11,248 research outputs found

    Legal Deposit Web Archives and the Digital Humanities: a Universe of Lost Opportunity?

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    Legal deposit libraries have archived the web for over a decade. Several nations, supported by legal deposit regu-lations, have introduced comprehensive national domain web crawling, an essential part of the national library re-mit to collect, preserve and make accessible a nation’s intellectual and cultural heritage (Brazier, 2016). Scholars have traditionally been the chief beneficiaries of legal de-posit collections: in the case of web archives, the poten-tial for research extends to contemporary materials, and to Digital Humanities text and data mining approaches. To date, however, little work has evaluated whether legal deposit regulations support computational approaches to research using national web archive data (Brügger, 2012; Hockx-Yu, 2014; Black, 2016). This paper examines the impact of electronic legal deposit (ELD) in the United Kingdom, particularly how the 2013 regulations influence innovative scholarship using the Legal Deposit UK Web Archive. As the first major case study to analyse the implementation of ELD, it will ad-dress the following key research questions:• • Is legal deposit, a concept defined and refined for print materials, the most suitable vehicle for suppor-ting DH research using web archives? • How does the current framing of ELD affect digital in-novation in the UK library sector? • How does the current information ecology, including not for-profit archives, influence the relationship between DH researchers and legal deposit libraries

    A casemix analysis of hospital admissions in six specialties for Barking & Havering Health Authority.

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    To examine admission rates for Barking & Havering residents to six surgical specialties by first looking at elective, emergency and total workloads, then at the casemix of elective work using Healthcare Resource Groups. To compare findings to other London areas

    The influence of non-neuronal cells on catecholamine and acetylcholine synthesis and accumulation in cultures of dissociated sympathetic neurons

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    The effects of several non-neuronal cell types on neurotransmitter synthesis in cultures of dissociated sympathetic neurons from the new-born rat were studied. Acetylcholine synthesis from radioactive choline was increased 100- to 1000-fold in the presence of non-neuronal cells from sympathetic ganglia. This increase was roughly dependent on the number of ganglionic non-neuronal cells present. The effect did not appear to be due to an increased plating efficiency of neurons, since the non-neuronal cells were capable of increasing acetylcholine synthesis after only 48-hr contact with neurons that had been previously grown without non-neuronal cells for 2 weeks. C6 rat glioma cells were also able to stimulate acetylcholine synthesis, but 3T3 mouse fibroblast cells had little or no effect. None of the non-neuronal cell types synthesized detectable acetylcholine in the absence of the neurons. The ganglionic non-neuronal cells had no significant effect on catecholamine synthesis (which occurs in the absence of non-neuronal cells)

    Evaluation of the South Yorkshire Restorative Justice programme (SYRJP)

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    The SYRJP was developed in partnership between South Yorkshire Police and the Local Criminal Justice Board (LCJB) with the aim of implementing a county wide model of Restorative Justice (RJ) for use in neighbourhood policing and other community applications. It is aimed at tackling low level crime and anti-social behaviour in neighbourhoods and gives police officers the discretion to use Youth and Adult Restorative disposals as an alternative to prosecution for low level offending behaviour where offenders have no previous convictions, make an admission of guilt and where both offender and victim consent to the RJ process

    Access, delivery and perceived efficacy of physiotherapy and use of complementary and alternative therapies by people with progressive multiple sclerosis in the United Kingdom: an online survey

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    Introduction: All people with progressive MS in the United Kingdom should have access to physiotherapy through the National Health Service (NHS). However levels of access and delivery are unknown. Furthermore there is no research on perceived efficacy of physiotherapy or the use of complementary and alternative medicine in people with progressive MS in the United Kingdom. Methods: An online survey was carried out via the UK MS Register. Inclusion criteria were diagnosis of progressive MS, a member of UK MS Register and 18 years or older. The survey asked participants regarding access and delivery of physiotherapy; perceived efficacy of physiotherapy and interventions received; barriers to accessing physiotherapy and use of complementary and alternative medicine. The following additional data were supplied from the UK MS Register: demographics, EQ5D, MSIS-29 physical and psychological sub-scales and geographical data. Results: Total number of respondents was 1,298 from an identified 2,538 potential registrants: 87% could access physiotherapy services, 77% received physiotherapy from the NHS and 32% were currently receiving physiotherapy. The most common interventions received were home exercise programme (86%), exercises with a physiotherapist (74%) and advice/education (67%). 40% had recently used complementary and alternative medicine. Perceived efficacy of physiotherapy was high with 70% reporting it to be either ‘beneficial’ or ‘very beneficial’. Main barriers to accessing physiotherapy were mobility, fatigue, continence, transport issues, requiring someone to go with them and pain. Discussion: Access to physiotherapy was high with most people reporting it as beneficial. However 13% reported not having access indicating a gap in accessibility. Considering some of the barriers reported may allow physiotherapy services to address this gap in accessibility

    The lin-15 locus encodes two negative regulators of Caenorhabditis elegans vulval development

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    During Caenorhabditis elegans vulval development, an inductive signal from the anchor cell stimulates three of the six vulval precursor cells (VPCs) to adopt vulval rather than nonvulval epidermal fates. Genes necessary for this induction include the lin-3 growth factor, the let-23 receptor tyrosine kinase, and let-60 ras. lin-15 is a negative regulator of this inductive pathway. In lin-15 mutant animals, all six VPCs adopt vulval fates, even in the absence of inductive signal. Previous genetic studies suggested that lin-15 is a complex locus with two independently mutable activities, A and B. We have cloned the lin-15 locus by germline transformation and find that it encodes two nonoverlapping transcripts that are transcribed in the same direction. The downstream transcript encodes the lin-15A function; the upstream transcript encodes the lin-15B function. The predicted lin-15A and lin- 15B proteins are novel and hydrophilic. We have identified a molecular null allele of lin-15 and have used it to analyze the role of lin-15 in the signaling pathway. We find that lin-15 acts upstream of let-23 and in parallel to the inductive signal

    Understanding occupational regulation

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    Sustainable Palm Oil Supply Chains : Complexity, Custody and Contention

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    Paper delivered at the 21st Logistics Research Network annual conference 2016, 7th-9th September 2016, Hull. Abstract Purpose: The sustainability of oil palm cultivation is highly contentious. Demand for the product is strong, albeit with the market being largely divided between the bulk sale of oil to Asian markets and premium certified sustainable palm products to Europe. These disparate end-user markets place different production demands on upstream suppliers. This paper will explore the complex and contentious nature of sustainability in the context of the palm oil supply chain. Specifically, this study considers the economic, ethical and environmental aspects emerging from efforts to create sustainable palm oil supply chains with a view to developing supply chain ‘regulation without government’ as a possible solution. Research Approach: Case-based research involved empirical observation of upstream actors, document analysis and consequent theory testing through semi-structured interviews with growers, mills, refiners, certifiers of sustainable palm oil, NGOs, retailers and leading European manufacturers of palm oil containing products. Findings and Originality: Different interpretations of sustainability have created conflict at the point of production with what are perceived to be Western values regularly conflicting with the perceived needs of palm oil producing countries. Traceable supply chain custodies created by large downstream manufacturers may isolate smallholders and reduce their ability to be incorporated into some certification schemes. Though downstream actors can pay a significant value-chain premium for certified products, due to a wider lack of global demand for certified palm oil, sustainable products are ending up in other supply chains with no premium being paid to growers. Research Impact: The presented study is relatively unique in palm oil research for its empirical grounding, bringing together the first-hand insight, thoughts and perceptions of stakeholders throughout the supply chain. Additionally, this paper contributes to the reactive-proactive continuum theory for sustainable supply chain practices by discussing how key stakeholders influence behaviour. Practical Impact: Insights from this research will help raise awareness of the supply chain dynamics of the palm oil industry, the challenges faced by upstream buyers and how well-meaning efforts to support socio-economic development, from various stakeholders, potentially harms efforts to drive sustainable production of oil palm. Alternative routes for developing sustainable supply chains should be initiated from within the supply chains rather than solely through external activism. The implications of this are far-reaching as the consumer base for palm oil continues to grow globally
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