Atlantis II : cruise 102 : moored and shipboard surface meteorological measurements during JASIN 1978

During cruise 102 of the R/V Atlantis-II in the Joint Air-Sea Interaction Project (JASIN), surface meteorological data were gathered by Woods Hole Oceanographic Institution personnel from two moored buoys and from the ship. One buoy (JASIN W2/WHOI 651) carried a Vector Averaging Wind Recorder (VAWR) and a Vector Measuring Wind Recorder (VMWR); these instruments provided 18 days of intercomparison data and 38 days of meteorological data from 30 July to 6 September 1978. The other buoy (JASIN H2) carried a VMWR and gave 25 total days of data from 16 July to 10 August, and from 26 August to 1 September. A PET computer, hardwired to sensors positioned on the ship, displayed data that were logged during both legs of the cruise. Manual data were gathered by the science watches. This report describes the PET system, and displays and compares all the data. VAWR hourly meteorological data are listed for the 38 day period. Scientific interpretation of these data, such as calculations of heat fluxes, will be published separately.Prepared for the National Science Foundation under Grants OCE77-25803 and OCE76-80174, and for the Office of Naval Research under Contract N00014-76-C-0197; NR 083-400 to the Woods Hole Oceanographic Institution

A simple ocean bottom hydrophone with 200 megabyte data capacity

The Woods Hole Ocean Bottom Hydrophone instrument records the digitized output of a single hydrophone sensor at rates between 250 and 1200 samples per second with a dynamic range of 98 dB and can be deployed at depths to 600 meters. The unit's 200 megabyte disk recorder allows operation for periods up to 5 days. Designed for typical marine seismic refraction operations the unit is reliable and simple to deploy and recover. A detailed description is provided of the instrument design and application including transfer function, clock accuracy, data format, sample data and power requirements.Funding provided by the National Science Foundation under Grant Nos. OCE-9019918 and OCE-8917628

Real-time tomography mooring

A real-time tomography system has been developed which combines ocean acoustic tomography with satellite-based time keeping and satellite telemetry. The basis of the system is the acoustic tomography transceiver and its associated acoustic navigation grid. To this basic system, a link to the surface has been added to provide a pathway for telemetry of the tomographic data to shore and a downlink for satellite-derived time which is used to correct the transceiver's clock. The surface buoy contains a GPS receiver, clock comparator, system controller and multiple ID Argos transmitters. Processed tomography signals, transceiver location data time, time drift and surface buoy engineering data are transmitted to satellite using a total of 32 data buffers transmitted every eight minutes. The report describes the real-time tomography system in detail, with particular emphasis on the modifications implemented to convert the standard tomography instrument to a real-time oceanographic tool.Funding was provided by the Office of Naval Technology under Contract No. N000-14-C-90-0098

Logics, rhetoric and 'the blob': populist logic in the Conservative reforms to English schooling

A lot has been written about the lasting implications of the Conservative reforms to English schooling, particularly changes made by Michael Gove as Education Secretary (2010–2014). There is a lot less work, however, on studying the role that language, strategy and the broader political framework played in the process of instituting and winning consent for these reforms. Studying these factors is important for ensuring that any changes to education and schooling are not read in isolation from their political context. Speeches particularly capture moments where intellectual and strategic political traditions meet, helping us to form a richer understanding of the motives behind specific reform goals and where they fit into a political landscape. This article analyses speeches and policy documents from prominent politicians who led the Conservative education agenda between 2010–2014 to illustrate how politicians mobilised a deliberate populist strategy and argumentation to achieve specific educational goals, but which have had broader social and political implications. Concepts from interpretive political studies are used to develop a case analysis of changes to teacher training provision and curriculum reform, illustrating how politicians constructed a frontier between ‘the people’ (commonly teachers or parents) and an illegitimate ‘elite’ (an educational establishment) that opposed change. This anti‐elite populist rhetoric, arguably first tested in the Department for Education, has now become instituted more widely in our current British politics

Risk Factors of Typhoid Infection in the Indonesian Archipelago.

BACKGROUND: Knowledge of risk factors and their relative importance in different settings is essential to develop effective health education material for the prevention of typhoid. In this study, we examine the effect of household level and individual behavioural risk factors on the risk of typhoid in three Indonesian islands (Sulawesi, Kalimantan and Papua) in the Eastern Indonesian archipelago encompassing rural, peri-urban and urban areas. METHODS: We enrolled 933 patients above 10 years of age in a health facility-based case-control study between June 2010 and June 2011. Individuals suspected of typhoid were tested using the typhoid IgM lateral flow assay for the serodiagnosis of typhoid fever followed by blood culture testing. Cases and controls were defined post-recruitment: cases were individuals with a culture or serology positive result (n = 449); controls were individuals negative to both serology and culture, with or without a diagnosis other than typhoid (n = 484). Logistic regression was used to examine the effect of household level and individual level behavioural risk factors and we calculated the population attributable fraction (PAF) of removing each risk significant independent behavioural risk factor. RESULTS: Washing hands at critical moments of the day and washing hands with soap were strong independent protective factors for typhoid (OR = 0.38 95% CI 0.25 to 0.58 for each unit increase in hand washing frequency score with values between 0 = Never and 3 = Always; OR = 3.16 95% CI = 2.09 to 4.79 comparing washing hands with soap sometimes/never vs. often). These effects were independent of levels of access to water and sanitation. Up to two thirds of cases could be prevented by compliance to these practices (hand washing PAF = 66.8 95% CI 61.4 to 71.5; use of soap PAF = 61.9 95%CI 56.7 to 66.5). Eating food out in food stalls or restaurant was an important risk factor (OR = 6.9 95%CI 4.41 to 10.8 for every unit increase in frequency score). CONCLUSIONS: Major gains could potentially be achieved in reducing the incidence of typhoid by ensuring adherence to adequate hand-washing practices alone. This confirms that there is a pivotal role for 'software' related interventions to encourage behavior change and create demand for goods and services, alongside development of water and sanitation infrastructure

Mutations in DCHS1 Cause Mitral Valve Prolapse

SUMMARY Mitral valve prolapse (MVP) is a common cardiac valve disease that affects nearly 1 in 40 individuals1–3. It can manifest as mitral regurgitation and is the leading indication for mitral valve surgery4,5. Despite a clear heritable component, the genetic etiology leading to non-syndromic MVP has remained elusive. Four affected individuals from a large multigenerational family segregating non-syndromic MVP underwent capture sequencing of the linked interval on chromosome 11. We report a missense mutation in the DCHS1 gene, the human homologue of the Drosophila cell polarity gene dachsous (ds) that segregates with MVP in the family. Morpholino knockdown of the zebrafish homolog dachsous1b resulted in a cardiac atrioventricular canal defect that could be rescued by wild-type human DCHS1, but not by DCHS1 mRNA with the familial mutation. Further genetic studies identified two additional families in which a second deleterious DCHS1 mutation segregates with MVP. Both DCHS1 mutations reduce protein stability as demonstrated in zebrafish, cultured cells, and, notably, in mitral valve interstitial cells (MVICs) obtained during mitral valve repair surgery of a proband. Dchs1+/− mice had prolapse of thickened mitral leaflets, which could be traced back to developmental errors in valve morphogenesis. DCHS1 deficiency in MVP patient MVICs as well as in Dchs1+/− mouse MVICs result in altered migration and cellular patterning, supporting these processes as etiological underpinnings for the disease. Understanding the role of DCHS1 in mitral valve development and MVP pathogenesis holds potential for therapeutic insights for this very common disease