A fluid model for closed queueing networks with PS stations

This technical report introduces a closed multi-class queueing network (QN) model with class-switching, where the service rates are de ned to represent multi-processor stations with a processor-sharing (PS) allocation policy. These transition rates are also able to consider traditional delay nodes, and therefore a QN model with these transition rates is well-suited for multi-threaded software applications. In this report, we de ne the QN model and use the results in [1] to show that the transient sample paths of the QN model converge to the solution of a system of ordinary di erential equations (ODEs). As the size of the ODE system grows linearly with the number of stations and job classes in the QN model, solving the ODE system becomes a scalable alternative to Markov chain representations

Variability-aware request replication for latency curtailment

Processing time variability is commonplace in distributed systems, where resources display disparate performance due to, e.g., different workload levels, background processes, and contention in virtualized environments. However, it is paramount for service providers to keep variability in response time under control in order to offer responsive services. We investigate how request replication can be used to exploit processing time variability to reduce response times, considering not only mean values but also the tail of the response time distribution. We focus on the distributed setup, where replication is achieved by running copies of requests on multiple servers that otherwise evolve independently, and waiting for the first replica to complete service. We construct models that capture the evolution of a system with replicated requests using approximate methods and observe that highly variable service times offer the best opportunities for replication ¿¿¿ reducing the response time tail in particular. Further, the effect of replication is non-uniform over the response time distribution: gains in one metric, e.g., the mean, can be at the cost of another, e.g., the tail percentiles. This is demonstrated in wide range of numerical virtual experiments. It can be seen that capturing service time variability is key to the evaluation of latency tolerance strategies and in their design

Pharmacology of airways and vessels in lung slices in situ: role of endogenous dilator hormones

Small airway and vessels play a critical role in chronic airway and pulmonary vascular diseases, but their pharmacology has not been well characterised. We have studied airway and vascular responses in rat lung slices and separately in vitro using myography. In lung slices, under basal conditions, acetylcholine contracted airways, but had no vascular effect. The thromboxane mimetic, U46619 contracted both vessels and airways. In the presence of U46619, acetylcholine dilated vessels, but further contracted airways, an effect that was blocked by the nitric oxide synthase inhibitor L-N(G)-nitro-L-arginine or apamin plus charybdotoxin, which inhibit endothelial-derived hyperpolarising factor. Airway responses in lung slices were unaffected by L-N(G)nitro-L-arginine methyl ester, indomethacin or apamin plus charybdotoxin. By contrast, apamin plus charybdotoxin contracted bronchi studied in isolation. Our observations are the first to identify mechanisms of endothelium dependent dilations in precision cut lung slices and the potential for transverse hormonal communication between airways and vessels

New Symmetries in Crystals and Handed Structures

For over a century, the structure of materials has been described by a combination of rotations, rotation-inversions and translational symmetries. By recognizing the reversal of static structural rotations between clockwise and counterclockwise directions as a distinct symmetry operation, here we show that there are many more structural symmetries than are currently recognized in right- or left-handed handed helices, spirals, and in antidistorted structures composed equally of rotations of both handedness. For example, though a helix or spiral cannot possess conventional mirror or inversion symmetries, they can possess them in combination with the rotation reversal symmetry. Similarly, we show that many antidistorted perovskites possess twice the number of symmetry elements as conventionally identified. These new symmetries predict new forms for "roto" properties that relate to static rotations, such as rotoelectricity, piezorotation, and rotomagnetism. They also enable symmetry-based search for new phenomena, such as multiferroicity involving a coupling of spins, electric polarization and static rotations. This work is relevant to structure-property relationships in all material structures with static rotations such as minerals, polymers, proteins, and engineered structures.Comment: 15 Pages, 4 figures, 3 Tables; Fig. 2b has error

Finite-element-model updating of civil engineering structures using a hybrid UKF-HS algorithm

This is the author accepted manuscript. The final version is available from Taylor & Francis via the DOI in this recordFinite-element-model updating allows reducing the discrepancies between the numerical and the experimental dynamic behaviour of civil engineering structures. Among the different methods to tackle the updating problem, the maximum likelihood method has been widely used for practical engineering applications. In this method, the updating problem is transformed into an optimization problem where the relative differences between the numerical and experimental modal properties of the structure are reduced via the modification of the most relevant physical parameters of the model. However, this method often presents the drawback of requiring high simulation times in order to perform the updating process when dealing with complex structures. To overcome this limitation, in this paper a novel hybrid Unscented Kalman Filter – Harmony Search (UKF-HS) algorithm is proposed and its implementation details are discussed. In order to validate such hybrid algorithm and further illustrate its performance, the finite-element-model updating of a benchmark footbridge is performed using two different approaches (single-objective and multi-objective) and three different computational algorithms, namely: (i) genetic algorithms; (ii) harmony search; and (iii) the novel UKF-HS hybrid algorithm. The obtained results reveal that the proposed hybrid algorithm may be considered as an adequate alternative tool to efficiently perform the finite-element-mMinisterio de Economía y Competitividad of SpainEuropean Regional Development Fund (ERDF)Universidad de Sevill

LHC Searches for Non-Chiral Weakly Charged Multiplets

Because the TeV-scale to be probed at the Large Hadron Collider should shed light on the naturalness, hierarchy, and dark matter problems, most searches to date have focused on new physics signatures motivated by possible solutions to these puzzles. In this paper, we consider some candidates for new states that although not well-motivated from this standpoint are obvious possibilities that current search strategies would miss. In particular we consider vector representations of fermions in multiplets of $SU(2)_L$ with a lightest neutral state. Standard search strategies would fail to find such particles because of the expected small one-loop-level splitting between charged and neutral states.Comment: 16 pages, 9 figure

Rapid reduction versus abrupt quitting for smokers who want to stop soon: a randomised controlled non-inferiority trial

Background: The standard way to stop smoking is to stop abruptly on a quit day with no prior reduction in consumption of cigarettes. Many smokers feel that reduction is natural and if reduction programmes were offered, many more might take up treatment. Few trials of reduction versus abrupt cessation have been completed. Most are small, do not use pharmacotherapy, and do not meet the standards necessary to obtain a marketing authorisation for a pharmacotherapy.\ud Design/Methods: We will conduct a non-inferiority andomised trial of rapid reduction versus standard abrupt cessation among smokers who want to stop smoking. In the reduction arm,participants will be advised to reduce smoking consumption by half in the first week and to 25% of baseline in the second, leading up to a quit day at which participants will stop smoking completely.This will be assisted by nicotine patches and an acute form of nicotine replacement therapy. In the abrupt arm participants will use nicotine patches only, whilst smoking as normal, for two weeks prior to a quit day, at which they will also stop smoking completely. Smokers in either arm will have standard withdrawal orientated behavioural support programme with a combination of nicotine patches and acute nicotine replacement therapy post-cessation.\ud Outcomes/Follow-up: The primary outcome of interest will be prolonged abstinence from smoking, with secondary trial outcomes of point prevalence, urges to smoke and withdrawal\ud symptoms. Follow up will take place at 4 weeks, 8 weeks and 6 months post-quit day

Rare Z-decay into light CP-odd Higgs bosons: a comparative study in different new physics models

Various new physics models predict a light CP-odd Higgs boson (labeled as $a$) and open up new decay modes for Z-boson, such as $Z \to \bar{f} f a$, $Z\to a\gamma$ and $Z\to aaa$, which could be explored at the GigaZ option of the ILC. In this work we investigate these rare decays in several new physics models, namely the type-II two Higgs doublet model (type-II 2HDM), the lepton-specific two Higgs doublet model (L2HDM), the nearly minimal supersymetric standard model (nMSSM) and the next-to-minimal supersymmetric standard model (NMSSM). We find that in the parameter space allowed by current experiments, the branching ratios can reach $10^{-4}$ for $Z \to \bar{f} f a$ ($f=b,\tau$), $10^{-9}$ for $Z\to a\gamma$ and $10^{-3}$ for $Z\to aaa$, which implies that the decays $Z \to \bar{f} f a$ and $Z \to a a a$ may be accessible at the GigaZ option. Moreover, since different models predict different patterns of the branching ratios, the measurement of these rare decays at the GigaZ may be utilized to distinguish the models.Comment: Version in JHEP (discussions added, errors corrected

Perturbative quantum gravity with the Immirzi parameter

We study perturbative quantum gravity in the first-order tetrad formalism. The lowest order action corresponds to Einstein-Cartan plus a parity-odd term, and is known in the literature as the Holst action. The coupling constant of the parity-odd term can be identified with the Immirzi parameter of loop quantum gravity. We compute the quantum effective action in the one-loop expansion. As in the metric second-order formulation, we find that in the case of pure gravity the theory is on-shell finite, and the running of Newton's constant and the Immirzi parameter is inessential. In the presence of fermions, the situation changes in two fundamental aspects. First, non-renormalizable logarithmic divergences appear, as usual. Second, the Immirzi parameter becomes a priori observable, and we find that it is renormalized by a four-fermion interaction generated by radiative corrections. We compute its beta function and discuss possible implications. The sign of the beta function depends on whether the Immirzi parameter is larger or smaller than one in absolute value, and the values plus or minus one are UV fixed-points (we work in Euclidean signature). Finally, we find that the Holst action is stable with respect to radiative corrections in the case of minimal coupling, up to higher order non-renormalizable interactions.Comment: v2 minor amendment

Overview of the Quench Heater Performance for MQXF, the Nb3Sn Low-β Quadrupole for the High Luminosity LHC

In the framework of the high-luminosity upgrade of the Large Hadron Collider, the U.S. LARP collaboration and CERN are jointly developing a 150 mm aperture Nb Sn quadrupole for the LHC interaction regions. Due to the large stored energy density and the low copper stabilizer section, the quench protection of these magnets is particularly challenging, relying on a combination of quench heaters attached to the coil surface and coupling loss induced quench (CLIQ) units electrically connected to the coils. This paper summarizes the performance of the quench heater strips in different configurations relevant to machine operation. The analysis is focused on the inner layer quench heaters, where several heater strips failed during powering tests. Failure modes are discussed in order to address the technology issues and provide guidance for future tests.