Agencias tridentinas en la Salamanca filipina

Les procès inquisitoriaux perpétrés entre 1584 et 1600 contre Sánchez de las Brozas, professeur à l’Université de Salamanque, semblent illustrer, au sein du catholicisme de la Renaissance, une polémique autour de la libre interprétation du christianisme. Mais penser la défaite humaniste à l’Époque moderne c’est aussi penser la violence judiciaire, monopole d’un État capable de définir les frontières de l’orthodoxie.Los procesos inquisitoriales perpetrados entre 1584 y 1600 contra Sánchez de las Brozas, profesor de la Universidad de Salamanca, aparecen como la materialización de una polémica al interior del catolicismo renacentista en torno de la libre interpretación del cristianismo. Pero pensar la caída del humanismo durante la Edad Moderna es también pensar la violencia judicial, monopolio de un Estado capaz de definir las fronteras de la ortodoxia.The inquisitorial trials held against Sánchez de las Brozas, Professor at the University of Salamanca, between 1584 and 1600, seem to illustrate, within the Renaissance Roman Catholicism, a controversy around the free interpretation of Christianism. Yet, to think in our times the humanist defeat is also to think judicial violence - the monopole of a State able to define the borders of orthodoxy

Pierre Charron y la teología escéptica. Tradición y verdad en el Otoño del Renacimiento

Se han intentado diversas interpretaciones respecto del carácter bifronte de PierreCharron: por un lado, un audaz divulgador de la tradición escéptica; por elotro, un entusiasta predicador y apologeta católico. Se sostiene aquí que ambascaras son expresiones de un ecléctico ánimo intelectual vinculado no sólo alescepticismo sino también a ciertas lecturas humanistas de la tradición platónica.Several interpretations had been tried to understand the Janus-faced nature of Pierre Charron: on one hand, a reckless sceptic philosopher; on the other hand, an enthusiastic preacher and apologist of the Catholic faith. This article stands that both characters are expressions of an eclectic intellectual attitude influenced not only by scepticism but by some specific humanist readings of Platonic tradition as well.Fil: Peña, Santiago Francisco. Universidad de Buenos Aires. Facultad de Filosofía y Letras. Departamento de Historia; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universite de Paris; Franci

Analysis of the converter synchronizing method for the contribution of battery energy storage systems to inertia emulation

This article belongs to the Special Issue Energy Storage for Grid Integration of Renewable Energy.This paper presents a comprehensive analysis of the effect of the converter synchronizing methods on the contribution that Battery Energy Storage Systems (BESSs) can provide for the support of the inertial response of a power system. Solutions based on phase-locked loop (PLL) synchronization and virtual synchronous machine (VSM) synchronization without PLL are described and then compared by using time-domain simulations for an isolated microgrid (MG) case study. The simulation results showed that inertial response can be provided both with and without the use of a PLL. However, the behavior in the first moments of the inertia response differed. For the PLL-based solutions, the transient response was dominated by the low-level current controllers, which imposed fast under-damped oscillations, while the VSM systems presented a slower response resulting in a higher amount of energy exchanged and therefore a greater contribution to the support of the system inertial response. Moreover, it was demonstrated that PLL-based solutions with and without derivative components presented similar behavior, which significantly simplified the implementation of the PLL-based inertia emulation solutions. Finally, results showed that the contribution of the BESS using VSM solutions was limited by the effect of the VSM-emulated inertia parameters on the system stability, which reduced the emulated inertia margin compared to the PLL-based solutions

Associated thyroidectomy with parathyroidectomy for primary and secondary hyperparathyroidism

[ES] Introducción: La asociación de patología tiroidea y paratiroidea es frecuente y puede dificultar el diagnóstico preoperatorio por lo que debe hacerse estudio tiroideo funcional y estructural en el hiperparatiroidismo. Objetivo: Conocer la incidencia de patología quirúrgica de paratiroides y tiroides asociadas. Material y método: Estudio histórico de casos y control en 105 pacientes sometidos a paratiroidectomía total o parcial por hiperparatiroidismo primario (83,81%) o secundario (16,19%) con o sin tiroidectomía (60% y 40% respectivamente) entre enero de 2006 y diciembre de 2013. Como grupo control se seleccionaron aleatoriamente 126 tiroidectomías realizadas en el mismo periodo excluyendo carcinoma medular de tiroides. Resultados: La incidencia de tiroidectomía asociada a paratiroidectomía fue del 60% [50,44-68,86%] sin diferencia significativa entre hiperparatiroidismo primario y secundario. La incidencia de carcinoma tiroideo no medular asociado a paratiroidectomía fue 7,62% [3,91-14,32%], la de carcinoma tiroideo incidental fue 6,67% [3,27-13,13%] ambos sin diferencia estadísticamente significativa respecto al grupo control (6,35%, [3,25-12,03%]). Discusión: La asociación de gammagrafía Tc99m-MIBI y ecografía incrementa la exactitud del diagnóstico preoperatorio, descarta patología tiroidea asociada y se recomienda como estudio rutinario. La indicación de tiroidectomía asociada a la paratiroidectomía debe tomarse preoperatoriamente con idénticos criterios que en la población general y solicitar al paciente consentimiento informado. Conclusiones: Un alto porcentaje de pacientes sometidos a paratiroidectomía precisan tiroidectomía por lo que es necesario hacer estudio tiroideo prequirúrgico para establecer la indicación de tiroidectomía si fuese necesaria y solicitar al paciente consentimiento para realizar tiroidectomía en todos los casos. [EN] Introduction: The association of thyroid and parathyroid disease is common and may hinder the preoperative diagnosis, this is the reason why a functional and structural thyroid study should be made in hyperparathyroidism. Objective: To determine the incidence of surgical pathology associated thyroid and parathyroid. Material and method: Historical study of 105 cases and control in patients undergoing total or partial parathyroidectomy for primary hyperparathyroidism (83.81%) or secondary (16.19%) with or without thyroidectomy (60% and 40 % respectively) between January 2006 and December 2013. a control group of 126 thyroidectomies performed in the same period excluding medullary thyroid carcinoma were randomly selected. Results: The incidence of thyroidectomy associated with parathyroidectomy was 60% [ from 50.44 to 68.86 %] with no significant difference between primary and secondary hyperparathyroidism. The incidence of non-medullary thyroid carcinoma associated with parathyroidectomy was 7.62% [3.91 to 14.3%] , the incidental thyroid carcinoma was 6.67% [3.27 to 13.13%] with no difference both statistically significant compared to the control group (6.35 % [3.25 to 12.03%]). Discussion: The association of 99mTc -MIBI scintigraphy and ultrasound increases the accuracy of the preoperative diagnosis, rule out thyroid disease associated and is recommended as a routine study. The indication for thyroidectomy associated with parathyroidectomy should be taken preoperatively with the same methods as in general population and obtain informed consent from the patient. Conclusions: A high percentage of patients undergoing parathyroidectomy require thyroidectomy so it is necessary to establish preoperative thyroid study indicating thyroidectomy if necessary and obtain the patient’s consent to perform thyroidectomy in all cases

Desing of 3D printed veterinary capsule devices for supplement administration

Urea is commonly employed in ruminant feed supplementation, however is rapidly hydrolyzed in the rumen. Therefore, modifying the urea release has become a pharmacotechnical challenge. In this work, a proof of concept study was developed to test the feasibility of using Fused Deposition Modeling-3D printing (3DP) to create veterinary capsule devices (CDs) that could allow the control of urea release. Three designs were assayed: D1 = one-compartment capsule with body and cover printed in polylactic acid (PLA), D2 = one-compartment capsule with body of PLA and cover of polyvinyl alcohol (PVA) and D3 = multi-compartment capsule with cover and body of PLA, the body presenting a PVA orifice in one extreme and five PVA partitions inside. The release of urea from the CDs was performed in 1 liter of distilled water, 40 ºC and 50 rpm. Two sinkers of differents weights and two types of paddles were evaluated. D1 showed no release of urea within 24 hours. D2 exhibited a retard release without influence of sinkers and paddles. D3 showed immediate and prolonged profiles, thus the release was affected by sinkers/paddles and some printing errors. These preliminary designs showed the possibility of using 3DP as a technological platform to modify the urea release in ruminant feed supplementation.Fil: Gallo, Loreana Carolina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Planta Piloto de Ingeniería Química. Universidad Nacional del Sur. Planta Piloto de Ingeniería Química; Argentina. Universidad Nacional del Sur. Departamento de Biología, Bioquímica y Farmacia; ArgentinaFil: Peña, Juan Francisco. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Planta Piloto de Ingeniería Química. Universidad Nacional del Sur. Planta Piloto de Ingeniería Química; ArgentinaFil: Palma, Santiago Daniel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Unidad de Investigación y Desarrollo en Tecnología Farmacéutica. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Unidad de Investigación y Desarrollo en Tecnología Farmacéutica; ArgentinaFil: Real, Juan Pablo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Unidad de Investigación y Desarrollo en Tecnología Farmacéutica. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Unidad de Investigación y Desarrollo en Tecnología Farmacéutica; ArgentinaFil: Cotabarren, Ivana María. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Bahía Blanca. Planta Piloto de Ingeniería Química. Universidad Nacional del Sur. Planta Piloto de Ingeniería Química; Argentina. Universidad Nacional del Sur. Departamento de Ingeniería Química; Argentina6ta Reunión Internacional de Ciencias Farmacéuticas (RICiFa 2020+1)CordobaArgentinaUniversidad Nacional de CórdobaUniversidad Nacional de Rosari

Sobre la presencia de Triguera osbeckii (L.) Willk. (Solanaceae) en Carmona (comarca de Los Alcores, Sevilla, Andalucía).

About Triguera osbeckii (L.) Willk. (Solanaceae) in Carmona (Alcores region, Seville, Andalusia)Palabras clave. Arcillas, endemismo ibero-magrebí, flora amenazada.Key words. Clay, Ibero-North African endemic, endangered flora

Estudia, emprende, innova

Memoria ID-049. Ayudas de la Universidad de Salamanca para la innovación docente, curso 2013-2014

Higher expression of activated CD8+ T lymphocytes (CD8+CD25+, CD8+CD69+ and CD8+CD95+) mediate early post-transplant acute tubular injury in kidney recipients

© 2023 The Author(s). This manuscript version is made available under the CC-BY 4.0 license http://creativecommons.org/licenses/by/4.0/. This document is the Published version of a Published Work that appeared in final form in Frontiers in Bioscience-Landmark (FBL). To access the final edited and published work see https://doi.org/10.31083/j.fbl2806119Background: Acute kidney injury (AKI) is a leading cause of early post-transplant kidney damage. Furthermore, acute tubular necrosis (ATN) is appointed as the most prevalent form of AKI, a frequent multifactorial process associated with high morbidity and mortality, yet giving rise to delayed graft function (DGF) and, ultimately, allograft dysfunction. Common factors such as prolonged cold ischemia time, advanced donor age, cadaveric versus living donor, donor history of hypertension, as well as donation after cardiac death have all been deemed risk factors for ATN. With the increasing number of older cadaveric and cardiac donors in the donation process, ATN could have a detrimental impact on patient welfare. Therefore understanding the underlying process would benefit the transplant outcome. We aimed to prospectively monitor several T cell subsets in a cohort of kidney transplant recipients (KTrs) to investigate whether there is an adaptive immune-mediated involvement in the ATN process. Methods: Peripheral blood was collected from 31 KTrs at different time points within the first-year post-transplantation for in vitro stimulation with Concanavalin-A (Con-A) in a humidified 5% CO2 incubator at 37 °C for 72 hours. Upon cell stimulation, flow cytometry was applied to quantify the surface expression through the median fluorescence intensity (MFI) of CD4+CD25+, CD8+CD25+, CD4+CD38+, CD8+CD38+, CD4+CD154+, CD8+CD154+, CD4+CD69+, CD8+CD69+, CD4+CD95+, and CD8+CD95+ T cells. Statistical analysis was carried out with SPSS Statistics IBM v.25 (IBM Corp, Armonk, NY, USA). MFIs values were compared using a univariate analysis by a nonparametric U-Mann Whitney test. ROC analysis was applied to define cut-off values most capable of stratifying patients at high risk of ATN. Spearman’s rank-order coefficient test was applied to correlate biomarkers with allograft function. Multivariate regression independently validated CD8+ T lymphocytes as surrogate biomarkers of ATN. A p-value < 0.05 was considered statistically significant. Results: KTrs who developed ATN upon transplantation had significantly higher expression of CD25, CD69, and CD95 on CD8+ and lower expression of CD95 on CD4+ T lymphocytes than patients with stable graft function. ROC curve analysis showed that MFIs ≥1015.20 for CD8+CD25+, ≥2489.05 for CD8+CD69+, ≥4257.28 for CD8+CD95+, and ≤1581.98 for CD4+CD95+ were capable of stratifying KTrs at high risk of ATN. Furthermore, patients with an MFI below any cut-off were significantly less likely to develop ATN than those with other values. The allograft function was correlated with the CD4+CD95+/CD8+CD95+ ratio in KTrs who developed ATN. The multivariate analysis confirmed that, within the first-month post-transplant, MFI values of CD8+CD25+, CD4+CD95+, and CD8+CD95+ T lymphocytes, along with donor age, serum creatinine, and GFR were independent risk factors to ATN. Moreover, we were also able to corroborate previous immune factors of importance in immune-mediated response to the allograft, such as the patient’s maximum panel reactive antibody (PRA) or the maintenance immunosuppression therapy. Conclusions: Our results demonstrate evidence for the implication of CD8+ T lymphocytes in the development of ATN early in the post-transplant phase. Post-transplant monitoring of activated CD8+ T lymphocytes may help identify which patients require further clinical intervention to prevent graft damage