15 research outputs found

    Pervasive gaps in Amazonian ecological research

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    Biodiversity loss is one of the main challenges of our time,1,2 and attempts to address it require a clear un derstanding of how ecological communities respond to environmental change across time and space.3,4 While the increasing availability of global databases on ecological communities has advanced our knowledge of biodiversity sensitivity to environmental changes,5–7 vast areas of the tropics remain understudied.8–11 In the American tropics, Amazonia stands out as the world’s most diverse rainforest and the primary source of Neotropical biodiversity,12 but it remains among the least known forests in America and is often underrepre sented in biodiversity databases.13–15 To worsen this situation, human-induced modifications16,17 may elim inate pieces of the Amazon’s biodiversity puzzle before we can use them to understand how ecological com munities are responding. To increase generalization and applicability of biodiversity knowledge,18,19 it is thus crucial to reduce biases in ecological research, particularly in regions projected to face the most pronounced environmental changes. We integrate ecological community metadata of 7,694 sampling sites for multiple or ganism groups in a machine learning model framework to map the research probability across the Brazilian Amazonia, while identifying the region’s vulnerability to environmental change. 15%–18% of the most ne glected areas in ecological research are expected to experience severe climate or land use changes by 2050. This means that unless we take immediate action, we will not be able to establish their current status, much less monitor how it is changing and what is being lostinfo:eu-repo/semantics/publishedVersio

    Pervasive gaps in Amazonian ecological research

    Get PDF

    Pervasive gaps in Amazonian ecological research

    Get PDF
    Biodiversity loss is one of the main challenges of our time,1,2 and attempts to address it require a clear understanding of how ecological communities respond to environmental change across time and space.3,4 While the increasing availability of global databases on ecological communities has advanced our knowledge of biodiversity sensitivity to environmental changes,5,6,7 vast areas of the tropics remain understudied.8,9,10,11 In the American tropics, Amazonia stands out as the world's most diverse rainforest and the primary source of Neotropical biodiversity,12 but it remains among the least known forests in America and is often underrepresented in biodiversity databases.13,14,15 To worsen this situation, human-induced modifications16,17 may eliminate pieces of the Amazon's biodiversity puzzle before we can use them to understand how ecological communities are responding. To increase generalization and applicability of biodiversity knowledge,18,19 it is thus crucial to reduce biases in ecological research, particularly in regions projected to face the most pronounced environmental changes. We integrate ecological community metadata of 7,694 sampling sites for multiple organism groups in a machine learning model framework to map the research probability across the Brazilian Amazonia, while identifying the region's vulnerability to environmental change. 15%–18% of the most neglected areas in ecological research are expected to experience severe climate or land use changes by 2050. This means that unless we take immediate action, we will not be able to establish their current status, much less monitor how it is changing and what is being lost

    Risk factors for recurrence of tuberculosis

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    Objetivo: Identificar fatores de risco para a recidiva da tuberculose. Métodos: Estudou-se uma coorte de 610 pacientes com tuberculose pulmonar bacilífera inscritos para tratamento entre 1989 e 1994 e curados com o esquema contendo rifampicina, isoniazida e pirazinamida (RHZ). Avaliaram-se os seguintes fatores de risco: idade, sexo, cor, duração dos sintomas, cavitação das lesões, extensão da doença, diabetes melito, alcoolismo, infecção pelo HIV, negativação tardia do escarro, adesão ao tratamento e doses dos fármacos. Para detecção das recidivas, os pacientes foram seguidos por 7,7 ± 2,0 anos, após a cura, pelo sistema de informação da Secretaria Estadual da Saúde do Rio Grande do Sul. Nas análises utilizaram-se os testes t de Student, qui-quadrado ou exato de Fisher e a regressão de Cox. Resultados: Ocorreram 26 recidivas (4,3%), correspondendo a 0,55/100 pessoas-ano. A taxa de recidiva foi de 5,95 e 0,48/100 pessoas-ano, respectivamente, nos pacientes HIV‑positivos e nos HIV-negativos (p < 0,0001). Na análise multivariada, a infecção pelo HIV [RR = 8,04 (IC95%: 2,35–27,50); p = 0,001] e o uso irregular da medicação [RR = 6,43 (IC95%: 2,02-20,44); p = 0,002] mostraram-se independentemente associados às recidivas. Conclusões: A recidiva da tuberculose foi mais freqüente nos pacientes HIV-positivos e naqueles que não aderiram ao tratamento auto-administrado (esquema-RHZ). Pacientes com pelo menos um destes fatores de risco poderão se beneficiar com a implantação de um sistema de vigilância pós-tratamento para detecção precoce de recidivas. Para prevenir a não-adesão ao tratamento da tuberculose, a alternativa seria a utilização de tratamento supervisionado.Objective: To identify risk factors for recurrence of tuberculosis. Methods: We studied a cohort of 610 patients with active pulmonary tuberculosis who were enrolled for treatment between 1989 and 1994 and cured using a three-drug treatment regimen of rifampin, isoniazid and pyrazinamide (RHZ). The risk factors studied were age, gender, race, duration of symptoms, lesion cavitation, extent of disease, diabetes mellitus, alcoholism, HIV infection, delayed negative sputum conversion, treatment compliance, and medication doses. In order to detect recurrence, the patients were monitored through the Rio Grande do Sul State Healt Department Information System for 7.7 ± 2.0 years after cure. Data were analyzed using the Student’s t-test, the chi-square test or Fisher’s exact test, and Cox regression models. Results: There were 26 cases of recurrence (4.3%), which corresponds to 0.55/100 patients-year. The recurrence rate was 5.95 and 0.48/100 patients-year in HIV-positive and HIV-negative patients, respectively (p < 0.0001). In the multivariate analysis, HIV infection [RR = 8.04 (95% CI: 2.35–27.50); p = 0.001] and noncompliance [RR = 6.43 (95% CI: 2.02-20.44); p = 0.002] proved to be independently associated with recurrence of tuberculosis. Conclusions: Recurrence of tuberculosis was more common in HIV-positive patients and in patients who did not comply with the self-administered treatment (RHZ regimen). Patients presenting at least one of these risk factors can benefit from the implementation of a post-treatment surveillance system for early detection of recurrence. An alternative to prevent noncompliance with tuberculosis treatment would be the use of supervised treatment

    O trabalho entre prazer, sofrimento e adoecimento: a realidade dos portadores de lesões por esforços repetitivos The relationship between work, pleasure, mental suffering and illness: the case of work-related musculoskeletal disorders

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    Neste artigo, apresenta-se e discute-se os resultados de pesquisa realizada no Ambulatório de Doenças do Trabalho do Hospital de Clínicas de Porto Alegre (ADT/HCPA), tendo como principal objetivo determinar as relações das Lesões por Esforços Repetitivos/Distúrbios Osteomusculares Relacionados ao Trabalho (LER/DORT) com o processo produtivo e suas conseqüências sobre a saúde física e mental dos trabalhadores estudados. Pode-se evidenciar um sofrimento associado à dor física, mas não só a ela. Para além dos aspectos fisiopatológicos da doença, percebemos que existe uma complexa relação que vincula a dor às vivências subjetivas e à identidade social.In this article we present and discuss the results of investigations that took place at the Ambulatório de Doenças do Trabalho (Occupational Medicine Ambulatory) in the Hospital de Clínicas of Porto Alegre (University Hospital). The main purpose was to determine the relationship between Work-Related Musculoskeletal Disorders, the work process and the consequences over the mental and physical health of the studied workers. We conclude that mental suffering is associated to physical pain, but not exclusively. Beyond the physiopathological aspects of the illness, we perceive the existence of a complex relationship between physical pain and the subjective experiences and social identity
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