Robotic manipulation for the shoe-packaging process

[EN] This paper presents the integration of a robotic system in a human-centered environment, as it can be found in the shoe manufacturing industry. Fashion footwear is nowadays mainly handcrafted due to the big amount of small production tasks. Therefore, the introduction of intelligent robotic systems in this industry may contribute to automate and improve the manual production steps, such us polishing, cleaning, packaging, and visual inspection. Due to the high complexity of the manual tasks in shoe production, cooperative robotic systems (which can work in collaboration with humans) are required. Thus, the focus of the robot lays on grasping, collision detection, and avoidance, as well as on considering the human intervention to supervise the work being performed. For this research, the robot has been equipped with a Kinect camera and a wrist force/ torque sensor so that it is able to detect human interaction and the dynamic environment in order to modify the robot¿s behavior. To illustrate the applicability of the proposed approach, this work presents the experimental results obtained for two actual platforms, which are located at different research laboratories, that share similarities in their morphology, sensor equipment and actuation system.This work has been partly supported by the Ministerio de Economia y Competitividad of the Spanish Government (Key No.: 0201603139 of Invest in Spain program and Grant No. RTC-2016-5408-6) and by the Deutscher Akademischer Austauschdienst (DAAD) of the German Government (Projekt-ID 54368155).Gracia Calandin, LI.; Perez-Vidal, C.; Mronga, D.; Paco, JD.; Azorin, J.; Gea, JD. (2017). Robotic manipulation for the shoe-packaging process. The International Journal of Advanced Manufacturing Technology. 92(1-4):1053-1067. https://doi.org/10.1007/s00170-017-0212-6S10531067921-4Pedrocchi N, Villagrossi E, Cenati C, Tosatti LM (2017) Design of fuzzy logic controller of industrial robot for roughing the uppers of fashion shoes. Int J Adv Manuf Technol 77(5):939–953Hinojo-Perez JJ, Davia-Aracil M, Jimeno-Morenilla A, Sanchez-Romero L, Salas F (2016) Automation of the shoe last grading process according to international sizing systems. Int J Adv Manuf Technol 85(1):455–467Dura-Gil JV, Ballester-Fernandez A, Cavallaro M, Chiodi A, Ballarino A, von Arnim V., Brondi C, Stellmach D (2016) New technologies for customizing products for people with special necessities: project fashion-able. Int J Comput Integr Manuf. In Press, doi: 10.1080/0951192X.2016.1145803Jatta F, Zanoni L, Fassi I, Negri S (2004) A roughing/cementing robotic cell for custom made shoe manufacture. Int J Comput Integr Manuf 17(7):645–652Nemec B, Zlajpah L (2008) Robotic cell for custom finishing operations. Int J Comput Integr Manuf 21(1):33–42Molfino R, et al (2004) Modular, reconfigurable prehensor for grasping and handling limp materials in the shoe industry. In: IMS international forum, CernobbioIntelishoe - integration and linking of shoe and auxiliary industries. 5Th FPSpecial shoes movement. 7th FP, NMP-2008-SME-2-R.229261, http://www.sshoes.euVilaca JL, Fonseca J (2007) A new software application for footwear industry. In: IEEE international symposium on intelligent signal processing WISP 2007, pp 1–6Custom, environment and comfort made shoe. 6TH FP [2004-2008]Framework of integrated technologies for user centred products. Grant agreement no.: CP-TP 229336-2. NMP2-SE-2009-229336 FIT4U -7TH FPRobofoot project website. http://www.robofoot.eu/ . Accessed 2016/ 09/16Montiel E (2007) Customization in the footwear industry. In: proceedings of the MIT congress on mass customizationSucan I, Kavraki LE (2012) A sampling-based tree planner for systems with complex dynamics, vol 28Kuffner JJ Jr, LaValle SM (2000) Rrt-connect: an efficient approach to single-query path planning. In: Proceedings of the IEEE international conference on robotics and automation, 2000. ICRA ’00, vol 2, pp 995–1001Ratliff N, Zucker M, Andrew Bagnell J, Srinivasa S (2009) Chomp: gradient optimization techniques for efficient motion planning. In: IEEE international conference on robotics and automation, 2009. ICRA ’09, pp 489–494Brock O, Khatib O (1997) Elastic strips: real-time path modification for mobile manipulationKroger T (2011) Opening the door to new sensor-based robot applications #x2014;the reflexxes motion libraries. In: 2011 IEEE international conference on robotics and automation (ICRA), pp 1–4Berg J, Ferguson D, Kuffner J (2006) Anytime path planning and replanning in dynamic environments. In: Proceedings of the IEEE international conference on robotics and automation (ICRA), pp 2366–2371Berenson D, Abbeel P, Goldberg K (2012) A robot path planning framework that learns from experience. In: IEEE international conference on robotics and automation. IEEE, pp 3671–3678Bischoff R, Kurth J, Schreiber G, Koeppe R, Albu-Schaeffer A, Beyer A, Eiberger O, Haddadin S, Stemmer A, Grunwald G, Hirzinger G (2010) The kuka-dlr lightweight robot arm — a new reference platform for robotics research and manufacturing. In: Robotics (ISR), 2010 41st international symposium on and 2010 6th German conference on robotics (ROBOTIK), pp 1–8Rooks B (2006) The harmonious robot. Industrial Robot-an International Journal 33:125–130Vahrenkamp N, Wieland S, Azad P, Gonzalez D, Asfour T, Dillmann R (2008) Visual servoing for humanoid grasping and manipulation tasks. In: 8th IEEE-RAS international conference on humanoid robots, 2008, Humanoids 2008, pp 406–412Pieters RS, et al. (2012) Direct trajectory generation for vision-based obstacle avoidance. In: Proceedings of the 2012 IEEE/RSJ international conference on intelligent robots and systemsKinect for windows sensor components and specifications, website. http://msdn.microsoft.com/en-us/library/jj131033.aspx . Accessed 2016/09/16Jatta F, Zanoni L, Fassi I, Negri S (2004) A roughing cementing robotic cell for custom made shoe manufacture. Int J Comput Integr Manuf 17(7):645–652Maurtua I, Ibarguren A, Tellaeche A (2012) Robotics for the benefit of footwear industry. In: International conference on intelligent robotics and applications. Springer, Berlin, pp 235–244Arkin RC (1998) Behavior-based robotics. MIT PressNilsson NJ (1980) Principles of artificial intelligence. Morgan KaufmannAsada H, Slotine J-JE (1986) Robot analysis and control. WileyROS official web page. http://www.ros.org , (Accessed on 2017/ 02/03)Langmann B, Hartmann K, Loffeld O (2012) Depth camera technology comparison and performance evaluation. In: 1st international conference on pattern recognition applications and methods, pp 438–444The player project. free software tools for robot and sensor applications. http://playerstage.sourceforge.net/ , (Accessed on 2017/ 02/03)Yet another robot platform (YARP). http://www.yarp.it/ , (Accessed on 2017/02/03)The OROCOS project. smarter control in robotics and automation. http://www.orocos.org/ , (Accessed on 2017/02/03)CARMEN: Robot navigation toolkit. http://carmen.sourceforge.net/ , (Accessed on 2017/02/03)ORCA: Components for robotics. http://orca-robotics.sourceforge.net/ , (Accessed on 2017/02/03)MOOS: Mission oriented operating suite. http://www.robots.ox.ac.uk/mobile/MOOS/wiki/pmwiki.php/Main/HomePage , (Accessed on 2017/02/03)Microsoft robotics studio. https://www.microsoft.com/en-us/download/details.aspx?id=29081 , (Accessed on 2017/02/03)Pr2 ros website. http://www.ros.org/wiki/Robots/PR2 . Accessed 2016/09/16Care-o-bot 3 ros website. http://www.ros.org/wiki/Robots/Care-O-bot . Accessed 2016/09/16Aila, mobile dual-arm manipulation, website. http://robotik.dfki-bremen.de/de/forschung/robotersysteme/aila.html . Accessed 2016/09/16Package libpcan documentation, website. http://www.ros.org/wiki/libpcan . Accessed 2016/09/16Pcan driver for linux, user manual. http://www.peak-system.com . Document version 7.1 (2011-03-21)Pcan driver for linux, user manual. http://wiki.ros.org/schunk_powercube_chain . Accessed 2016/09/16Ros nodes documentation, website. http://www.ros.org/wiki/Nodes . Accessed 2016/09/16Ros messages documentation, website. http://www.ros.org/wiki/Messages . Accessed 2016/09/16Ros topics documentation, website. http://www.ros.org/wiki/Topics . Accessed 2016/09/16Ros services documentation, website. http://www.ros.org/wiki/Services . Accessed 2016/09/16Yaml files officials website. http://www.yaml.org/ . Accessed 2016/ 09/16Ros robot model (urdf) documentation website. http://www.ros.org/wiki/urdf . Accessed 2016/09/16Point cloud library (pcl), website. http://www.pointclouds.org/ . Accessed 2016/09/16Arm navigation ros stack, website. http://wiki.ros.org/arm_navigation . Accessed 2016/09/16Hornung A, Wurm KM, Bennewitz M, Stachniss C, Burgard W (2013) Octomap: an efficient probabilistic 3d mapping framework based on octrees Autonomous RobotsOrocos kdl documentation, website. http://www.orocos.org/kdl . Accessed 2016/09/16Ioan A, Şucan MM, Kavraki LE (2012) The open motion planning library, vol 19. http://ompl.kavrakilab.orgWaibel M, Beetz M, Civera J, D’Andrea R, Elfring J, Galvez-Lopez D, Haussermann K, Janssen R, Montiel JMM, Perzylo A, Schiessle B, Tenorth M, Zweigle O, van de Molengraft R (2011) Roboearth. IEEE Robot Autom Mag 18(2):69–82Simox toolbox. http://simox.sourceforge.net/ . Accessed 2016/09/16Moreels P, Perona P (2007) Evaluation of features detectors and descriptors based on 3d objects. Int J Comput Vis 73:263–284Viola P, Jones M (2001) Rapid object detection using a boosted cascade of simple features. In: Proceedings of the IEEE computer society conference on computer vision and pattern recognition, 2001. CVPR 2001, vol 1Teuliere C, Marchand E, Eck L (2010) Using multiple hypothesis in model-based tracking. In: 2010 IEEE international conference on robotics and automation (ICRA), pp 4559–4565Moulianitis VC, Dentsoras AJ, Aspragathos NA (1999) A knowledge-based system for the conceptual design of grippers for handling fabrics. Artif Intell Eng Des Anal Manuf 13(1):13–25Davis S, Tsagarakis NG, Caldwell DG (2008) The initial design and manufacturing process of a low cost hand for the robot icub. In: 8th IEEE-RAS international conference on humanoid robots, pp 40–45Cerruti G, Chablat D, Gouaillier D, Sakka S (2017) Design method for an anthropomorphic hand able to gesture and grasp. In: IEEE international conference on robotics and automation. IEEE, pp 3671–367

Selection of extreme phenotypes: the role of clinical observation in translational research

Systematic collection of phenotypes and their correlation with molecular data has been proposed as a useful method to advance in the study of disease. Although some databases for animal species are being developed, progress in humans is slow, probably due to the multifactorial origin of many human diseases and to the intricacy of accurately classifying phenotypes, among other factors. An alternative approach has been to identify and to study individuals or families with very characteristic, clinically relevant phenotypes. This strategy has shown increased efficiency to identify the molecular features underlying such phenotypes. While on most occasions the subjects selected for these studies presented harmful phenotypes, a few studies have been performed in individuals with very favourable phenotypes. The consistent results achieved suggest that it seems logical to further develop this strategy as a methodology to study human disease, including cancer. The identification and the study with high-throughput techniques of individuals showing a markedly decreased risk of developing cancer or of cancer patients presenting either an unusually favourable prognosis or striking responses following a specific treatment, might be promising ways to maximize the yield of this approach and to reveal the molecular causes that explain those phenotypes and thus highlight useful therapeutic targets. This manuscript reviews the current status of selection of extreme phenotypes in cancer research and provides directions for future development of this methodology

Is higher physical fitness associated with better psychological health in young pediatric cancer survivors? A cross-sectional study from the iBoneFIT project

Objective To examine the associations of self-perceived and objectively-measured physical fitness with psychological well-being and distress indicators in young pediatric cancer survivors. Materials and Methods A total of 116 participants (12.1 ± 3.3 years, 56.9% boys) from the iBoneFIT project participated in this cross-sectional study. Objectively-measured physical fitness (muscular fitness) was obtained by handgrip strength and standing long jump tests for the upper and lower body, respectively. Self-perceived physical fitness was obtained by the International Fitness Scale (IFIS). Positive and negative affect were assessed by the positive affect schedule for children (PANAS-C), happiness by Subjective Happiness Scale (SHS), optimism by Life Orientation Test-Revised (LOT-R), self-esteem by the Rosenberg Self-Esteem Scale (RSE), anxiety by State–Trait Anxiety Inventory for Children (STAIC-R), and depression by Children Depression Inventory (CDI). Multiple linear regressions adjusted by key covariates were performed to analyze associations. Results No associations were found between objectively-measured muscular fitness and any of the psychological well-being and distress indicators (p > 0.05). Self-perceived overall fitness and flexibility were positively associated with positive affect (β ≥ 0.258, p < 0.05). Self-perceived cardiorespiratory fitness, speed/agility, and flexibility were negatively associated with depression (β ≥ −0.222, p < 0.05). Finally, self-perceived cardiorespiratory fitness was also negatively associated with anxiety and negative affect (β ≥ −0.264, p < 0.05). Conclusions Perceived physical fitness, but not objectively physical fitness, seems to be inversely related to psychological distress variables and to less extent positively related to psychological well-being. The findings from this study highlight the importance of promoting self-perceived fitness in the pediatric oncology population

Tratamiento del cáncer de próstata en función de la esperanza de vida, la comorbilidad y las guías de práctica clínica

En un número anterior de la revista de Anales del Sistema Sanitario de Navarra, Barceló y col realizaron una interesante y útil revisión de los pacientes con cáncer de próstata tratados en un gran centro hospitalario español durante un año, centrándose en sus características basales, el tratamiento realizado y el grado de seguimiento de las Guías de Práctica Clínica (GPC) y las complicaciones asociadas a los tratamientos realizados

Endoscopical and pathological dissociation in severe colitis induced by immune-checkpoint inhibitors

Checkpoint inhibitors have improved the survival of patients with advanced tumors and show a manageable toxicity profile. However, auto-immune colitis remains a relevant side effect, and combinations of anti-PD1/PDL1 and anti-CTLA-4 increase its incidence and severity. Here, we report the case of a 50-year-old patient diagnosed with stage IV cervical cancer that relapsed following radical surgery, external radiation/brachytherapy and standard chemotherapy. She was subsequently treated with Nivolumab and Ipilimumab combination and developed grade 2 colitis presenting a dissociation between endoscopic and pathological findings. At cycle 10 the patient reported grade 3 diarrhea and abdominal discomfort, without blood or mucus in the stools. Immunotherapy was withheld and a colonoscopy was performed, showing normal mucosa in the entire colon. Puzzlingly, histologic evaluation of randomly sampled mucosal biopsy of the distal colon showed an intense intraepithelial lymphocyte infiltration with crypt loss and some regenerating crypts with a few apoptotic bodies set in a chronically inflamed lamina propria, consistent with the microscopic diagnosis of colitis. Treatment with methylprednisolone 2 mg/kg was initiated which led to a decrease in the number of stools to grade 1. Additional investigations to exclude other causes of diarrhea rendered negative results. The patient experienced a major partial response and, following the resolution of diarrhea, she was re-challenged again with immunotherapy, with the reappearance of grade 2 diarrhea, leading to permanent immunotherapy interruption. We conclude and propose that performing random colonic biopsies should be considered in cases of immune checkpoint-associated unexplained diarrhea, even when colonoscopy shows macroscopically normal colonic mucosa inflammatory lesions

SEOM clinical guideline for treatment of kidney cancer (2017)

The goal of this article is to provide recommendations about the management of kidney cancer. Based on pathologic and molecular features, several kidney cancer variants were described. Nephron-sparing techniques are the gold standard of localized disease. After a randomized trial, sunitinib could be considered in adjuvant treatment in high-risk patients. Patients with advanced disease constitute a heterogeneous population. Prognostic classification should be considered. Both sunitinib and pazopanib are the standard options for first-line systemic therapy in advanced renal cell carcinoma. Based on the results of two randomized trials, both nivolumab and cabozantinib should be considered the standard for second and further lines of therapy. Response evaluation for present therapies is a challenge

Genetic signatures of demographic changes in an avian top predator during the last century : Bottlenecks and expansions of the Eurasian eagle owl in the Iberian Peninsula

Peer reviewe

Células dendríticas especializadas en presentación de antígenos exógenos a linfocitos T citotóxicos

Dendritic cells (DC) are cells of hematopoietic origin, which constitutively express MHC class I and II, and are functionally the most potent inducers of T-lymphocyte activation and proliferation. CD8+ T lymphocytes proliferate and acquire cytotoxic functions upon recognition of their cognate antigen on the surface of one or various dendritic cells with which they interact. However, only some DC subsets are able to present antigen to cytotoxic T cell precursors as taken up from extracellular sources. This function is termed cross-presentation (in Spanish, presentación cruzada or presentación subrogada) and requires shuttle mechanisms from phagosomes to the cytosol for antigen processing. It has been demonstrated that the differentiation of DC with these capabilities is dependent on FLT-3L and the transcription factor BATF3. They express peculiar functions and differentiation markers. These cells are distinguished in mice by surface CD8 features, while CD141 (BDCA-3) marks these cells in the human. These subpopulations are capable of selective internalization of necrotic cell debris by means of their CLEC9A lectin which is a receptor for extracellular polymerized actin. Expression of the chemokine receptor XCR1 favours contact with CD8+ T cells. Therapeutic vaccination with tumour antigens using DC is a strategy under development for the treatment of cancer. The use of DC subsets with more prominent capabilities for cross-presentation would mimic the natural mechanisms of immunization to induce cytolitic T lymphocytes. In vivo targeting of antigens with monoclonal antibodies against DEC-205 or CLEC9A attains very robust immune responses and is a strategy undergoing clinical trials for chronic viral diseases and malignancies

Cytokines in clinical cancer immunotherapy

Cytokines are soluble proteins that mediate cell-to-cell communication. Based on the discovery of the potent anti-tumour activities of several pro-inflammatory cytokines in animal models, clinical research led to the approval of recombinant interferon-alpha and interleukin-2 for the treatment of several malignancies, even if efficacy was only modest. These early milestones in immunotherapy have been followed by the recent addition to clinical practice of antibodies that inhibit immune checkpoints, as well as chimeric antigen receptor T cells. A renewed interest in the anti-tumour properties of cytokines has led to an exponential increase in the number of clinical trials that explore the safety and efficacy of cytokine-based drugs, not only as single agents, but also in combination with other immunomodulatory drugs. These second-generation drugs under clinical development include known molecules with novel mechanisms of action, new targets, and fusion proteins that increase half-life and target cytokine activity to the tumour microenvironment or to the desired effector immune cells. In addition, the detrimental activity of immunosuppressive cytokines can be blocked by antagonistic antibodies, small molecules, cytokine traps or siRNAs. In this review, we provide an overview of the novel trends in the cytokine immunotherapy field that are yielding therapeutic agents for clinical trials