A meta-analysis of resuscitative endovascular balloon occlusion of the aorta (REBOA) or open aortic cross-clamping by resuscitative thoracotomy in non-compressible torso hemorrhage patients

Background The objective of this systematic review and meta-analysis was to determine the effect of REBOA, compared to resuscitative thoracotomy, on mortality and among non-compressible torso hemorrhage trauma patients. Methods Relevant articles were identified by a literature search in MEDLINE and EMBASE. We included studies involving trauma patients suffering non-compressible torso hemorrhage. Studies were eligible if they evaluated REBOA and compared it to resuscitative thoracotomy. Two investigators independently assessed articles for inclusion and exclusion criteria and selected studies for final analysis. We conducted meta-analysis using random effect models. Results We included three studies in our systematic review. These studies included a total of 1276 patients. An initial analysis found that although lower in REBOA-treated patients, the odds of mortality did not differ between the compared groups (OR 0.42; 95% CI 0.17–1.03). Sensitivity analysis showed that the risk of mortality was significantly lower among patients who underwent REBOA, compared to those who underwent resuscitative thoracotomy (RT) (RR 0.81; 95% CI 0.68–0.97). Conclusion Our meta-analysis, mainly from observational data, suggests a positive effect of REBOA on mortality among non-compressible torso hemorrhage patients. However, these results deserve further investigation

CONFIGURACIÓN DE UNA RED DE NUEVA GENERACIÓN PARA CONECTIVIDAD CON INTERNET RESPALDADO POR UN SERVICIO DNS CON SOPORTE PARA IPV4 E IPV6.

Se presentan las características mas representativas de la implementación de la isla ipv6 del centro de computación de alto desempeño CECAD, realizando pruebas de conexión y desempeño en el tráfico interno con las subredes de la Universidad Distrital y posteriormente con su conexión a Internet a través del protocolo NAT-PT secundado por un servidor de nombres de domino recursivo como base de conectividad y soporte sobre estructuras Ipv4 e Ipv6 nativas

Comparative analysis of the biosimilar and innovative G-CSF modulated pathways on umbilical cord blood–derived mononuclear cells

Biosimilars of granulocyte colony-stimulating factor (G-CSF) have been routinely introduced into clinical practice. However, not functional genomics characterization has been performed yet in comparison with the innovator G-CSF. This study aimed to evaluate the transcriptomic changes in an in vitro model of umbilical cord blood cells (UBC) exposed to G-CSF for the identification of their modulated pathways. Umbilical cord blood cells–derived mononuclear cells (MNCs) were treated with biosimilar and innovator G-CSF for further gene expression profiling analysis using a microarray-based platform. Comparative analysis of biosimilar and innovator G-CSF gene expression signatures allowed us to identify the most commonly modulated pathways by both drugs. In brief, we observed predominantly upmodulation of transcripts related to PI3K-Akt, NF-kappaB, and tumor necrosis factor (TNF) signaling pathways as well as transcripts related to negative regulation of apoptotic process among others. In addition, hematopoietic colony-forming cell assays corroborate the G-CSF phenotypic effects over UBC-derived MNCs. In conclusion, our study suggests that G-CSF impacts UBC-derived cells through the modulation of several signaling pathways associated with cell survival, migration, and proliferation. The concordance observed between biosimilar and innovator G-CSF emphasizes their similarity in regards to their specificity and biological responses.Fil: Ávila Portillo, Luz Mabel. Universidad Nacional de Colombia; Colombia. Stem Medicina Regenerativa/CryoHoldco; Colombia. Hospital Militar Central. Unidad de Investigación; ColombiaFil: Aristizabal, F.. Universidad Nacional de Colombia; ColombiaFil: Perdomo, S.. Universidad El Bosque. Facultad de Odontología; ColombiaFil: Riveros, A.. Stem Medicina Regenerativa/CryoHoldco; ColombiaFil: Ospino, B.. Stem Medicina Regenerativa/CryoHoldco; ColombiaFil: Avila, J. P.. Stem Medicina Regenerativa/CryoHoldco; ColombiaFil: Butti, M.. Universidad Nacional de La Plata. Facultad de Ciencias Médicas. Centro de Investigaciones Inmunológicas Básicas y Aplicadas; Argentina. Provincia de Buenos Aires. Gobernación. Comisión de Investigaciones Científicas; ArgentinaFil: Abba, Martín Carlos. Universidad Nacional de La Plata. Facultad de Ciencias Médicas. Centro de Investigaciones Inmunológicas Básicas y Aplicadas; Argentina. Provincia de Buenos Aires. Gobernación. Comisión de Investigaciones Científicas; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata; Argentin

New insights into the fossil record of the turtle genus Chelus Duméril, 1806 including new specimens with information on cervicals and limb bones

Matamata turtles (Chelus Duméril, 1806) are composed of two extant species, Chelus fimbriata ­Schneider, 1783 and Chelus orinocensis Vargas-Ramírez, Caballero, Morales-Betancourt, Lasso, Amaya, Martínez, Silva-Viana, Vogt, Farias, Hrbek, Campbell & Fritz, 2020, inhabitants of the main freshwater drainages of northern South America. The systematics and palaeobiogeography of Chelus is still unresolved. Here, we describe several new fossil specimens from the Late Miocene of Urumaco (Venezuela) and Tatacoa (Colombia). The fossils are mostly complete, articulated shells that allow reestablishing validity of two extinct taxa, Chelus colombiana Wood, 1976 and Chelus lewisi Wood, 1976. One of the specimens of C. lewisi from Urumaco represents the first record within the genus for which autopodial bones (a left manus) and additional limb bones are preserved together with ashell, demonstrating evolutionary conservatism in limb anatomy for the genus. The specimen comes from the Socorro Formation, representing the earliest so far known record of Chelus for the Urumaco sequence. Additionally, one specimen from Tatacoa is the first fossil for which cervical and pectoral girdle elements are preserved. Phylogenetic analysis supports the existence of two separate clades inside of Chelus, one formed by the extinct species and the other by the extant ones

Utility of recombinant human TSH stimulation test in the follow-up of patients with differentiated thyroid cancer depending on basal thyroglobulin results

Background: Thyroglobulin (Tg) is fundamental for differentiated thyroid cancer (DTC) monitoring. Tg detection can be enhanced using recombinant human thyroidstimulating hormone (TSH) (rhTSH). This study is aimed to evaluate the use of the rhTSH stimulation test when using a high-sensitivity Tg assay. Methods: We retrospectively studied 181 rhTSH tests from 114 patients with DTC and negative for antithyroglobulin antibodies (anti-TgAb). Image studies were performed in all cases. Serum Tg and anti-TgAb were measured using specific immunoassays. Results: rhTSH stimulation in patients with basal serum Tg (b-Tg) concentrations lower than 0.2 ng/mL always resulted in rhTSH-stimulated serum Tg (s-Tg) concentrations lower than 1.0 ng/mL and negative structural disease. In patients with bTg concentration between 0.2 and 1.0 ng/mL, s-Tg detected one patient (1/30) who showed biochemical incomplete response. Patients with negative images had lower s-Tg than thosewith nonspecific or abnormal findings (p<0.05).Receiver operating characteristic curve analysis of the s-Tg to detect altered images showed an area under the curve of 0.763 (p<0.05).With an s-Tg cutoff of 0.85 ng/mL, the sensitivity was 100%, decreasing to 96.15% with an s-Tg cutoff of 2 ng/mL. Conclusions: Patients with DTC with b-Tg concentrations equal or higher than 0.2 ng/mL can benefit from the rhTSH stimulation test

Vibrations Analysis of the Fruit-Pedicel System of Coffea arabica var. Castillo Using Time-Frequency and Wavelets Techniques

Colombian coffee production is well-known, and selective manual harvesting plays a vital task in guaranteeing high ripe coffee fruit rates in this process, leading to its known worldwide aroma and flavor. To maintain this quality approach, selective harvesting methods based on mechanical vibrations are a promising alternative for developing technologies that could accomplish the challenging Colombian coffee production context. In this study, a vibrations analysis in coffee fruits at three ripening stages was carried out to evaluate the dynamic behavior at two frequency windows: 10 to 100 Hz and 100 to 1000 Hz. Two groups of fruits previously classified in the CIELab color space were chosen for the vibration test study samples. Time and frequency signals were characterized via FFT (fast Fourier transform), and bump wavelets were determined to obtain the frequency-time magnitude scalograms. The measurements were obtained in three degrees of freedom over the fruits: one for measuring the input force (computed in voltage way) and the other two measured by the velocity. The results revealed frequency ranges with specific resonant peaks between 24 and 45 Hz, and close to 700 Hz, where the ripe fruits presented higher magnitudes in the calculated parameters. FFT of the velocity and scaled mechanical impedance were used to estimate these frequency ranges. This work is an important step to identify a "vibrational fingerprint " of each Coffea arabica var. Castillo fruit-ripening stage. However, we consider that more experiments should be performed to reconstruct the modal shape in each resonance. In future studies, fatigue analysis could show which are the most effective frequency ranges to detach the ripe fruits from the perspective of a real selective coffee-harvesting scenario.</p

Reducing natural vegetation loss in Amazonia critically depends on the formal recognition of indigenous lands

The Brazilian Amazon contains the world's largest tract of tropical forest, about 22 % of which is within demarcated indigenous territories. Formal governmental recognition of these traditional territories is often a critical deterrent to deforestation, but the relative conservation performance of Indigenous Lands (ILs) under different legal categories and geographic contexts remains poorly understood. We used 30-m resolution Landsat satellite imagery to quantitatively assess the land cover status and annual rates of natural vegetation loss between 1985 and 2020 for 381 indigenous territories amounting to ~115 million hectares. Using a comprehensive set of environmental and socio-economic covariates and a mixed-modelling approach, we found that all stages of formal IL recognition consistently inhibit natural vegetation loss throughout the Brazilian Amazon compared to adjacent unprotected areas. Formal physical demarcation and distance from roads were the main proximate drivers of avoided natural vegetation loss inside ILs. Forest loss associated with road access is substantially curbed by ILs, showing the importance of frontier expansion when assessing indigenous reserve performance in counteracting natural vegetation loss. Because loss of natural forest and savannah areas associated with agribusiness frontiers and infrastructure projects are likely to intensify, the importance of ecosystem services provided by ILs is expected to increase across the Brazilian Amazon. Cultural profile and human density exerted no impacts on IL effectiveness in precluding natural vegetation loss. Given widespread encroachment of timber extraction and agribusiness, formal recognition of indigenous territories is a critical factor in decelerating primary habitat conversion across the Amazon