The measurement of enhancement in mathematical abilities as a result of joint cognitive trainings in numerical and visual-spatial skills: A preliminary study

A body of literature shows the significant role of visual-spatial skills played in the improvement of mathematical skills in the primary school. The main goal of the current study was to investigate the impact of a combined visuo-spatial and mathematical training on the improvement of mathematical skills in 146 second graders of several schools located in Italy. Participants were presented single pencil-and-paper visuo-spatial or mathematical trainings, computerised version of the above mentioned treatments, as well as a combined version of computer-assisted and pencil-and-paper visuo-spatial and mathematical trainings, respectively. Experimental groups were presented with training for 3 months, once a week. All children were treated collectively both in computer-assisted or pencil-and-paper modalities. At pre and post-test all our participants were presented with a battery of objective tests assessing numerical and visuo-spatial abilities. Our results suggest the positive effect of different types of training for the empowerment of visuo-spatial and numerical abilities. Specifically, the combination of computerised and pencil-and-paper versions of visuo-spatial and mathematical trainings are more effective than the single execution of the software or of the pencil-and-paper treatment

Does institutionalization influence perceived metamemory, psychological well-being, and working-memory efficiency in Italian elders? A preliminary study

Background/Purpose: This study was mainly aimed at investigating the impact of institutionalization on working-memory and self-referent metamemory abilities in a sample of cognitively healthy Italian elders. Methods: Fifteen participants (70-91 years old) were recruited from several nursing homes located in Ogliastra, the central eastern area of Sardinia, which is characterized by a higher longevity of its inhabitants. A further sample of 15 community-dwelling elders was recruited in the same areas. The participants were asked to complete several visuospatial and verbal working-memory tasks, and a battery of questionnaires assessing their psychological well-being, general beliefs about global and prospective-memory efficiency, and personal metamnestic abilities. Results: The results showed that, compared with the community-dwelling participants, the institutionalized elders self-rated lower metamemory efficiency, but they trust more general metamemory functions of a stereotypical adult. Furthermore, no differences were found on the well-being measures between the two groups. These outcomes are not biased by social desirability. Conclusion: These findings suggest that institutionalization selectively impacts self-assessed metamemory functions, but not psychological well-being

Laboratorio online: tutoring e vantaggi per lo studente universitario

Il presente lavoro nasce con l’intento di realizzare una ricerca che ha come obiettivo principale quello di analizzare la funzione del tutoring e dei laboratori online su un gruppo di matricole frequentanti il primo anno del Corso di Laurea di Scienze dell’Educazione dell’Università di Cagliari. In tali attività, ruolo cruciale è svolto dal tutor online che funge da facilitatore e contribuisce a chiarire e a raggiungere il conseguimento degli obiettivi educativi e delle interazioni. Il tutor induce lo sviluppo di apprendimento autonomo dei singoli discenti, facendo leva sulla loro curiosità, individuando il loro bisogni formativi, formulando obiettivi compatibili con le loro possibilità e identificando le risorse per loro più adeguate. Partendo da questi presupposti ci siamo chiesti quale sia stata la soddisfazione generale sul ruolo del tutor e l’efficacia del laboratorio in termini di percezione dell’aumento delle proprie abilità di problem solving, dell’autostima, della motivazione, del locus of control e delle competenze informatiche. In generale, si può affermare che l’esperienza del laboratorio di didattica si è rivelata positiva e ha rappresentato un elemento di supporto per gli studenti che vi hanno partecipato

the measurement of statistical reasoning in verbal numerical and graphical forms a pilot study

Numerous subjects have trouble in understanding various conceptions connected to statistical problems. Research reports how students' ability to solve problems (including statistical problems) can be influenced by exhibiting proofs. In this work we aim to contrive an original and easy instrument able to assess statistical reasoning on uncertainty and on association, regarding two different forms of proof presentation: pictorial-graphical and verbal–numerical. We have conceived eleven pairs of simple problems in the verbal–numerical and pictorial–graphical form and we have presented the proofs to 47 undergraduate students. The purpose of our work was to evaluate the goodness and reliability of these problems in the assessment of statistical reasoning. Each subject solved each pair of proofs in the verbal-numerical and in the pictorial–graphical form, in different problem presentation orders. Data analyses have highlighted that six out of the eleven pairs of problems appear to be useful and adequate to estimate statistical reasoning on uncertainty and that there is no effect due to the order of presentation in the verbal–numerical and pictorial–graphical form

Catestatin Improves Post-Ischemic Left Ventricular Function and Decreases Ischemia/Reperfusion Injury in Heart

The Chromogranin A (CgA)-derived anti-hypertensive peptide catestatin (CST) antagonizes catecholamine secretion, and is a negative myocardial inotrope acting via a nitric oxide-dependent mechanism. It is not known whether CST contributes to ischemia/reperfusion injury or is a component of a cardioprotective response to limit injury. Here, we tested whether CST by virtue of its negative inotropic activity improves post-ischemic cardiac function and cardiomyocyte survival. Three groups of isolated perfused hearts from adult Wistar rats underwent 30-min ischemia and 120-min reperfusion (I/R, Group 1), or were post-conditioned by brief ischemic episodes (PostC, 5-cycles of 10-s I/R at the beginning of 120-min reperfusion, Group 2), or with exogenous CST (75 nM for 20 min, CST-Post, Group-3) at the onset of reperfusion. Perfusion pressure and left ventricular pressure (LVP) were monitored. Infarct size was evaluated with nitroblue-tetrazolium staining. The CST (5 nM) effects were also tested in simulated ischemia/reperfusion experiments on cardiomyocytes isolated from young-adult rats, evaluating cell survival with propidium iodide labeling. Infarct size was 61 ± 6% of risk area in hearts subjected to I/R only. PostC reduced infarct size to 34 ± 5%. Infarct size in CST-Post was 36 ± 3% of risk area (P < 0.05 respect to I/R). CST-Post reduced post-ischemic rise of diastolic LVP, an index of contracture, and significantly improved post-ischemic recovery of developed LVP. In isolated cardiomyocytes, CST increased the cell viability rate by about 65% after simulated ischemia/reperfusion. These results suggest a novel cardioprotective role for CST, which appears mainly due to a direct reduction of post-ischemic myocardial damages and dysfunction, rather than to an involvement of adrenergic terminals and/or endothelium

Miltefosine in the Treatment of Cutaneous Leishmaniasis Caused by Leishmania braziliensis in Brazil: A Randomized and Controlled Trial

Cutaneous leishmaniasis (CL) is characterized by skin ulcerations and occurs in rural poor areas of developing countries. It is treated with daily injections of antimony for 20 days, which is associated with irregular use and increasingly lower cure rates. Miltefosine is an oral medication with activity against the agent of CL (Leishmania). We have studied the efficacy and safety of miltefosine compared with antimony in patients with CL caused by Leishmania braziliensis in Bahia, Brazil. A total of 90 patients participated; 60 received miltefosine and 30 were treated with antimony. Six months after treatment, 75% of patients treated with miltefosine were cured, compared with 53% of the patients in the antimony group, a difference considered significant (p = 0.04). We also found that miltefosine was more effective than antimony in adults than in children. The incidence of side effects was similar with both drugs (76.7% vs. 78.3%), but all patients were able to finish the treatments. Our study shows that miltefosine is more effective than antimony for the treatment of CL in Bahia, Brazil and can contribute to the control of this disease due to its activity and easier administration

Shake-table testing of a stone masonry building aggregate: overview of blind prediction study

City centres of Europe are often composed of unreinforced masonry structural aggregates, whose seismic response is challenging to predict. To advance the state of the art on the seismic response of these aggregates, the Adjacent Interacting Masonry Structures (AIMS) subproject from Horizon 2020 project Seismology and Earthquake Engineering Research Infrastructure Alliance for Europe (SERA) provides shake-table test data of a two-unit, double-leaf stone masonry aggregate subjected to two horizontal components of dynamic excitation. A blind prediction was organized with participants from academia and industry to test modelling approaches and assumptions and to learn about the extent of uncertainty in modelling for such masonry aggregates. The participants were provided with the full set of material and geometrical data, construction details and original seismic input and asked to predict prior to the test the expected seismic response in terms of damage mechanisms, base-shear forces, and roof displacements. The modelling approaches used differ significantly in the level of detail and the modelling assumptions. This paper provides an overview of the adopted modelling approaches and their subsequent predictions. It further discusses the range of assumptions made when modelling masonry walls, floors and connections, and aims at discovering how the common solutions regarding modelling masonry in general, and masonry aggregates in particular, affect the results. The results are evaluated both in terms of damage mechanisms, base shear forces, displacements and interface openings in both directions, and then compared with the experimental results. The modelling approaches featuring Discrete Element Method (DEM) led to the best predictions in terms of displacements, while a submission using rigid block limit analysis led to the best prediction in terms of damage mechanisms. Large coefficients of variation of predicted displacements and general underestimation of displacements in comparison with experimental results, except for DEM models, highlight the need for further consensus building on suitable modelling assumptions for such masonry aggregates

Estimating Dengue Transmission Intensity from Case-Notification Data from Multiple Countries

Despite being the most widely distributed mosquito-borne viral infection, estimates of dengue transmission intensity and associated burden remain ambiguous. With advances in the development of novel control measures, obtaining robust estimates of average dengue transmission intensity is key for assessing the burden of disease and the likely impact of interventions.We estimated the force of infection (λ) and corresponding basic reproduction numbers (R0) by fitting catalytic models to age-stratified incidence data identified from the literature. We compared estimates derived from incidence and seroprevalence data and assessed the level of under-reporting of dengue disease. In addition, we estimated the relative contribution of primary to quaternary infections to the observed burden of dengue disease incidence. The majority of R0 estimates ranged from one to five and the force of infection estimates from incidence data were consistent with those previously estimated from seroprevalence data. The baseline reporting rate (or the probability of detecting a secondary infection) was generally low (<25%) and varied within and between countries.As expected, estimates varied widely across and within countries, highlighting the spatio-temporally heterogeneous nature of dengue transmission. Although seroprevalence data provide the maximum information, the incidence models presented in this paper provide a method for estimating dengue transmission intensity from age-stratified incidence data, which will be an important consideration in areas where seroprevalence data are not available