Don Angus: Lanzamiento de productos y Organización de evento

Este trabajo de fin de grado (TFG) ha consistido en la Organización de un evento y el lanzamiento de productos para la empresa Don Angus. Esta propuesta tiene como objetivo la organización de dicho evento, basándonos en nueve pasos fundamentales como son: la designación de la titularidad del evento, especificación del carácter del acto, identificación de los objetivos, definición del mensaje, la elaboración de listados de invitados, armonización entre anfitrionazgo, presidencia y precedencias, elección del lugar y el momento, distribución de espacios y tiempos y evaluación final. La organización de este evento nos llevará a alcanzar dos objetivos secundarios. El aumento de la notoriedad de la empresa Don Angus, actualizando sus redes sociales y creando contenido específico y, posteriormente, alcanzar un mayor número de ventas. Apoyado todo esto como bien hemos mencionado por la presencia en redes sociales y en internet mediante la web creada.Universidad de Sevilla. Grado en Publicidad y Relaciones Pública

The output effects of tax changes : narrative evidence from Spain

En este artículo estimamos el efecto sobre el PIB de los cambios impositivos a partir de una base datos narrativa que hemos construido para el periodo 1986-2015. La estimación base muestra que un aumento de los impuestos equivalente al 1 % del PIB reduce el producto un 1,3 % después de un añotendiendo este efecto a desaparecer en horizontes más amplios. Los resultados también muestran que el efecto de la imposición indirecta es mayor y que, después de un aumento impositivo, la inversión reacciona más que el consumo. En su conjunto, nuestra estimaciones sugieren que los aumentos impositivos tienen consecuencias negativas sobre el PIB. No obstante, el grado de caída del producto está sujeto a incertidumbre, ya que las bandas de confianza son amplias. Este resultado está en línea con la literatura narrativa para otros paísesThis paper estimates the GDP impact of legislated tax changes in Spain using a newly constructed narrative record for the period 1986-2015. Our baseline estimates suggest that a 1% of GDP increase in exogenous taxes depresses output by around 1.3% after one year, this negative effect fading away at more distant horizons. We also find that the effect of changes in indirect taxes are larger and that, following a tax increase, investment reacts more than consumption. Overall, our set of estimates is consistent with negative output effects triggered by tax increases, yet the quantitative effects are subject to non-negligible uncertainty that is refected in wide confidence bands, in line with the extant literature for other countrie

Genetic biomarkers in osteoarthritis: a quick overview

[Abstract] Osteoarthritis (OA) is a chronic musculoskeletal disease with a polygenic and heterogeneous nature. In addition, when clinical manifestations appear, the evolution of the disease is usually already irreversible. Therefore, the efforts on OA research are focused mainly on the discovery of therapeutic targets and reliable biomarkers that permit the early identification of different OA-related parameters such as diagnosis, prognosis, or phenotype identification. To date, potential candidate protein biomarkers have been associated with different aspects of the disease; however, there is currently no gold standard. In this sense, genomic data could act as complementary biomarkers of diagnosis and prognosis or even help to identify therapeutic targets of the disease. In this review, we will describe the most recent advances in genetic biomarkers in OA over the past three years.Instituto de Salud Carlos III; PI17/00210Instituto de Salud Carlos III; PI16/02124Instituto de Salud Carlos III; PI20/00614Instituto de salud Carlos III; RETIC-RIER-RD16/0012/0002Instituto de Salud Carlos III; PRB3-ISCIII-PT17/0019/0014Xunta de Galicia; IN607A2017/1

Mitochondrial genetics and epigenetics in osteoarthritis

Review[Abstract] During recent years, the significant influence of mitochondria on osteoarthritis (OA), the most common joint disease, has been consistently demonstrated. Not only mitochondrial dysfunction but also mitochondrial genetic polymorphisms, specifically the mitochondrial DNA haplogroups, have been shown to have an important influence on different OA-related features, including the prevalence, severity, incidence, and progression of the disease. This influence could probably be mediated by the role of mitochondria in the regulation of different processes involved in the pathogenesis of OA, such as energy production, the generation of reactive oxygen and nitrogen species, apoptosis, and inflammation. The regulation of these processes is at least partially controlled by the bi-directional communication between the nucleus and mitochondria, which permits the regulation of adaptation to a wide range of stressors and the maintenance of cellular homeostasis. This bi-directional communication consists of an “anterograde regulation” by which the nucleus regulates mitochondrial biogenesis and activity and a “retrograde regulation” by which both mitochondria and mitochondrial genetic variation exert a regulatory signaling control over the nuclear epigenome, which leads to the modulation of nuclear genes. Throughout this mini review, we will describe the evidence that demonstrates the profound influence of the mitochondrial genetic background in the pathogenesis of OA, as well as its influence on the nuclear DNA methylome of the only cell type present in the articular cartilage, the chondrocyte. This evidence leads to serious consideration of the mitochondrion as an important therapeutic target in OA.Instituto de Salud Carlos III; CIBERCB06/01/0040Instituto de Salud Carlos III; RETIC-RIER-RD16/0012/0002Instituto de Salud Carlos III; PRB2-ISCIII-PT17/0019/0014Instituto de Salud Carlos III; PI14/01254Instituto de Salud Carlos III; PI16/02124Instituto de Salud Carlos III; PI17/00210Instituto de Salud Carlos III; (CPII17/00026

An active tectonic field for CO2 storage management: the Hontomín onshore case study (Spain)

One of the concerns of underground CO2 onshore storage is the triggering of induced seismicity and fault reactivation by the pore pressure increasing. Hence, a comprehensive analysis of the tectonic parameters involved in the storage rock formation is mandatory for safety management operations. Unquestionably, active faults and seal faults depicting the storage bulk are relevant parameters to be considered. However, there is a lack of analysis of the active tectonic strain field affecting these faults during the CO2 storage monitoring. The advantage of reconstructing the tectonic field is the possibility to determine the strain trajectories and describing the fault patterns affecting the reservoir rock. In this work, we adapt a methodology of systematic geostructural analysis to underground CO2 storage, based on the calculation of the strain field from kinematics indicators on the fault planes (ey and ex for the maximum and minimum horizontal shortening, respectively). This methodology is based on a statistical analysis of individual strain tensor solutions obtained from fresh outcrops from the Triassic to the Miocene. Consequently, we have collected 447 fault data in 32 field stations located within a 20 km radius. The understanding of the fault sets’ role for underground fluid circulation can also be established, helping further analysis of CO2 leakage and seepage. We have applied this methodology to Hontomín onshore CO2 storage facilities (central Spain). The geology of the area and the number of high-quality outcrops made this site a good candidate for studying the strain field from kinematics fault analysis. The results indicate a strike-slip tectonic regime with maximum horizontal shortening with a 160 and 50◦ E trend for the local regime, which activates NE–SW strike-slip faults. A regional extensional tectonic field was also recognized with a N–S trend, which activates N–S extensional faults, and NNE–SSW and NNW– SSE strike-slip faults, measured in the Cretaceous limestone on top of the Hontomín facilities. Monitoring these faults within the reservoir is suggested in addition to the possibility of obtaining a focal mechanism solutions for microearthquakes (M < 3)This work has been partially supported by the European Project ENOS: ENabling Onshore CO2 Storage in Europe, H2020 Project ID: 653718 and the Spanish project 3GEO, CGL2017-83931-C3-2-P, MICIU-FEDE

Longitudinal Growth Curve Trajectories of Family Dynamics after Pediatric Traumatic Brain Injury in Mexico

Pediatric traumatic brain injury (TBI) represents a serious public health concern. Family members are often caregivers for children with TBI, which can result in a significant strain on familial relationships. Research is needed to examine aspects of family functioning in the context of recovery post-TBI, especially in Latin America, where cultural norms may reinforce caregiving by family members, but where resources for these caregivers may be scarce. This study examined caregiver-reported family satisfaction, communication, cohesion, and flexibility at three time points in the year post-injury for 46 families of a child with TBI in comparison to healthy control families. Families experiencing pediatric TBI were recruited from a large hospital in Guadalajara, Mexico, while healthy controls were recruited from a local educational center. Results from multilevel growth curve models demonstrated that caregivers of children with a TBI reported significantly worse family functioning than controls at each assessment. Families experiencing pediatric TBI were unable to attain the level of functioning of controls during the time span studied, suggesting that these families are likely to experience long-term disruptions in family functioning. The current study highlights the need for family-level intervention programs to target functioning for families affected by pediatric TBI who are at risk for difficulties within a rehabilitation context.This study was supported by the Department of Veterans Affairs Office of Academic Affiliations Advanced Fellowship Program in Mental Illness Research and Treatment, the Medical Research Service of the Veterans Affairs Central Virginia Health Care System, and the Department of Veterans Affairs Mid-Atlantic Mental Illness Research, Education, and Clinical Center (MIRECC). Ramos-Usuga, D. was supported by a predoctoral fellowship from the Basque Government (PRE_2019_1_0164)

Oleate prevents palmitate-induced mitochondrial dysfunction in chondrocytes

[Abstract] The association between obesity and osteoarthritis (OA) in joints not subjected to mechanical overload, together with the relationship between OA and metabolic syndrome, suggests that there are systemic factors related to metabolic disorders that are involved in the metabolic phenotype of OA. The aim of this work is study the effects of palmitate and oleate on cellular metabolism in an “in vitro” model of human chondrocytes. The TC28a2 chondrocyte cell line was used to analyze the effect of palmitate and oleate on mitochondrial and glycolytic function, Adenosine triphosphate (ATP) production and lipid droplets accumulation. Palmitate, but not oleate, produces mitochondrial dysfunction observed with a lower coupling efficiency, maximal respiration and spare respiratory capacity. Glycolytic function showed lower rates both glycolytic capacity and glycolytic reserve when cells were incubated with fatty acids (FAs). The production rate of total and mitochondrial ATP showed lower values in chondrocytes incubated with palmitic acid (PA). The formation of lipid droplets increased in FA conditions, being significantly higher when the cells were incubated with oleic acid (OL). These results may help explain, at least in part, the close relationship of metabolic pathologies with OA, as well as help to elucidate some of the factors that can define a metabolic phenotype in OA.Instituto de Salud Carlos III; PI14/01254Instituto de Salud Carlos III; PI16/02124Instituto de Salud Carlos III; RETIC-RIER-RD16/0012/0002Instituto de Salud Carlos III; PRB3-ISCIII-PT17/0019/0014Xunta de Galicia; IN607A2017/1

Effect of marine heat waves on carbon metabolism, optical characterization, and bioavailability of dissolved organic carbon in coastal vegetated communities

Dissolved organic carbon (DOC) plays an essential role in the global marine carbon cycle, with coastal vegetated communities as important DOC producers. However, the ultimate fate of this DOC remains still largely unknown due to the lack of knowledge about its chemical composition and lability. Furthermore, global change could alter both DOC fluxes and its bioavailability, affecting the carbon sequestration capacity of coastal vegetated communities. This study explores, in two contrasting seasons (winter and summer), the effects of an in situ simulated marine heatwave on carbon metabolism and DOC fluxes produced by seagrass (Cymodocea nodosa) and macroalgae (Caulerpa prolifera) communities. In addition, the fluorescent characteristics and biodegradability of the dissolved organic matter released directly by the communities under such conditions are evaluated. Under marine heatwave conditions, a significant increase in net community production (NCP) in C. nodosa and a shift to negative DOC fluxes in C. prolifera were observed. In control treatments, the seagrass-dominated community produced a substantial amount of labile (between 44% and 58%) and recalcitrant DOC (between 42% and 56%), while C. prolifera community produced mainly recalcitrant DOC (between 64% and 87%). Therefore, this research revealed that temperature is an important factor determining the NCP in benthic communities and the chemical structure and bioavailability of DOC produced by these communities, since both communities tended to produce more humic-like and less bioavailable DOC with increasing temperature. © 2022 The Authors. Limnology and Oceanography published by Wiley Periodicals LLC on behalf of Association for the Sciences of Limnology and Oceanography

Síndrome de overlap: hepatitis autoinmune - cirrosis biliar primaria. Reporte de caso clínico

Autoimmune liver diseases are characterized by an abnormal immune response directed to the hepatocytes or bile ducts. Its implications are provoked by chronic liver damage with fibrosis and cirrhosis. Autoimmune hepatitis (AIH) is characterized by hepatocellular damage and primary biliary cirrhosis (PBC) due to cholestasis. The overlap syndromes include a subgroup of patients diagnosed with AIH, but with characteristics of PBC, in addition to analytical, chemical and histological findings. We present the case of a 53-year-old woman admitted to the emergency department with a 7-day clinical course consisting of emesis, pain in the right hypochondrium, unquantified fever, and fetid diarrhea and no mucus. It also refers to progressive weight loss of about 11kg in the last year. With a family history of cholangiocarcinoma on the part of the brother and gastric adenocarcinoma on the part of the mother. No toxic background of alcohol or cigarette. Abdominal ultrasound shows chronic cholecystitis with cholelithiasis and there is dilation in the extrahepatic bile duct. Clinical, serological, immunological, imaging and histopathological studies show characteristics of an active chronic hepatitis with autoimmune etiology vs primary biliary cirrhosis.Las enfermedades hepáticas autoinmunes son enfermedades caracterizadas por una respuesta inmune anormal dirigida a los hepatocitos o conductos biliares. Sus implicaciones se desencadenan en daño hepático crónico con fibrosis y cirrosis. La hepatitis autoinmune (HAI) se caracteriza por daño hepatocelular y la cirrosis biliar primaria (CBP) por una colestasis. Los síndromes de sobreposición abarcan un subgrupo de pacientes diagnosticados con HAI, pero con características de CBP, además de hallazgos analíticos, químicos e histológicos. Presentamos el caso de una mujer de 53 años que ingresó al servicio de urgencias con un cuadro clínico de evolución de 7 días consistente en emesis, dolor en el hipocondrio derecho, fiebre no cuantificada, y deposiciones diarreicas fétidas sin presencia de moco. Refiere, además, pérdida de peso progresiva de unos 11kg en el último año. Con antecedentes familiares de colangiocarcinoma por parte del hermano y adenocarcinoma gástrico por parte de la mamá. Sin antecedentes tóxicos de alcohol ni cigarrillo. En la ecografía abdominal se evidencia colecistitis crónica con colelitiasis y hay presencia de dilatación en la vía biliar extra-hepática. Los estudios clínicos, serológicos, inmunológicos, imagenológicos e histopatológicos evidencian características de una hepatitis crónica activa con etiología autoinmune vs cirrosis biliar primaria.&nbsp