Prediction of non-genotoxic carcinogenicity based on genetic profiles of short term exposure assays

Non-genotoxic carcinogens are substances that induce tumorigenesis by non-mutagenic mechanisms and long term rodent bioassays are required to identify them. Recent studies have shown that transcription profiling can be applied to develop early identifiers for long term phenotypes. In this study, we used rat liver expression profiles from the NTP (National Toxicology Program, Research Triangle Park, USA) DrugMatrix Database to construct a gene classifier that can distinguish between non-genotoxic carcinogens and other chemicals. The model was based on short term exposure assays (3 days) and the training was limited to oxidative stressors, peroxisome proliferators and hormone modulators. Validation of the predictor was performed on independent toxicogenomic data (TG-GATEs, Toxicogenomics Project-Genomics Assisted Toxicity Evaluation System, Osaka, Japan). To build our model we performed Random Forests together with a recursive elimination algorithm (VarSelRF). Gene set enrichment analysis was employed for functional interpretation. A total of 770 microarrays comprising 96 different compounds were analyzed and a predictor of 54 genes was built. Prediction accuracy was 0.85 in the training set, 0.87 in the test set and increased with increasing concentration in the validation set: 0.6 at low dose, 0.7 at medium doses and 0.81 at high doses. Pathway analysis revealed gene prominence of cellular respiration, energy production and lipoprotein metabolism. The biggest target of toxicogenomics is accurately predict the toxicity of unknown drugs. In this analysis, we presented a classifier that can predict non-genotoxic carcinogenicity by using short term exposure assays. In this approach, dose level is critical when evaluating chemicals at early time points.Fil: Perez, Luis Orlando. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Centro Nacional Patagónico. Instituto Patagónico para el Estudio de los Ecosistemas Continentales; ArgentinaFil: González José, Rolando. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Centro Nacional Patagónico. Instituto Patagónico para el Estudio de los Ecosistemas Continentales; ArgentinaFil: Peral Garcia, Pilar. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico CONICET- La Plata. Instituto de Genética Veterinaria ; Argentin

Análisis de las pérdidas generadas debido a los gases contaminantes emitidos por los motores de combustión interna del parque automotor en la ciudad de Arequipa

El objetivo principal de esta investigación, es determinar las pérdidas económicas debidos a los gases contaminantes emitidos por los motores de combustión interna del parque automotor en la ciudad de Arequipa La presente investigación se enmarca dentro de un tipo de investigación explicativa, que establece la relación causal entre los gases contaminante emitidos por los motores de combustión interna y las pérdidas económicas generadas en el sector salud, agricultura, ganadería e infraestructura El resultado nos lleva a la conclusión que las pérdidas económicas superan los 143´829,920 dólares en promedio anual, lo que permite afirmar que es una relación negativa para la economía de las personas que se desarrollan en el ámbito comercial de la ciudad, es decir que existe una relación causal de manera proporcional entre las variables, asumiendo el cumplimiento de la hipótesis

Strategy and Organisational Cybersecurity: A Knowledge-Problem Perspective

Purpose: The purpose of this paper is to frame organisational cybersecurity through a strategic lens, as a function of an interplay of pragmatism, inference, holism and adaptation. The authors address the hostile epistemic climate for intellectual capital management presented by the dynamics of cybersecurity as a phenomenon. The drivers of this hostility are identified and their implications for research and practice are discussed. Design/methodology/approach: The philosophical foundations of cybersecurity in its relation with strategy, knowledge and intellectual capital are explored through a review of the literature as a mechanism to contribute to the emerging theoretical underpinnings of the cybersecurity domain. Findings: This conceptual paper argues that a knowledge-based perspective can serve as the necessary platform for a phenomenon-based view of organisational cybersecurity, given its multi-disciplinary nature. Research limitations/implications: By recognising the knowledge-related vectors, mechanisms and tendencies at play, a novel perspective on the topic can be developed: cybersecurity as a “knowledge problem”. In order to facilitate such a perspective, the paper proposes an emergent epistemology, rooted in systems thinking and pragmatism. Practical implications: In practice, the knowledge-problem narrative can underpin the development of new organisational support constructs and systems. These can address the distinctiveness of the strategic challenges that cybersecurity poses for the growing operational reliance on intellectual capital. Originality/value: The research narrative presents a novel knowledge-based analysis of organisational cybersecurity, with significant implications for both interdisciplinary research in the field, and practice

Melhoria da Atenção à Pessoa com Hipertensão e/ou Diabetes na UBS Vila Kolping, Batalha/PI

RODRIGUEZ, ORLANDO PEREZ. Melhoria da Atenção à Pessoa com Hipertensão e/ou Diabetes na UBS Vila Kolping, Batalha/PI. 2015. 80f. Trabalho de Conclusão de Curso (Curso de Especialização em Saúde da Família) - Departamento de Medicina Social, Faculdade de Medicina, Universidade Federal de Pelotas, Pelotas, Ano 2015. A hipertensão Arterial Sistêmica (HAS) é a mais frequente das doenças cardiovasculares e quando é acompanhada pela Diabetes Mellitus (DM), tende a trazer complicações aos indivíduos nestas condições. A carga de doença representada pela morbimortalidade devido à essa enfermidade é muito alta e por isso a HAS é considerada um problema de saúde pública no Brasil e no mundo. A DM configura-se como uma epidemia mundial, traduzindo-se em grande desafio para os sistemas de saúde de todo o mundo. Com o objetivo de melhorar a atenção a saúde dos usuários hipertensos e diabéticos, realizou se uma intervenção na Unidade Básica de Saúde (UBS) Vila Kolping, no município Batalha PI, durante 16 semanas. Para isso foram coordenadas ações nos quatro eixos temáticos do curso sendo eles, monitoramento e avaliação, organização e gestão do serviço, engajamento público e qualificação da pratica clínica. Foram utilizados prontuários, fichas espelhos e planilha eletrônica de coleta de dados, além do Manual de Hipertensão e Diabetes do Ministério da Saúde. Os resultados evidenciaram que 379 usuários hipertensos foram cadastrados, o que representa 58,1% e 100 usuários diabéticos, o que corresponde a 62,1%; realizamos exame clínico apropriado em 99,7% dos hipertensos e em 99% dos diabéticos; além disso 99,5% dos hipertensos e o 99% dos diabéticos tiveram ficha de acompanhamento atualizada e foi realizada busca ativa a 100% dos hipertensos e diabéticos. Evidenciamos ainda que 96,8% dos hipertensos e 94% dos diabéticos, estão com estratificação do risco cardiovascular em dia, e 100% dos hipertensos e diabéticos receberam orientação nutricional sobre alimentação saudável, sobre a importância de prática regular de atividade física, sobre os riscos do tabagismo e sobre a importância de uma correta higiene bucal. A intervenção demonstrou resultados satisfatórios em relação à melhoria na qualidade do atendimento dos hipertensos e diabéticos e organizou-se melhor o trabalho. Foi possível uma atualização constante dos registros, melhorou-se o acolhimento dos usuários alvo e as atividades foram implementadas na rotina de trabalho do serviço. Palavras-chave: atenção primária à saúde; saúde da família; doença crônica; hipertensão; diabetes mellitus

Are social enterprises technological innovative?:A quantitative analysis on social entrepreneurs in emerging countries

Technological innovation is the new backbone for companies. Exploiting and exploring new knowledge increase the chance of survival in the current dynamic market. Alongside, there are countries were be an innovative need to face up social and political challenges. This has transformed their economy, spreading an entrepreneurial mindset mingled with the willing to help a local community. This phenomenon is called social entrepreneurship which is leveraging new economies and building wealth, environmental system. In this vein, the present research seeks to offer qualitative research on 142 social entrepreneurs in an emerging country. The scope is to analyse if social entrepreneurship, entrepreneurial characteristics, and entrepreneurial ecosystem influence innovation. As emerged, technological innovation is affected by the first two factors but the entrepreneurial ecosystem is still not supportive. New, several activities should be organised by the government to assist entrepreneurs, whereas, the entrepreneurs are socially motivated to build up his enterprise.</p

Estudio ergonómico de carga y descarga de moldes para prensa neumática en una Empresa de caucho, Lima 2019

El presente trabajo de investigación trata sobre el estudio descriptivo en el Estudio Ergonómico de carga y descarga de moldes para prensa neumática en una Empresa de caucho, Lima 2019. Objetivo general: Describir un estudio ergonómico descriptivo para determinar los factores de riesgo disergonómicos a los que se encuentran expuestos los trabajadores durante sus actividades de carga y descarga de moldes en una presa neumática. Metodología: Investigación tipo aplicada, con enfoque cuantitativo, diseño no experimental de corte transversal, el alcance de la investigación es descriptivo. El universo de estudio fue un total de 6 trabajadores que laboran en operaciones de carga y descarga de moldes para prensa neumática en una Empresa de caucho, Lima 2019. Para estimar el riesgo de padecer trastornos musculoesqueléticos relacionados con el trabajo se realizó una evaluación mediante el método Ergonómico; REBA (Rapid Entire Body Assessment) posteriormente el método RULA (Rapid Upper Limb Assessment). Resultados: En la evaluación por REBA se demostró que existe riesgo alto y muy alto con respecto a factores ergonómicos con puntuaciones de 13 y 12, el nivel de riesgo entre 3 y 4 siendo necesario la actuación inmediata y cuanto antes. En la evaluación por RULA se demostró que el riesgo es nivel 3 y 4 sugiriendo cambios en la tarea y rediseño. Conclusión: Al final del estudio se observó que la intervención ergonómica debe ser inmediata para los operadores mecánicos que hacen operaciones de carga y descarga de moldes para prensa neumática. Recomendación: Se recomienda la intervención del jefe médico ocupacional para analizar cada una de las actividades de carga y descarga de moldes para prensa neumática y analizar los planes de acción para mejorar los puestos laborales

Adaptive Path Following for an Underactuated Nonholonomic Mobile Manipulator

We investigate an adaptive path following problem for an underactuated nonholonomic mobile manipulator system and closed planar curves. As opposed to adapting to uncertain or unknown dynamics in the plant, we apply an adaptation approach with respect to an unknown geometric path. First, we present a solution to the non-adaptive path following problem using the concept of a path following output and apply it to circular and elliptical paths. To overcome a drawback associated with our first proposed solution and set the stage for our approach to the adaptive case, we apply an approximation approach based on osculating circles for strictly convex closed curves. We transition to the adaptive path following case by first presenting an algorithm to estimate unknown path parameters in the case of a circular path. We use our estimation algorithm and our path following solution for circular paths in an indirect adaptive control scheme. Thereafter, again using the osculating circle of a curve and the approximation technique of our second non-adaptive path following solution, we extend our adaptive solution, under some mild assumptions, for unknown strictly convex closed curves in the plane

Gestión institucional y su influencia en la convivencia escolar, de una institución educativa de nivel primario - Callao 2019

Este trabajo ha tenido como propósito principal establecer el efecto de la gestión institucional en la coexistencia educativa y como propósitos precisos determinar el efecto de la planeación, organización, dirección y control en la coexistencia educativa de una I.E. de nivel primario en la provincia constitucional del Perú a lo largo del 2019. Se aplicó el método del enfoque cuantitativo, diseño no experimental, descriptivo correlacional. Para la recopilación de informaciones se usó el método de las encuestas, se aplicó como herramienta dos cuestionarios, el de gestión institucional con 16 ítems y el de convivencia escolar con 15 ítems. La parte de la conclusión y las sugerencias en las cuales se ha determinado lograran que la influencia de la gestión institucional vaya mejorando en beneficio de la coexistencia educativa y en especial a la referente al ámbito educativo de nivel primario ya que esta va influir y va a tener un significado muy importante ya sea al grado individual como al grado comunitario

The characteristics of stress cardiomyopathy in an ethnically heterogeneous population

OBJECTIVES: Stress cardiomyopathy is a cardiac syndrome that is characterized by transient left ventricular systolic dysfunction in the absence of obstructive coronary artery disease. Its epidemiology has been described in homogeneous Asian, Caucasian and Black populations, but its characteristics in heterogeneous populations are poorly understood. Our aim was to assess the characteristics of stress cardiomyopathy in a heterogeneous population that included a large percentage of Hispanics. METHODS: We reviewed 59 consecutive cases of stress cardiomyopathy that were confirmed by coronary angiography and were in agreement with the Mayo Clinic diagnostic criteria. RESULTS: The mean age of the patients was 74 years (range, 39-91 years), and 37 patients were female (62.7%). Twenty-nine patients (49.2%) were Latino/Hispanic, 26 (44%) were Caucasian, 3 (5%) were Asian, and 1 patient (1.7%) was Black. The most common chief symptom was dyspnea, followed by chest pain and an absence of symptoms in 54.2, 28.8, and 18.6% of the patients, respectively. The primary EKG abnormalities consisted of a T wave inversion, an ST segment elevation, and ST segment depression in 69.5%, 25.4%, and 15.3% of the patients, respectively. The stressor event was identified in 90% of the cases. In 32 cases (54%), the stressor event was physical stress or a medical illness, and in 21 cases (35.6%), the stressor event was emotional stress. The in-hospital mortality rate was 8.5%. CONCLUSIONS: In our heterogeneous study population, stress cardiomyopathy presented with a 3:2 female-to-male ratio, and dyspnea was the most common chief complaint. Stress cardiomyopathy exhibited a T wave inversion as the primary EKG abnormality. These findings differ from previous cases that have been reported, and further studies are needed