smatraju da volontiranjem mogu unaprijediti postojeće i razviti nove vještine. Pokazalo se da nema ispitanika koji smatra da volontiranjem ne bi mogao unaprijediti postojeće i razviti nove vještine.The scope of this paper is to analyze the role of volunteering in developing and improving better managerial knowledge, skills and abilities to be more competent in the labor market. In the theoretical part of the paper the differences between knowledge, skills and abilities are defined, the most common classifications of managerial skills and the most popular researches about volunteering are presented. In the empirical part of the paper the extent to which 36 graduate students from the Faculty of Economics and Business in Zagreb and 85 volunteers in Croatia think that they could improve their skills through volunteering is determined. The research has shown that there are no respondents who think that they could not improve their skills through volunteering

The role of volunteering in developing managerial competencies

Svrha rada je analizirati ulogu volontiranja u unapređenju postojećih i razvoju novih kompetencija. U teorijskom dijelu rada pojmovno se definiraju znanje, vještine, sposobnosti i kompetencije, predstavljaju se najčešće klasifikacije ključnih menadžerskih vještina, te su prikazana istraživanja koja navode ključne vještine koje se volontiranjem mogu steći. U empirijskom dijelu rada provedeno je istraživanje na uzorku od 36 studenata Diplomskog sveučilišnog studija na Ekonomskom fakultetu u Zagrebu i 85 volontera u Republici Hrvatskoj o tome u kojoj mjeri smatraju da volontiranjem mogu unaprijediti postojeće i razviti nove vještine. Pokazalo se da nema ispitanika koji smatra da volontiranjem ne bi mogao unaprijediti postojeće i razviti nove vještine.The scope of this paper is to analyze the role of volunteering in developing and improving better managerial knowledge, skills and abilities to be more competent in the labor market. In the theoretical part of the paper the differences between knowledge, skills and abilities are defined, the most common classifications of managerial skills and the most popular researches about volunteering are presented. In the empirical part of the paper the extent to which 36 graduate students from the Faculty of Economics and Business in Zagreb and 85 volunteers in Croatia think that they could improve their skills through volunteering is determined. The research has shown that there are no respondents who think that they could not improve their skills through volunteering

The International Linear Collider: Report to Snowmass 2021

The International Linear Collider (ILC) is on the table now as a new global energy-frontier accelerator laboratory taking data in the 2030s. The ILC addresses key questions for our current understanding of particle physics. It is based on a proven accelerator technology. Its experiments will challenge the Standard Model of particle physics and will provide a new window to look beyond it. This document brings the story of the ILC up to date, emphasizing its strong physics motivation, its readiness for construction, and the opportunity it presents to the US and the global particle physics community