458 research outputs found
Monopole Vacuum in Non-Abelian Theories
It is shown that, in the theory of interacting Yang -Mills fields and a Higgs
field, there is a topological degeneracy of Bogomol'nyi-Prasad-Sommerfield
(BPS) monopoles and that there arises, in this case, a chromoelectric monopole
characterized by a new topological variable that describes transitions between
topological states of the monopole in the Minkowski space (in just the same way
as an instanton describes such transitions in the Euclidean space). The limit
of an infinitely large mass of the Higgs field at a finite density of the BPS
monopole is considered as a model of the stable vacuum in the pure Yang-Mills
theory. It is shown that, in QCD, such a monopole vacuum may lead to a rising
potential, a topological confinement and an additional mass of the
meson. The relationship between the result obtained here for the generating
functional of perturbation theory and Faddeev-Popov integral is discussed
Bogolyubov Quasiparticles in Constrained Systems
The paper is devoted to the formulation of quantum field theory for an early
universe in General Relativity considered as the Dirac general constrained
system. The main idea is the Hamiltonian reduction of the constrained system in
terms of measurable quantities of the observational cosmology: the world proper
time, cosmic scale factor, and the density of matter. We define " particles" as
field variables in the holomorphic representation which diagonalize the
measurable density. The Bogoliubov quasiparticles are determined by
diagonalization of the equations of motion (but not only of the initial
Hamiltonian) to get the set of integrals of motion (or conserved quantum
numbers, in quantum theory). This approach is applied to describe particle
creation in the models of the early universe where the Hubble parameter goes to
infinity.Comment: 13 pages, Late
Pion Polarizability in the NJL model and Possibilities of its Experimental Studies in Coulomb Nuclear Scattering
The charge pion polarizability is calculated in the Nambu-Jona-Lasinio model,
where the quark loops (in the mean field approximation) and the meson loops (in
the approximation) are taken into account. We show that quark loop
contribution dominates, because the meson loops strongly conceal each other.
The sigma-pole contribution plays the main role and
contains strong t-dependence of the effective pion polarizability at the region
. Possibilities of experimental test of this sigma-pole
effect in the reaction of Coulomb Nuclear Scattering are estimated for the
COMPASS experiment.Comment: 11 pages, 8 figure
Heavy--light mesons in a bilocal effective theory
Heavy--light mesons are described in an effective quark theory with a
two--body vector--type interaction. The bilocal interaction is taken to be
instantaneous in the rest frame of the bound state, but formulated covariantly
through the use of a boost vector. The chiral symmetry of the light flavor is
broken spontaneously at mean field level. The framework for our discussion of
bound states is the effective bilocal meson action obtained by bosonization of
the quark theory. Mesons are described by 3--dimensional wave functions
satisfying Salpeter equations, which exhibit both Goldstone solutions in the
chiral limit and heavy--quark symmetry for . We present
numerical solutions for pseudoscalar -- and --mesons. Heavy--light meson
spectra and decay constants are seen to be sensitive to the description of
chiral symmetry breaking (dynamically generated vs.\ constant quark mass).Comment: (34 p., standard LaTeX, 7 PostScript figures appended)
UNITUE-THEP-17/9
Inertial mechanism: dynamical mass as a source of particle creation
A kinetic theory of vacuum particle creation under the action of an inertial
mechanism is constructed within a nonpertrubative dynamical approach. At the
semi-phenomenological level, the inertial mechanism corresponds to quantum
field theory with a time-dependent mass. At the microscopic level, such a
dependence may be caused by different reasons: The non-stationary Higgs
mechanism, the influence of a mean field or condensate, the presence of the
conformal multiplier in the scalar-tensor gravitation theory etc. In what
follows, a kinetic theory in the collisionless approximation is developed for
scalar, spinor and massive vector fields in the framework of the oscillator
representation, which is an effective tool for transition to the quasiparticle
description and for derivation of non-Markovian kinetic equations. Properties
of these equations and relevant observables (particle number and energy
densities, pressure) are studied. The developed theory is applied here to
describe the vacuum matter creation in conformal cosmological models and
discuss the problem of the observed number density of photons in the cosmic
microwave background radiation. As other example, the self-consistent evolution
of scalar fields with non-monotonic self-interaction potentials (the
W-potential and Witten - Di Vecchia - Veneziano model) is considered. In
particular, conditions for appearance of tachyonic modes and a problem of the
relevant definition of a vacuum state are considered.Comment: 51 pages, 18 figures, submitted to PEPAN (JINR, Dubna); v2: added
reference
Unconstrained Hamiltonian Formulation of SU(2) Gluodynamics
SU(2) Yang-Mills field theory is considered in the framework of the
generalized Hamiltonian approach and the equivalent unconstrained system is
obtained using the method of Hamiltonian reduction. A canonical transformation
to a set of adapted coordinates is performed in terms of which the
Abelianization of the Gauss law constraints reduces to an algebraic operation
and the pure gauge degrees of freedom drop out from the Hamiltonian after
projection onto the constraint shell. For the remaining gauge invariant fields
two representations are introduced where the three fields which transform as
scalars under spatial rotations are separated from the three rotational fields.
An effective low energy nonlinear sigma model type Lagrangian is derived which
out of the six physical fields involves only one of the three scalar fields and
two rotational fields summarized in a unit vector. Its possible relation to the
effective Lagrangian proposed recently by Faddeev and Niemi is discussed.
Finally the unconstrained analog of the well-known nonnormalizable groundstate
wave functional which solves the Schr\"odinger equation with zero energy is
given and analysed in the strong coupling limit.Comment: 20 pages REVTEX, no figures; final version to appear in Phys. Rev. D;
minor changes, notations simplifie
State sampling dependence of the Hopfield network inference
The fully connected Hopfield network is inferred based on observed
magnetizations and pairwise correlations. We present the system in the glassy
phase with low temperature and high memory load. We find that the inference
error is very sensitive to the form of state sampling. When a single state is
sampled to compute magnetizations and correlations, the inference error is
almost indistinguishable irrespective of the sampled state. However, the error
can be greatly reduced if the data is collected with state transitions. Our
result holds for different disorder samples and accounts for the previously
observed large fluctuations of inference error at low temperatures.Comment: 4 pages, 1 figure, further discussions added and relevant references
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The ansamycin antibiotic, rifamycin SV, inhibits BCL6 transcriptional repression and forms a complex with the BCL6-BTB/POZ domain
BCL6 is a transcriptional repressor that is over-expressed due to chromosomal translocations, or other abnormalities, in ~40% of diffuse large B-cell lymphoma. BCL6 interacts with co-repressor, SMRT, and this is essential for its role in lymphomas. Peptide or small molecule inhibitors, which prevent the association of SMRT with BCL6, inhibit transcriptional repression and cause apoptosis of lymphoma cells in vitro and in vivo. In order to discover compounds, which have the potential to be developed into BCL6 inhibitors, we screened a natural product library. The ansamycin antibiotic, rifamycin SV, inhibited BCL6 transcriptional repression and NMR spectroscopy confirmed a direct interaction between rifamycin SV and BCL6. To further determine the characteristics of compounds binding to BCL6-POZ we analyzed four other members of this family and showed that rifabutin, bound most strongly. An X-ray crystal structure of the rifabutin-BCL6 complex revealed that rifabutin occupies a partly non-polar pocket making interactions with tyrosine58, asparagine21 and arginine24 of the BCL6-POZ domain. Importantly these residues are also important for the interaction of BLC6 with SMRT. This work demonstrates a unique approach to developing a structure activity relationship for a compound that will form the basis of a therapeutically useful BCL6 inhibitor
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