The Finslerian quantum cosmology

We present a Friedmann-Robertson-Walker (FRW) quantum cosmological model within the framework of Finslerian geometry. In this work, we consider a specific fluid. We obtain the corresponding Wheeler-DeWitt equation as the usual constraint equation as well as Schr\"odinger equation following Dirac, although the approaches yields the same equation of time independent equation for the wave function of the universe. We provide exact classical and quantum mechanical solutions. We use the eigenfunctions to study the time evolution of the expectation value of the scale factor. Finally we discuss the physical meaning of the results.Comment: To appear in Can.J.Phy

Long-Term Survivors of Childhood Cancer: The Late Effects of Therapy

The overall cure rate for pediatric malignancies is significantly improved to over 75% with an estimated 270,000 survivors of childhood cancer in the United States currently. The achievement of high cure rates for most pediatric malignancies has been accompanied by a growing population of childhood cancer survivors who are at an increased risk for a myriad of health problems resulting from their cancer or its treatment. Some cancer-related complications do not become apparent until several years following cancer treatment. As the survivors of childhood cancers age, the effects of therapy may be exacerbated by effects of aging on organ function. Late effects encompass a variety of detrimental conditions including organ dysfunction, psychosocial complications, and subsequent malignancies that may negatively impact quality of life and may predispose them to early mortality. In contrast to the multitude of publications describing treatment-related sequelae in childhood cancer survivors, relatively few provide specific recommendations for health screening and risk-reduction counseling to guide healthcare providers in monitoring this vulnerable population. In this chapter, we will summarize the evaluation and management of childhood cancer survivors who may be encountered across a wide variety of healthcare settings, salient issues influencing healthcare for childhood cancer survivors, of which guidelines currently available and limitations in current practice

The Finslerian compact star model

We construct a toy model for compact stars based on the Finslerian structure of spacetime. By assuming a particular mass function, we find an exact solution of the Finsler-Einstein field equations with an anisotropic matter distribution. The solutions are revealed to be physically interesting and pertinent for the explanation of compact stars.Comment: Published in Eur.Phys.J.

The Finslerian wormhole models

We present models of wormhole under the Finslerian structure of spacetime. This is a sequel of our previous work (Eur Phys J 75:564, 2015) where we constructed a toy model for compact stars based on the Finslerian spacetime geometry. In the present investigation, a wide variety of solutions are obtained that explore wormhole geometry by considering different choices for the form function and energy density. The solutions, like the previous work, are revealed to be physically interesting and viable models for the explanation of wormholes as far as the background theory and literature are concerned.Comment: 9 pages and 7 figue

VEuPathDB: the eukaryotic pathogen, vector and host bioinformatics resource center in 2023.

The Eukaryotic Pathogen, Vector and Host Informatics Resource (VEuPathDB, https://veupathdb.org) is a Bioinformatics Resource Center funded by the National Institutes of Health with additional funding from the Wellcome Trust. VEuPathDB supports >600 organisms that comprise invertebrate vectors, eukaryotic pathogens (protists and fungi) and relevant free-living or non-pathogenic species or hosts. Since 2004, VEuPathDB has analyzed omics data from the public domain using contemporary bioinformatic workflows, including orthology predictions via OrthoMCL, and integrated the analysis results with analysis tools, visualizations, and advanced search capabilities. The unique data mining platform coupled with >3000 pre-analyzed data sets facilitates the exploration of pertinent omics data in support of hypothesis driven research. Comparisons are easily made across data sets, data types and organisms. A Galaxy workspace offers the opportunity for the analysis of private large-scale datasets and for porting to VEuPathDB for comparisons with integrated data. The MapVEu tool provides a platform for exploration of spatially resolved data such as vector surveillance and insecticide resistance monitoring. To address the growing body of omics data and advances in laboratory techniques, VEuPathDB has added several new data types, searches and features, improved the Galaxy workspace environment, redesigned the MapVEu interface and updated the infrastructure to accommodate these changes

Reducing the environmental impact of surgery on a global scale: systematic review and co-prioritization with healthcare workers in 132 countries

Abstract Background Healthcare cannot achieve net-zero carbon without addressing operating theatres. The aim of this study was to prioritize feasible interventions to reduce the environmental impact of operating theatres. Methods This study adopted a four-phase Delphi consensus co-prioritization methodology. In phase 1, a systematic review of published interventions and global consultation of perioperative healthcare professionals were used to longlist interventions. In phase 2, iterative thematic analysis consolidated comparable interventions into a shortlist. In phase 3, the shortlist was co-prioritized based on patient and clinician views on acceptability, feasibility, and safety. In phase 4, ranked lists of interventions were presented by their relevance to high-income countries and low–middle-income countries. Results In phase 1, 43 interventions were identified, which had low uptake in practice according to 3042 professionals globally. In phase 2, a shortlist of 15 intervention domains was generated. In phase 3, interventions were deemed acceptable for more than 90 per cent of patients except for reducing general anaesthesia (84 per cent) and re-sterilization of ‘single-use’ consumables (86 per cent). In phase 4, the top three shortlisted interventions for high-income countries were: introducing recycling; reducing use of anaesthetic gases; and appropriate clinical waste processing. In phase 4, the top three shortlisted interventions for low–middle-income countries were: introducing reusable surgical devices; reducing use of consumables; and reducing the use of general anaesthesia. Conclusion This is a step toward environmentally sustainable operating environments with actionable interventions applicable to both high– and low–middle–income countries

Rotation Curve and Dark Matter Halo profile in Finsler Geometry

Galactic dark matter is an active area of research in recent time. Several researchers proposed several descriptions of radial profiles of dark matter halos by using N-body simulations. Among them, Navarro, Frenk and White (NFW) dark matter profile provides the most accurate description of dark matter halos. It is believed that dark matter is smooth and distributed uniformly throughout space. Using Finslerian geometrical background and a specific equation of state, we propose a new way to estimate the rotational velocity of galaxies based on the NFW dark matter profile. On small scales the first few distances (about 30 kpc) the velocity increases whereas in the outer region of the galaxies, the rotational velocity is found to be more or less constant which supports observed rotational velocities.The accepted manuscript in pdf format is listed with the files at the bottom of this page. The presentation of the authors' names and (or) special characters in the title of the manuscript may differ slightly between what is listed on this page and what is listed in the pdf file of the accepted manuscript; that in the pdf file of the accepted manuscript is what was submitted by the author