The twin paradox in compact spaces

Twins travelling at constant relative velocity will each see the other's time dilate leading to the apparent paradox that each twin believes the other ages more slowly. In a finite space, the twins can both be on inertial, periodic orbits so that they have the opportunity to compare their ages when their paths cross. As we show, they will agree on their respective ages and avoid the paradox. The resolution relies on the selection of a preferred frame singled out by the topology of the space.Comment: to be published in PRA, 3 page

The Copernican Principle in Compact Spacetimes

Copernicus realised we were not at the centre of the universe. A universe made finite by topological identifications introduces a new Copernican consideration: while we may not be at the geometric centre of the universe, some galaxy could be. A finite universe also picks out a preferred frame: the frame in which the universe is smallest. Although we are not likely to be at the centre of the universe, we must live in the preferred frame (if we are at rest with respect to the cosmological expansion). We show that the preferred topological frame must also be the comoving frame in a homogeneous and isotropic cosmological spacetime. Some implications of topologically identifying time are also discussed.Comment: 5 page

Design and Experimental Validation of a Ducted Counter-rotating Axial-flow Fans System

An experimental study on the design of counter-rotating axial-flow fans was carried out. The fans were designed using an inverse method. In particular, the system is designed to have a pure axial discharge flow. The counter-rotating fans operate in a ducted-flow configuration and the overall performances are measured in a normalized test bench. The rotation rate of each fan is independently controlled. The relative axial spacing between fans can vary from 17% to 310%. The results show that the efficiency is strongly increased compared to a conventional rotor or to a rotor-stator stage. The effects of varying the rotation rates ratio on the overall performances are studied and show that the system has a very flexible use, with a large patch of high efficient operating points in the parameter space. The increase of axial spacing causes only a small decrease of the efficiencyComment: accepted in Journal of Fluid Engineerin

There was movement that was stationary, for the four-velocity had passed around

Is the Doppler interpretation of galaxy redshifts in a Friedmann-Lemaitre-Robertson-Walker (FLRW) model valid in the context of the approach to comoving spatial sections pioneered by de Sitter, Friedmann, Lemaitre and Robertson, i.e. according to which the 3-manifold of comoving space is characterised by both its curvature and topology? Holonomy transformations for flat, spherical and hyperbolic FLRW spatial sections are proposed. By quotienting a simply-connected FLRW spatial section by an appropriate group of holonomy transformations, the Doppler interpretation in a non-expanding Minkowski space-time, obtained via four-velocity parallel transport along a photon path, is found to imply that an inertial observer is receding from herself at a speed greater than zero, implying contradictory world-lines. The contradiction in the multiply-connected case occurs for arbitrary redshifts in the flat and spherical cases, and for certain large redshifts in the hyperbolic case. The link between the Doppler interpretation of redshifts and cosmic topology can be understood physically as the link between parallel transport along a photon path and the fact that the comoving spatial geodesic corresponding to a photon's path can be a closed loop in an FLRW model of any curvature. Closed comoving spatial loops are fundamental to cosmic topology.Comment: 8 pages, 2 figures; v2: missing dot added to Defn 1, minor corrections; submitted to MNRA

Homotopy symmetry in the multiply connected twin paradox of special relativity

In a multiply connected space, the two twins of the special relativity twin paradox move with constant relative speed and meet a second time without acceleration. The twins' situations appear to be symmetrical despite the need for one to be younger due to time dilation. Here, the suggestion that the apparent symmetry is broken by homotopy classes of the twins' worldlines is reexamined using space-time diagrams. It is found that each twin finds her own spatial path to have zero winding index and that of the other twin to have unity winding index, i.e. the twins' worldlines' relative homotopy classes are symmetrical. Although the twins' apparent symmetry is in fact broken by the need for the non-favoured twin to non-simultaneously identify spatial domain boundaries, the non-favoured twin {\em cannot} detect her disfavoured state if she only measures the homotopy classes of the two twins' projected worldlines, contrary to what was previously suggested. We also note that for the non-favoured twin, the fundamental domain can be chosen by identifying time boundaries (with a spatial offset) instead of space boundaries (with a temporal offset).Comment: 11 pages, 9 figures, v6: more elementary algebra, extra figure, accepted in MNRAS, the definitive version will be available at http://www.blackwell-synergy.co

Artificial intelligence exceeds humans in epidemiological job coding

BACKGROUND: Work circumstances can substantially negatively impact health. To explore this, large occupational cohorts of free-text job descriptions are manually coded and linked to exposure. Although several automatic coding tools have been developed, accurate exposure assessment is only feasible with human intervention. METHODS: We developed OPERAS, a customizable decision support system for epidemiological job coding. Using 812,522 entries, we developed and tested classification models for the Professions et Catégories Socioprofessionnelles (PCS)2003, Nomenclature d'Activités Française (NAF)2008, International Standard Classifications of Occupation (ISCO)-88, and ISCO-68. Each code comes with an estimated correctness measure to identify instances potentially requiring expert review. Here, OPERAS' decision support enables an increase in efficiency and accuracy of the coding process through code suggestions. Using the Formaldehyde, Silica, ALOHA, and DOM job-exposure matrices, we assessed the classification models' exposure assessment accuracy. RESULTS: We show that, using expert-coded job descriptions as gold standard, OPERAS realized a 0.66-0.84, 0.62-0.81, 0.60-0.79, and 0.57-0.78 inter-coder reliability (in Cohen's Kappa) on the first, second, third, and fourth coding levels, respectively. These exceed the respective inter-coder reliability of expert coders ranging 0.59-0.76, 0.56-0.71, 0.46-0.63, 0.40-0.56 on the same levels, enabling a 75.0-98.4% exposure assessment accuracy and an estimated 19.7-55.7% minimum workload reduction. CONCLUSIONS: OPERAS secures a high degree of accuracy in occupational classification and exposure assessment of free-text job descriptions, substantially reducing workload. As such, OPERAS significantly outperforms both expert coders and other current coding tools. This enables large-scale, efficient, and effective exposure assessment securing healthy work conditions

Chemical composition of B-type supergiants in the OB8, OB10, OB48, OB78 associations of M31

Absolute and differential chemical abundances are presented for the largest group of massive stars in M31 studied to date. These results were derived from intermediate resolution spectra of seven B-type supergiants, lying within four OB associations covering a galactocentric distance of 5 - 12 kpc. The results are mainly based on an LTE analysis, and we additionally present a full non-LTE, unified model atmosphere analysis of one star (OB78-277) to demonstrate the reliability of the differential LTE technique. A comparison of the stellar oxygen abundance with that of previous nebular results shows that there is an offset of between ~0.15 - 0.4 dex between the two methods which is critically dependent on the empirical calibration adopted for the R23 parameter with [O/H]. However within the typical errors of the stellar and nebular analyses (and given the strength of dependence of the nebular results on the calibration used) the oxygen abundances determined in each method are fairly consistent. We determine the radial oxygen abundance gradient from these stars, and do not detect any systematic gradient across this galactocentric range. We find that the inner regions of M31 are not, as previously thought, very 'metal rich'. Our abundances of C, N, O, Mg, Si, Al, S and Fe in the M31 supergiants are very similar to those of massive stars in the solar neighbourhood.Comment: 15 pages, 9 figures and 9 tables. Submitted to A&A April 200

Calcium intake and colorectal adenoma risk: Dose-response meta-analysis of prospective observational studies.

Evidence from randomized controlled trials suggests that calcium may protect against recurrence of colorectal adenomas, which could lead to the subsequent prevention of cancer. Yet, because the trials used only a large single dose and were of small sizes, knowledge of the dose-response relationship and influence on high-risk adenomas is limited. To address these issues, we conducted linear and non-linear dose-response meta-analyses primarily based on prospective observational studies published up to July 2014 identified from PubMed and Embase. Summary relative risks (RRs) and 95% confidence intervals (CIs) were calculated for total and supplemental calcium intake, respectively, using a random-effects model. For total calcium intake, summary RR for each 300mg/day increase was 0.95(95% CI=0.92-0.98; I(2) =45%; 8 studies with 11,005 cases; range of intake=333-2,229 mg/day). Evidence of non-linearity was indicated: approximately, compared to 550 mg/day of total calcium intake, the summary RR was 0.92(95% CI=0.89-0.94) at 1000 mg/day and 0.87(95% CI=0.84-0.90) at 1450 mg/day (Pnon -linearity <0.01). Associations were stronger for high-risk adenomas (≥1 cm in diameter, (tubulo)villous histology, dysplasia, or multiplicity): approximately, compared to 550 mg/day of total calcium intake, the summary RR was 0.77(95% CI=0.74-0.81) at 1000 mg/day and reduced to 0.69(95% CI=0.66-0.73) at 1450 mg/da (Pnon -linearity <0.01). For supplemental calcium intake, summary RR of total adenoma risk for each 300mg/day increase was 0.96(95% CI=0.93-0.99; I(2) =0%; 3 studies with 4,548 cases; range of supplementation=0-1,366 mg/day). In conclusion, calcium intake may continue to decrease the risk of adenomas, particularly high-risk adenomas, over a wide range of calcium intake

Selling Through Referrals

We endogenize intermediaries' choice to operate as agents or merchants in a market where there are frictions due to asymmetric information about consumption values. A seller has an object for sale and can reach buyers only through intermediaries. Intermediaries can either mediate the transaction by buying and reselling—the merchant mode—or refer buyers to the seller for a fee—the referral mode. When the seller has a strong bargaining position and can condition the asking price to the intermediaries' business model choice, all intermediaries specialize in agency. The seller's and intermediaries' joint profits equal the seller's profits when he has access to all buyers. When the seller does not have such bargaining power, the level of the referral fee and the degree of competition among intermediaries determine the business mode adoption. A hybrid agency–merchant mode may be adopted in equilibrium. Banning the referral mode can decrease welfare because the merchant mode is associated with additional allocative distortions due to asymmetric information

AntigenDB: an immunoinformatics database of pathogen antigens

The continuing threat of infectious disease and future pandemics, coupled to the continuous increase of drug-resistant pathogens, makes the discovery of new and better vaccines imperative. For effective vaccine development, antigen discovery and validation is a prerequisite. The compilation of information concerning pathogens, virulence factors and antigenic epitopes has resulted in many useful databases. However, most such immunological databases focus almost exclusively on antigens where epitopes are known and ignore those for which epitope information was unavailable. We have compiled more than 500 antigens into the AntigenDB database, making use of the literature and other immunological resources. These antigens come from 44 important pathogenic species. In AntigenDB, a database entry contains information regarding the sequence, structure, origin, etc. of an antigen with additional information such as B and T-cell epitopes, MHC binding, function, gene-expression and post translational modifications, where available. AntigenDB also provides links to major internal and external databases. We shall update AntigenDB on a rolling basis, regularly adding antigens from other organisms and extra data analysis tools. AntigenDB is available freely at http://www.imtech.res.in/raghava/antigendb and its mirror site http://www.bic.uams.edu/raghava/antigendb