Do Exergames Allow Children To Achieve Physical Activity Intensity Commensurate With National Guidelines?

The purpose of this study was to determine if two popular exergames, Wii Fit™ and EA Sports Active™, both games for the Nintendo Wii™ console, help children achieve intensity consistent with recommended physical activity guidelines. Thirty children (19 males and 11 females, Mean age = 9.4 ± 1.8 years) participated in this study by playing each game during one research session. During the session participants wore a heart rate monitor and accelerometer to measure exercise intensity. Perceived exertion (RPE) was measured with the children’s run/walk OMNI scale. All three measures of exercise intensity (heart rate, accelerometer counts, and RPE) found that the EA Sports Active™ game session elicited higher exercise intensity. However, heart rate data found both games to achieve moderate intensity (65-68% age-predicted HRmax). When using heart rate as an indicator of exercise intensity it appears that both exergames were of sufficient intensity to achieve physical activity guidelines. Future studies should continue to investigate the utility of exergaming in helping children to become more physically active

Jumelages institutionnels : les limites d’un apprentissage collectif

Alors que les huit premiers pays d’Europe centrale et orientale sont officiellement devenus membres de l’UE, une évaluation des jumelages, instrument mis en place par la Commission en 1998 dans le cadre du programme PHARE semble opportune. Il s’agit dans un premier temps d’analyser le fonctionnement de cet outil et les types d’interactions entre les différents acteurs en jeu. On pourra ainsi mettre en évidence l’adaptation ou non des procédures aux objectifs qui visent l’harmonisation et la convergence entre les différents systèmes, la qualité de la prise en compte des besoins et des attentes des participants et pour finir la réussite du processus d’européanisation. L’enjeu central étant in fine celui de l’apprentissage des bonnes pratiques, comme processus d’accompagnement, d’imitation, de correction et en fin de compte d’adaptation des règles et normes de l’UE

Pyrogenic iron: The missing link to high iron solubility in aerosols

Atmospheric deposition is a source of potentially bioavailable iron (Fe) and thus can partially control biological productivity in large parts of the ocean. However, the explanation of observed high aerosol Fe solubility compared to that in soil particles is still controversial, as several hypotheses have been proposed to explain this observation. Here, a statistical analysis of aerosol Fe solubility estimated from four models and observations compiled from multiple field campaigns suggests that pyrogenic aerosols are the main sources of aerosols with high Fe solubility at low concentration. Additionally, we find that field data over the Southern Ocean display a much wider range in aerosol Fe solubility compared to the models, which indicate an underestimation of labile Fe concentrations by a factor of 15. These findings suggest that pyrogenic Fe-containing aerosols are important sources of atmospheric bioavailable Fe to the open ocean and crucial for predicting anthropogenic perturbations to marine productivity

Evaluation of labile iron formation in the atmosphere

Atmospheric deposition of labile iron (Fe) to the ocean has been suggested to modulate primary ocean productivity and thus indirectly affect the climate. A key process contributing to atmospheric sources of labile Fe is associated with atmospheric acidity, which leads to Fe transformation from insoluble to soluble forms. Significant progress has been made in our understanding of atmospheric inputs of labile Fe from natural and anthropogenic sources to the oceans. However, there are still large uncertainties regarding the relative importance of different sources of Fe and effects of atmospheric processing on the bioavailability of the delivered Fe. Here, we investigate the effects of atmospheric processing on Fe solubility and contribution of different sources of Fe to labile Fe in the atmosphere. We compiled Fe loading and solubility in aerosols from four atmospheric chemistry transport models and a number of field measurements. Fe-containing aerosols from combustion sources are characterized by low loading and high solubility, compared to mineral dust. Therefore, labile Fe loading may be separately attributed to combustion and dust aerosols, assuming their distinct emission sources and atmospheric processes. The results suggest that combustion aerosols substantially contribute to labile Fe loading measured in the atmosphere. Thus, assessments of dust-borne Fe fertilization of the oceans should include Fe-containing mineral aerosols affected by combustion sources.Poster presented at Ocean Sciences Meeting 2018, AGU, ASLO, the Oceanography Society. Portland, Oregon, Feb. 11-16, 201

The GESAMP global model intercomparison: Evaluation of labile iron in aerosols

Oral session abstract EGU2018-2243, European Geosciences Union (EGU) General Assembly 2018 (8-13 April, 2018, Vienna, Austria

DNA cleavage and methylation specificity of the single polypeptide restriction–modification enzyme LlaGI

LlaGI is a single polypeptide restriction–modification enzyme encoded on the naturally-occurring plasmid pEW104 isolated from Lactococcus lactis ssp. cremoris W10. Bioinformatics analysis suggests that the enzyme contains domains characteristic of an mrr endonuclease, a superfamily 2 DNA helicase and a γ-family adenine methyltransferase. LlaGI was expressed and purified from a recombinant clone and its properties characterised. An asymmetric recognition sequence was identified, 5′-CTnGAyG-3′ (where n is A, G, C or T and y is C or T). Methylation of the recognition site occurred on only one strand (the non-degenerate dA residue of 5′-CrTCnAG-3′ being methylated at the N6 position). Double strand DNA breaks at distant, random sites were only observed when two head-to-head oriented, unmethylated copies of the site were present; single sites or pairs in tail-to-tail or head-to-tail repeat only supported a DNA nicking activity. dsDNA nuclease activity was dependent upon the presence of ATP or dATP. Our results are consistent with a directional long-range communication mechanism that is necessitated by the partial site methylation. In the accompanying manuscript [Smith et al. (2009) The single polypeptide restriction–modification enzyme LlaGI is a self-contained molecular motor that translocates DNA loops], we demonstrate that this communication is via 1-dimensional DNA loop translocation. On the basis of this data and that in the third accompanying manuscript [Smith et al. (2009) An Mrr-family nuclease motif in the single polypeptide restriction–modification enzyme LlaGI], we propose that LlaGI is the prototype of a new sub-classification of Restriction-Modification enzymes, named Type I SP (for Single Polypeptide)

Evaluation of labile iron processing in atmospheric models

Conference abstract (August 13-18, 2017. Goldschmidt 2017 in Paris, France

Changing atmospheric acidity as a modulator of nutrient deposition and ocean biogeochemistry

Anthropogenic emissions to the atmosphere have increased the flux of nutrients, especially nitrogen, to the ocean, but they have also altered the acidity of aerosol, cloud water, and precipitation over much of the marine atmosphere. For nitrogen, acidity-driven changes in chemical speciation result in altered partitioning between the gas and particulate phases that subsequently affect long-range transport. Other important nutrients, notably iron and phosphorus, are affected, because their soluble fractions increase upon exposure to acidic environments during atmospheric transport. These changes affect the magnitude, distribution, and deposition mode of individual nutrients supplied to the ocean, the extent to which nutrient deposition interacts with the sea surface microlayer during its passage into bulk seawater, and the relative abundances of soluble nutrients in atmospheric deposition. Atmospheric acidity change therefore affects ecosystem composition, in addition to overall marine productivity, and these effects will continue to evolve with changing anthropogenic emissions in the future

Integrating multiple lines of evidence to assess the effects of maternal BMI on pregnancy and perinatal outcomes

Background: Higher maternal pre-pregnancy body mass index (BMI) is associated with adverse pregnancy and perinatal outcomes. However, whether these associations are causal remains unclear. Methods: We explored the relation of maternal pre-/early-pregnancy BMI with 20 pregnancy and perinatal outcomes by integrating evidence from three different approaches (i.e. multivariable regression, Mendelian randomisation, and paternal negative control analyses), including data from over 400,000 women. Results: All three analytical approaches supported associations of higher maternal BMI with lower odds of maternal anaemia, delivering a small-for-gestational-age baby and initiating breastfeeding, but higher odds of hypertensive disorders of pregnancy, gestational hypertension, preeclampsia, gestational diabetes, pre-labour membrane rupture, induction of labour, caesarean section, large-for-gestational age, high birthweight, low Apgar score at 1 min, and neonatal intensive care unit admission. For example, higher maternal BMI was associated with higher risk of gestational hypertension in multivariable regression (OR = 1.67; 95% CI = 1.63, 1.70 per standard unit in BMI) and Mendelian randomisation (OR = 1.59; 95% CI = 1.38, 1.83), which was not seen for paternal BMI (OR = 1.01; 95% CI = 0.98, 1.04). Findings did not support a relation between maternal BMI and perinatal depression. For other outcomes, evidence was inconclusive due to inconsistencies across the applied approaches or substantial imprecision in effect estimates from Mendelian randomisation. Conclusions: Our findings support a causal role for maternal pre-/early-pregnancy BMI on 14 out of 20 adverse pregnancy and perinatal outcomes. Pre-conception interventions to support women maintaining a healthy BMI may reduce the burden of obstetric and neonatal complications. Funding: Medical Research Council, British Heart Foundation, European Research Council, National Institutes of Health, National Institute for Health Research, Research Council of Norway, Wellcome Trust.</p