Observations of Site Amplification and Liquefaction in the Jun 23, 2001, Southern Peru Earthquake

The Mw 8.4 Southern Peru Earthquake of June 23, 2001 caused extensive damage in a widespread area in southern Peru and northern Chile, including several important population centers. Damage in some of these cities was correlated with local soil conditions and topography, suggesting the influence of local site amplification effects in damage distributions. The earthquake caused numerous instances of other types of geotechnical related ground failures, including liquefaction and lateral spreads in river valleys, seismic compression of highway fills, and slope failures. This work focuses on case histories documenting site amplification and liquefaction in the Southern Peru earthquake. Among the liquefaction events observed in this earthquake, the liquefaction of a heap-leach pad is the first reported failure of its type in a seismic event

Biomimetic Ca-P coatings Incorporating bisphosphonates produced on starch-based degradable biomaterials

In this study, sodium clodronate, a well-known therapeutic agent from the family of bisphosphonates (BPs), is incorporated in a biomimetic calcium phosphate (CaP) coating, previously formed on the surface of a starch-based biomaterial by a sodium silicate methodology, as a strategy to develop a site-specific drug delivery system for bone tissue regeneration applications. The effects on the resulting CaP coatings were evaluated in terms of morphology, chemistry, and structure. The dissolution of Ca and P from the coating and the release profiles of sodium clodronate was also assessed. As a preliminary approach, this first study also aimed at evaluating the effects of this BP on the viability of a human osteoblastic cell line since there is still little information available on the interaction between BPs and this type of cells. Sodium clodronate was successfully incorporated, at different doses, in the structure of a biomimetic CaP layer previously formed by a sodium silicate process. This type of BPs had a stimulatory effect on osteoblastic activity, particularly at the specific concentration of 0.32 mg/mL. It is foreseen that these coatings can, for instances, be produced on the surface of degradable polymers and then used for regulating the equilibrium on osteoblastic/osteoclastic activity, leading to a controlled regenerative effect at the interface between the biomaterial and bone

The HIV/AIDS Epidemic in Miami: Perspectives of Stakeholders and Frontline Providers

Background: Miami, Florida persists as an epicenter of HIV/AIDS nationally and has been more delayed than other areas with high HIV burden in implementing public health measures that mitigate transmission risk. These issues among other social and structural-level determinants have complicated progress in addressing HIV/AIDS in Miami. Purpose: The stagnated progress in improving HIV outcomes in Miami necessitated a more comprehensive understanding of the experiences and insights of stakeholders within the system. We used a stakeholder analysis approach to understand the complexity of driving factors and key challenges facing this HIV epidemic. Methods: A stakeholder analysis was conducted through 11 focus groups (64 participants) with front line workers working in non-profit, community-based agencies in Miami. The interview guide was designed to elicit a broad discussion on the social and intermediary determinants of HIV/AIDS, as well as the context surrounding barriers to treatment. Data were analyzed using qualitative software for thematic analysis. Results: Participants highlighted particular populations vulnerable to HIV/AIDS and insufficiently engaged in treatment, including immigrants and people who use drugs. Stigma surrounding HIV/AIDS as well as sexual orientation, mental health, and drug use was a noted persisting barrier. Participants expressed needs for more targeted outreach and education for both prevention and treatment. Numerous systemic gaps were identified as barriers to treatment engagement and retention. Other comorbidities and socioeconomic challenges, including criminal justice histories, housing instability and low educational attainment, also hamper HIV/AIDS management. Discussion: Through these discussions with stakeholders representing a diversity of voices, findings can inform comprehensive and coordinated strategies for curbing the HIV/AIDS epidemic in Miami. The development of prevention and treatment interventions should consider cultural contexts of health behaviors, multi-level stigma related to HIV/AIDS and other comorbid and socioeconomic challenges, and increased implementation of harm reduction programs such as PrEP delivery and syringe exchange programs

The Role of ABA in Plant Immunity is Mediated through the PYR1 Receptor

[EN] ABA is involved in plant responses to a broad range of pathogens and exhibits complex antagonistic and synergistic relationships with salicylic acid (SA) and ethylene (ET) signaling pathways, respectively. However, the specific receptor of ABA that triggers the positive and negative responses of ABA during immune responses remains unknown. Through a reverse genetic analysis, we identified that PYR1, a member of the family of PYR/PYL/RCAR ABA receptors, is transcriptionally upregulated and specifically perceives ABA during biotic stress, initiating downstream signaling mediated by ABA-activated SnRK2 protein kinases. This exerts a damping effect on SA-mediated signaling, required for resistance to biotrophic pathogens, and simultaneously a positive control over the resistance to necrotrophic pathogens controlled by ET. We demonstrated that PYR1-mediated signaling exerted control on a priori established hormonal cross-talk between SA and ET, thereby redirecting defense outputs. Defects in ABA/PYR1 signaling activated SA biosynthesis and sensitized plants for immune priming by poising SA-responsive genes for enhanced expression. As a trade-off effect,pyr1-mediated activation of the SA pathway blunted ET perception, which is pivotal for the activation of resistance towards fungal necrotrophs. The specific perception of ABA by PYR1 represented a regulatory node, modulating different outcomes in disease resistance.This research was founded by the Spanish AEI agency by grant BIO2017-82503-R to P.L.R. and by grant RTI2018-098501-B-I00 to P.V.García-Andrade, J.; González, B.; Gonzalez-Guzman, M.; Rodríguez Egea, PL.; Vera Vera, P. (2020). The Role of ABA in Plant Immunity is Mediated through the PYR1 Receptor. International Journal of Molecular Sciences. 21(16):1-21. https://doi.org/10.3390/ijms21165852S1212116Malamy, J., Carr, J. P., Klessig, D. F., & Raskin, I. (1990). Salicylic Acid: A Likely Endogenous Signal in the Resistance Response of Tobacco to Viral Infection. Science, 250(4983), 1002-1004. doi:10.1126/science.250.4983.1002Métraux, J. P., Signer, H., Ryals, J., Ward, E., Wyss-Benz, M., Gaudin, J., … Inverardi, B. (1990). Increase in Salicylic Acid at the Onset of Systemic Acquired Resistance in Cucumber. Science, 250(4983), 1004-1006. doi:10.1126/science.250.4983.1004Glazebrook, J. (2005). Contrasting Mechanisms of Defense Against Biotrophic and Necrotrophic Pathogens. Annual Review of Phytopathology, 43(1), 205-227. doi:10.1146/annurev.phyto.43.040204.135923Verhage, A., van Wees, S. C. M., & Pieterse, C. M. J. (2010). Plant Immunity: It’s the Hormones Talking, But What Do They Say?: Figure 1. Plant Physiology, 154(2), 536-540. doi:10.1104/pp.110.161570Broekaert, W. F., Delauré, S. L., De Bolle, M. F. C., & Cammue, B. P. A. (2006). The Role of Ethylene in Host-Pathogen Interactions. Annual Review of Phytopathology, 44(1), 393-416. doi:10.1146/annurev.phyto.44.070505.143440Grant, M. R., & Jones, J. D. G. (2009). Hormone (Dis)harmony Moulds Plant Health and Disease. Science, 324(5928), 750-752. doi:10.1126/science.1173771Pieterse, C. M. J., Van der Does, D., Zamioudis, C., Leon-Reyes, A., & Van Wees, S. C. M. (2012). Hormonal Modulation of Plant Immunity. Annual Review of Cell and Developmental Biology, 28(1), 489-521. doi:10.1146/annurev-cellbio-092910-154055Thaler, J. S., & Bostock, R. M. (2004). INTERACTIONS BETWEEN ABSCISIC-ACID-MEDIATED RESPONSES AND PLANT RESISTANCE TO PATHOGENS AND INSECTS. Ecology, 85(1), 48-58. doi:10.1890/02-0710Spoel, S. H., Koornneef, A., Claessens, S. M. C., Korzelius, J. P., Van Pelt, J. A., Mueller, M. J., … Pieterse, C. M. J. (2003). NPR1 Modulates Cross-Talk between Salicylate- and Jasmonate-Dependent Defense Pathways through a Novel Function in the Cytosol. The Plant Cell, 15(3), 760-770. doi:10.1105/tpc.009159Thomma, B. P. H. J., Eggermont, K., Tierens, K. F. M.-J., & Broekaert, W. F. (1999). Requirement of Functional Ethylene-Insensitive 2Gene for Efficient Resistance of Arabidopsis to Infection by Botrytis cinerea  . Plant Physiology, 121(4), 1093-1101. doi:10.1104/pp.121.4.1093Gu, Y.-Q., Yang, C., Thara, V. K., Zhou, J., & Martin, G. B. (2000). Pti4 Is Induced by Ethylene and Salicylic Acid, and Its Product Is Phosphorylated by the Pto Kinase. The Plant Cell, 12(5), 771-785. doi:10.1105/tpc.12.5.771Berrocal-Lobo, M., Molina, A., & Solano, R. (2002). Constitutive expression ofETHYLENE-RESPONSE-FACTOR1inArabidopsisconfers resistance to several necrotrophic fungi. The Plant Journal, 29(1), 23-32. doi:10.1046/j.1365-313x.2002.01191.xDı́az, J., ten Have, A., & van Kan, J. A. L. (2002). The Role of Ethylene and Wound Signaling in Resistance of Tomato to Botrytis cinerea  . Plant Physiology, 129(3), 1341-1351. doi:10.1104/pp.001453Leslie, C. A., & Romani, R. J. (1988). Inhibition of Ethylene Biosynthesis by Salicylic Acid. Plant Physiology, 88(3), 833-837. doi:10.1104/pp.88.3.833Chen, H., Xue, L., Chintamanani, S., Germain, H., Lin, H., Cui, H., … Zhou, J.-M. (2009). ETHYLENE INSENSITIVE3 and ETHYLENE INSENSITIVE3-LIKE1 Repress SALICYLIC ACID INDUCTION DEFICIENT2 Expression to Negatively Regulate Plant Innate Immunity in Arabidopsis    . The Plant Cell, 21(8), 2527-2540. doi:10.1105/tpc.108.065193Huang, P., Dong, Z., Guo, P., Zhang, X., Qiu, Y., Li, B., … Guo, H. (2019). Salicylic Acid Suppresses Apical Hook Formation via NPR1-Mediated Repression of EIN3 and EIL1 in Arabidopsis. The Plant Cell, 32(3), 612-629. doi:10.1105/tpc.19.00658Spoel, S. H., Johnson, J. S., & Dong, X. (2007). Regulation of tradeoffs between plant defenses against pathogens with different lifestyles. Proceedings of the National Academy of Sciences, 104(47), 18842-18847. doi:10.1073/pnas.0708139104Cutler, S. R., Rodriguez, P. L., Finkelstein, R. R., & Abrams, S. R. (2010). Abscisic Acid: Emergence of a Core Signaling Network. Annual Review of Plant Biology, 61(1), 651-679. doi:10.1146/annurev-arplant-042809-112122Mauch-Mani, B., & Mauch, F. (2005). The role of abscisic acid in plant–pathogen interactions. Current Opinion in Plant Biology, 8(4), 409-414. doi:10.1016/j.pbi.2005.05.015Asselbergh, B., De Vleesschauwer, D., & Höfte, M. (2008). Global Switches and Fine-Tuning—ABA Modulates Plant Pathogen Defense. Molecular Plant-Microbe Interactions®, 21(6), 709-719. doi:10.1094/mpmi-21-6-0709Fan, J., Hill, L., Crooks, C., Doerner, P., & Lamb, C. (2009). Abscisic Acid Has a Key Role in Modulating Diverse Plant-Pathogen Interactions      . Plant Physiology, 150(4), 1750-1761. doi:10.1104/pp.109.137943Sánchez-Vallet, A., López, G., Ramos, B., Delgado-Cerezo, M., Riviere, M.-P., Llorente, F., … Molina, A. (2012). Disruption of Abscisic Acid Signaling Constitutively Activates Arabidopsis Resistance to the Necrotrophic Fungus Plectosphaerella cucumerina    . Plant Physiology, 160(4), 2109-2124. doi:10.1104/pp.112.200154Adie, B. A. T., Pérez-Pérez, J., Pérez-Pérez, M. M., Godoy, M., Sánchez-Serrano, J.-J., Schmelz, E. A., & Solano, R. (2007). ABA Is an Essential Signal for Plant Resistance to Pathogens Affecting JA Biosynthesis and the Activation of Defenses in Arabidopsis. The Plant Cell, 19(5), 1665-1681. doi:10.1105/tpc.106.048041García-Andrade, J., Ramírez, V., Flors, V., & Vera, P. (2011). Arabidopsis ocp3 mutant reveals a mechanism linking ABA and JA to pathogen-induced callose deposition. The Plant Journal, 67(5), 783-794. doi:10.1111/j.1365-313x.2011.04633.xJensen, M. K., Hagedorn, P. H., de Torres-Zabala, M., Grant, M. R., Rung, J. H., Collinge, D. B., & Lyngkjaer, M. F. (2008). Transcriptional regulation by an NAC (NAM-ATAF1,2-CUC2) transcription factor attenuates ABA signalling for efficient basal defence towardsBlumeria graminisf. sp.hordeiin Arabidopsis. The Plant Journal, 56(6), 867-880. doi:10.1111/j.1365-313x.2008.03646.xDe Torres-Zabala, M., Truman, W., Bennett, M. H., Lafforgue, G., Mansfield, J. W., Rodriguez Egea, P., … Grant, M. (2007). Pseudomonas syringae pv. tomato hijacks the Arabidopsis abscisic acid signalling pathway to cause disease. The EMBO Journal, 26(5), 1434-1443. doi:10.1038/sj.emboj.7601575Mine, A., Berens, M. L., Nobori, T., Anver, S., Fukumoto, K., Winkelmüller, T. M., … Tsuda, K. (2017). Pathogen exploitation of an abscisic acid- and jasmonate-inducible MAPK phosphatase and its interception by Arabidopsis immunity. Proceedings of the National Academy of Sciences, 114(28), 7456-7461. doi:10.1073/pnas.1702613114Peng, Z., Hu, Y., Zhang, J., Huguet-Tapia, J. C., Block, A. K., Park, S., … White, F. F. (2019). Xanthomonas translucens commandeers the host rate-limiting step in ABA biosynthesis for disease susceptibility. Proceedings of the National Academy of Sciences, 116(42), 20938-20946. doi:10.1073/pnas.1911660116Chen, W., Provart, N. J., Glazebrook, J., Katagiri, F., Chang, H.-S., Eulgem, T., … Zhu, T. (2002). Expression Profile Matrix of Arabidopsis Transcription Factor Genes Suggests Their Putative Functions in Response to Environmental Stresses[W]. The Plant Cell, 14(3), 559-574. doi:10.1105/tpc.010410Anderson, J. P., Badruzsaufari, E., Schenk, P. M., Manners, J. M., Desmond, O. J., Ehlert, C., … Kazan, K. (2004). Antagonistic Interaction between Abscisic Acid and Jasmonate-Ethylene Signaling Pathways Modulates Defense Gene Expression and Disease Resistance in Arabidopsis. The Plant Cell, 16(12), 3460-3479. doi:10.1105/tpc.104.025833Yang, Z., Tian, L., Latoszek-Green, M., Brown, D., & Wu, K. (2005). Arabidopsis ERF4 is a transcriptional repressor capable of modulating ethylene and abscisic acid responses. Plant Molecular Biology, 58(4), 585-596. doi:10.1007/s11103-005-7294-5Dittrich, M., Mueller, H. M., Bauer, H., Peirats-Llobet, M., Rodriguez, P. L., Geilfus, C.-M., … Hedrich, R. (2019). The role of Arabidopsis ABA receptors from the PYR/PYL/RCAR family in stomatal acclimation and closure signal integration. Nature Plants, 5(9), 1002-1011. doi:10.1038/s41477-019-0490-0Hubbard, K. E., Nishimura, N., Hitomi, K., Getzoff, E. D., & Schroeder, J. I. (2010). Early abscisic acid signal transduction mechanisms: newly discovered components and newly emerging questions. Genes & Development, 24(16), 1695-1708. doi:10.1101/gad.1953910Klingler, J. P., Batelli, G., & Zhu, J.-K. (2010). ABA receptors: the START of a new paradigm in phytohormone signalling. Journal of Experimental Botany, 61(12), 3199-3210. doi:10.1093/jxb/erq151Raghavendra, A. S., Gonugunta, V. K., Christmann, A., & Grill, E. (2010). ABA perception and signalling. Trends in Plant Science, 15(7), 395-401. doi:10.1016/j.tplants.2010.04.006Umezawa, T., Sugiyama, N., Mizoguchi, M., Hayashi, S., Myouga, F., Yamaguchi-Shinozaki, K., … Shinozaki, K. (2009). Type 2C protein phosphatases directly regulate abscisic acid-activated protein kinases in Arabidopsis. Proceedings of the National Academy of Sciences, 106(41), 17588-17593. doi:10.1073/pnas.0907095106Vlad, F., Rubio, S., Rodrigues, A., Sirichandra, C., Belin, C., Robert, N., … Merlot, S. (2009). Protein Phosphatases 2C Regulate the Activation of the Snf1-Related Kinase OST1 by Abscisic Acid inArabidopsis . The Plant Cell, 21(10), 3170-3184. doi:10.1105/tpc.109.069179Fujii, H., Chinnusamy, V., Rodrigues, A., Rubio, S., Antoni, R., Park, S.-Y., … Zhu, J.-K. (2009). In vitro reconstitution of an abscisic acid signalling pathway. Nature, 462(7273), 660-664. doi:10.1038/nature08599Ma, Y., Szostkiewicz, I., Korte, A., Moes, D., Yang, Y., Christmann, A., & Grill, E. (2009). Regulators of PP2C Phosphatase Activity Function as Abscisic Acid Sensors. Science, 324(5930), 1064-1068. doi:10.1126/science.1172408Park, S.-Y., Fung, P., Nishimura, N., Jensen, D. R., Fujii, H., Zhao, Y., … Cutler, S. R. (2009). Abscisic Acid Inhibits Type 2C Protein Phosphatases via the PYR/PYL Family of START Proteins. Science, 324(5930), 1068-1071. doi:10.1126/science.1173041Umezawa, T., Sugiyama, N., Takahashi, F., Anderson, J. C., Ishihama, Y., Peck, S. C., & Shinozaki, K. (2013). Genetics and Phosphoproteomics Reveal a Protein Phosphorylation Network in the Abscisic Acid Signaling Pathway in Arabidopsis thaliana. Science Signaling, 6(270). doi:10.1126/scisignal.2003509Gonzalez-Guzman, M., Pizzio, G. A., Antoni, R., Vera-Sirera, F., Merilo, E., Bassel, G. W., … Rodriguez, P. L. (2012). Arabidopsis PYR/PYL/RCAR Receptors Play a Major Role in Quantitative Regulation of Stomatal Aperture and Transcriptional Response to Abscisic Acid. The Plant Cell, 24(6), 2483-2496. doi:10.1105/tpc.112.098574González-Guzmán, M., Rodríguez, L., Lorenzo-Orts, L., Pons, C., Sarrión-Perdigones, A., Fernández, M. A., … Rodríguez, P. L. (2014). Tomato PYR/PYL/RCAR abscisic acid receptors show high expression in root, differential sensitivity to the abscisic acid agonist quinabactin, and the capability to enhance plant drought resistance. Journal of Experimental Botany, 65(15), 4451-4464. doi:10.1093/jxb/eru219Helander, J. D. M., Vaidya, A. S., & Cutler, S. R. (2016). Chemical manipulation of plant water use. Bioorganic & Medicinal Chemistry, 24(3), 493-500. doi:10.1016/j.bmc.2015.11.010Antoni, R., Gonzalez-Guzman, M., Rodriguez, L., Rodrigues, A., Pizzio, G. A., & Rodriguez, P. L. (2011). Selective Inhibition of Clade A Phosphatases Type 2C by PYR/PYL/RCAR Abscisic Acid Receptors    . Plant Physiology, 158(2), 970-980. doi:10.1104/pp.111.188623Tischer, S. V., Wunschel, C., Papacek, M., Kleigrewe, K., Hofmann, T., Christmann, A., & Grill, E. (2017). Combinatorial interaction network of abscisic acid receptors and coreceptors fromArabidopsis thaliana. Proceedings of the National Academy of Sciences, 114(38), 10280-10285. doi:10.1073/pnas.1706593114Antoni, R., Gonzalez-Guzman, M., Rodriguez, L., Peirats-Llobet, M., Pizzio, G. A., Fernandez, M. A., … Rodriguez, P. L. (2012). PYRABACTIN RESISTANCE1-LIKE8 Plays an Important Role for the Regulation of Abscisic Acid Signaling in Root      . Plant Physiology, 161(2), 931-941. doi:10.1104/pp.112.208678Fujii, H., Verslues, P. E., & Zhu, J.-K. (2007). Identification of Two Protein Kinases Required for Abscisic Acid Regulation of Seed Germination, Root Growth, and Gene Expression in Arabidopsis. The Plant Cell, 19(2), 485-494. doi:10.1105/tpc.106.048538García-Andrade, J., Ramírez, V., López, A., & Vera, P. (2013). Mediated Plastid RNA Editing in Plant Immunity. PLoS Pathogens, 9(10), e1003713. doi:10.1371/journal.ppat.1003713Rubio, S., Rodrigues, A., Saez, A., Dizon, M. B., Galle, A., Kim, T.-H., … Rodriguez, P. L. (2009). Triple Loss of Function of Protein Phosphatases Type 2C Leads to Partial Constitutive Response to Endogenous Abscisic Acid      . Plant Physiology, 150(3), 1345-1355. doi:10.1104/pp.109.137174Schweighofer, A., Hirt, H., & Meskiene, I. (2004). Plant PP2C phosphatases: emerging functions in stress signaling. Trends in Plant Science, 9(5), 236-243. doi:10.1016/j.tplants.2004.03.007Carrasco, J. L. (2003). A novel transcription factor involved in plant defense endowed with protein phosphatase activity. The EMBO Journal, 22(13), 3376-3384. doi:10.1093/emboj/cdg323Carrasco, J. L., Castelló, M. J., Naumann, K., Lassowskat, I., Navarrete-Gómez, M., Scheel, D., & Vera, P. (2014). Arabidopsis Protein Phosphatase DBP1 Nucleates a Protein Network with a Role in Regulating Plant Defense. PLoS ONE, 9(3), e90734. doi:10.1371/journal.pone.0090734Clarke, J. D., Volko, S. M., Ledford, H., Ausubel, F. M., & Dong, X. (2000). Roles of Salicylic Acid, Jasmonic Acid, and Ethylene in cpr-Induced Resistance in Arabidopsis. The Plant Cell, 12(11), 2175-2190. doi:10.1105/tpc.12.11.2175Wildermuth, M. C., Dewdney, J., Wu, G., & Ausubel, F. M. (2001). Isochorismate synthase is required to synthesize salicylic acid for plant defence. Nature, 414(6863), 562-565. doi:10.1038/35107108Garcion, C., Lohmann, A., Lamodière, E., Catinot, J., Buchala, A., Doermann, P., & Métraux, J.-P. (2008). Characterization and Biological Function of the ISOCHORISMATE SYNTHASE2 Gene of Arabidopsis. Plant Physiology, 147(3), 1279-1287. doi:10.1104/pp.108.119420Mauch-Mani, B., Baccelli, I., Luna, E., & Flors, V. (2017). Defense Priming: An Adaptive Part of Induced Resistance. Annual Review of Plant Biology, 68(1), 485-512. doi:10.1146/annurev-arplant-042916-041132Gaffney, T., Friedrich, L., Vernooij, B., Negrotto, D., Nye, G., Uknes, S., … Ryals, J. (1993). Requirement of Salicylic Acid for the Induction of Systemic Acquired Resistance. Science, 261(5122), 754-756. doi:10.1126/science.261.5122.754Cheng, W.-H., Endo, A., Zhou, L., Penney, J., Chen, H.-C., Arroyo, A., … Sheen, J. (2002). A Unique Short-Chain Dehydrogenase/Reductase in Arabidopsis Glucose Signaling and Abscisic Acid Biosynthesis and Functions. The Plant Cell, 14(11), 2723-2743. doi:10.1105/tpc.006494Koiwai, H., Nakaminami, K., Seo, M., Mitsuhashi, W., Toyomasu, T., & Koshiba, T. (2004). Tissue-Specific Localization of an Abscisic Acid Biosynthetic Enzyme, AAO3, in Arabidopsis. Plant Physiology, 134(4), 1697-1707. doi:10.1104/pp.103.036970Endo, A., Koshiba, T., Kamiya, Y., & Nambara, E. (2008). Vascular system is a node of systemic stress responses. Plant Signaling & Behavior, 3(12), 1138-1140. doi:10.4161/psb.3.12.7145Endo, A., Sawada, Y., Takahashi, H., Okamoto, M., Ikegami, K., Koiwai, H., … Nambara, E. (2008). Drought Induction of Arabidopsis 9-cis-Epoxycarotenoid Dioxygenase Occurs in Vascular Parenchyma Cells    . Plant Physiology, 147(4), 1984-1993. doi:10.1104/pp.108.116632Alvarez, M. E., Pennell, R. I., Meijer, P.-J., Ishikawa, A., Dixon, R. A., & Lamb, C. (1998). Reactive Oxygen Intermediates Mediate a Systemic Signal Network in the Establishment of Plant Immunity. Cell, 92(6), 773-784. doi:10.1016/s0092-8674(00)81405-1Yu, A., Lepere, G., Jay, F., Wang, J., Bapaume, L., Wang, Y., … Navarro, L. (2013). Dynamics and biological relevance of DNA demethylation in Arabidopsis antibacterial defense. Proceedings of the National Academy of Sciences, 110(6), 2389-2394. doi:10.1073/pnas.1211757110Flors, V., Ton, J., Van Doorn, R., Jakab, G., García-Agustín, P., & Mauch-Mani, B. (2007). Interplay between JA, SA and ABA signalling during basal and induced resistance against Pseudomonas syringae and Alternaria brassicicola. The Plant Journal, 54(1), 81-92. doi:10.1111/j.1365-313x.2007.03397.xPétriacq, P., Stassen, J. H. M., & Ton, J. (2016). Spore Density Determines Infection Strategy by the Plant Pathogenic Fungus Plectosphaerella cucumerina. Plant Physiology, 170(4), 2325-2339. doi:10.1104/pp.15.00551Koornneef, A., & Pieterse, C. M. J. (2008). Cross Talk in Defense Signaling. Plant Physiology, 146(3), 839-844. doi:10.1104/pp.107.112029Ton, J., Flors, V., & Mauch-Mani, B. (2009). The multifaceted role of ABA in disease resistance. Trends in Plant Science, 14(6), 310-317. doi:10.1016/j.tplants.2009.03.006De Vleesschauwer, D., Yang, Y., Vera Cruz, C., & Höfte, M. (2010). Abscisic Acid-Induced Resistance against the Brown Spot Pathogen Cochliobolus miyabeanus in Rice Involves MAP Kinase-Mediated Repression of Ethylene Signaling      . Plant Physiology, 152(4), 2036-2052. doi:10.1104/pp.109.152702De Torres Zabala, M., Bennett, M. H., Truman, W. H., & Grant, M. R. (2009). Antagonism between salicylic and abscisic acid reflects early host-pathogen conflict and moulds plant defence responses. The Plant Journal, 59(3), 375-386. doi:10.1111/j.1365-313x.2009.03875.xBelin, C., de Franco, P.-O., Bourbousse, C., Chaignepain, S., Schmitter, J.-M., Vavasseur, A., … Thomine, S. (2006). Identification of Features Regulating OST1 Kinase Activity and OST1 Function in Guard Cells  . Plant Physiology, 141(4), 1316-1327. doi:10.1104/pp.106.079327Planes, M. D., Niñoles, R., Rubio, L., Bissoli, G., Bueso, E., García-Sánchez, M. J., … Serrano, R. (2014). A mechanism of growth inhibition by abscisic acid in germinating seeds of Arabidopsis thaliana based on inhibition of plasma membrane H+-ATPase and decreased cytosolic pH, K+, and anions. Journal of Experimental Botany, 66(3), 813-825. doi:10.1093/jxb/eru44

Modelling the Inorganic Bromine Partitioning in the Tropical Tropopause over the Pacific Ocean

The stratospheric inorganic bromine burden (Bry) arising from the degradation of brominated very short-lived organic substances (VSL org ), and its partitioning between reactive and reservoir species, is needed for a comprehensive assessment of the ozone depletion potential of brominated trace gases. Here we present modelled inorganic bromine abundances over the Pacific tropical tropopause based on aircraft observations of VSL org of two campaigns of the Airborne Tropical TRopopause EXperiment (ATTREX 2013 carried out over eastern Pacific and ATTREX 2014 carried out over the western Pacific) and chemistry-climate simulations (along ATTREX flight tracks) using the specific meteorology prevailing. Using the Community Atmosphere Model with Chemistry (CAM-Chem), we model that BrO and Br are the daytime dominant species. Integrated across all ATTREX flights BrO represents ~ 43 % and 48 % of daytime Bry abundance at 17 km over the Western and Eastern Pacific, respectively. The results also show zones where Br/BrO >1 depending on the solar zenith angle (SZA), ozone concentration and temperature. On the other hand, BrCl and BrONO 2 were found to be the dominant night-time species with ~ 61% and 56 % of abundance at 17 km over the Western and Eastern Pacific, respectively. The western-to-eastern differences in the partitioning of inorganic bromine are explained by different abundances of ozone (O3), nitrogen dioxide (NO2) , and total inorganic chlorine (Cly).Fil: Navarro, María A.. University of Miami; Estados UnidosFil: Saiz-lopez, Alfonso. Consejo Superior de Investigaciones Científicas. Instituto de Química Física; EspañaFil: Cuevas, Carlos Alberto. Consejo Superior de Investigaciones Científicas. Instituto de Química Física; EspañaFil: Fernandez, Rafael Pedro. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza; Argentina. Universidad Nacional de Cuyo. Facultad de Ciencias Exactas y Naturales; Argentina. Universidad Tecnologica Nacional. Facultad Regional Mendoza. Secretaría de Ciencia, Tecnología y Postgrado; ArgentinaFil: Atlas, Elliot. University of Miami; Estados UnidosFil: Rodriguez Lloeveras, Xavier. Consejo Superior de Investigaciones Científicas. Instituto de Química Física; EspañaFil: Kinnison, Douglas E.. National Center For Atmospheric Research. Amospheric Chemistry División; Estados UnidosFil: Lamarque, Jean Francois. National Center For Atmospheric Research. Amospheric Chemistry División; Estados UnidosFil: Tilmes, Simone. National Center For Atmospheric Research. Amospheric Chemistry División; Estados UnidosFil: Thornberry, Troy. State University of Colorado at Boulder; Estados Unidos. Earth System Research Laboratory; Estados UnidosFil: Rollins, Andrew. State University of Colorado at Boulder; Estados Unidos. Earth System Research Laboratory; Estados UnidosFil: Elkins, James W.. Earth System Research Laboratory; Estados UnidosFil: Hintsa, Eric J.. State University of Colorado at Boulder; Estados Unidos. Earth System Research Laboratory; Estados UnidosFil: Moore, Fred L.. State University of Colorado at Boulder; Estados Unidos. Earth System Research Laboratory; Estados Unido

A low-mass planet candidate orbiting Proxima Centauri at a distance of 1.5 AU

Copyright © 2020 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works. Distributed under a Creative Commons Attribution NonCommercial License 4.0 (CC BY-NC).Our nearest neighbor, Proxima Centauri, hosts a temperate terrestrial planet. We detected in radial velocities evidence of a possible second planet with minimum mass m c sin i c = 5.8 ± 1.9 M ⊕ and orbital period P c = 5.21 - 0.22 + 0.26 years. The analysis of photometric data and spectro-scopic activity diagnostics does not explain the signal in terms of a stellar activity cycle, but follow-up is required in the coming years for confirming its planetary origin. We show that the existence of the planet can be ascertained, and its true mass can be determined with high accuracy, by combining Gaia astrometry and radial velocities. Proxima c could become a prime target for follow-up and characterization with next-generation direct imaging instrumentation due to the large maximum angular separation of ~1 arc second from the parent star. The candidate planet represents a challenge for the models of super-Earth formation and evolution.Peer reviewedFinal Published versio

Unnatural agrochemical ligands for engineered abscisic acid receptors

[EN] Existing agrochemicals can be endowed with new applications through protein engineering of plant receptors. A recent study shows an engineered PYR1 ABA receptor can be activated by mandipropamid. Plants engineered with such PYR1 variant are responsive to this agrochemical, which confers protection against drought through activation of ABA signaling.Rodríguez Egea, PL.; Lozano Juste, J. (2015). Unnatural agrochemical ligands for engineered abscisic acid receptors. Trends in Plant Science. 20(6):330-332. doi:10.1016/j.tplants.2015.04.001S33033220