Representing and Capturing the Experts´ Knowledge in a Design Process

An object-oriented framework to support the modeling and management of the design process is introduced. It naturally integrates the representation of both the design process itself, and the outcomes that are achieved as the result of the various design activities. The integral view of tracing that was adopted not only captures and manages the products being generated but also the activities that occurred, their associated context and the adopted decisions. The Version Administration System introduced in this paper provides an explicit mechanism to manage the different model versions being generated during the course of a design project as design activities are executed.Fil: Gonnet, Silvio Miguel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Instituto de Desarrollo y Diseño. Universidad Tecnológica Nacional. Facultad Regional Santa Fe. Instituto de Desarrollo y Diseño; ArgentinaFil: Leone, Horacio Pascual. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Instituto de Desarrollo y Diseño. Universidad Tecnológica Nacional. Facultad Regional Santa Fe. Instituto de Desarrollo y Diseño; ArgentinaFil: Henning, Gabriela Patricia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Instituto de Desarrollo Tecnológico para la Industria Química. Universidad Nacional del Litoral. Instituto de Desarrollo Tecnológico para la Industria Química; Argentin

Elucidation of the molecular and bionergetic mechanisms underlying the resistance to oxidatives stress and the pro-recovery effect of H2O2- preconditioned adipose-derived stem cells

209 p.In the field of regenerative medicine, it has been pointed out the relevance of human adipose derived stem cells (hASCs) for cell therapy. They can be easily obtained, have low immunogenicity, and secrete soluble factors that could regulate neuroinflammation and oxidative stress. However, their transplantation at the site of injury results in a low percentage of survival and engraftment, mainly due to the harsh microenvironment they encounter. To address this issue, it is imperative to pre-adapt cells, so that they resist harmful environmental factors such as oxidative stress. In this study, we preconditioned hASCs (PC-hASCs) with low doses of H2O2 and evaluated their resistance to an oxidative stress insult. PC-hASCs displayed lower levels of ROS, apoptosis and cytotoxicity than hASCs, indicating their increased capacity to resist to oxidative stress. In addition, we analyzed the molecular and bioenergetic mechanisms underlying the survival and adaptation of PC-hASCs under oxidative stress. On these conditions, PC-hASCs i, reduce intracellular ROS levels by overexpressing the transcription factor NRF2 and their related antioxidant enzymes HO-1, SOD-1, GPx-1, and CAT; ii, reduce the secretion of pro-inflammatory molecules COX-2 and IL-1ß by attenuating the expression of NF-kB, and iii, increase the total ATP production rate by adapting their metabolism in order to meet the bioenergetic demand required to survive. Finally, we evaluated the therapeutic role of PC-hASCs to overcome the deleterious effect of oxidative stress in an oligodendroglial cell population, and proved that PC-hASCs restored cell viability and diminished the intracellular ROS levels of these damaged oligodendrocytes by promoting their antioxidant response.Altogether, these findings support that PC-hASCs, given their beneficial advantages, might be considered an important breakthrough in cell¿based therapies

Contribution of green turtles Chelonia mydas to total herbivore biomass in shallow tropical habitats of oceanic islands

Green turtles are megaherbivores with a key role in the dynamics of tropical seagrass meadows, but little is known about their relevance as herbivores in tropical reef habitats. We conducted underwater censuses of green turtles, herbivorous fishes and sea urchins in two distinct tropical regions: Fernando de Noronha (Western Atlantic Ocean) and the Hawaiian Archipelago (Central Pacific Ocean), to assess the contribution of green turtles to the total herbivore biomass in shallow reef habitats of tropical oceanic islands. Juvenile green turtles ranging 40-60 cm were observed at most of the surveyed sites, and hence, could be considered typical components of the shallow reef fauna of tropical oceanic islands. Furthermore, they were usually one of the most abundant species of roving herbivores in many of the sites surveyed. However, the biomass of green turtles was usually much lower than the aggregated biomass of fishes or sea urchins, which usually constituted most of the total herbivore biomass. Green turtles made a major contribution to the total herbivore biomass only in sheltered sites with low rugosity, low coral cover and high algal cover. Further investigation on the trophic redundancy between herbivores is required to assess the actual relevance of green turtles in reef ecosystems of oceanic islands, compared to herbivorous fishes and sea urchins, because different herbivores may target different algal resources and complementarity may be needed to maintain ecosystem functioning across large, naturally varied reefscapes

Hey children! Do you feel listened by your politicians? Evaluating a participative democratic programme

The objective of this study was to evaluate a participative democracy programme called Ágora infantil, carried out with students between the ages of 10 and 12. As in participatory budgets, the process is based on the research-action model (Lewin, 1946) and consists of the city council opening up decision-making on a part of the municipal budget or a concrete policy to the children of the municipality. This process of diagnosis, prioritization and decision-making was completed over the course of 5 to 7 sessions during school hours and implemented by the Coglobal association. Once the participants make a decision, the city council carries out the project selected in the municipality (the decision made is binding). The main goal of Ágora Infantil is to generate psychological empowerment and wellbeing amongst its participants, and to measure the effects of this programme on children’s psychological empowerment. To this end, we used Zimmerman´s model (Zimmerman, 1995; Zimmerman, 2000). The operationalization of the strengthening was based on: 1) knowledge of local politics (as a component of the interactional dimension of psychological empowerment) and 2) the self-perception of being able to influence the future of the municipality (component of the intrapersonal dimension of psychological empowerment). In addition, wellbeing was evaluated through the perception of being heard (Casas y Bello, 2012) and trust in the city council.Universidad de Málaga. Campus de Excelencia Internacional Andalucía Tech

El museo como recurso educativo. Propuesta de intervención para un aula de Educación Infantil

El arte y por consiguiente la Educación Artística son uno de los sectores más subestimados dentro de la Educación. Por ello, el principal objetivo del presente Trabajo de Fin de Grado es acercar al alumnado de Educación Infantil al ámbito del arte, por medio del museo, ofreciéndoles un nuevo medio de comunicación y expresión de sentimientos. Por otro lado, en el documento proponemos aproximar el museo al aula y conocer artistas segovianos para comprender el Patrimonio cultural mas cercano y su memoria; y para mostrar al alumnado que ellos también pueden ser artistas. Así, podemos decir que dentro de las conclusiones que se presentan en el último epígrafe, resumiríamos que consideramos que es muy importante que el alumnado en sus edades mas tempranas este en contacto con el mundo del arte, puesto que con ello conseguirán obtener un desarrollo general.Departamento de Didáctica de la Expresión Musical, Plástica y CorporalGrado en Educación Infanti

The resting microstate networks (RMN): cortical distributions, dynamics, and frequency specific information flow

A brain microstate is characterized by a unique, fixed spatial distribution of electrically active neurons with time varying amplitude. It is hypothesized that a microstate implements a functional/physiological state of the brain during which specific neural computations are performed. Based on this hypothesis, brain electrical activity is modeled as a time sequence of non-overlapping microstates with variable, finite durations (Lehmann and Skrandies 1980, 1984; Lehmann et al 1987). In this study, EEG recordings from 109 participants during eyes closed resting condition are modeled with four microstates. In a first part, a new confirmatory statistics method is introduced for the determination of the cortical distributions of electric neuronal activity that generate each microstate. All microstates have common posterior cingulate generators, while three microstates additionally include activity in the left occipital/parietal, right occipital/parietal, and anterior cingulate cortices. This appears to be a fragmented version of the metabolically (PET/fMRI) computed default mode network (DMN), supporting the notion that these four regions activate sequentially at high time resolution, and that slow metabolic imaging corresponds to a low-pass filtered version. In the second part of this study, the microstate amplitude time series are used as the basis for estimating the strength, directionality, and spectral characteristics (i.e., which oscillations are preferentially transmitted) of the connections that are mediated by the microstate transitions. The results show that the posterior cingulate is an important hub, sending alpha and beta oscillatory information to all other microstate generator regions. Interestingly, beyond alpha, beta oscillations are essential in the maintenance of the brain during resting state.Comment: pre-print, technical report, The KEY Institute for Brain-Mind Research (Zurich), Kansai Medical University (Osaka

Desarrollo de grafismos para videojuego educativo para la mejora de la pronunciación de personas con Síndrome de Down

En este trabajo se detalla el proceso y criterios seguidos en del diseño de la interfaz gráfica de un videojuego para personas con necesidades especiales. Este videojuego será utilizado por alumnos con Síndrome de Down y otras discapacidades como herramienta para mejorar sus habilidades comunicativas. Para el desarrollo se ha realizado un estudio sobre las características de las personas con síndrome de Down y se ha analizado su comportamiento con la aplicación. También se habla de la metodología utilizada en el proyecto y se explica cómo ha sido el trabajo cooperativo entre personas de diferentes áreas del conocimiento, extrapolando este método de trabajo de cara a una actividad profesional. También se habla de las herramientas (hardware y software) utilizadas, y se plantean unas conclusiones con los resultados obtenidos de las pruebas hechas con alumnos reales.Departamento de Informática (Arquitectura y Tecnología de Computadores, Ciencias de la Computación e Inteligencia Artificial, Lenguajes y Sistemas Informáticos)Grado en Ingeniería en Diseño Industrial y Desarrollo de Product

Empowering children in politics: evaluating a participative democratic programme

The objective of this study was to evaluate a participative democracy programme called Ágora infantil, carried out with students between the ages of 10 and 12. As in participatory budgets, the process is based on the research-action model (Lewin, 1946) and consists of the city council opening up decision-making on a part of the municipal budget or a concrete policy to the children of the municipality. This process of diagnosis, prioritization and decision-making was completed over the course of 5 to 7 sessions during school hours and implemented by the Coglobal association. Once the participants make a decision, the city council carries out the project selected in the municipality (the decision made is binding). The main goal of Ágora Infantil is to generate psychological empowerment and wellbeing amongst its participants, and to measure the effects of this programme on children’s psychological empowerment. To this end, we used Zimmerman´s model (Zimmerman, 1995; Zimmerman, 2000). The operationalization of the strengthening was based on: 1) knowledge of local politics (as a component of the interactional dimension of psychological empowerment) and 2) the self-perception of being able to influence the future of the municipality (component of the intrapersonal dimension of psychological empowerment). In addition, wellbeing was evaluated through the perception of being heard (Casas y Bello, 2012) and trust in the city council.Universidad de Málaga. Campus de Excelencia Internacional Andalucía Tech

Héroes y poetas. Influencias literarias en la discografía de Héroes del Silencio

The relationship between music and literature is a constant since the beginning of both with song being, clearly, the genre where this relationship is most evident. Literature has influenced music decisively, in the same way the latter has served as inspiration for literati. In this article we seek to show literary influences present at «Héroes del Silencio» musical output, especially those coming from symbolist poetry. Verse handling, artist's standpoint on society or praising of the mundane pleasures are part of the legacy in this poetry that makes itself apparent by listening songs from the aragonese band.La relación entre música y literatura es una constante desde el inicio de ambas y la canción es, sin duda, el género donde esta relación se hace más evidente. La literatura ha influido de forma decisiva en la música, igual que esta ha servido en numerosas ocasiones de inspiración a los literatos. En el presente artículo pretendemos mostrar las influencias literarias presentes en la producción musical de Héroes del Silencio, especialmente aquellas procedentes de la poesía simbolista. El manejo del verso, la actitud del artista ante la sociedad o la exaltación de los placeres mundanos son algunas de las herencias de esta poesía que se hacen evidentes al escuchar las canciones del grupo aragonés

Estudio histórico-publicitario del Jarabe Superior de Nuez de Cola Coca y su influencia en los orígenes de la Coca Cola

Este Trabajo de Fin de Grado tiene como propósito llevar a cabo una aproximación fidedigna a la historia de una marca y producto valenciano, el Licor de Nuez de Kola Coca, y su influencia en los orígenes de una de las marcas más populares a escala mundial: Coca Cola. Partiendo de una investigación histórico-publicitaria exhaustiva, la metodología propuesta se enfoca posteriormente en el análisis de diversos elementos publicitarios utilizados para la promoción y distribución del Jarabe Superior de Nuez de Cola Coca y posterior Licor de Nuez de Kola Coca a lo largo del tiempo, prestando especial atención a las etiquetas del producto y su evolución en cuanto a diseño, a las tipografías y la gama cromática utilizada en cada una de ellas. Paralelamente, este estudio busca proporcionar un nuevo enfoque y conocimiento sobre el Licor de Nuez de Kola Coca a través del impacto que este ha tenido en la cultura y en la sociedad local, abordando su fábrica centenaria y explorando cómo la historia de este producto ha influido en las tradiciones de la región.Grado en Publicidad y Relaciones Pública