Restorative Justice for Young Adults: Lessons from School Discipline

Public policy debates about discipline and punishment often center around a tension between punitive and rehabilitative ideals. Since the 1970s, there has been a trend in criminal justice away from rehabilitation and toward increasingly retributive forms of punishment. Both state and federal governments began to enact “zero-tolerance” laws in an effort to make up for perceived shortcomings in the criminal justice system. This led to a system where individuals were automatically punished for crimes that previously would have been addressed through more rehabilitative methods. The resulting zero-tolerance regime had a particularly disproportionate impact on the young-adult population being funneled through the criminal justice system. This same movement has occurred in education. School districts began drafting similar zero-tolerance policies during the “tough on-crime” era in an effort to make up for similarly perceived shortcomings in educational discipline and achievement.6 School-based zero-tolerance policies relied on exclusionary discipline, where students were automatically suspended or expelled for predetermined offenses.7 Instead of being a solution, zero-tolerance laws are often part of the problem. An alternative to zero-tolerance policies is an approach known as restorative justice

Thirteen polymorphic microsatellite markers for the European green toad Bufo viridis viridis , a declining amphibian species

We report 13 new polymorphic microsatellite markers for the European green toad Bufo viridis viridis (B. viridis subgroup), a declining amphibian from Central, Southeastern and Eastern Europe. Diversity at these loci estimated for 19 individuals ranged from two to ten alleles. Most of these primers also cross-amplify in related West-Mediterranean green toad species (Bufo balearicus, B. siculus and B. boulengeri). These microsatellites will be useful for conservation genetics of threatened Bufo viridis viridis populations and evolutionary studies of green toad taxa in secondary contact to examine hybridizatio

IMP321 (sLAG-3), an immunopotentiator for T cell responses against a HBsAg antigen in healthy adults: a single blind randomised controlled phase I study

BACKGROUND: LAG-3 (CD223) is a natural high affinity ligand for MHC class II. The soluble form (sLAG-3) induces maturation of monocyte-derived dendritic cells in vitro and is used as a potent Th1-like immune enhancer with many antigens in animal models. To extend this observation to human, a proof of concept study was conducted with a clinical-grade sLAG-3, termed IMP321, coinjected with alum-non-absorbed recombinant hepatitis B surface antigen. METHODS: In a randomised, single blind controlled phase I dose escalation study, 48 seronegative healthy volunteers aged 18–55 years were vaccinated at 0, 4 and 8 weeks by subcutaneous injection with 10 μg HBsAg mixed with saline (control) or with IMP321 at one of four doses (3, 10, 30 and 100 μg). To evaluate the efficacy of this three injections over 2 months immunization protocol, an additional control group was injected with the commercial vaccine Engerix-B(®). RESULTS: IMP321 was very well tolerated. Indeed, a lower incidence of adverse events was reported from the HBsAg plus IMP321 groups than from the Engerix-B(® )group. HBsAg-specific antibody responses (anti-HBs) appeared sooner and were higher at 8 and 12 weeks in IMP321 recipients compared to HBsAg control subjects. More importantly, increased numbers of responders to HBsAg were found in IMP321 recipients compared HBsAg group, as revealed by higher post-vaccination frequencies of CD4 Th1 or CD8 Tc1 antigen specific T cells. IMP321 induced CD4 Th1 antigen-specific T cells in some of these naïve individuals after only one injection, especially in the 10 and 30 μg dose groups. CONCLUSION: IMP321 as an adjuvant to HBsAg was well-tolerated and enhanced T cell response vaccine immunogenicity (i.e. induced both CD4 Th1 and CD8 Tc1 antigen-specific T cells). This latter property has allowed the development of IMP321 as an immunopotentiator for therapeutic vaccines

Methodology for a global bicycle real world accidents reconstruction

The use of the bicycle on a large scale encouraged in the context to develop an eco friendly environment is facing today on a range of barriers. One of these barriers identified by researchers and governments is observed to include ‘road safety’. Hence, it is necessary to set up a protection system for bicyclists especially for the cephalic segment. Currently only few studies are available concerning the head impact loading in case of real accidents. Therefore, the objective of this work is to identify the initial condition of head impact in case of real accident. Head impact velocity and head impact area are extracted and implemented in the last generation of head injury prediction tool to simulate the head trauma by impacting directly the Strasbourg University Finite Element Head Model (SUFEHM) on the vehicle structures. The present study can be divided into three activities i.e. obtain real bicyclist accidents data issued from in depth accident investigation databases, cyclist body kinematic reconstruction to obtain the initial conditions of the head just before the impact and head impact simulation to evaluate the head loading during impact and the injury risk. A total of 26 bicyclists’ accident cases with head injuries have been collected from both a French and a German accident database. For each accident case, body kinematic has been simulated using Madymo® software. Two methodologies and human multibody models were used: 10 accident cases have been reconstructed by IFSTTAR using its owned developed human model and 16 accident cases have been reconstructed by Unistra using the human pedestrian TNO model. The results show that the head is impacted more often on top parietal zone, and the mean impact velocity is 6.8 ± 2.7 m/s with 5.5 ± 3.0 m/s and 3.4 ± 2.1 m/s for normal and tangential components respectively. Among these real accidents, 19 cases have been selected to be simulated by finite element computations by coupling the human head model and a windscreen model whose properties were extracted from literature. All reconstructed head impact gave results in accordance with the damage actually incurred to the victims. The objective of this study is to demonstrate the feasibility of numerical reconstruction as an understanding tool of the head impact conditions in bicyclist's accident cases, and hence providing knowledge for helmet optimization using biomechanical criteria

Strong reproductive barriers in a narrow hybrid zone of West-Mediterranean green toads (Bufo viridis subgroup) with Plio-Pleistocene divergence

Background One key question in evolutionary biology deals with the mode and rate at which reproductive isolation accumulates during allopatric speciation. Little is known about secondary contacts of recently diverged anuran species. Here we conduct a multi-locus field study to investigate a contact zone between two lineages of green toads with an estimated divergence time of 2.7 My, and report results from preliminary experimental crosses. Results The Sicilian endemic Bufo siculus and the Italian mainland-origin B. balearicus form a narrow hybrid zone east of Mt. Etna. Despite bidirectional mtDNA introgression over a ca. 40 km North-South cline, no F1 hybrids could be found, and nuclear genomes display almost no admixture. Populations from each side of the contact zone showed depressed genetic diversity and very strong differentiation (FST = 0.52). Preliminary experimental crosses point to a slightly reduced fitness in F1 hybrids, a strong hybrid breakdown in backcrossed offspring (F1 x parental, with very few reaching metamorphosis) and a complete and early mortality in F2 (F1 x F1). Conclusion Genetic patterns at the contact zone are molded by drift and selection. Local effective sizes are reduced by the geography and history of the contact zone, B. balearicus populations being at the front wave of a recent expansion (late Pleistocene). Selection against hybrids likely results from intrinsic genomic causes (disruption of coadapted sets of genes in backcrosses and F2-hybrids), possibly reinforced by local adaptation (the ranges of the two taxa roughly coincide with the borders of semiarid and arid climates). The absence of F1 in the field might be due to premating isolation mechanisms. Our results, show that these lineages have evolved almost complete reproductive isolation after some 2.7 My of divergence, contrasting sharply with evidence from laboratory experiments that some anuran species may still produce viable F1 offspring after > 20 My of divergence

The researcher role in the attitude-behaviour gap

In the green consumer behaviour literature the attitude-behaviour gap is well-established. Studies show that although people condone environmentally friendly actions, their green attitudes do not necessarily translate into green behaviours. Even when green behaviours are reported, this is not borne out by sales figures or recycling rates. The attitude-behaviour gap has been debated across disciplines researching different aspects of green consumer behaviour, such as recycling, purchasing green energy, or household goods. Researchers have debated how attitudes and behaviours may be related or unrelated. Within the field of sustainable tourism researchers have used these ideas to investigate tourist attitudes and behaviours with respect to flying. Our research falls within this tradition. Data from two studies of the flying behaviour of green consumers have raised the question of whether researchers are erroneously equating attitudes with behaviour because of how questions are presented and data are interpreted. We contend that this may be contributing to the attitude-behaviour gap

Zur Bedeutung von Normativität in den Bildungswissenschaften: Editorial

Das Editorial bietet einen Überblick über die Beiträge des vorliegenden Hefts. […] „Aufgrund der eingegangenen Artikel haben die Autoren einen Versuch der Klassifizierung unternommen und dabei folgende Normativitätsbezüge in der erziehungswissenschaftlichen Forschung ausmachen können: A. Orientierung an sozial anerkannten Werten und Normen und gegebenenfalls Überprüfung ihrer Berücksichtigung in der Praxis, B. Vorgabe von theoriegeleiteten bzw. evidenz-basierten Standards, Rahmenkonzepten oder Qualitätsmerkmalen, die für die Praxis handlungsleitenden Charakter haben, und schliesslich C. Überprüfung des Vorhandenseins wissenschaftlich anerkannter Normen, Standards oder Qualitätsmerkmale in der Praxis bzw. in der berufspraktischen Ausbildung. Selbstverständlich handelt es sich bei dieser Klassifizierung um ein Raster, das keine Allgemeingültigkeit beansprucht, sondern induktiv aus den vorliegenden Artikeln hergeleitet worden ist.“ (DIPF/Orig.

New complete genome sequences of human rhinoviruses shed light on their phylogeny and genomic features

<p>Abstract</p> <p>Background</p> <p>Human rhinoviruses (HRV), the most frequent cause of respiratory infections, include 99 different serotypes segregating into two species, A and B. Rhinoviruses share extensive genomic sequence similarity with enteroviruses and both are part of the picornavirus family. Nevertheless they differ significantly at the phenotypic level. The lack of HRV full-length genome sequences and the absence of analysis comparing picornaviruses at the whole genome level limit our knowledge of the genomic features supporting these differences.</p> <p>Results</p> <p>Here we report complete genome sequences of 12 HRV-A and HRV-B serotypes, more than doubling the current number of available HRV sequences. The whole-genome maximum-likelihood phylogenetic analysis suggests that HRV-B and human enteroviruses (HEV) diverged from the last common ancestor after their separation from HRV-A. On the other hand, compared to HEV, HRV-B are more related to HRV-A in the capsid and 3B-C regions. We also identified the presence of a 2C <it>cis</it>-acting replication element (<it>cre</it>) in HRV-B that is not present in HRV-A, and that had been previously characterized only in HEV. In contrast to HEV viruses, HRV-A and HRV-B share also markedly lower GC content along the whole genome length.</p> <p>Conclusion</p> <p>Our findings provide basis to speculate about both the biological similarities and the differences (e.g. tissue tropism, temperature adaptation or acid lability) of these three groups of viruses.</p

Continuing Distance Education: A Capacity-Building Tool for the De-isolation of Care Professionals and Researchers

Background: There are large disparities in access to health-care professionals (HCP) in low-income African countries, leading to imbalanced and suboptimal health delivery. Part of the difficulty is recruiting and retaining care professionals to work in isolated settings. Aim: To evaluate the impact of distance continuing education as a way to build capacity, increase satisfaction and enhance the performance of care professionals in these isolated health-care facilities. Setting: Care professionals using RAFT (Telemedicine Network in French-speaking Africa) in isolated care facilities. Program Description: Within RAFT, an organizational framework and computer-based tools have been developed and evolved to provide useful, qualitative, applicable training material. Program Evaluation: The activity, satisfaction, perceptions and impact of RAFT on remote health-care workers are being monitored. RAFT's potential to improve the recruitment, satisfaction and retention of care professionals in remote settings is widely recognized; however, the actual impact on the performance and quality of care remains to be demonstrate

Ketamine as the anaesthetic for electroconvulsive therapy:the KANECT randomised controlled trial

C.AS. reports grants from Vifor Pharma, outside the submitted work. I.C.R. (deceased) declared personal fees from AstraZeneca, Sanofi Aventis and Sunovion, and non-financial support from Lundbeck, between 2009 and 2014 and all outside the submitted work. Volume 212, Issue 5 May 2018 , p. 323 Ketamine as the anaesthetic for electroconvulsive therapy: the KANECT randomised controlled trial – CORRIGENDUM Gordon Fernie, James Currie, Jennifer S. Perrin, Caroline A. Stewart... https://doi.org/10.1192/bjp.2018.76 Published online: 06 April 2018 Summary: This notice describes a correction to the above mentioned paper.Peer reviewedPublisher PD