Non-geometric fluxes and mixed-symmetry potentials

We discuss the relation between generalised fluxes and mixed-symmetry potentials. We first consider the NS fluxes, and point out that the `non-geometric' $R$ flux is dual to a mixed-symmetry potential with a set of nine antisymmetric indices. We then consider the T-duality family of fluxes whose prototype is the Scherk-Schwarz reduction of the S-dual of the RR scalar of IIB supergravity. Using the relation with mixed-symmetry potentials, we are able to give a complete classification of these fluxes, including the ones that are non-geometric. The non-geometric fluxes again turn out to be dual to potentials containing nine antisymmetric indices. Our analysis suggests that all these fluxes can be understood in the context of double field theory, although for the non-geometric ones one expects a violation of the strong constraint.Comment: 19 pages, refs. adde

Soybean Chlorosis Studies on High pH Bottomland Soils

Soybean varieties are different in tolerance to lime-induced chlorosis. Field trials were conducted to evaluate variety performance on soils where chlorosis in soybeans was a known problem. Thirty-six varieties out of 177 were identified as tolerant to soil conditions that cause chlorosis. Eleven varieties of these 36 were found to have the most consistent yield performance on high pH soils. Tolerant varieties must be planted at adequate densities for best performance. A seeding rate of 13.5 seeds per foot of row, the highest seeding rate employed, did not appear to maximize yield on soils where chlorosis was severe. On some soils, chlorosis is so severe that even tolerant varieties planted at adequate densities will not produce seed. Under conditions where soils cause moderate to severe chlorosis in tolerant varieties, yields were improved by the use of a high pH stable chelate (Fe-EDDHA) with the seed

Soybean Chlorosis Studies on High pH Bottomland Soils

Soybean varieties are different in tolerance to lime-induced chlorosis. Field trials were conducted to evaluate variety performance on soils where chlorosis in soybeans was a known problem. Thirty-six varieties out of 177 were identified as tolerant to soil conditions that cause chlorosis. Eleven varieties of these 36 were found to have the most consistent yield performance on high pH soils. Tolerant varieties must be planted at adequate densities for best performance. A seeding rate of 13.5 seeds per foot of row, the highest seeding rate employed, did not appear to maximize yield on soils where chlorosis was severe. On some soils, chlorosis is so severe that even tolerant varieties planted at adequate densities will not produce seed. Under conditions where soils cause moderate to severe chlorosis in tolerant varieties, yields were improved by the use of a high pH stable chelate (Fe-EDDHA) with the seed

Diversity of oat varieties in eliciting the early inflammatory events in celiac disease

Purpose Celiac disease (CD) is an autoimmune enteropathy, triggered by dietary gluten. The only treatment is a strict gluten-free diet. Oats are included in the list of gluten-free ingredients by European Regulation, but the safety of oats in CD is still a matter of debate. The present study examined the capability of different oat cultivars of activating the gliadin-induced transglutaminase-2 (TG2)-dependent events in some in vitro models of CD. In addition, we compared this capability with the electrophoresis pattern of peptic\u2013tryptic digests of the proteins of the oat cultivars. Methods K562(S) cells agglutination, transepithelial electrical resistance of T84-cell monolayers, intracellular levels of TG2 and phosphorylated form of protein 42\u201344 in T84 cells were the early gliadin-dependent events studied. Results The results showed that the Nave oat cultivar elicited these events, whereas Irina and Potenza varieties did not. The ability of a cultivar to activate the above-described events was associated with the electrophoretic pattern of oat proteins and their reactivity to anti-gliadin antibodies. Conclusion We found significant differences among oat cultivars in eliciting the TG2-mediated events of CD inflammation. Therefore, the safety of an oat cultivar in CD might be screened in vitro by means of biochemical and biological assays, before starting a clinical trial to definitely assess its safety

Automatic Balancing Mechanisms for Mixed Pension Systems under Different Investment Strategies

State pension systems are usually pay-as-you-go financed, i.e. current contributions cover pension expenditure. However, some countries combine funding and pay-as-you-go (PAYG) elements within the first pillar. The aim of this paper is twofold. First, using nonlinear optimisation based on Godínez-Olivares, Boado-Penas, and Haberman (2016), it seeks to assess the impact of a compulsory funded defined contribution (DC) pension scheme that complements the traditional defined benefit (DB) PAYG on the level of pension benefits. Future expected returns for both the funded part and the buffer fund of the PAYG are simulated through the non-overlapping block bootstrap technique. Second, in the case of a partial financial sustainability, we design different optimal strategies, that involve variables such as the contribution rate, age of retirement and indexation of pensions, to restore the long-term financial equilibrium of the system. We show that the adjustments needed to ensure sustainability for the mixed pension systems are less severe that the pure DB PAYG but the total replacement rate for the former is lower in most of the cases studied. When calculating the return that the individuals would receive, we prove that some cohorts are better off under a mixed pension system

Toll-like receptor signaling adapter proteins govern spread of neuropathic pain and recovery following nerve injury in male mice.

BackgroundSpinal Toll-like receptors (TLRs) and signaling intermediaries have been implicated in persistent pain states. We examined the roles of two major TLR signaling pathways and selected TLRs in a mononeuropathic allodynia.MethodsL5 spinal nerve ligation (SNL) was performed in wild type (WT, C57BL/6) male and female mice and in male Tlr2-/-Tlr3-/-, Tlr4-/-, Tlr5-/-, Myd88-/-, Triflps2, Myd88/Triflps2, Tnf-/-, and Ifnar1-/- mice. We also examined L5 ligation in Tlr4-/- female mice. We examined tactile allodynia using von Frey hairs. Iba-1 (microglia) and GFAP (astrocytes) were assessed in spinal cords by immunostaining. Tactile thresholds were analyzed by 1- and 2-way ANOVA and the Bonferroni post hoc test was used.ResultsIn WT male and female mice, SNL lesions resulted in a persistent and robust ipsilateral, tactile allodynia. In males with TLR2, 3, 4, or 5 deficiencies, tactile allodynia was significantly, but incompletely, reversed (approximately 50%) as compared to WT. This effect was not seen in female Tlr4-/- mice. Increases in ipsilateral lumbar Iba-1 and GFAP were seen in mutant and WT mice. Mice deficient in MyD88, or MyD88 and TRIF, showed an approximately 50% reduction in withdrawal thresholds and reduced ipsilateral Iba-1. In contrast, TRIF and interferon receptor null mice developed a profound ipsilateral and contralateral tactile allodynia. In lumbar sections of the spinal cords, we observed a greater increase in Iba-1 immunoreactivity in the TRIF-signaling deficient mice as compared to WT, but no significant increase in GFAP. Removing MyD88 abrogated the contralateral allodynia in the TRIF signaling-deficient mice. Conversely, IFNβ, released downstream to TRIF signaling, administered intrathecally, temporarily reversed the tactile allodynia.ConclusionsThese observations suggest a critical role for the MyD88 pathway in initiating neuropathic pain, but a distinct role for the TRIF pathway and interferon in regulating neuropathic pain phenotypes in male mice

The combined impact of sauerkraut with Leuconostoc mesenteroides to enhance immunomodulatory activity in Escherichia coli-infected mice

This study investigated the combined impact of sauerkraut and Leuconostoc mesenteroides culture on immunomodulatory activity in experimental animal. The in vivo immunomodulatory activity of Escherichia coli-infected Balb-C mice was ascertained in fermented sauerkrauts [test vs. control]. Both sauerkrauts enhanced the adaptive immune response [evidenced by an increase in CD4+ CD8+ IFN-γ, TNFα] and innate immune response [represented by a decrease of CD68-IL-6]. Nev- ertheless, the in vivo immunomodulatory activity of sauerkraut combined with L. mesenteroides was higher than that shown in sauerkraut control solely

Effectiveness of manual therapy compared to usual care by the general practitioner for chronic tension-type headache: design of a randomised clinical trial

<p>Abstract</p> <p>Background</p> <p>Patients with Chronic Tension Type Headache (CTTH) report functional and emotional impairments (loss of workdays, sleep disturbances, emotional well-being) and are at risk for overuse of medication. Manual therapy may improve symptoms through mobilisation of the spine, correction of posture, and training of cervical muscles.</p> <p>We present the design of a randomised clinical trial (RCT) evaluating the effectiveness of manual therapy (MT) compared to usual care by the general practitioner (GP) in patients with CTTH.</p> <p>Methods and design</p> <p>Patients are eligible for participation if they present in general practice with CTTH according to the classification of the International Headache Society (IHS).</p> <p>Participants are randomised to either usual GP care according to the national Dutch general practice guidelines for headache, or manual therapy, consisting of mobilisations (high- and low velocity techniques), exercise therapy for the cervical and thoracic spine and postural correction. The primary outcome measures are the number of headache days and use of medication. Secondary outcome measures are severity of headache, functional status, sickness absence, use of other healthcare resources, active cervical range of motion, algometry, endurance of the neckflexor muscles and head posture. Follow-up assessments are conducted after 8 and 26 weeks.</p> <p>Discussion</p> <p>This is a pragmatic trial in which interventions are offered as they are carried out in everyday practice. This increases generalisability of results, but blinding of patients, GPs and therapists is not possible.</p> <p>The results of this trial will contribute to clinical decision making of the GP regarding referral to manual therapy in patients with chronic tension headache.</p

COVID-19 in a social reinsurance framework: Forewarned is forearmed

The crisis caused by COVID-19 revealed the global unpreparedness to handle the impact of a pandemic. In this paper, we present a statistical analysis of the data related to the COVID-19 outbreak in China, specifically the infection speed, death and fatality rates in Hubei province. By fitting distributions of these quantities we design a parametric reinsurance contract whose trigger and cap are based on the probability distributions of the infection speed, death and fatality rates. In particular, fitting the distribution for the infection speed and death rates we provide a measure of the effectiveness of a state's action during an epidemic, and propose a reinsurance contract as a supplement to a state's social insurance to alleviate financial costs