Experimental Evaluation of Steady-State Control Properties of an Electron-Bombardment Ion Thrustor

Examined in this report are the experimental steady-state gains, or changes, in beam-current output with changes in thrustor inputs for a 10-centimeter-diameter electron-bombardment ion thrustor. A general leveling off of beam current as a function of an input variable was found at the upper range of each variable, At the design operating point, the filament-heating current exhibited the greatest sensitivity, or percentage beam-current output change for a percentage change in the input (2 to 4). Accelerator voltage showed the least effect (0.04) while discharge voltage, magnetic field, and neutral propellant flow exhibited about the same sensitivity (0.4 to 0.5). Some effects of nonlinearity are shown that may require consideration in the design of a closed-loop control system

Solar electric propulsion system tests

Design and performance of solar-powered electric propulsion system for interplanetary space exploratio

Monte Carlo study of tunable negative-zero-positive index of refraction in nanosphere dispersed liquid crystals

Khoo et al.1, 2 have shown that nanosphere dispersed nematic liquid crystal (NDLC) constitutes a new type of metamaterial with index of refraction tunable from negative to positive values. Recently3 we have combined this approach with Monte Carlo simulations of inhomogeneous molecular order in planar NLC cells. Lebwohl - Lasher effective hamiltonian with Rapini - Papoular term for anchoring forces was used. Electric field and amplitude of anchoring forces are control parameters which determine the profiles of order parameter. In this paper we study, using the same approach, local spatial distribution of refractive index in NDLC planar cell. We show that NDLC material consists of layers with negative-zero-positive index of refraction. The spatial organization of those layers strongly depends on incident light wavelength. The role of spatially modulated external electric field for tuning of refractive index of NDLC is briefly discussed

The role of the light source in antimicrobial photodynamic therapy

This work was financially supported by the European Union's Horizon 2020 research and innovation programme under the Marie Sklodowska-Curie grant (agreement no. 764837) and NCN Opus grant no. 2019/35/B/ST4/03280. We are also grateful to the Engineering and Physical Sciences Research Council of the UK for financial support from grants EP/R511778/1 and EP/L015110/1.Antimicrobial photodynamic therapy (APDT) is a promising approach to fight the growing problem of antimicrobial resistance that threatens health care, food security and agriculture. APDT uses light to excite a light-activated chemical (photosensitiser), leading to the generation of reactive oxygen species (ROS). Many APDT studies confirm its efficacy in vitro and in vivo against bacteria, fungi, viruses and parasites. However, the development of the field is focused on exploring potential targets and developing new photosensitisers. The role of light, a crucial element for ROS production, has been neglected. What are the main parameters essential for effective photosensitiser activation? Does an optimal light radiant exposure exist? And finally, which light source is best? Many reports have described the promising antibacterial effects of APDT in vitro, however, its application in vivo, especially in clinical settings remains very limited. The restricted availability may partially be due to a lack of standard conditions or protocols, arising from the diversity of selected photosensitising agents (PS), variable testing conditions including light sources used for PS activation and methods of measuring anti-bacterial activity and their effectiveness in treating bacterial infections. We thus sought to systematically review and examine the evidence from existing studies on APDT associated with the light source used. We show how the reduction of pathogens depends on the light source applied, radiant exposure and irradiance of light used, and type of pathogen, and so critically appraise the current state of development of APDT and areas to be addressed in future studies. We anticipate that further standardisation of the experimental conditions will help the field advance, and suggest key optical and biological parameters that should be reported in all APDT studies. More in vivo and clinical studies are needed and are expected to be facilitated by advances in light sources, leading to APDT becoming a sustainable, alternative therapeutic option for bacterial and other microbial infections in the future.Publisher PDFPeer reviewe

Hydrologic and Water Quality Monitoring on Turkey Creek Watershed, Francis Marion National Forest, SC

2008 S.C. Water Resources Conference - Addressing Water Challenges Facing the State and Regio

Treatment of antibiotic-resistant bacteria colonizing diabetic foot ulcers by OLED induced antimicrobial photodynamic therapy

KM, KJP and IDWS were supported by the European Union’s Horizon 2020 research and innovation programme under the Marie Sklodowska-Curie grant (Agreement N°764837) and NCN Opus Grant No. 2019/35/B/ST4/03280.We evaluate the efficacy of antimicrobial Photodynamic Therapy (APDT) for inactivating a variety of antibiotic-resistant clinical strains from diabetic foot ulcers. Here we are focused on APDT based on organic light-emitting diodes (OLED). The wound swabs from ten patients diagnosed with diabetic foot ulcers were collected and 32 clinical strains comprising 22 bacterial species were obtained. The isolated strains were identified with the use of mass spectrometry coupled with a protein profile database and tested for antibiotic susceptibility. 74% of isolated bacterial strains exhibited adaptive antibiotic resistance to at least one antibiotic. All strains were subjected to the APDT procedure using an OLED as a light source and 16 µM methylene blue as a photosensitizer. APDT using the OLED led to a large reduction in all cases. For pathogenic bacteria, the reduction ranged from 1.1-log to > 8 log (Klebsiella aerogenes, Enterobacter cloaca, Staphylococcus hominis) even for high antibiotic resistance (MRSA 5-log reduction). Opportunistic bacteria showed a range from 0.4-log reduction for Citrobacter koseri to > 8 log reduction for Kocuria rhizophila. These results show that OLED-driven APDT is effective against pathogens and opportunistic bacteria regardless of drug resistance.Publisher PDFPeer reviewe

System Response Kernel Calculation for List-mode Reconstruction in Strip PET Detector

Reconstruction of the image in Positron Emission Tomographs (PET) requires the knowledge of the system response kernel which describes the contribution of each pixel (voxel) to each tube of response (TOR). This is especially important in list-mode reconstruction systems, where an efficient analytical approximation of such function is required. In this contribution, we present a derivation of the system response kernel for a novel 2D strip PET.Comment: 10 pages, 2 figures; Presented at Symposium on applied nuclear physics and innovative technologies, Cracow, 03-06 June 201

Beam profile investigation of the new collimator system for the J-PET detector

Jagiellonian Positron Emission Tomograph (J-PET) is a multi-purpose detector which will be used for search for discrete symmetries violations in the decays of positronium atoms and for investigations with positronium atoms in life-sciences and medical diagnostics. In this article we present three methods for determination of the beam profile of collimated annihilation gamma quanta. Precise monitoring of this profile is essential for time and energy calibration of the J-PET detector and for the determination of the library of model signals used in the hit-time and hit-position reconstruction. We have we have shown that usage of two lead bricks with dimensions of 5x10x20 cm^3 enables to form a beam of annihilation quanta with Gaussian profile characterized by 1 mm FWHM. Determination of this characteristic is essential for designing and construction the collimator system for the 24-module J-PET prototype. Simulations of the beam profile for different collimator dimensions were performed. This allowed us to choose optimal collimation system in terms of the beam profile parameters, dimensions and weight of the collimator taking into account the design of the 24 module J-PET detector.Comment: 14 pages, 9 figure