433 research outputs found
A Close Companion Search Around L Dwarfs Using Aperture Masking Interferometry and Palomar Laser Guide Star Adaptive Optics
We present a close companion search around 16 known early L dwarfs using aperture masking interferometry with Palomar laser guide star adaptive optics (LGS AO). The use of aperture masking allows the detection of close binaries, corresponding to projected physical separations of 0.6-10.0 AU for the targets of our survey. This survey achieved median contrast limits of ÎK ~ 2.3 for separations between 1.2λ/D-4λ/D and ÎK ~ 1.4 at 2/3λ/D. We present four candidate binaries detected with moderate-to-high confidence (90%-98%). Two have projected physical separations less than 1.5 AU. This may indicate that tight-separation binaries contribute more significantly to the binary fraction than currently assumed, consistent with spectroscopic and photometric overluminosity studies. Ten targets of this survey have previously been observed with the Hubble Space Telescope as part of companion searches. We use the increased resolution of aperture masking to search for close or dim companions that would be obscured by full aperture imaging, finding two candidate binaries. This survey is the first application of aperture masking with LGS AO at Palomar. Several new techniques for the analysis of aperture masking data in the low signal-to-noise regime are explored
A Novel Combination of Serum Markers in a Multivariate Model to Help Triage Patients Into âLow-â and âHigh-Riskâ Categories for Prostate Cancer
BACKGROUND: Almost 50,000 men in the United Kingdom (UK) are diagnosed each year with prostate cancer (PCa). Secondary referrals for investigations rely on serum prostate-specific antigen (PSA) levels and digital rectal examination. However, both tests lack sensitivity and specificity, resulting in unnecessary referrals to secondary care for costly and invasive biopsies. MATERIALS AND METHODS: Serum samples and clinical information were collected from N = 125 age-matched patients (n = 61 non-PCa and n = 64 PCa) and analyzed using Biochip Array Technology on high-sensitivity cytokine array I (IL-2, IL-4, IL-6, IL-8, IL-10, IL-1α, IL-1ÎČ, TNFα, MCP-1, INFÎł, EGF, and VEGF), cerebral array II (CRP, D-dimer, neuron-specific enolase, and sTNFR1), and tumor PSA oncology array (fPSA, tPSA, and CEA). RESULTS: The data showed that 11/19 (68.8%) markers were significantly different between the non-PCa and the PCa patients. A combination of EGF, log(10) IL-8, log(10) MCP-1, and log(10) tPSA significantly improved the predictive potential of tPSA alone to identify patients with PCa (DeLong, p < 0.001). This marker combination had an increased area under the receiver operator characteristic (0.860 vs. 0.700), sensitivity (78.7 vs. 68.9%), specificity (76.5 vs. 67.2%), PPV (76.2 vs. 66.7%), and NPV (79.0 vs. 69.4%) compared with tPSA. CONCLUSIONS: The novel combination of serum markers identified in this study could be employed to help triage patients into âlow-â and âhigh-riskâ categories, allowing general practitioners to improve the management of patients in primary care settings and potentially reducing the number of referrals for unnecessary, invasive, and costly treatments
The cell wall of Arabidopsis thaliana influences actin network dynamics
In plant cells, molecular connections link the cell wallâplasma membraneâactin cytoskeleton to form a continuum. It is hypothesized that the cell wall provides stable anchor points around which the actin cytoskeleton remodels. Here we use live cell imaging of fluorescently labelled marker proteins to quantify the organization and dynamics of the actin cytoskeleton and to determine the impact of disrupting connections within the continuum. Labelling of the actin cytoskeleton with green fluorescent protein (GFP)âfimbrin actin-binding domain 2 (FABD2) resulted in a network composed of fine filaments and thicker bundles that appeared as a highly dynamic remodelling meshwork. This differed substantially from the GFPâLifeact-labelled network that appeared much more sparse with thick bundles that underwent âsimple movementâ, in which the bundles slightly change position, but in such a manner that the structure of the network was not substantially altered during the time of observation. Label-dependent differences in actin network morphology and remodelling necessitated development of two new image analysis techniques. The first of these, âpairwise image subtractionâ, was applied to measurement of the more rapidly remodelling actin network labelled with GFPâFABD2, while the second, âcumulative fluorescence intensityâ, was used to measure bulk remodelling of the actin cytoskeleton when labelled with GFPâLifeact. In each case, these analysis techniques show that the actin cytoskeleton has a decreased rate of bulk remodelling when the cell wallâplasma membraneâactin continuum is disrupted either by plasmolysis or with isoxaben, a drug that specifically inhibits cellulose deposition. Changes in the rate of actin remodelling also affect its functionality, as observed by alteration in Golgi body motility
Evidence for an FU Orionis-like Outburst from a Classical T Tauri Star
We present pre- and post-outburst observations of the new FU Orionis-like
young stellar object PTF 10qpf (also known as LkHa 188-G4 and HBC 722). Prior
to this outburst, LkHa 188-G4 was classified as a classical T Tauri star on the
basis of its optical emission-line spectrum superposed on a K8-type
photosphere, and its photometric variability. The mid-infrared spectral index
of LkHa 188-G4 indicates a Class II-type object. LkHa 188-G4 exhibited a steady
rise by ~1 mag over ~11 months starting in Aug. 2009, before a subsequent more
abrupt rise of > 3 mag on a time scale of ~2 months. Observations taken during
the eruption exhibit the defining characteristics of FU Orionis variables: (i)
an increase in brightness by > 4 mag, (ii) a bright optical/near-infrared
reflection nebula appeared, (iii) optical spectra are consistent with a G
supergiant and dominated by absorption lines, the only exception being Halpha
which is characterized by a P Cygni profile, (iv) near-infrared spectra
resemble those of late K--M giants/supergiants with enhanced absorption seen in
the molecular bands of CO and H_2O, and (v) outflow signatures in H and He are
seen in the form of blueshifted absorption profiles. LkHa 188-G4 is the first
member of the FU Orionis-like class with a well-sampled optical to mid-infrared
spectral energy distribution in the pre-outburst phase. The association of the
PTF 10qpf outburst with the previously identified classical T Tauri star LkHa
188-G4 (HBC 722) provides strong evidence that FU Orionis-like eruptions
represent periods of enhanced disk accretion and outflow, likely triggered by
instabilities in the disk. The early identification of PTF 10qpf as an FU
Orionis-like variable will enable detailed photometric and spectroscopic
observations during its post-outburst evolution for comparison with other known
outbursting objects.Comment: 14 pages, 11 figures, ApJ accepte
Rapidly Decaying Supernova 2010X: A Candidate ".Ia" Explosion
We present the discovery, photometric and spectroscopic follow-up
observations of SN 2010X (PTF 10bhp). This supernova decays exponentially with
tau_d=5 days, and rivals the current recordholder in speed, SN 2002bj. SN 2010X
peaks at M_r=-17mag and has mean velocities of 10,000 km/s. Our light curve
modeling suggests a radioactivity powered event and an ejecta mass of 0.16
Msun. If powered by Nickel, we show that the Nickel mass must be very small
(0.02 Msun) and that the supernova quickly becomes optically thin to
gamma-rays. Our spectral modeling suggests that SN 2010X and SN 2002bj have
similar chemical compositions and that one of Aluminum or Helium is present. If
Aluminum is present, we speculate that this may be an accretion induced
collapse of an O-Ne-Mg white dwarf. If Helium is present, all observables of SN
2010X are consistent with being a thermonuclear Helium shell detonation on a
white dwarf, a ".Ia" explosion. With the 1-day dynamic-cadence experiment on
the Palomar Transient Factory, we expect to annually discover a few such
events.Comment: 6 pages, 5 figures; Minor Changes; Note correction in Fig 4 caption;
published by ApJ
PTF10nvg: An Outbursting Class I Protostar in the Pelican/North American Nebula
During a synoptic survey of the North American Nebula region, the Palomar
Transient Factory (PTF) detected an optical outburst (dubbed PTF10nvg)
associated with the previously unstudied flat or rising spectrum infrared
source IRAS 20496+4354. The PTF R-band light curve reveals that PTF10nvg
brightened by more than 5 mag during the current outburst, rising to a peak
magnitude of R~13.5 in 2010 Sep. Follow-up observations indicate PTF10nvg has
undergone a similar ~5 mag brightening in the K band, and possesses a rich
emission-line spectrum, including numerous lines commonly assumed to trace mass
accretion and outflows. Many of these lines are blueshifted by ~175 km/s from
the North American Nebula's rest velocity, suggesting that PTF10nvg is driving
an outflow. Optical spectra of PTF10nvg show several TiO/VO bandheads fully in
emission, indicating the presence of an unusual amount of dense (> 10^10
cm^-3), warm (1500-4000 K) circumstellar material. Near-infrared spectra of
PTF10nvg appear quite similar to a spectrum of McNeil's Nebula/V1647 Ori, a
young star which has undergone several brightenings in recent decades, and
06297+1021W, a Class I protostar with a similarly rich near--infrared emission
line spectrum. While further monitoring is required to fully understand this
event, we conclude that the brightening of PTF10nvg is indicative of enhanced
accretion and outflow in this Class-I-type protostellar object, similar to the
behavior of V1647 Ori in 2004-2005.Comment: Accepted to the Astronomical Journal; 21 pages, 11 figures, 6 tables
in emulateapj format; v2 fixes typo in abstract; v3 updates status to
accepted, adjusts affiliations, adds acknowledgmen
PTF10fqs: A Luminous Red Nova in the Spiral Galaxy Messier 99
The Palomar Transient Factory (PTF) is systematically charting the optical
transient and variable sky. A primary science driver of PTF is building a
complete inventory of transients in the local Universe (distance less than 200
Mpc). Here, we report the discovery of PTF10fqs, a transient in the luminosity
"gap" between novae and supernovae. Located on a spiral arm of Messier 99, PTF
10fqs has a peak luminosity of Mr = -12.3, red color (g-r = 1.0) and is slowly
evolving (decayed by 1 mag in 68 days). It has a spectrum dominated by
intermediate-width H (930 km/s) and narrow calcium emission lines. The
explosion signature (the light curve and spectra) is overall similar to thatof
M85OT2006-1, SN2008S, and NGC300OT. The origin of these events is shrouded in
mystery and controversy (and in some cases, in dust). PTF10fqs shows some
evidence of a broad feature (around 8600A) that may suggest very large
velocities (10,000 km/s) in this explosion. Ongoing surveys can be expected to
find a few such events per year. Sensitive spectroscopy, infrared monitoring
and statistics (e.g. disk versus bulge) will eventually make it possible for
astronomers to unravel the nature of these mysterious explosions.Comment: 12 pages, 12 figures, Replaced with published versio
- âŠ