Reconfiguring the Firm’s Assets for Innovation

The innovation process and the generation of sustainable competitive advantage are permanently on the agenda in technology management. According to Teece (2007), one way to achieve a competitive advantage is to develop dynamic capabilities, a process in which the author identifies three moments: i) to perceive and shape opportunities and threats (sensing), ii) to grasp the opportunities (seizing), iii) to increase, to combine, to secure and, when necessary, to reconfigure the tangible and intangible assets. The aim of this paper is to investigate how the strategic internal changes were introduced to influence on developing the innovation capability in order to sustain and expand the competitive advantages of the firm. To do so, a case study was carried out in a firm that work within the furniture sector more than 30 years and took decision to increase its competitive advantage by investing in product design, what created conditions for the development of new capabilities. Interviews were conducted using questions that allowed the respondents to freely express their experiences and perceptions about the changes that have occurred in their sectors as a result of this process and was possible to identify the intensity of reconfigurations in capabilities that resulted from the creation of the Design Center

A CONTRIBUIÇÃO DO MINISTÉRIO UNIVERSIDADES RENOVADAS PARA A FORMAÇÃO DOS ACADEMICOS DO CURSO DE ADMINISTRAÇÃO DA FACULDADE CATÓLICA DOM ORIONE

O objetivo deste artigo é de analisar a contribuição do Ministério Universidades Renovadas para a formação do acadêmico em administração da Faculdade Católica Dom Orione. Para isso buscou-se entender o conceito de Universidade e suas relações na construção do saber. O estudo evidencia ainda a importância de considerar a religião, tomando como recorte o GOUDO, como uma variável significativa na formação do profissional em Administração que agrega valores éticos e de responsabilidade social em suas praticas. O trabalho seguiu uma abordagem qualitativa, realizando uma pesquisa de campo através da aplicação de um questionário contendo 15 perguntas a 20 acadêmicos do curso de administração que participam do GOUDO. Por fim, verificou-se a importância do GOUDO dentro da universidade, de forma a contribuir para a formação dos acadêmicos

Professores tecnológicos: o uso pessoal de dispositivos digitais móveis e a prática profissional

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Maternal vaccination as an additional approach to improve the protection of the nursling: Anti-infective properties of breast milk

Human milk constitutes a secretion with unique functions of both nourishing the nursling and providing protection against enteric and respiratory infections, mainly due to its content of secretory IgA antibodies but also due to the presence of a plethora of bioactive factors. Specific IgA antibodies are produced locally by plasma cells derived from B lymphocytes that migrate from other mucosae to the mammary gland during lactation, particularly from the gastrointestinal and respiratory tracts. Therefore, here, the authors will provide a comprehensive review of the content and functions of different nutritional and bioactive anti-infectious components from breast milk, such as oligosaccharides, lactoferrin, haptocorrin, α-lactalbumin, k-casein, lysozyme, lactoperoxidase, mucin, fatty acids, defensins, cytokines and chemokines, hormones and growth factors, complement proteins, leukocytes and nucleic acids, including microRNAs, among many others, and the induction of antibody responses in breast milk after maternal vaccination with several licensed vaccines, including the anti-SARS-CoV-2 vaccine preparations used worldwide. Currently, in the midst of the pandemic, maternal vaccination has re-emerged as a crucial source of passive immunity to the neonate through the placenta and breastfeeding, considering that maternal vaccination can induce specific antibodies if performed during pregnancy and after delivery. There have been some reports in the literature about milk IgA antibodies induced by bacterial antigens or inactivated virus vaccines, such as anti-diphtheria-tetanus-pertussis, anti-influenza viruses, anti-pneumococcal and meningococcal polysaccharide preparations. Regarding anti-SARS-CoV-2 vaccines, most studies demonstrate elevated levels of specific IgA and IgG antibodies in milk with virus-neutralizing ability after maternal vaccination, which represents an additional approach to improve the protection of the nursling during the entire breastfeeding period

Reflexoes sobre o trabalho secretarial e questoes para futuros estubos : uma contribuicao conceitual

This study presents a reflection on issues related to secretarial work. The aim of this paper is to generate ideas and raise questions to encourage more research in the area. The article presents a literature review on the secretarial work context such as technology and gender. The context of the secretarial work presents a challenge for the division of labor secretaries and context also shows that this is still a segregated occupation. The article also presents some reflections on working definitions secretarial and secretarial role substantiating it with theories of identity. In conclusion, the study presents some topics for future research work in the secretarial field

Relación Brasil-Colombia: dinámicas transfronterizas, migratorias y de integración

Brazil-Colombia relationship started in the seventies of the twentieth century despite the consolidation of the border between the two countries in 1934, after the dispute over the city of Leticia, between Colombia and Peru. This context allows us to place a question: How is the development of the migration and the relationship between Brazil and Colombia? From a historical perspective of International Relations, Geography and Political Science and from a review of literature both migration and integration have had their own dynamics. However, from the early 2000s they tend to converge, even though the integration is limited to issues of security and military control of the border. In recent years, although the interactions between the two countries have increased, especially on issues such as migration, trade and common public policy, they are still limited due to poor knowledge of society, tensions generated by foreign countries and the fact that Brazil and Colombia belong to different economic blocs: CAN and MERCOSUR.La relación Brasil-Colombia data de la década del setenta del siglo XX pese a que la consolidación de la frontera entre ambos países sucediera en 1934, posterior a la disputa por la ciudad de Leticia entre Colombia y Perú. Este contexto nos permite situar la pregunta por ¿cómo se ha desarrollado la migración y la integración en la frontera Brasil-Colombia? Indicando, desde una perspectiva histórica de las Relaciones Internacionales, la Geografía y la Ciencia Política y, a partir de una revisión de literatura, que tanto la migración como la integración, han tenido sus propias dinámicas, aunque, hacia la década del 2000 éstas tienden a converger; así mismo, la integración se limita a temas de seguridad y control militar de la frontera. En los últimos años, aunque las interacciones entre ambos países han aumentado en temas migratorios, comerciales y en políticas públicas comunes, éstas aún son limitadas debido al poco conocimiento de la sociedad, las tensiones generadas por países externos y la pertenencia a dos bloques económicos poco dialogantes: la CAN y el MERCOSUR

IgG Placental Transfer in Healthy and Pathological Pregnancies

Placental transfer of maternal IgG antibodies to the fetus is an important mechanism that provides protection to the infant while his/her humoral response is inefficient. IgG is the only antibody class that significantly crosses the human placenta. This crossing is mediated by FcRn expressed on syncytiotrophoblast cells. There is evidence that IgG transfer depends on the following: (i) maternal levels of total IgG and specific antibodies, (ii) gestational age, (iii) placental integrity, (iv) IgG subclass, and (v) nature of antigen, being more intense for thymus-dependent ones. These features represent the basis for maternal immunization strategies aimed at protecting newborns against neonatal and infantile infectious diseases. In some situations, such as mothers with primary immunodeficiencies, exogenous IgG acquired by intravenous immunoglobulin therapy crosses the placenta in similar patterns to endogenous immunoglobulins and may also protect the offspring from infections in early life. Inversely, harmful autoantibodies may cross the placenta and cause transitory autoimmune disease in the neonate

Possible adverse drug events leading to hospital admission in a Brazilian teaching hospital

OBJECTIVES: Drug safety problems can lead to hospital admission. In Brazil, the prevalence of hospitalization due to adverse drug events is unknown. This study aims to estimate the prevalence of hospitalization due to adverse drug events and to identify the drugs, the adverse drug events, and the risk factors associated with hospital admissions. METHOD: A cross-sectional study was performed in the internal medicine ward of a teaching hospital in São Paulo State, Brazil, from August to December 2008. All patients aged ≥18 years with a length of stay ≥24 hours were interviewed about the drugs used prior to hospital admission and their symptoms/complaints/causes of hospitalization. RESULTS: In total, 248 patients were considered eligible. The prevalence of hospitalization due to potential adverse drug events in the ward was 46.4%. Overprescribed drugs and those indicated for prophylactic treatments were frequently associated with possible adverse drug events. Frequently reported symptoms were breathlessness (15.2%), fatigue (12.3%), and chest pain (9.0%). Polypharmacy was a risk factor for the occurrence of possible adverse drug events. CONCLUSION: Possible adverse drug events led to hospitalization in a high-complexity hospital, mainly in polymedicated patients. The clinical outcomes of adverse drug events are nonspecific, which delays treatment, hinders causality analysis, and contributes to the underreporting of cases