2,783 research outputs found
Coordination polymers and isomerism; a study using silver(I) and a â-stacked ligand
The ligand 2,5-bis(2-pyridylmethylsulfanylmethyl)pyrazine (L) was prepared by the base coupling of 2-(sulfanylmethyl)pyridine and 2,5-bis(chloromethyl)pyrazine. This new ligand was treated with AgClOâ in a 1 1 metal-to-ligand ratio and with AgNOâin a 2 1 metal-to-ligand ratio to give coordination polymers. The crystal structures of {[Ag(L)]ClOâ}â ( 1) and {[Agâ(L)](NOâ)â}â ( 2) were determined. The Ag(I) ions in the one-dimensional polymeric chains of 1 adopted square-pyramidal geometries with the pyridine and pyrazine N donors coordinated in an extremely bent fashion. The structure of 2 revealed two isomeric polymer chains in the one crystal forming a single supramolecular array. The isomeric polymers differed in the donor atoms about the Ag(I) ions and in the arrangement of adjacent ligands along the chain. A feature of both structures was that L adopted a three-layer â-stacked arrangement
joineR: Joint modelling of repeated measurements and time-to-event data
The joineR package implements methods for analysing data from longitudinal studies in which the response
from each subject consists of a time-sequence of repeated measurements and a possibly censored time-toevent
outcome. The modelling framework for the repeated measurements is the linear model with random
effects and/or correlated error structure. The model for the time-to-event outcome is a Cox proportional
hazards model with log-Gaussian frailty. Stochastic dependence is captured by allowing the Gaussian
random effects of the linear model to be correlated with the frailty term of the Cox proportional hazards
model
Framework Programmable Platform for the Advanced Software Development Workstation: Preliminary system design document
The Framework Programmable Software Development Platform (FPP) is a project aimed at combining effective tool and data integration mechanisms with a model of the software development process in an intelligent integrated software environment. Guided by the model, this system development framework will take advantage of an integrated operating environment to automate effectively the management of the software development process so that costly mistakes during the development phase can be eliminated. The focus here is on the design of components that make up the FPP. These components serve as supporting systems for the Integration Mechanism and the Framework Processor and provide the 'glue' that ties the FPP together. Also discussed are the components that allow the platform to operate in a distributed, heterogeneous environment and to manage the development and evolution of software system artifacts
Assembling life history narratives from quantitative longitudinal panel data: whatâs the story for families using social work?
Embedded within quantitative longitudinal panel or cohort studies is narrative potential that is arguably untapped but might enrich our understanding of individual and social lives across time. This paper discusses a methodology to assemble the life history narratives of families using social work by drawing on quantitative data from the British Household Panel Survey. It explores whether this person-centred approach helps us to understand the counterintuitive results of a parallel multivariate analyses, which suggest that families using social work fare worse than similar others over time. Our findings are tentative, due to the experimental use of this narrative method and the limits of social work information in the dataset. Nonetheless, the life histories presented bring to light complexities, diversity and the non-linear pathways between familiesâ needs, support and outcomes that the aggregates obscure. We conclude that reconstructing familiesâ lives in this way, especially in the absence of complementary longitudinal qualitative data, affords the wider opportunity to interrogate and better understand the findings of quantitative longitudinal studies
Executive functions and functional impairment in Latin seniors suffering from depression
Functional impairment (FI) relates to the condition of executive functions (EFs). While EFs become affected by age and educational level (EL). Seniors suffering from depression (SSDs) on the other hand show EF-related deficiencies; however, there is hardly any literature available regarding their relationship with FI in Latin SSDs, who usually have low ELs.
Objective: To verify the relationship between EFs and FI in SSDs of Latin origins, by controlling the effects associated with age and educational level.
Methodology: Cross-sectional study, of cases and controls, conducted on a nonprobability sample, made up of 102 self-sufficient SSDs and 142 control subjects over age 50, monolinguals of Latin origin (Chileans), all assessed by means of a battery of assessments such as: Geriatric Depression Scale, Addenbrook's Cognitive Assessment III, Trail making Tests A and B, STROOP word-color test, and semantic and phonological verbal fluency tests. A domain of composite EFs was established with standardized Chilean population scores, where age and educational levels were controlled. A simple linear regression analysis was conducted to determine the relationship between EFs and FI in SSDs.
Results: Upon controlling age and educational levels, EFs explained an FI variance of 3.9% in SSDs; depression explained an EF variance of 3.2%, and 3.7% of FI.
Conclusion: The results of the present study highlight the importance of a timely intervention when it comes to geriatric depression, considering the negative effect it has over the executive functions and the functionality of seniors
Utilização do sistema especialista para diagnóstico de obesidade infantil em uma creche no DF / Use of the specialist system for diagnosis of childhood obesity in a creche in the DF
O Sistema Especialista (SE) estĂĄ sendo utilizado para facilitar o diagnĂłstico nutricional da Obesidade Infantil, sendo utilizado o Shell Expert Sinta, que Ă© considerado uma plataforma que utiliza regras de produção, para modelar o conhecimento humano. Ă uma ferramenta que trabalha com tĂ©cnicas da InteligĂȘncia Artificial para gerar automaticamente esse SE. A obesidade Infantil Ă© considerada um grave problema de saĂșde pĂșblica e vem crescendo assustadoramente. Existem vĂĄrios fatores de risco, como hĂĄbitos alimentares errĂŽneos, fatores genĂ©ticos e fator atividade fĂsica, aumentando assim as chances de obesidade, principalmente nas crianças. O SE, o Expert Sinta, foi desenvolvido por regras de produção a partir de variĂĄveis, baseadas nos fatores de risco da obesidade infantil e tambĂ©m na avaliação nutricional de medidas antropomĂ©tricas como peso/altura, onde no SE sĂŁo lançadas variĂĄveis e regras e ao solicitarem um resultado ao programa, ele gera perguntas, facilitando o diagnĂłstico nutricional da obesidade infantil, ou seja, o SE responde se estĂĄ Obeso Infantil ou nĂŁo. Logo, a pesquisa desenvolvida em uma creche no DF, apresenta uma mĂ©dia no perfil de 96 crianças, sendo que 5,2% foram diagnosticadas com obesidade e 15,62% com sobrepeso, o que significa que essa implantação do SE no Expert Sinta Ă© importante, pois a partir dessa detecção, pode-se começar a reeducação alimentar infantil e os que apresentam sobrepeso, mesmo nĂŁo sendo enfoque da pesquisa, realizada a prevenção e reeducação alimentar, menores serĂŁo as chances de crescimentos dos nĂșmeros de crianças obesas.
Rates, causes, place and predictors of mortality in adults with intellectual disabilities with and without Down syndrome : cohort study with record linkage
Funding: UK Medical Research Council, grant number: MC_PC_17217), and the Scottish Government via the Scottish Learning Disabilities Observatory.Objectives To investigate mortality in adults with intellectual disabilities: rates, causes, place, demographic and clinical predictors. Design Cohort study with record linkage to death data. Setting General community. Participants 961/1023 (94%) adults (16â83 years; mean=44.1 years; 54.6% male) with intellectual disabilities, clinically examined in 2001â2004; subsequently record-linked to their National Health Service number, allowing linkage to death certificate data, 2018. Outcome measures Standardised mortality ratios (SMRs), underlying and all contributing causes of death, avoidable deaths, place, and demographic and clinical predictors of death. Results 294/961 (30.6%) had died; 64/179 (35.8%) with Down syndrome, 230/783 (29.4%) without Down syndrome. SMR overall=2.24 (1.98, 2.49); Down syndrome adults=5.28 (3.98, 6.57), adults without Down syndrome=1.93 (1.68, 2.18); male=1.69 (1.42, 1.95), female=3.48 (2.90, 4.06). SMRs decreased as age increased. More severe intellectual disabilities increased SMR, but ability was not retained in the multivariable model. SMRs were higher for most International Statistical Classification of Diseases and Related Health Problems, 10th Revision chapters. For adults without Down syndrome, aspiration/reflux/choking and respiratory infection were the the most common underlying causes of mortality; for Down syndrome adults âDown syndromeâ, and dementia were most common. Amenable deaths (29.8%) were double that in the general population (14%); 60.3% died in hospital. Mortality risk related to percutaneous endoscopic gastrostomy/tube fed, Down syndrome, diabetes, lower respiratory tract infection at cohort-entry, smoking, epilepsy, hearing impairment, increasing number of prescribed drugs, increasing age. Bowel incontinence reduced mortality risk. Conclusions Adults with intellectual disabilities with and without Down syndrome have different SMRs and causes of death which should be separately reported. Both die younger, from different causes than other people. Some mortality risks are similar to other people, with earlier mortality reflecting more multimorbidity; amenable deaths are also common. This should inform actions to reduce early mortality, for example, training to avoid aspiration/choking, pain identification to address problems before they are advanced, and reasonable adjustments to improve healthcare quality.Publisher PDFPeer reviewe
Quantum Correlations in Multipartite Quantum Systems
We review some concepts and properties of quantum correlations, in particular
multipartite measures, geometric measures and monogamy relations. We also
discuss the relation between classical and total correlationsComment: to be published as a chapter of the book "Lectures on general quantum
correlations and their applications" edited by F. Fanchini, D. Soares-Pinto,
and G. Adesso (Springer, 2017
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