The Influence of the Dorsal Pathway on Enhanced Visual Processing

Overall our visual experience is such a seamless one that unless specifically told, we might never know that what we see is actually the visual system taking the very simple input provided by cells in the retina and constructing an image based on rules and calculations and algorithms neuroscientists have yet to fully uncover. This is an incredible feat given the plethora of visual stimuli within our environment, that this information is used to inform and plan actions, and if that wasnt enough, the visual system also has the capacity to selectively enhance certain aspects of visual processing if needs be. The research contained within this dissertation seeks to investigate how the dorsal visual pathway enhances both decision-making processes and visual stimuli presented near the hand. Our findings suggest that the formation of object representations in the dorsal pathway can include both ventral (colour, contrast) and dorsal (speed) stream features (chapters two and three), which in turn greatly speed decision-making processes within the dorsal pathway. In addition, contrast and speed are integrated automatically but purely ventral stream features, such as colour, require top-down attention to facilitate enhanced processing speeds (chapter three). In chapter four we find that visual processing near the hand is enhanced in a novel way. When the hand is nearby, orientation tuning is sharpened in a manner not consistent with either oculomotor-driven spatial or feature based attention. In addition, response variability is reduced when the hand is nearby, raising the possibility that enhanced processing near the hand maybe be driven by feedback from frontoparietal reaching and grasping regions. The research within this dissertation includes important new information regarding how the dorsal pathway can speed visual processing, and provides insight as to the next stage in understanding how we use vision for action

Color Improves Speed of Processing But Not Perception in a Motion Illusion

When two superimposed surfaces of dots move in different directions, the perceived directions are shifted away from each other. This perceptual illusion has been termed direction repulsion and is thought to be due to mutual inhibition between the representations of the two directions. It has further been shown that a speed difference between the two surfaces attenuates direction repulsion. As speed and direction are both necessary components of representing motion, the reduction in direction repulsion can be attributed to the additional motion information strengthening the representations of the two directions and thus reducing the mutual inhibition. We tested whether bottom-up attention and top-down task demands, in the form of color differences between the two surfaces, would also enhance motion processing, reducing direction repulsion. We found that the addition of color differences did not improve direction discrimination and reduce direction repulsion. However, we did find that adding a color difference improved performance on the task. We hypothesized that the performance differences were due to the limited presentation time of the stimuli. We tested this in a follow-up experiment where we varied the time of presentation to determine the duration needed to successfully perform the task with and without the color difference. As we expected, color segmentation reduced the amount of time needed to process and encode both directions of motion. Thus we find a dissociation between the effects of attention on the speed of processing and conscious perception of direction. We propose four potential mechanisms wherein color speeds figure-ground segmentation of an object, attentional switching between objects, direction discrimination and/or the accumulation of motion information for decision-making, without affecting conscious perception of the direction. Potential neural bases are also explored

University of Vermont student research on Vermont topics

Occasional paper (University of Vermont. Center for Research on Vermont ; no. 1

Throttling for the game of Cops and Robbers on graphs

We consider the cop-throttling number of a graph $G$ for the game of Cops and Robbers, which is defined to be the minimum of $(k + \text{capt}_k(G))$, where $k$ is the number of cops and $\text{capt}_k(G)$ is the minimum number of rounds needed for $k$ cops to capture the robber on $G$ over all possible games. We provide some tools for bounding the cop-throttling number, including showing that the positive semidefinite (PSD) throttling number, a variant of zero forcing throttling, is an upper bound for the cop-throttling number. We also characterize graphs having low cop-throttling number and investigate how large the cop-throttling number can be for a given graph. We consider trees, unicyclic graphs, incidence graphs of finite projective planes (a Meyniel extremal family of graphs), a family of cop-win graphs with maximum capture time, grids, and hypercubes. All the upper bounds on the cop-throttling number we obtain for families of graphs are $O(\sqrt n)$.Comment: 22 pages, 4 figure

The prevalence of self-reported deliberate self harm in Irish adolescents

Background: Deliberate self harm is major public health problem, in particular among young people. Although several studies have addressed the prevalence of deliberate self harm among young people in the community, little is known about the extent to which deliberate self harm comes to the attention of medical services, the self harm methods used and the underlying motives. The aim of this study was to determine the prevalence of deliberate self harm in adolescents and the methods, motives and help seeking behaviour associated with this behaviour. Methods: A cross-sectional survey using an anonymous self-report questionnaire was administered in 39 schools in the Southern area of the Health Service Executive, Ireland. Of the 4,583 adolescents aged 15–17 years who were invited to participate in the survey, 3,881 adolescents took part (response: 85%). Results: A lifetime history of DSH was reported by 9.1% (n = 333) of the adolescents. DSH was more common among females (13.9%) than males (4.3%). Self cutting (66.0%) and overdose (35.2%) were the most common DSH methods. A minority of participants accessed medical services after engaging in DSH (15.3%). Conclusion: DSH is a significant problem in Irish adolescents and the vast majority do not come to the attention of health services. Innovative solutions for prevention and intervention are required to tackle DSH in adolescents

Optimizing the trade-off between number of cops and capture time in Cops and Robbers

The cop throttling number $th_c(G)$ of a graph $G$ for the game of Cops and Robbers is the minimum of $k + capt_k(G)$, where $k$ is the number of cops and $capt_k(G)$ is the minimum number of rounds needed for $k$ cops to capture the robber on $G$ over all possible games in which both players play optimally. In this paper, we construct a family of graphs having $th_c(G)= \Omega(n^{2/3})$, establish a sublinear upper bound on the cop throttling number, and show that the cop throttling number of chordal graphs is $O(\sqrt{n})$. We also introduce the product cop throttling number $th_c^{\times}(G)$ as a parameter that minimizes the person-hours used by the cops. This parameter extends the notion of speed-up that has been studied in the context of parallel processing and network decontamination. We establish bounds on the product cop throttling number in terms of the cop throttling number, characterize graphs with low product cop throttling number, and show that for a chordal graph $G$, $th_c^{\times}=1+rad(G)$.Comment: 19 pages, 3 figure

A Case of IgE Myeloma: Methodology and Review of the Literature

A 56-year-old man presented with a one-year history of progressive weakness predominantly affecting his extremities and persistent low back pain. Ouchterlony immunodiffusion of the concentrated urine detected a marked increase in lambda light chains. A sternal bone marrow documented a diagnosis of multiple myeloma. Screening high resolution agarose gel electrophoresis revealed diffuse hypogammaglobulinemia and, retrospectively, an equivocal, faint band which migrated in the fast gamma region. By using a combination of Immunoelectrophoresis and immunofixation electrophoresis, this questionable band was determined to represent an IgE lambda monoclonal protein. Radioimmunoassay for IgE documented a serum concentration of 50.6 mg/dl. No intact IgE was found in the urine. Following chemotherapy, the patient\u27s serum IgE level decreased significantly, and he is presently asymptomatic. Features of special interest in this case include the low serum IgE level on presentation, which was difficult to detect on the screening electrophoretogram, and the use of immunofixation electrophoresis in the detection and characterization of these difficult gammopathies

Cop throttling number: Bounds, values, and variants

The cop throttling number thc(G) of a graph G for the game of Cops and Robbers is the minimum of k+captk(G), where k is the number of cops and captk(G) is the minimum number of rounds needed for k cops to capture the robber on G over all possible games in which both players play optimally. In this paper, we answer in the negative a question from [Breen et al., Throttling for the game of Cops and Robbers on graphs, {\em Discrete Math.}, 341 (2018) 2418--2430.] about whether the cop throttling number of any graph is O(n−−√) by constructing a family of graphs having thc(G)=Ω(n2/3). We establish a sublinear upper bound on the cop throttling number and show that the cop throttling number of chordal graphs is O(n−−√). We also introduce the product cop throttling number th×c(G) as a parameter that minimizes the person-hours used by the cops. We establish bounds on the product cop throttling number in terms of the cop throttling number, characterize graphs with low product cop throttling number, and show that for a chordal graph G, th×c(G)=1+rad(G)

Geographic Variation in Larval Metabolic Rate Between Northern and Southern Populations of the Invasive Gypsy Moth

Thermal regimes can diverge considerably across the geographic range of a species, and accordingly, populations can vary in their response to changing environmental conditions. Both local adaptation and acclimatization are important mechanisms for ectotherms to maintain homeostasis as environments become thermally stressful, which organisms often experience at their geographic range limits. The spatial spread of the gypsy moth (Lymantria dispar L.) (Lepidoptera: Erebidae) after introduction to North America provides an exemplary system for studying population variation in physiological traits given the gradient of climates encompassed by its current invasive range. This study quantifies differences in resting metabolic rate (RMR) across temperature for four populations of gypsy moth, two from the northern and two from southern regions of their introduced range in North America. Gypsy moth larvae were reared at high and low thermal regimes, and then metabolic activity was monitored at four temperatures using stop-flow respirometry to test for an acclimation response. For all populations, there was a significant increase in RMR as respirometry test temperature increased. Contrary to our expectations, we did not find evidence for metabolic adaptation to colder environments based on our comparisons between northern and southern populations. We also found no evidence for an acclimation response of RMR to rearing temperature for three of the four pairwise comparisons examined. Understanding the thermal sensitivity of metabolic rate in gypsy moth, and understanding the potential for changes in physiology at range extremes, is critical for estimating continued spatial spread of this invasive species both under current and potential future climatic constraints