Living with climate variability and change: lessons from Tanzania

A Thesis Submitted to the Faculty of Science, University of the Witwatersrand, Johannesburg, in fulfilment of the requirements for the degree of Doctor of Philosophy May, 2015.There is sufficient evidence supporting that climate change and variability are pervasive realities that are strongly impacting on smallholder farmers in the Great Ruaha River sub-Basin of Tanzania. This PhD study examines smallholder farmers’ vulnerability, coping and adaptation strategies to climate change and variability (including non-climatic stresses), and investigates how such coping and adaptation may be constrained or enhanced given climate variability and change. Both quantitative and qualitative data collection methods were used when engaging with smallholder farmers and government officials. Primary data collection was undertaken in two phases, with phase one using participatory tools (e.g. focus group discussions, wealth ranking, community mapping and transect walk, and historical time lines). Data collected include climatic and non-climatic extreme events, farmers’ perceptions, coping and adaptation strategies. Phase two involved detailed individual interviews (questionnaire surveys) and key informant interviews (case studies), so as to obtain in-depth information on issues of interest. Secondary data were collected from existing statistical sources, literature surveys in archives, libraries and documentation centres, and from governmental agencies (e.g. TMA). Demographic, agricultural production and livestock statistics, and rainfall and temperature records were collected. Results from selected meteorological stations and farmers’ perceptions (74%) indicate that there has been an increase in average maximum temperatures, and both dry and wet years with varying magnitudes during the past four decades. Other climatic stresses include delayed onset and later cessation of the rain seasons. The agreement between farmers’ perceptions and rainfall trends provides good evidence that the climate has become increasingly variable in the GRRB during the past four decades. Achieving sustainable livelihoods is further compounded by non-climatic stresses such as access to markets and coordinating institutions. Results indicate that vulnerability is a complex phenomenon that entails two approaches (end-point and starting-point perspectives). The end-point perspective views vulnerability as the net projected climate change impacts after adaptation has taken place, whilst the starting-point perspective looks at both the current and future multiple stresses and places much emphasis in improving the adaptive capacity. In the study villages, such a nuanced picture highlighted areas for enhanced adaptation strategies. Farmers respond by using various strategies to deal with droughts, floods and other stresses when they occur. During droughts, they mostly use irrigation (canal, pumping and cans), or plant short-term maturing crops. During food shortages, farmers use strategies such as buying food, borrowing money, temporary migration, working in other people’s farms for cash, and reducing consumption. Moreover, the farmers’ choice of adaptation and coping strategies is influenced by factors such as location, access to resources, education levels and institutions. This calls for a whole system approach, which entails defining vulnerability of smallholder farmers to climatic and non-climatic stresses and thus designing appropriate response strategies. For example, mainstreaming adaptation to such stresses when considering development plans, projects, programmes and policies at all scales

The Role of Agricultural Social Enterprise to Smallholder Farmers’ Adaptive Capacity to Climatic Stresses in Tanzania

This paper intended to ascertain the implications of agricultural social enterprise on the adaptive capacity of smallholder farmers to climatic stresses in the Kilolo District, Tanzania. The study used a sample of 90 households. Household questionnaires, focus group discussions (FGD), and key informant interviews were used to collect primary data for this study. Secondary data were collected through a review of literature relevant to this study. The content analysis was used to analyse qualitative data, whereas quantitative data were subjected to Statistical Product and Service Solution (SPSS) version 20 for analysis. Microsoft Excel 2007 was used to analyse rainfall and temperature data trends of the study area. Findings revealed that the agricultural social enterprise found in the study area (i.e. One Acre Fund-OAF) enhanced the adaptive capacity of smallholder farmers since the services it provided to its clients positively influenced the functioning of the determinants of adaptive capacity and consequently led to the increase of average maize production per acre by 54.5%. This study concludes that agricultural social enterprises such as OAF have the potential to enhance smallholder farmers’ adaptive capacity to climatic stresses, however other stakeholders should come together to support this cause. Keywords  Climatic stresses; Adaptive capacity; Social enterprises; Social entrepreneurshi

Politics and Conflict Management in Manufacturing Organizations and its Implication on National Transformation: a Case of Ajaokuta Iron and Steel Company, Kogi State Nigeria.

The study investigated politics and conflict management in manufacturing organizations and its implication on National transformation with particular reference to Ajaokuta Iron and Steel company.  Four research questions were articulated and four hypotheses were formulated to guided the study.  The study a descriptive survey research design.  The population for study was 1800 workers. 1046 workers in the study constitute the sample for the study.  The instrument for data collection was a 20-item structured questionnaire captioned management of politics and conflict questionnaire (NAPCA).  The instrument was faced and content validated.  Using Pearson moment correlation coefficient, a reliability index of 0.81 was obtained.  The implications of the study was discussed and various recommendations were made as the incidence of communication gap in the management of the organization should be reduced; seminars and workshop on conflict management staff and experts in conflict management should be invited and resource person to discuss the subject matter intensively. Keywords: Politics; Conflicts; Management; National and Transformatio

Effects of Biochar on Soil Fertility and Crop Yields: Experience from the Southern Highlands of Tanzania

The world’s agricultural production is declining due to severe loss of soil fertility through natural processes or because of human activities. Biochar has been identified as a potential soil amendment to regain its fertility and increase crop productivity. This study aimed to assess the effects of biochar on soil nutrients and crop yields in the southern highlands of Tanzania. Data were collected through key informant and household interviews, and from sampling of soils in coffee farms where biochar of maize cobs origin was incorporated at the rate of 3 t ha-1. Purposive sampling approach was deployed to identify the villages in which farmers have been incorporating biochar in farms. A total of 172 households, 30 key informants, and 12 top and subsoil samples were involved in this study. Quantitative data were analyzed using SPSS version 20, and excel spreadsheet was used for descriptive results and relationships. The findings revealed that biochar significantly increased soil pH, iron (Fe), organic carbon (OC), cation exchange capacity (CEC) and exchangeable bases (potassium-K, magnesium-Mg). T - tests showed significant increase of soil nutrients in biochar treated soils. In addition, biochar increased coffee and maize yields from 1 t ha-1 to 3 t ha-1. Keywords: Biochar; Soil Nutrients; Food Security; Resilience; Adaptatio

Intravenous artesunate plus Artemisnin based Combination Therapy (ACT) or intravenous quinine plus ACT for treatment of severe malaria in Ugandan children: a randomized controlled clinical trial.

BACKGROUND: Severe malaria is a medical emergency associated with high mortality. Adequate treatment requires initial parenteral therapy for fast parasite clearance followed by longer acting oral antimalarial drugs for cure and prevention of recrudescence. METHODS: In a randomized controlled clinical trial, we evaluated the 42-day parasitological outcomes of severe malaria treatment with intravenous artesunate (AS) or intravenous quinine (QNN) followed by oral artemisinin based combination therapy (ACT) in children living in a high malaria transmission setting in Eastern Uganda. RESULTS: We enrolled 300 participants and all were included in the intention to treat analysis. Baseline characteristics were similar across treatment arms. The median and interquartile range for number of days from baseline to parasite clearance was significantly lower among participants who received intravenous AS (2 (1-2) vs 3 (2-3), P < 0.001). Overall, 63.3% (178/281) of the participants had unadjusted parasitological treatment failure over the 42-day follow-up period. Molecular genotyping to distinguish re-infection from recrudescence was performed in a sample of 127 of the 178 participants, of whom majority 93 (73.2%) had re-infection and 34 (26.8%) had recrudescence. The 42 day risk of recrudescence did not differ with ACT administered. Adverse events were of mild to moderate severity and consistent with malaria symptoms. CONCLUSION: In this high transmission setting, we observed adequate initial treatment outcomes followed by very high rates of malaria re-infection post severe malaria treatment. The impact of recurrent antimalarial treatment on the long term efficacy of antimalarial regimens needs to be investigated and surveillance mechanisms for resistance markers established since recurrent malaria infections are likely to be exposed to sub-therapeutic drug concentrations. More strategies for prevention of recurrent malaria infections in the most at risk populations are needed. TRIAL REGISTRATION: The study was registered with the Pan African Clinical Trial Registry ( PACTR201110000321348 )

Effect of early tranexamic acid administration on mortality, hysterectomy, and other morbidities in women with post-partum haemorrhage (WOMAN): an international, randomised, double-blind, placebo-controlled trial

Background Post-partum haemorrhage is the leading cause of maternal death worldwide. Early administration of tranexamic acid reduces deaths due to bleeding in trauma patients. We aimed to assess the effects of early administration of tranexamic acid on death, hysterectomy, and other relevant outcomes in women with post-partum haemorrhage. Methods In this randomised, double-blind, placebo-controlled trial, we recruited women aged 16 years and older with a clinical diagnosis of post-partum haemorrhage after a vaginal birth or caesarean section from 193 hospitals in 21 countries. We randomly assigned women to receive either 1 g intravenous tranexamic acid or matching placebo in addition to usual care. If bleeding continued after 30 min, or stopped and restarted within 24 h of the first dose, a second dose of 1 g of tranexamic acid or placebo could be given. Patients were assigned by selection of a numbered treatment pack from a box containing eight numbered packs that were identical apart from the pack number. Participants, care givers, and those assessing outcomes were masked to allocation. We originally planned to enrol 15 000 women with a composite primary endpoint of death from all-causes or hysterectomy within 42 days of giving birth. However, during the trial it became apparent that the decision to conduct a hysterectomy was often made at the same time as randomisation. Although tranexamic acid could influence the risk of death in these cases, it could not affect the risk of hysterectomy. We therefore increased the sample size from 15 000 to 20 000 women in order to estimate the effect of tranexamic acid on the risk of death from post-partum haemorrhage. All analyses were done on an intention-to-treat basis. This trial is registered with ISRCTN76912190 (Dec 8, 2008); ClinicalTrials.gov, number NCT00872469; and PACTR201007000192283. Findings Between March, 2010, and April, 2016, 20 060 women were enrolled and randomly assigned to receive tranexamic acid (n=10 051) or placebo (n=10 009), of whom 10 036 and 9985, respectively, were included in the analysis. Death due to bleeding was significantly reduced in women given tranexamic acid (155 [1·5%] of 10 036 patients vs 191 [1·9%] of 9985 in the placebo group, risk ratio [RR] 0·81, 95% CI 0·65–1·00; p=0·045), especially in women given treatment within 3 h of giving birth (89 [1·2%] in the tranexamic acid group vs 127 [1·7%] in the placebo group, RR 0·69, 95% CI 0·52–0·91; p=0·008). All other causes of death did not differ significantly by group. Hysterectomy was not reduced with tranexamic acid (358 [3·6%] patients in the tranexamic acid group vs 351 [3·5%] in the placebo group, RR 1·02, 95% CI 0·88–1·07; p=0·84). The composite primary endpoint of death from all causes or hysterectomy was not reduced with tranexamic acid (534 [5·3%] deaths or hysterectomies in the tranexamic acid group vs 546 [5·5%] in the placebo group, RR 0·97, 95% CI 0·87-1·09; p=0·65). Adverse events (including thromboembolic events) did not differ significantly in the tranexamic acid versus placebo group. Interpretation Tranexamic acid reduces death due to bleeding in women with post-partum haemorrhage with no adverse effects. When used as a treatment for postpartum haemorrhage, tranexamic acid should be given as soon as possible after bleeding onset. Funding London School of Hygiene & Tropical Medicine, Pfizer, UK Department of Health, Wellcome Trust, and Bill & Melinda Gates Foundation

Adjunctive rifampicin for Staphylococcus aureus bacteraemia (ARREST): a multicentre, randomised, double-blind, placebo-controlled trial.

BACKGROUND: Staphylococcus aureus bacteraemia is a common cause of severe community-acquired and hospital-acquired infection worldwide. We tested the hypothesis that adjunctive rifampicin would reduce bacteriologically confirmed treatment failure or disease recurrence, or death, by enhancing early S aureus killing, sterilising infected foci and blood faster, and reducing risks of dissemination and metastatic infection. METHODS: In this multicentre, randomised, double-blind, placebo-controlled trial, adults (≥18 years) with S aureus bacteraemia who had received ≤96 h of active antibiotic therapy were recruited from 29 UK hospitals. Patients were randomly assigned (1:1) via a computer-generated sequential randomisation list to receive 2 weeks of adjunctive rifampicin (600 mg or 900 mg per day according to weight, oral or intravenous) versus identical placebo, together with standard antibiotic therapy. Randomisation was stratified by centre. Patients, investigators, and those caring for the patients were masked to group allocation. The primary outcome was time to bacteriologically confirmed treatment failure or disease recurrence, or death (all-cause), from randomisation to 12 weeks, adjudicated by an independent review committee masked to the treatment. Analysis was intention to treat. This trial was registered, number ISRCTN37666216, and is closed to new participants. FINDINGS: Between Dec 10, 2012, and Oct 25, 2016, 758 eligible participants were randomly assigned: 370 to rifampicin and 388 to placebo. 485 (64%) participants had community-acquired S aureus infections, and 132 (17%) had nosocomial S aureus infections. 47 (6%) had meticillin-resistant infections. 301 (40%) participants had an initial deep infection focus. Standard antibiotics were given for 29 (IQR 18-45) days; 619 (82%) participants received flucloxacillin. By week 12, 62 (17%) of participants who received rifampicin versus 71 (18%) who received placebo experienced treatment failure or disease recurrence, or died (absolute risk difference -1·4%, 95% CI -7·0 to 4·3; hazard ratio 0·96, 0·68-1·35, p=0·81). From randomisation to 12 weeks, no evidence of differences in serious (p=0·17) or grade 3-4 (p=0·36) adverse events were observed; however, 63 (17%) participants in the rifampicin group versus 39 (10%) in the placebo group had antibiotic or trial drug-modifying adverse events (p=0·004), and 24 (6%) versus six (2%) had drug interactions (p=0·0005). INTERPRETATION: Adjunctive rifampicin provided no overall benefit over standard antibiotic therapy in adults with S aureus bacteraemia. FUNDING: UK National Institute for Health Research Health Technology Assessment

The James Webb Space Telescope Mission

Twenty-six years ago a small committee report, building on earlier studies, expounded a compelling and poetic vision for the future of astronomy, calling for an infrared-optimized space telescope with an aperture of at least $4m$. With the support of their governments in the US, Europe, and Canada, 20,000 people realized that vision as the $6.5m$ James Webb Space Telescope. A generation of astronomers will celebrate their accomplishments for the life of the mission, potentially as long as 20 years, and beyond. This report and the scientific discoveries that follow are extended thank-you notes to the 20,000 team members. The telescope is working perfectly, with much better image quality than expected. In this and accompanying papers, we give a brief history, describe the observatory, outline its objectives and current observing program, and discuss the inventions and people who made it possible. We cite detailed reports on the design and the measured performance on orbit.Comment: Accepted by PASP for the special issue on The James Webb Space Telescope Overview, 29 pages, 4 figure