Dynamic energy budget approach to evaluate antibiotic effects on biofilms

Quantifying the action of antibiotics on biofilms is essential to devise therapies against chronic infections. Biofilms are bacterial communities attached to moist surfaces, sheltered from external aggressions by a polymeric matrix. Coupling a dynamic energy budget based description of cell metabolism to surrounding concentration fields, we are able to approximate survival curves measured for different antibiotics. We reproduce numerically stratified distributions of cell types within the biofilm and introduce ways to incorporate different resistance mechanisms. Qualitative predictions follow that are in agreement with experimental observations, such as higher survival rates of cells close to the substratum when employing antibiotics targeting active cells or enhanced polymer production when antibiotics are administered. The current computational model enables validation and hypothesis testing when developing therapies.Comment: to appear in Communications in Nonlinear Science and Numerical Simulatio

End Police Discrimination Against Poor Filipino Children

Coalition to Stop Child Detention Through Restorative Justic

History - LL.M. Roadmap: An International Student’s Guide to U.S. Law School Programs

From 2007 to 2008, Perfecto `Boyet´ Caparas conceptualized, originated & transmitted to Prof. George Edwards, in Edwards’ concurrent capacity then as IU McKinney External Faculty Director of the Graduate Programs & Co-Chair of the Graduate Affairs Committee, his (Caparas’) own original, comprehensive & integrated body of written work & system containing seed ideas, approaches, principles, concepts & perspectives on various facets of LLM, JD & SJD education in the US, from the point of view, perspective, based on the interests, needs, aspirations of & intended for foreign attorneys & professionals as well as law school administrators, that Prof. Edwards used for & in LL.M. Roadmap: An International Student’s Guide to US Law School Programs. This document shows Caparas' own original body of work

Ahimsa and Karma - Principles of Peace Struggle

Transcript of the extemporaneous speech titled Ahimsa and Karma – Principles for Peace Struggle given by Perfecto `Boyet´ Caparas during the commemoration of the UN-declared International Day of Peace, held at the City Market West Plaza, Indianapolis, Indiana, USA, on Saturday, 21 September 2013

Integrating Root Crop Research and Extension for Subsistence Households in the Philippines: An Indepth Inquiry

The establishment of the Root Crop Research Institute (RCRI) at Eastern State College of Agriculture and Applied Sciences (ESCAAS), at Bucgay, Lemar Province (All names of persons, places and institutions in italics are fictitious.) triggered the impetus for root crop research and extension. The major programme of RCRI is the Integrated Root Crop Programme (IRCP). This study focused on the IRCP's operations, functions, processes and consequences as an integrated research and extension programme for the subsistence farmers and their households in the Philippines. The methodological approaches employed were indepth interviews, participant observation qualitative research

Control judicial del poder político

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