Synergistic Treatment of Congo Red Dye with Heat Treated Low Rank Coal and Micro-Nano Bubbles

In this study, the adsorption method and micro-nano bubble (MNB) technology were combined to improve the efficiency of organic pollutant removal from dye wastewater. The adsorption properties of Congo red (CR) on raw coal and semi-coke (SC) with and without MNBs were studied. The mesoporosity of the coal strongly increased after the heat treatment, which was conducive to the adsorption of macromolecular organics, such as CR, and the specific surface area increased greatly from 2.787 m2/g to 80.512 m2/g. MNBs could improve the adsorption of both raw coal and SC under different pH levels, temperatures and dosages. With the use of MNBs, the adsorption capacity of SC reached 169.49 mg/g, which was much larger than that of the raw coal at 15.75 mg/g. The MNBs effectively reduced the adsorption time from 240 to 20 min. In addition, the MNBs could ensure the adsorbent maintained a good adsorption effect across a wide pH range. The removal rate was above 90% in an acidic environment and above 70% in an alkaline environment. MBs can effectively improve the rate of adsorption of pollutants by adsorbents. SC was obtained from low-rank coal through a rapid one-step heating treatment and was used as a kind of cheap adsorbent. The method is thus simple and easy to implement in the industrial context and has the potential for industrial promotion

LncRNA H19 inhibits oxidative stress injury of cochlear hair cells by regulating miR-653-5p/SIRT1 axis

Oxidative stress is one of the important mechanisms of inner ear cell damage, which can lead to age-related hearing loss (ARHL). LncRNA H19 is significantly downregulated in the cochlea of old mouse, however, the role of H19 in the development of ARHL remains unclear. In this study, we aim to investigate the expression and function of H19 in oxidative stress injury of cochlear hair cells induced by H2O2. RT-qPCR and western blot analysis confirms that HEI-OC1 cells stimulated with H2O2 decreases the expressions of H19 and SIRT1, but increases the expression of miR-653-5p. Overexpression of H19 could increase cell viability, ATP level and mitochondrial membrane potential, but reduce mitochondrial ROS generation and cell apoptosis ratio in H2O2-stimulated HEI-OC1 cells. MiR-653-5p is a target of H19, which can bind to the 3′-UTR of SIRT1. H19 is found to regulate the expression of SIRT1 through miR-653-5p. Further experiments demonstrates that H19 regulates HEI-OC1 cell viability, ATP level, mitochondrial membrane potential, mitochondrial ROS generation, and cell apoptosis ratio via the miR-653-5p/SIRT1 axis. In conclusion, lncRNA H19 inhibits oxidative stress injury of cochlear hair cells via the miR-653-5p/SIRT1 axis

Iron Single Atom Catalysed Quinoline Synthesis

10.1002/adma.202101382Advanced Materials333