RELACIÓN ENTRE LA CONFIGURACIÓN ESPACIAL INTERIOR Y LAS CONDUCTAS DE LOS CONSUMIDORES DENTRO DEL CENTRO COMERCIAL: UN MANUAL DE APLICACIÓN

 El objetivo de esta investigación es analizar las variables de la configuración del espacio interior y los patrones de comportamiento de los usuarios en un centro comercial. El trabajo realiza una revisión bibliográfica de homólogos para la construcción de matrices que evalúa dichas variables, dando como resultado final un manual de levantamiento de información que permite tomar datos sobre la dinámica social en el espacio interior del centro comercial y las características físicas del espacio. El manual está validado por parte de expertos en la gestión y diseño de centros comerciales de la ciudad de Cuenca – Ecuador.Palabras clave: Dinámica social, patrones, atractores espaciales, diseño comercial, composición espacial, manual de aplicación.   AbstractThe objective of this research is to analyze the variables of the interior space configuration and the behavior patterns of the users in a shopping center. This work carries out a bibliographic review of homologs for the construction of matrices that evaluates these variables, giving as a final result a manual for gathering information that allows taking data on the social dynamics in the interior space of the shopping center and the physical characteristics of the space. The manual is validated by experts in the management and design of shopping centers in the city of Cuenca - Ecuador. Keywords: Social dynamics, patterns, spatial attractors, commercial design, spatial composition, applicationmanual.   &nbsp

Evidence of rapid adaptation integrated into projections of temperature-related excess mortality

Few studies have used empirical evidence of past adaptation to project temperature-related excess mortality under climate change. Here, we assess adaptation in future projections of temperature-related excess mortality by employing evidence of shifting minimum mortality temperatures (MMTs) concurrent with climate warming of recent decades. The study is based on daily non-external mortality and daily mean temperature time-series from 11 Spanish cities covering four decades (1978–2017). It employs distributed lag non-linear models (DLNMs) to describe temperature-mortality associations, and multivariate mixed-effect meta-regression models to derive city- and subperiod-specific MMTs, and subsequently MMT associations with climatic indicators. We use temperature projections for one low- and one high-emission scenario (ssp126, ssp370) derived from five global climate models. Our results show that MMTs have closely tracked mean summer temperatures (MSTs) over time and space, with meta-regression models suggesting that the MMTs increased by 0.73 °C (95%CI: 0.65, 0.80) per 1 °C rise in MST over time, and by 0.84 °C (95%CI: 0.76, 0.92) per 1 °C rise in MST across cities. Future projections, which include adaptation by shifting MMTs according to observed temporal changes, result in 63.5% (95%CI: 50.0, 81.2) lower heat-related excess mortality, 63.7% (95%CI: 30.2, 166.7) higher cold-related excess mortality, and 11.2% (95%CI: −5.5, 39.5) lower total temperature-related excess mortality in the 2090s for ssp370 compared to estimates that do not account for adaptation. For ssp126, assumptions on adaptation have a comparatively small impact on excess mortality estimates. Elucidating the adaptive capacities of societies can motivate strengthened efforts to implement specific adaptation measures directed at reducing heat stress under climate change

Impact of Saccharomyces cerevisiae yeast inoculation mode on wine composition

Inoculation modes are known to affect yeast behavior. Here, we characterized the impact of ADY and pre-culturing on the composition of the resulting wine, fermented by four commercial strains of Saccharomyces cerevisiae. Classical oenological parameters were not affected by the yeast inoculation mode. Using an untargeted metabolomic approach, a significant distinction in wine composition was noted regardless of the strain between the two inoculation modes, each associated with a specific metabolomic signature. 218 and 895 biomarkers were annotated, respectively, for ADYs associated with the preservation of wine polyphenols, and for pre-cultures related to the modulation of yeast nitrogen metabolism. Volatilome analysis revealed that the ester family was that most impacted by the inoculation mode whatever the strain. Ester production was enhanced in ADY condition. For the first time, the complete reprogramming of the yeast metabolism was revealed as a function of yeast preparation, which significantly impacts its volatilome and exometabolome

Temperature-related excess mortality in German cities at 2 °C and higher degrees of global warming

Background: Investigating future changes in temperature-related mortality as a function of global mean temperature (GMT) rise allows for the evaluation of policy-relevant climate change targets. So far, only few studies have taken this approach, and, in particular, no such assessments exist for Germany, the most populated country of Europe. Methods: We assess temperature-related mortality in 12 major German cities based on daily time-series of all-cause mortality and daily mean temperatures in the period 1993–2015, using distributed-lag non-linear models in a two-stage design. Resulting risk functions are applied to estimate excess mortality in terms of GMT rise relative to pre-industrial levels, assuming no change in demographics or population vulnerability. Results: In the observational period, cold contributes stronger to temperature-related mortality than heat, with overall attributable fractions of 5.49% (95%CI: 3.82–7.19) and 0.81% (95%CI: 0.72–0.89), respectively. Future projections indicate that this pattern could be reversed under progressing global warming, with heat-related mortality starting to exceed cold-related mortality at 3 °C or higher GMT rise. Across cities, projected net increases in total temperature-related mortality were 0.45% (95%CI: −0.02–1.06) at 3 °C, 1.53% (95%CI: 0.96–2.06) at 4 °C, and 2.88% (95%CI: 1.60–4.10) at 5 °C, compared to today's warming level of 1 °C. By contrast, no significant difference was found between projected total temperature-related mortality at 2 °C versus 1 °C of GMT rise. Conclusions: Our results can inform current adaptation policies aimed at buffering the health risks from increased heat exposure under climate change. They also allow for the evaluation of global mitigation efforts in terms of local health benefits in some of Germany's most populated cities. © 2020 The Author

Avaliação econômica e tomada de decisão em saúde ambiental

Due to the increasing deterioration of the enviroment and its possible consequences for the health of the population the design and implementation of policies for the control of economic activities according to criteria for the protection of human health and the environment itself have become an unquestionable need. Such policies would incluede the economic feasibility of existing alternatives for protection. Due to the huge interests involved, however, other factors, both social and political should also be taken into consideration. Economic evaluation has been seen as a promising foundation for the decision making process in this subject. This tool's capacity systematically to organize and compare the costs and the benefits of the alternatives for the solution of enviromental problems is analysed.The main characteristics of cost-benefit and cost-effectiveness studies are summarized, as well as the possible forms of economic evalution, of the enviroment and the detailsof this field for the application of such techiniques of analysis. The limits of these tools for the quantifycation of the non-monetary costs of environmental risks and the consequent damage to health, whethea as pain,suffering or the disability of non-economic ally active persons are set out as these constitute the methodological challenge of the economic evaluation in the area. The importance of the enhancement of information input for the decision-making process relating to environmental health issues such as the distributions of costs and benefits among the different social groups is scrutinized. Lastly, the growuing political concern with environment issues is stated, as well as the techinical possibility of the manipulation of these analytical tools. On the basis of these elements,the need for evaluators to be conscious on the political implications of their studies, as well as the importance of their relationship with the decision-makers in view of the need for effective relevance to current environmental issuesAnte el creciente deterioro ambiental y sus posibles consecuencias en la salud de la población resulta una prioridad indiscutible el diseño e instrumentación de políticas que controlen las actividades económicas bajo el criterio de protección a la salud humana y al ambiente mismo. Es preciso que dichas políticas consideren la factibilidad económica de las alternativas de protección existentes. Sin embargo, por la cantidad de intereses dentro del área ambiental, otros factores como el social y el político deben también ser considerados. La evaluación económica ha sido vista como un promisorio fundamento para la toma de decisiones en esta materia. Los autores analizan la capacidad de esta herramienta para organizar en forma sistemática y comparable los costos y los beneficios de alternativas para la solución de problemas ambientales. Se resumen las principales características de los estudios de costo-beneficio y costo-efectividad, las formas de evaluación económica del ambiente, y las particularidades de esta área para la aplicación de dichas técnicas de análisis. Se señalan los límites encontrados en estas herramientas para cuantificar los costos no monetarios de los riesgos ambientales y de los consecuentes daños a la salud, tales como el dolor, el sufrimiento ó la incapacidad de personas económicamente inactivas, constituyendo estos aspectos el reto metodológico de la evaluación económica en el área. Se reflexiona sobre la importancia de ampliar los insumos informativos para la toma de decisiones en materia de salud ambiental en aspectos como la distribución de los costos y los beneficios entre los distintos grupos sociales. Por último se señala tanto la creciente politización del tema ambiental, como la posibilidad técnica de manipulación de estas herramientas de análisis. Partiendo de estos elementos se señala la necesidad, por parte de los evaluadores, de ser conscientes sobre las implicaciones políticas de sus estudios, así como de la importancia de su vinculación con los tomadores de decisión con el objetivo de lograr pertinencia en el ejercicio académico.Devido à crescente deterioração ambiental e as suas possíveis conseqüências para a saúde da polulação,torna-se necessário priorizar o desenho e instrumentação de políticas que controlem as atividades econômicas, considerando a proteção à saúde humana e ao próprio ambiente. É preciso que essas políticas considerem a factibilidade econômica das alternativas de proteção existentes. Não obstante, pela quantidade de interesses na área ambiental, outros fatores como o social e o político também devem ser considerados. A avaliação econômica tem sido vista como fundamental para a tomada de decisões nessa matéria. Foi analisada a capacidade desta ferramenta para organizar de forma sistemática e comparável os custos e os benefícios de alternativas para a solução dos problemas ambientais.Foram sintetizadas as principais características dos estudos de custo-benefício e custo-efetividade,as formas de avaliação econômica do ambiente e as particularidades desta área para a aplicação dessas técnicas de análise. Foram analisados os limites encontrados nessas ferramentas para calcular os custos não monetários dos riscos ambientais e dos danos conseqüentes à saúde, como a dor, o sofrimento ou a incapacidade de pessoas economicamente inativas, sendo que estes aspectos constituem o desafio metodológico da avaliação econômica na área. Analisa-se a importância de ampliar a informação para a tomada de decisões a respeito da saúde ambiental em aspectos como a distribuição dos custos e os benefícios entre os diferentes grupos sociais.Por último,assinala-se tanto a crescente politização do tema ambiental,como a possibilidade técnica de manipulação dessas ferramentas de analise.Partindo desses elementos, destaca-se a necessidade, por parte dos avaliadores, de tomar a consciência das implicações políticas dos seus estudos,assim como da importância da sua relação com as pessoas que tomam decisões para alcançar pertinência no exercício acadêmico

Dataset of the sperm proteome of stallions with different motility

This paper provides a detailed set of data on how the stal-lion sperm proteome differs among stallions with different sperm motilities, although within normal ranges. Findings distinguish proteins that may help to identify stallions of su-perior sperm motility. Sperm proteins were analyzed using a UHPLC/MS/MS system comprising of an Agilent 1290 in-finity series UHPLC coupled to an Agilent 6550 Q-TOF mass spectrometer (Agilent Technologies, Santa Clara, CA, USA). These data can be used to disclose potential targets to iden-tify good sperm samples and to study specific pathways in-volved in the regulation of sperm motility. This data article is linked to the paper "Proteins involved in mitochondrial metabolic functions and fertilization predominate in stallions with better motility Journal of Proteomics 247:104335 doi: 10.1016/j.jprot.2021.104335".(c) 2022 The Author(s). Published by Elsevier Inc.This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/

Pulse Doppler ultrasound as a tool for the diagnosis of chronic testicular dysfunction in stallions

[EN] Testicular function is particularly susceptible to vascular insult, resulting in a negative impact on sperm production and quality of the ejaculate. A prompt diagnosis of testicular dysfunction enables implementation of appropriate treatment, hence improving fertility forecasts for stallions. The present research aims to: (1) assess if Doppler ultrasonography is a good tool to diagnose stallions with testicular dysfunction; (2) to study the relationship between Doppler parameters of the testicular artery and those of sperm quality assessed by flow cytometry and (3) to establish cut off values to differentiate fertile stallions from those with pathologies causing testicular dysfunction. A total of 10 stallions (n: 7 healthy stallions and n: 3 sub-fertile stallions) were used in this study. Two ejaculates per stallion were collected and preserved at 5ÊC in a commercial extender. The semen was evaluated at T0, T24 and T48h by flow cytometry. Integrity and viability of sperm (YoPro®-1/EthD-1), mitochondrial activity (MitoTracker® Deep Red FM) and the DNA fragmentation index (Sperm Chromatin Structure Assay) were assessed. Doppler parameters were measured at three different locations on the testicular artery (Supratesticular artery (SA); Capsular artery (CA) and Intratesticular artery (IA)). The Doppler parameters calculated were: Resistive Index (RI), Pulsatility Index (PI), Peak Systolic Velocity (PSV), End Diastolic Velocity (EDV), Time Average Maximum Velocity (TAMV), Total Arterial Blood Flow (TABF) and TABF rate. The capsular artery was the most reliable location to carry out spectral Doppler assessment, since blood flow parameters of this artery were most closely correlated with sperm quality parameters. Significant differences in all the Doppler parameters studied were observed between fertile and subfertile stallions (p0.05). The principal components analysis assay determined that fertile stallions are characterized by high EDV, TAMV, TABF and TABF rate values (high vascular perfusion). In contrast, subfertile stallions tend to present high values of PI and RI (high vascular resistance). The ROC curves revealed that the best Doppler parameters to predict sperm quality in stallions were: Doppler velocities (PSV, EDV and TAMV), the diameter of the capsular artery and TABF parameters (tissue perfusion parameters). Cut off values were established using a YoudenÂs Index to identify fertile stallions from stallions with testicular dysfunction. Spectral Doppler ultrasound is a good predictive tool for sperm quality since correlations were determined among Doppler parameters and markers of sperm quality. Doppler ultrasonography could be a valuable diagnostic tool for use by clinical practitioners for the diagnosis of stallions with testicular dysfunction and could be a viable alternative to invasive procedures traditionally used for diagnosis of sub-fertility disorders.SIC.O.F. is supported by a postdoctoral grant from “Ministerio de Economía y Competitividad “. "Juan de la Cierva” IJCI-2014-21671. The authors received financial support from: the Ministerio de Economía y Competitividad-FEDER, Madrid, Spain,grant AGL2013-43211-R;Junta de Extremadura-FEDER (GR 10010 and PCE1002). P.M.M. is supported by a predoctoral grant from the Ministerio de Educación, Cultura y Deporte, Madrid Spain FPU13/03991

Una experiencia sobre la conformación de Semilleros de Investigación en la formación inicial de Profesores.

En esta ponencia se presenta la experiencia en la conformación y creación de un semillero de investigación en el Departamento de Física de la Universidad Pedagógica Nacional. Se muestra como el semillero surge a raíz de un proyecto de investigación transversal de la Facultad de Ciencia y Tecnología; se discute como el semillero se instaura dentro de la línea de investigación en didáctica de la Física denominada Aprendizaje Activo de la Física. Se hace una reflexión sobre como el ejercicio investigativo favorece la formación inicial de profesores desde el enfoque de la didáctica de la física y finalmente se presenta una mirada sobre la manera en como la actividad del semillero contribuye en la formación de los estudiantes que lo integran como futuros profesores. ABSTRACT This paper presents the experience in shaping and creating a hotbed of research in the Department of Physics of the National Pedagogical University. We show how the seed stems from a research project cross the Faculty of Science and Technology, is discussed as the seed is established within the research in physics education called Active Learning Physics. It is a reflection on how the research exercise promotes initial training from the standpoint of physics education and finally presents a look at how hotbed activity contributes to the formation of the students within it as future teachers

La imagen y la narrativa como herramientas para el abordaje psicosocial en escenarios de violencia. Departamentos de Antioquia y Caldas

En Colombia se ha vivido una guerra de más de 60 años que ha involucrado al Estado, los grupos armados al margen de la ley, los narcotraficantes y organizaciones criminales en general que como resultado han dejado a millones de personas de la población civil como víctimas de un conflicto que ni siquiera les pertenece. Es por eso que en este informe se abordará el relato de Modesto Pacayá como muestra de la esperanza y resiliencia que demuestra el país ante los horrores de la guerra, este es un indígena que fue obligado a ingresar a las Farc y que gracias a su familia logra desmovilizarse, para esto se proponen nueve preguntas (estratégicas, circulares y reflexivas) que podrían realizarse al protagonista para generar un acercamiento psicosocial ético y proactivo que favorezca la superación de la condición de víctima. Así mismo se hace un abordaje psicosocial del caso de “Peñas coloradas” que hace referencia a un pueblo construido por la comunidad que vivía entre la guerrilla y los cultivos de coca, que era invisibilizado por el Estado y que luego de una intervención militar su gente tuvo que salir desplazada a Cartagena del Chairá; por lo que el grupo colaborativo construyó unas estrategias psicosociales que permiten la potencialización de los recursos de afrontamiento de la población. El informe finaliza con análisis de la foto voz que muestra las diferentes violencias encontradas en los departamentos de Antioquia y Caldas, además del enlace que los direccionará a la galería virtual para visualizar el ejercicio.Colombia has experienced a war of more than 60 years that has involved the State, armed groups outside the law, drug traffickers and criminal organizations in general that as a result have left millions of civilians as victims of aconflict that does not even it belongs to them. That is why this report will address the story of Modesto Pacayá as a sign of the hope and resilience that the country demonstrates in the face of the horrors of war, this is an indigenous man who was forced to enter the FARC and thanks to his family manages to demobilize, for this nine questions (strategic, circular and reflective) that could be asked to the protagonist to generate an ethical and proactive psychosocial approach that favors overcoming the condition of victim. Likewise, a psychosocial approach is made to the case of "Peñas coloradas" that refers to a town built by the community that lived between the guerrillas and the coca crops, which was made invisible by the State and that after a military intervention its people had to leave displaced to Cartagena del Chairá; Therefore, the collaborative group built psychosocial strategies that allow the potentiation of coping resources for the population. The report ends with analysis of the photo voice that shows the different violences found in the departments of Antioquia and Caldas, in addition to the link that will direct them to the virtual gallery to visualize the exercise