L’élaboration du matériau musical dans les dernières oeuvres vocales de Claude Vivier

Les mêmes principes stylistiques animent les cinq dernières oeuvres vocales de Claude Vivier (Lonely Child, Bouchara, Prologue pour un Marco Polo, Wo bist du Licht !, Trois airs pour un opéra imaginaire). Le concept de dyade, soit un intervalle formé d’une note de basse et d’une note mélodique, joue un rôle primordial dans l’élaboration du matériau musical. Les mélodies sont construites à partir de bassins de hauteurs d’inspiration diatonique. Généralement soutenus par une note de basse, ils peuvent être décalés par rapport à celle-ci, ou encore varier de façon à créer un univers polytonal. L’harmonie repose largement sur des algorithmes de construction spectrale précis. La présentation de ces spectres sonores varie d’oeuvre en oeuvre. L’analyse réductionnelle révèle que le déploiement des oeuvres est sous-tendu par des pratiques harmoniques diatoniques, sinon franchement tonales.The last five vocal works (Lonely Child, Bouchara, Prologue pour un Marco Polo, Wo bist du Licht!, Trois airs pour un opéra imaginaire) of Claude Vivier are all governed by the same stylistic principles. The concept of a dyad, that is, an interval formed by a bass note and a melodic one, plays a fundamental role in the elaboration of the musical material. Melodies are constructed from a reservoir of diatonically-inspired pitches. Generally subtended by a bass note, these melodies can also be out of step with them, or varied in such a way as to create a polytonal universe. The harmony largely results from algorithms of precise spectral construction. The way these spectra are presented varies from work to work. A reductive analysis reveals that the works progress according to diatoni

Étude descriptive et comparative de la condition physique chez les adolescents de niveau secondaire de Saguenay et Montréal

Protocole d'entente en médecine expérimentale offert en extension entre l'Université Laval et l'Université du Québec à ChicoutimiÀ la demande du Réseau du sport étudiant du Québec, la batterie de tests « En forme au secondaire » a été développée. Un total de 1626 élèves de niveau secondaire à Montréal et Saguenay ont été testés par une série d’épreuves d’évaluation de la condition physique : la course navette de 20 mètres avec palier de 1 minute, le test anaérobie RSEQ, le sprint 2 x 15 mètres, le saut vertical, les pompes et semi-redressement assis sur rythme imposé et le V-test. Des analyses multivariées avec distinctions des disparités sexuelles et régionales ont permis de dresser un portrait de la condition physique. Il y a corroboration que les garçons ont des résultats supérieurs aux tests musculaires et que les filles ont des résultats supérieurs à la flexibilité. Quarante-quatre pour cent (44 %) des participants ont un bilan de santé à risque relié à l’obésité. Entre 1981 et 2014, les jeunes sont plus grands (♀ +1,67 cm, ♂ +2,25 cm), sont plus lourds (♀ +5,8 kg, ♂ +5,6 kg) et leur VO2max a chuté de 13 % (♀ -5 ml min-1 kg-1, ♂ -7 ml min-1 kg-1). Le VO2max régresse entre 12 et 17 ans chez les Québécois. Des normes préliminaires ont été bâties avec la méthode LMS pour l’ensemble des tests. La recherche démontre que la batterie du RSEQ évalue et suit l’évolution de la condition physique au secondaire. Notre étude démontre également que la condition physique des jeunes est vraissemblablement affectée par l'épidémie mondiale d'obésité et que des changements importants à leurs habitudes de vie seront nécessaires afin de renverser la situation.At the request of the “Réseau du Sport étudiant du Québec”, the “En forme au secondaire” fitness test (B-EFAS) was developed. A total of 1626 high school students in Montreal and Saguenay were tested through a series of physical fitness tests : the 20-metre shuttle run test with 1 minute stage, the RSEQ anaerobic test, the fifteen-metre sprint round trip, the vertical jump, the paced push-ups, the paced sit-ups and the V-test. Multivariate analysis with distinctions of sexual and regional disparities was used to obtain a portrait of fitness. It is corroborated that boys get higher score at muscular tests and that girls perform better in flexibility. Forty-four percent (44%) of participants have obesity-related health risk. Between 1981 and 2014, the young were taller (♀ +1.67 cm, ♂ +2.25 cm), heavier (♀ +5.8 kg, ♂ + 5.6 kg) and their VO2max fell 13% (♀ -5 ml min-1 kg-1, ♂ -7 ml min-1 kg-1). The VO2max regresses between the ages of 12 and 17 among Quebeckers. Preliminary norms were built using LMS methods for all tests. Our research demonstrate that the RSEQ battery is evaluating and monitoring the progress of fitness at the High School level. Our study also shows that the physical condition of young people is likely to be affected by the global obesity epidemic and that significant changes in their lifestyle will be needed in order to reverse the situation

An asynchronous and task-based implementation of Peridynamics utilizing HPX -- the C++ standard library for parallelism and concurrency

On modern supercomputers, asynchronous many task systems are emerging to address the new architecture of computational nodes. Through this shift of increasing cores per node, a new programming model with the focus on handle the fine-grain parallelism of this increasing amount of cores per computational node is needed. Asynchronous Many Task (AMT) run time systems represent an emerging paradigm for addressing fine-grain parallelism since they handle the increasing amount of threads per node and concurrency. HPX, a open source C++ standard library for parallelism and concurrency, is one AMT which is confirm with the C++ standard. Which means that HPX's Application Programming Interface (API) is confirm with its definition by the C++ standard committee. For example for the concept of futurization the hpx:future can be replaced by std::future without breaking the API. Peridynamics is a non-local generalization of continuum mechanics tailored to address discontinuous displacement fields arising in fracture mechanics. As many non-local approaches, peridynamics requires considerable computing resources to solve practical problems. This paper investigates the implementation of a peridynamics EMU nodal discretization in an asynchronous task-based fashion. The scalability of asynchronous task-based implementation is to be in agreement with theoretical estimations. In addition, to the scalabilty the code is convergent for implicit time integration and recovers theoretical solutions. Explicit time integration, convergence results are presented to showcase the agreement of results with theoretical claims in previous works

Using a Self-Determination Theory Approach to Understand Student Perceptions of Inquiry-Based Learning

Inquiry-based laboratory activities, as a part of science curricula, have been advocated to increase students’ learning outcomes and improve students’ learning experiences, but students sometimes struggle with open-inquiry activities. This study aims to investigate students’ perceptions of inquiry-based learning in a set of laboratory activities, specifically from a psychological (i.e., Self-Determination Theory) perspective. Students’ ratings of the level of inquiry in these activities indicate that students’ perceptions of inquiry align with the instructor-intended amount of inquiry in each exercise. Students’ written responses, explaining their ratings, indicate that students’ perceptions of the amount of inquiry in a given lab exercise relate to their feeling of freedom (or autonomy), competence, and relatedness (or support), during the inquiry-based learning activities. The results imply that instructors implementing inquiry-based learning activities should consider student motivation, and Self-Determination Theory can be a useful diagnostic tool during teaching development

Using a self-determination theory approach to understand student perceptions of inquiry-based learning

Inquiry-based laboratory activities, as a part of science curricula, have been advocated to increase students’ learning outcomes and improve students’ learning experiences, but students sometimes struggle with open-inquiry activities. This study aims to investigate students’ perceptions of inquiry-based learning in a set of laboratory activities, specifically from a psychological (i.e., Self-Determination Theory) perspective. Students’ ratings of the level of inquiry in these activities indicate that students’ perceptions of inquiry align with the instructor-intended amount of inquiry in each exercise. Students’ written responses, explaining their ratings, indicate that students’ perceptions of the amount of inquiry in a given lab exercise relate to their feeling of freedom (or autonomy), competence, and relatedness (or support), during the inquiry-based learning activities. The results imply that instructors implementing inquiry-based learning activities should consider student motivation, and Self-Determination Theory can be a useful diagnostic tool during teaching development.publishedVersio

WIDEBAND VALIDATION OF A PHASE RETRIEVAL PROCESS APPLIED TO INFRARED PLANAR NEAR-FIELD MEASUREMENTS

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The Prognostic Value of a Single, Randomly Timed Circulating Tumor DNA Measurement in Patients with Metastatic Melanoma

Simple Summary In this study, we investigated the associations of circulating tumor DNA (ctDNA), measured at a random time point during the patient’s treatment, with tumor progression and routine blood markers (protein S100, lactate dehydrogenase (LDH), and C-reactive protein (CRP)) in a cohort of patients with metastatic melanoma. Detectable ctDNA was associated with the presence of extracerebral disease, tumor progression, and poorer overall survival (OS). Elevated S100 and CRP was correlated with detectable ctDNA, whereas LDH was not. Our results further support the use of ctDNA in the clinical management of patients with metastatic melanoma. Abstract Melanoma currently lacks validated blood-based biomarkers for monitoring and predicting treatment efficacy. Circulating tumor DNA (ctDNA), originating from tumor cells and detectable in plasma, has emerged as a possible biomarker in patients with metastatic melanoma. In this retrospective, single-center study, we collected 129 plasma samples from 79 patients with stage IIIB–IV melanoma as determined by the American Joint Committee on Cancer (AJCC, 8th edition). For the determination of ctDNA levels, we used eight different assays of droplet digital polymerase chain reaction (ddPCR) to detect the most common hotspot mutations in the BRAF and NRAS genes. The aim of the study was to investigate the association of the detectability of ctDNA at a non-prespecified time point in a patient’s treatment with tumor progression, and to correlate ctDNA with commonly used biomarkers (protein S100, LDH, and CRP). Patients with detectable ctDNA progressed more frequently in PET-CT within 12 months than those without detectable ctDNA. Detectability of ctDNA was associated with shorter OS in univariate and multivariate analyses. ctDNA was detectable in a statistically significantly larger proportion of patients with distant metastases (79%) than in patients with no distant metastases or only intracranial metastases (32%). Elevated protein S100 and CRP correlated better with detectable ctDNA than LDH. This study supports the potential of ctDNA as a prognostic biomarker in patients with metastatic melanoma. However, additional prospective longitudinal studies with quantitative assessments of ctDNA are necessary to investigate the limitations and strengths of ctDNA as a biomarker. Keywords: ctDNA; melanoma; tumor progression; PET-CT; S100; biomarke

A parallel-group, randomised controlled trial of a multimedia, self-directed, coping skills training intervention for patients with cancer and their partners: design and rationale

Introduction:Coping skills training interventions have been found to be efficacious in helping both patients and their partners manage the physical and emotional challenges they face following a cancer diagnosis. However, many of these interventions are costly and not sustainable. To overcome these issues, a self-directed format is increasingly used. The efficacy of self-directed interventions for patients has been supported; however, no study has reported on the outcomes for their partners. This study will test the efficacy of Coping-Together&mdash;a multimedia, self-directed, coping skills training intervention for patients with cancer and their partners.Methods and analysis:The proposed three-group, parallel, randomised controlled trial will recruit patients diagnosed in the past 4 months with breast, prostate, colorectal cancer or melanoma through their treating clinician. Patients and their partners will be randomised to (1) a minimal ethical care (MEC) condition&mdash;selected Cancer Council New South Wales booklets and a brochure for the Cancer Council Helpline, (2) Coping-Together generic&mdash;MEC materials, the six Coping-Together booklets and DVD, the Cancer Council Queensland relaxation audio CD and login to the Coping-Together website or (3) Coping-Together tailored&mdash;MEC materials, the Coping-Together DVD, the login to the website and only those Coping-Together booklet sections that pertain to their direct concerns. Anxiety (primary outcome), distress, depression, dyadic adjustment, quality of life, illness or caregiving appraisal, self-efficacy and dyadic and individual coping will be assessed before receiving the study material (ie, baseline) and again at 3, 6 and 12 months postbaseline. Intention-to-treat and per protocol analysis will be conducted.Ethics and dissemination:This study has been approved by the relevant local area health and University ethics committees. Study findings will be disseminated not only through peer-reviewed publications and conference presentations but also through educational outreach visits, publication of lay research summaries in consumer newsletters and publications targeting clinicians.</div

Patterns of radiological response to tebentafusp in patients with metastatic uveal melanoma

Metastatic uveal melanoma (mUM) is a rare type of melanoma with poor outcomes. The first systemic treatment to significantly prolong overall survival (OS) in patients with mUM was tebentafusp, a bispecific protein that can redirect T-cells to gp-100 positive cells. However, the objective response rate according to Response Evaluation Criteria in Solid Tumors (RECIST) may underestimate the clinical impact of tebentafusp. As metabolic response assessed by PET Response Criteria in Solid Tumors (PERCIST) has been reported to better correlate with clinical outcome, we here compared the patterns of radiological and morphological responses in HLA-A*02:01-positive patients with mUM treated with tebentafusp. In the 19 enrolled patients, RECIST showed an overall response rate (ORR) of 10%, median progression-free survival of 2.8 months (95% CI 2.5–8.4), and median OS (mOS) of 18.8 months. In 10 patients, where both RECIST and PERCIST evaluation was available, the ORR was 10% for both; however, the PFS was longer for PERCIST compared to RECIST, 3.1 and 2.4 months, respectively. A poor agreement between the criteria was observed at all assessments (Cohen’s kappa ≤0), yet they differed significantly only at the first on-treatment imaging (P = 0.037). Elevated baseline LDH and age were associated with an increased risk for RECIST progression, while lymphocyte decrease after the first infusions correlated to reduced risk of RECIST progression. Detectable ctDNA at baseline did not correlate with progression. Early response to tebentafusp may be incompletely captured by conventional imaging, leading to a need to consider both tumor morphology and metabolism

Le Forum, Vol. 43 #3

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