Analog implementation of a robust control strategy for mechanical systems

An analog implementation of a control structure with disturbance identification for mechanical systems is presented. This control structure is based on a discontinuous observer that estimates the state and the disturbances in the plant, improving the robustness of the closed loop system which also displays a control input free from chattering. The control structure, built with operational amplifiers, is simple, showing good performance for stabilization, regulation, and tracking objectives. The performance of the circuit is compared with a digital implementation based on a real-time data acquisition card to control a simple pendulum. In addition, the circuit performance is illustrated on an industrial 2-DOF robot

In-phase and anti-phase synchronization of oscillators with Huygens' coupling

In this experimental study, the synchronized motion observed in pairs of nonlinear oscillators coupled through a suspended rigid bar, is analyzed. In particular, the dynamics of two mass-spring-damper oscillators and the dynamics of two van der Pol oscillators are considered. It is shown that in both cases, the oscillators may exhibit in-phase and anti-phase synchronization. The experiments are executed in an experimental setup, consisting of two mass-spring-damperoscillators coupled through a suspended rigid bar. A relation between the obtained results and Huygens’ experiment of pendulum clocks is emphasized

Synchronization of weakly nonlinear oscillators with Huygens' coupling

In this paper, the occurrence of synchronization in pairs of weakly nonlinear selfsustained oscillators that interact via Huygens’ coupling, i.e. a suspended rigid bar, is treated. In the analysis, a generalized version of the classical Huygens’ experiment of synchronization of two coupled pendulum clocks is considered, in which the clocks are replaced by arbitrary self-sustained oscillators. Sufficient conditions for the existence and stability of synchronous solutions in the coupled system are derived by using the Poincar´e method. The obtained results are supported by computer simulations and experiments conducted on a dedicated experimental platform. It is demonstrated that the mass of the coupling bar is an important parameter with respect to the limit synchronous behaviour in the oscillators

VVV High Proper Motion Survey

Here we present survey of proper motion stars towards the Galactic Bulge and an adjacent plane region base on VISTA-VVV data. The searching method based on cross-matching photometric Ks-band CASU catalogs. The most interesting discoveries are shown.Peer reviewe

Measurement driven quantum evolution

We study the problem of mapping an unknown mixed quantum state onto a known pure state without the use of unitary transformations. This is achieved with the help of sequential measurements of two non-commuting observables only. We show that the overall success probability is maximized in the case of measuring two observables whose eigenstates define mutually unbiased bases. We find that for this optimal case the success probability quickly converges to unity as the number of measurement processes increases and that it is almost independent of the initial state. In particular, we show that to guarantee a success probability close to one the number of consecutive measurements must be larger than the dimension of the Hilbert space. We connect these results to quantum copying, quantum deleting and entanglement generation.Comment: 7 pages, 1 figur

1H, 13C, and 15N resonance assignments for the tandem PHD finger motifs of human CHD4

The plant homeodomain (PHD) zinc finger is a structural motif of about 40–60 amino acid residues found in many eukaryotic proteins that are involved in chromatin-mediated gene regulation. The human chromodomain helicase DNA binding protein 4 (CHD4) is a multi-domain protein that harbours, at its N-terminal end, a pair of PHD finger motifs (dPHD) connected by a ~30 amino acid linker. This tandem PHD motif is thought to be involved in targeting CHD4 to chromatin via its interaction with histone tails. Here we report the 1H, 13C and 15N backbone and side-chain resonance assignment of the entire dPHD by heteronuclear multidimensional NMR spectroscopy. These assignments provide the starting point for the determination of the structure, dynamics and histone-binding properties of this tandem domain pair

VVV High proper motion stars I. The catalogue of bright Ks stars

The final, definitive version of this paper has been published in Monthly Notices of the Royal Astronomical Society, Vol. 464(1): 1247-1258, January 2017, DOI: 10.1093/mnras/stw2357, first published on line September 16, 2016, published by Oxford University Press on behalf of MNRAS.Knowledge of the stellar content near the Sun is important for a broad range of topics ranging from the search for planets to the study of Milky Way structure. The most powerful method for identifying potentially nearby stars is proper motion (PM) surveys. All old optical surveys avoid, or are at least substantially incomplete, near the Galactic plane. The depth and breadth of the "Vista Variables in Via Lactea" (VVV) near-IR survey significantly improves this situation. Taking advantage of the VVV survey database, we have measured PMs in the densest regions of the MW bulge and southern plane in order to complete the census of nearby objects. We have developed a custom PM pipeline based on VVV catalogues from the Cambridge Astronomy Survey Unit (CASU), by comparing the first epoch of JHKs with the multi-epoch Ks-bands acquired later. Taking advantage of the large time baseline between the 2MASS and the VVV observations, we also obtained 2MASS-VVV PMs. We present a near-IR proper motion catalogue for the whole area of the VVV survey, which includes 3003 moving stellar sources. All of these have been visually inspected and are real PM objects. Our catalogue is in very good agreement with the proper motion data supplied in IR catalogues outside the densest zone of the MW. The majority of the PM objects in our catalogue are nearby M-dwarfs, as expected. This new database allow us to identify 57 common proper motion binary candidates, among which are two new systems within ~30pc of the Sun.Peer reviewe

SSRI use and clinical outcomes in epithelial ovarian cancer

Selective serotonin reuptake inhibitor (SSRI) use is common among ovarian cancer patients. We examined the effect of SSRIs on survival and progression in ovarian cancer patients and effects of 5-HT on ovarian cancer cell (OCC) proliferation. Ovarian cancer patients from a 6-site study between 1994 and 2010 were included. Cox proportional hazards models were used for multivariate analysis. SSRI use was associated with decreased time to disease recurrence (HR 1.3, CI 1.0-1.6, p=0.03), but not overall survival (HR 1.1, CI 0.9-1.3, p=0.56). Compared to normal ovarian cells, most OCCs had elevated 5-HT2A receptor mRNA expression (up to 1600 fold greater expression). Clonogenic survival increased in cells treated with 10 uM (1.6 fold, p<0.001) and 20uM (1.9 fold, p=0.018) 5-HT. Mice receiving 5-HT injections had increases in tumor weight (p=0.07) and nodules (p=0.08) with increased Ki67 expression. Injections with sertraline doubled mean tumor weight in mice (p=0.16). 5-HT and sertraline both increased Ki67 expression in mouse tumors (p < 0.001). Patients using SSRIs had significantly decreased time to disease progression. It is possible that SSRIs alter serotonin levels in the tumor microenvironment, resulting in activation of proliferation pathways. Further characterization of serotonergic pathways in ovarian cancer is recommended to demonstrate safety of these medications

LAMP kit for diagnosis of non-falciparum malaria in Plasmodium ovale infected patients

Background: Microscopy and rapid diagnosis tests have a limited sensitivity in diagnosis of malaria by Plasmodium ovale. The LAMP kit (LoopAMP (R)) can be used in the field without special equipment and could have an important role in malaria control programmes in endemic areas and for malaria diagnosis in returned travellers. The performance of the Pan primer of the kit in detecting malaria by P. ovale was compared with the results of standard nPCR in samples of patients returning from P. ovale endemic areas. Methods: Plasmodium ovale positive samples (29, tested by PCR and/or microscopy) and malaria negative specimens (398, tested by microscopy and PCR) were collected in different hospitals of Europe from June 2014 to March 2016 and frozen at -20 degrees C. Boil and spin method was used to extract DNA from all samples and amplification was performed with LoopAMP (R) MALARIA kit (Eiken Chemical, Japan) in an automated turbidimeter (Eiken 500). The results of LAMP read by turbidimetry and with the naked eye were compared. Results: The kit showed a sensitivity of 100% and a specificity of 97.24% with positive and negative predictive values of 72.5 and 100%, respectively. Naked eyed readings were in accordance with turbidimetry readings (sensitivity, 92.5%, specificity, 98.96% and positive and negative predictive values, respectively, 90.24 and 99.22%). The limit of detection of LAMP assay for P. ovale was between 0.8 and 2 parasites/mu l. Conclusions: The Pan primer of the Malaria kit LoopAMP (R) can detect P. ovale at very low-levels and showed a predictive negative value of 100%. This tool can be useful in malaria control and elimination programmes and in returned travellers from P. ovale endemic areas. Naked eye readings are equivalent to automated turbidimeter readings in specimens obtained with EDTA.Peer reviewe