346 research outputs found

    Junior Recital:Dakota M. Pawlicki, Tuba

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    Kemp Recital Hall Tuesday Evening April 17, 2007 8:00p.m

    The results of chemotherapy in 976 patients with non-small lung cancer

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    Primary microRNA transcript retention at sites of transcription leads to enhanced microRNA production

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    MicroRNAs (miRNAs) are noncoding RNAs with important roles in regulating gene expression. In studying the earliest nuclear steps of miRNA biogenesis, we observe that primary miRNA (pri-miRNA) transcripts retained at transcription sites due to the deletion of 3′-end processing signals are converted more efficiently into precursor miRNAs (pre-miRNAs) than pri-miRNAs that are cleaved, polyadenylated, and released. Flanking exons, which also increase retention at transcription sites, likewise contribute to increased levels of intronic pri-miRNAs. Consistently, efficiently processed endogenous pri-miRNAs are enriched in chromatin-associated nuclear fractions. In contrast, pri-miRNAs that accumulate to high nuclear levels after cleavage and polyadenylation because of the presence of a viral RNA element (the ENE of the Kaposi's sarcoma–associated herpes virus polyadenylated nuclear RNA) are not efficiently processed to precursor or mature miRNAs. Exogenous pri-miRNAs unexpectedly localize to nuclear foci containing splicing factor SC35; yet these foci are unlikely to represent sites of miRNA transcription or processing. Together, our results suggest that pri-miRNA processing is enhanced by coupling to transcription

    New anticancer drugs - future directions

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    Exact relations between damage spreading and thermodynamic functions for the N-color Ashkin-Teller model

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    Exact results are derived relating quantities computable by the so-called damage spreading method and thermodynamic functions for the N-color Ashkin-Teller model. The results are valid for any ergodic dynamics. Since we restrict our analysis to the ferromagnetic case the results are also valid for any translational invariant lattice. The derived relations should be used in order to determine numerically the N-color Ashkin-Teller critical exponents with better accuracy and less computational efforts than standard Monte Carlo simulations.Comment: 6 pages, to be published in JSTAT (Journal of Statistical Mechanics: Theory and Experiment). The results of a computer simulation were included for N=3 as an example on how to use the analytical relations derived in the paper as a guide to obtain the critical temperature and critical exponent

    Correlated Electrical and Chemical Nanoscale Properties in Potassium-Passivated, Triple-Cation Perovskite Solar Cells

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    Perovskite semiconductors are an exciting class of materials due to their promising performance outputs in photovoltaic devices. To boost their efficiency further, researchers introduce additives during sample synthesis, such as KI. However, it is not well understood how KI changes the material and, often, leaves precipitants. To fully resolve the role of KI, multiple microscopy techniques are applied and the electrical and chemical behavior of a Reference (untreated) and a KI‐treated perovskite are compared. Upon correlation between electrical and chemical nanoimaging techniques, it is discovered that these local properties are linked to the macroscopic voltage enhancement of the KI‐treated perovskite. The heterogeneity revealed in both the local electrical and chemical responses indicates that the additive partially migrates to the surface, yet surprisingly does not deteriorate the performance locally, rather, the voltage response homogeneously increases. The research presented within provides a diagnostic methodology, which connects the nanoscale electrical and chemical properties of materials, relevant to other perovskites, including multication and Pb‐free alternatives

    Correlated Electrical and Chemical Nanoscale Properties in Potassium-Passivated, Triple-Cation Perovskite Solar Cells

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    Perovskite semiconductors are an exciting class of materials due to their promising performance outputs in optoelectronic devices. To boost their efficiency further, researchers introduce additives during sample synthesis, such as KI. However, it is not well understood how KI changes the material and, often, leaves precipitants. To fully resolve the role of KI, a multiple microscopy techniques is applied and the electrical and chemical behavior of a Reference (untreated) and a KI-treated perovskite are compared. Upon correlation between electrical and chemical nanoimaging techniques, it is discovered that these local properties are linked to the macroscopic voltage enhancement of the KI-treated perovskite. The heterogeneity revealed in both the local electrical and chemical responses indicates that the additive partially migrates to the surface, yet surprisingly; does not deteriorate the performance locally, rather, the voltage response homogeneously increases. The research presented within provides a diagnostic methodology, which connects the nanoscale electrical and chemical properties of materials, relevant to other perovskites, including multication and Pb-free alternatives.University of Maryland All-S.T.A.R. Fellowship Hulka Energy Research Fellowship National Science Foundation US Department of Energy The Royal Society Office of Naval Researc

    A Study in Depth of f0(1370)

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    Claims have been made that f0(1370) does not exist. The five primary sets of data requiring its existence are refitted. Major dispersive effects due to the opening of the 4pi threshold are included for the first time; the sigma -> 4pi amplitude plays a strong role. Crystal Barrel data on pbar-p -> 3pizero at rest require f0(1370) signals of at least 32 and 33 standard deviations in 1S0 and 3P1 annihilation respectively. Furthermore, they agree within 5 MeV for mass and width. Data on pbar-p -> eta-eta-pizero agree and require at least a 19 standard deviation contribution. This alone is sufficient to demonstrate the existence of f0(1370). BES II data for J/Psi -> phi-pi-pi contain a visible f0(1370) signal > 8 standard devations. In all cases, a resonant phase variation is required. The possibility of a second pole in the sigma amplitude due to the opening of the 4pi channel is excluded. Cern-Munich data for pi-pi elastic scattering are fitted well with the inclusion of some mixing between sigma, f0(1370) and f0(1500). The pi-pi widths for f2(1565), rho3(1690), rho3(1990) and f4(2040) are determined.Comment: 25 pages, 22 figures. Typos corrected in Eqs 2 and 7. Introduction rewritten. Conclusions unchange

    Scalar meson production in nucleon-nucleon collisions near threshold

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    We establish the model-independent spin structure of the matrix elements for the near-threshold scalar meson production in pppp- and npnp-collisions, when the final particles are emitted in S-state. Polarization phenomena are derived in a general form. The properties of the tt-channel dynamics, which is based on different meson exchanges, are studied in terms of the ss-channel parametrization of the matrix element. The prediction of a 'realistic' model, based on π+σ\pi+\sigma-exchanges are also presented.Comment: 16 pages 6 figure
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