160 research outputs found
An EMG study of the lip muscles during covert auditory verbal hallucinations in schizophrenia
Purpose: Auditory verbal hallucinations (AVHs) are speech perceptions in the
absence of a external stimulation. An influential theoretical account of AVHs
in schizophrenia claims that a deficit in inner speech monitoring would cause
the verbal thoughts of the patient to be perceived as external voices. The
account is based on a predictive control model, in which verbal self-monitoring
is implemented. The aim of this study was to examine lip muscle activity during
AVHs in schizophrenia patients, in order to check whether inner speech
occurred. Methods: Lip muscle activity was recorded during covert AVHs (without
articulation) and rest. Surface electromyography (EMG) was used on eleven
schizophrenia patients. Results: Our results show an increase in EMG activity
in the orbicularis oris inferior muscle, during covert AVHs relative to rest.
This increase is not due to general muscular tension since there was no
increase of muscular activity in the forearm muscle. Conclusion: This evidence
that AVHs might be self-generated inner speech is discussed in the framework of
a predictive control model. Further work is needed to better describe how the
inner speech monitoring dysfunction occurs and how inner speech is controlled
and monitored. This will help better understanding how AVHs occur
Ethical difficulties in clinical practice : experiences of European doctors
Background: Ethics support services are growing in Europe to help doctors in dealing with ethical difficulties.
Currently, insufficient attention has been focused on the experiences of doctors who have faced ethical
difficulties in these countries to provide an evidence base for the development of these services.
Methods: A survey instrument was adapted to explore the types of ethical dilemma faced by European
doctors, how they ranked the difficulty of these dilemmas, their satisfaction with the resolution of a recent
ethically difficult case and the types of help they would consider useful. The questionnaire was translated and
given to general internists in Norway, Switzerland, Italy and the UK.
Results: Survey respondents (n = 656, response rate 43%) ranged in age from 28 to 82 years, and averaged
25 years in practice. Only a minority (17.6%) reported having access to ethics consultation in individual
cases. The ethical difficulties most often reported as being encountered were uncertain or impaired decisionmaking
capacity (94.8%), disagreement among caregivers (81.2%) and limitation of treatment at the end of
life (79.3%). The frequency of most ethical difficulties varied among countries, as did the type of issue
considered most difficult. The types of help most often identified as potentially useful were professional
reassurance about the decision being correct (47.5%), someone capable of providing specific advice
(41.1%), help in weighing outcomes (36%) and clarification of the issues (35.9%). Few of the types of help
expected to be useful varied among countries.
Conclusion: Cultural differences may indeed influence how doctors perceive ethical difficulties. The type of
help needed, however, did not vary markedly. The general structure of ethics support services would not have
to be radically altered to suit cultural variations among the surveyed countries
Investigating Host Microbiota Relationships Through Functional Metagenomics
The human Intestinal mucus is formed by glycoproteins, the O- and N-linked glycans which constitute a crucial source of carbon for commensal gut bacteria, especially when deprived of dietary glycans of plant origin. In recent years, a dozen carbohydrate-active enzymes from cultivated mucin degraders have been characterized. But yet, considering the fact that uncultured species predominate in the human gut microbiota, these biochemical data are far from exhaustive. In this study, we used functional metagenomics to identify new metabolic pathways in uncultured bacteria involved in harvesting mucin glycans. First, we performed a high-throughput screening of a fosmid metagenomic library constructed from the ileum mucosa microbiota using chromogenic substrates. The screening resulted in the isolation of 124 clones producing activities crucial in the degradation of human O- and N-glycans, namely sialidases, beta-D-N-acetyl-glucosaminidase, beta-D-N-acetyl-galactosaminidase, and/or beta-D-mannosidase. Thirteen of these clones were selected based on their diversified functional profiles and were further analyzed on a secondary screening. This step consisted of lectin binding assays to demonstrate the ability of the clones to degrade human intestinal mucus. In total, the structural modification of several mucin motifs, sialylated mucin ones in particular, was evidenced for nine clones. Sequencing their metagenomic loci highlighted complex catabolic pathways involving the complementary functions of glycan sensing, transport, hydrolysis, deacetylation, and deamination, which were sometimes associated with amino acid metabolism machinery. These loci are assigned to several Bacteroides and Feacalibacterium species highly prevalent and abundant in the gut microbiome and explain the metabolic flexibility of gut bacteria feeding both on dietary and human glycans
Galaxy Clusters Associated with Short GRBs. II. Predictions for the Rate of Short GRBs in Field and Cluster Early-Type Galaxies
We determine the relative rates of short GRBs in cluster and field early-type
galaxies as a function of the age probability distribution of their
progenitors, P(\tau) \propto \tau^n. This analysis takes advantage of the
difference in the growth of stellar mass in clusters and in the field, which
arises from the combined effects of the galaxy stellar mass function, the
early-type fraction, and the dependence of star formation history on mass and
environment. This approach complements the use of the early- to late-type host
galaxy ratio, with the added benefit that the star formation histories of
early-type galaxies are simpler than those of late-type galaxies, and any
systematic differences between progenitors in early- and late-type galaxies are
removed. We find that the ratio varies from R(cluster)/R(field) ~ 0.5 for n =
-2 to ~ 3 for n = 2. Current observations indicate a ratio of about 2,
corresponding to n ~ 0 - 1. This is similar to the value inferred from the
ratio of short GRBs in early- and late-type hosts, but it differs from the
value of n ~ -1 for NS binaries in the Milky Way. We stress that this general
approach can be easily modified with improved knowledge of the effects of
environment and mass on the build-up of stellar mass, as well as the effect of
globular clusters on the short GRB rate. It can also be used to assess the age
distribution of Type Ia supernova progenitors.Comment: ApJ accepted versio
High mass photon pairs in lepton+ lepton-gamma gamma events at LEP
High mass photon pairs in lepton+ lepton-gamma gamma events at LEP Adriani, O.; Aguilar-Benitez, M.; Ahlen, S.P.; Alcaraz, J.; Aloisio, A.; Alverson, G.; Alviggi, M.G.; Ambrosi, G.; Linde, F.L. Published in: Physics Letters B DOI: 10.1016/0370-2693(92)91576-U Link to publication Citation for published version (APA): Adriani, O., Aguilar-Benitez, M., Ahlen, S. P., Alcaraz, J., Aloisio, A., Alverson, G., ... Linde, F. L. (1992). High mass photon pairs in lepton+ lepton-gamma gamma events at LEP. Physics Letters B, 295,[337][338][339][340][341][342][343][344][345][346] https://doi.org/10.1016/0370-2693(92)91576-U General rights It is not permitted to download or to forward/distribute the text or part of it without the consent of the author(s) and/or copyright holder(s), other than for strictly personal, individual use, unless the work is under an open content license (like Creative Commons). Disclaimer/Complaints regulations If you believe that digital publication of certain material infringes any of your rights or (privacy) interests, please let the Library know, stating your reasons. In case of a legitimate complaint, the Library will make the material inaccessible and/or remove it from the website. Please Ask the Library: https://uba.uva.nl/en/contact, or a letter to: Library of the University of Amsterdam, Secretariat, Singel 425, 1012 WP Amsterdam, The Netherlands. You will be contacted as soon as possible. Download date: 28 Jun 2019 Physics Letters B 295 (1992) From the analysis of the reactions e + e-~ g + g-(n?) (g = e, #, ~) we observe four events, one e+e -~'7 and three #+ ~-??, with the invariant mass of the photon pairs close to 60 GeV. These events were selected from a data sample collected in the L3 detector corresponding to 950000 produced Z°'s. More data are necessary to ascertain the origin of these events
Search for non-minimal Higgs bosons in Z 0 decays
We report on a search for the neutral and charged Higgs bosons predicted by models of spontaneous symmetry breaking with more than one Higgs doublet field. No signals are observed. We set model-independent limits on masses or branching ratios of singly and pair-produced neutral and charged Higgs bosons. In addition, we interpret our results in the framework of a general two-doublet Higgs model and the Minimal Supersymmetric extension of the Standard Model.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/47892/1/10052_2005_Article_BF01474331.pd
Measurement of cross sections and leptonic forward-backward asymmetries at the Z pole and determination of electroweak parameters
We report on the measurement of the leptonic and hadronic cross sections and leptonic forward-backward asymmetries at the Z peak with the L3 detector at LEP. The total luminosity of 40.8 pb −1 collected in the years 1990, 1991 and 1992 corresponds to 1.09·10 6 hadronic and 0.98·10 5 leptonic Z decays observed. These data allow us to determine the electroweak parameters. From the cross sections we derive the properties of the Z boson: assuming lepton universality. We obtain an invisible width of Γ inv =496.5±7.9 MeV which, in the Standard Model, corresponds to a number of light neutrino species of N v =2.981±0.050.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/47894/1/10052_2005_Article_BF01574160.pd
- …