670 research outputs found

    Projeto de intervenção na Associação de Andebol de Aveiro: plano de marketing

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    Mestrado em MarketingEste trabalho de projeto tem como objetivo geral a elaboração de um plano de Marketing para a Associação de Andebol de Aveiro. Tem como objetivos específicos a realização de uma análise diagnóstico da situação, a definição de objetivos, o estabelecimento de opções estratégicas, a definição do plano operacional para esta associação e a concretização de parte do plano. Em termos metodológicos, este trabalho baseou-se em dados primários, nomeadamente, entrevistas e os trabalhos efetuados de acordo com o plano de Marketing escolhido, apesar de também ter havido recolha de dados secundários, nomeadamente na história da Associação de Andebol de Aveiro. Realizámos uma revisão da literatura sobre Marketing, Marketing de serviços e Marketing desportivo e analisámos alguns modelos de planos de Marketing, propostos por alguns dos principais autores, adaptando-os e respondendo às necessidades do nosso projeto. Este trabalho propõe a transformação da Associação de Andebol de Aveiro numa associação impactante no mundo tecnológico-digital e físico, proativa, e, consequentemente, geradora de fundos para si própria e também para a região em que se insere, aumentando a sua capacidade de competição face a outros desportos e a outras instituições da mesma modalidade. Consideramos que foram atingidos os objetivos propostos no início deste trabalho de projeto, tendo-se desenvolvido um plano de intervenção de Marketing e concretizado parte deste, conseguindo dar à Associação uma maior visibilidade e proporcionando uma maior interação com os ‘clientes’ da Associação, atendendo aos dados recolhidos nas entrevistas efetuadas e na coleta de dados das redes sociais no período de colaboração-intervenção.The present project work has the general aim of eleborating a Marketing plan for the Handball Association of Aveiro. Its specific objectives are to carry out a diagnostic analysis of its situation, defining objectives, establishing strategies, delineating an operational plan and implementing part of it. Concercing the methods used, this work was based on primary data, namely, interviews and the carried out works according to the chosen marketing plan; as well as secondary data, like the history of the Aveiro’s Handball Association. In order to meet our project requirements, we performed a thorough review of the literature on Marketing, Service Marketing and Sports Marketing and then analyzed and adapted marketing models proposed by some of the main authors. This thesis proposes the transformation of the Handball Association of Aveiro into an outstanding and proactive association in the technological-digital and physical world, consequently, generating funds for itself and its the region, increasing its competitive value compared to other sports and same modality institutions. According to data collected over conducted interviews and social networks in the collaboration-intervention period, we consider that the initially proposed aims for this project work were accomplished by developing and initiating a Marketing intervention plan which gave the Association greater visibility and interaction with its comunity

    Múltiplas Pápulas na Face

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    Validation of psychophysiological measures for caffeine oral films characterization by machine learning approaches

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    Background: The oral films are a new delivery system that can carry several molecules, such as neuromodulator molecules, including caffeine. These delivery systems have been developed and characterized by pharmacokinetics assays. However, new methodologies, such as psychophysiological measures, can complement their characterization. This study presents a new protocol with psychophysiological parameters to characterize the oral film delivery systems based on a caffeine model. (2) Methods: Thirteen volunteers (61.5% females and 38.5% males) consumed caffeine oral films and placebo oral films (in different moments and without knowing the product). Electrocardiogram (ECG), electrodermal (EDA), and respiratory frequency (RF) data were monitored for 45 min. For the data analysis, the MATLAB environment was used to develop the analysis program. The ECG, EDA, and RF signals were digitally filtered and processed, using a windowing process, for feature extraction and an energy mean value for 5 min segments. Then, the data were computed and presented to the entries of a set of Machine Learning algorithms. Finally, a data statistical analysis was carried out using SPSS. (3) Results: Compared with placebo, caffeine oral films led to a significant increase in power energy in the signal spectrum of heart rate, skin conductance, and respiratory activity. In addition, the ECG time-series power energy activity revealed a better capacity to detect caffeine activity over time than the other physiological modalities. There was no significant change for the female or male gender. (4) Conclusions: The protocol developed, and the psychophysiological methodology used to characterize the delivery system profile were efficient to characterize the drug delivery profile of the caffeine. This is a non-invasive, cheap, and easy method to apply, can be used to determine the neuromodulator drugs delivery profile, and can be implemented in the future.info:eu-repo/semantics/publishedVersio

    An overview of different approaches in hydrogen network optimization via mathematical programming

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    Goal: Hydrogen has shown increasing demand in oil refineries, due to the importance of its use as a sulfur capture element. As different oils and products require different amounts of hydrogen, their use optimally is an essential tool for refinery production scheduling. A comparison was made between the different approaches used in optimization via mathematical programming.Design / Methodology / Approach: One of the most used methods for hydrogen network optimization is through mathematical programming. Linear and non-linear models are discussed, positive aspects of each formulation and different initialization techniques for non-linear modeling were considered.Results: The optimization through the linear model was more satisfactory, taking into account the payback of the new proposed design, combined with the use of compressor rearrangement, which reduces the investment cost.Limitations of the investigation: The objective function chosen is based on the operational cost, but another approach to be considered would be the total annual cost. In addition, the parameters related to costs are obtained from the literature and may change over the years.Practical implications: The proposal is to discuss the main aspects of each model, showing which models more robust and easier to converge are capable of providing competitive results. Also, different initialization techniques that can be used in future works.Originality / Value: The main contribution is the relationship between hydrogen management and production scheduling and for that, a discussion is made about possible formulations. Linear model is sufficient to optimize the problem, due to its main characteristics discussed

    MILP formulation for solving and initializing MINLP problems applied to retrofit and synthesis of hydrogen networks

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    The demand for hydrogen in refineries is growing due to its importance as a sulfur capture element. Therefore, hydrogen management is critical for fulfilling demands as efficiently as possible. Through mathematical modeling, hydrogen network management can be better performed. Cost-efficient Mixed-Integer Linear Programming (MILP) and Mixed-Integer Nonlinear Programming (MINLP) optimization models for (re)designing were proposed and implemented in GAMS with two case studies. Linear programming has the limitation of no stream mixing allowed; therefore, to overcome this limitation, an algorithm-based procedure called the Virtual Compressor Approach was proposed. Based on the MILP optimal solution obtained, the streams and compressors were merged. As a result, the number of compressors was reduced, along with the inherent investment costs. An operational cost reduction of more than 28% (example 1) and 26% (example 2) was obtained with a linear model. The optimal MILP solution after rearranging compressors was then provided as a good starting point to the MINLP. The operating costs were decreased by more than 31% (example 1) and 32% (example 2). Most of the cost reduction was obtained only with the usage of the MILP model. Besides, a higher level of cost reduction was only obtained when the linear model was used as the starting point

    A PRODUÇÃO DE SENTIDOS SOBRE A SEXUALIDADE POR UMA JOVEM COM PARAPLEGIA CONGÊNITA

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    As mulheres e as pessoas com deficiência historicamente tiveram as suas vidas marcadas por preconceitos, que se refletem, inclusive, no campo da sexualidade. Nesse sentido, buscou-se problematizar a constituição da subjetividade de uma jovem com deficiência no que se refere aos sentidos construídos relativos à sexualidade, visto que a juventude é um processo de constituição do sujeito influenciado pelo meio no qual se desenvolve. Verificada a escassez de estudos que abordem conjuntamente essas questões, a presente pesquisa objetivou apreender os sentidos produzidos sobre a sexualidade por uma jovem com paraplegia congênita. Para tanto, foi utilizada a técnica do depoimento pessoal e a análise dos dados procedeu-se a partir da proposta dos núcleos de significação. Os resultados mostraram que a jovem participante não se enxerga como incapaz de manter relações amorosas, visto que a deficiência não representa um impedimento para a vivência de sua sexualidade

    NDM-1-producing Providencia stuartii isolates in a Portuguese Hospital

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    Objective: Providencia stuartii is an opportunistic pathogen typically associated with urinary infections, and is intrinsically resistance to a wide range of antibiotics. The main aim of this study was to characterize five carbapenemase (CA) NDM-1-producing P. stuartii isolates obtained during an outbreak detected in a Hospital. Methods: MICs were obtained by the reference microdilution broth method, according to EUCAST guidelines. PCR amplification and DNA sequencing were applied to identify the presence of CA genes from class A, B and D. Direct transfer of the CA resistance phenotype was attempted by mating-out assays. Genetic relatedness was examined by PFGE. One isolate, INSRA21868, recovered from the urine of an 88-year-old male patient admitted to the intensive care unit, was selected for genetic characterization using whole-genome sequencing (WGS), performed using 150 bp paired-end reads on a MiSeq (Illumina). A set of bioinformatic web tools were used to estimate the presence of pathogenicity determinants, antibiotic resistance (AR) genes, and clinically relevant mobile genetic elements. Results: All isolates, genetically indistinguishable by PFGE, presented multidrug-resistance with non-susceptibility to all carbapenems tested. Transconjugants had AR profiles similar to those of their parental clinical isolates. All NDM-1 determinants tested were found to be carried on conjugative plasmids. In silico AR analyses using ResFinder-v2.1 revealed genes conferring resistance to β-lactams [blaNDM-1, blaCMY-4 and ΔblaDHA-1), aminoglycosides (aac(2’)-Ia, armA), tetracycline (tetB), macrolides (mphE and msrE), chloramphenicol (catB3), and sulfonamides (sul1). PlasmidFinder-v1.2 analyses revealed the presence of an IncA/C2, which has been associated with wide dissemination of blaNDM-1. In the 3’ region, the blaNDM-1 gene was adjacent to a bleomycin resistance-encoding gene (bleMBL), followed by a trpF and part of the blaDHA-1-ampR region. The ISAba125 element upstream of blaNDM-1 was interrupted by an IS26 element. Conclusion: This study emphasizes the elements involved in dissemination of nosocomial infections and the potential of WGS in epidemiological investigations in the prevention of CA dissemination among hospitals as well as to other bacterial genera.info:eu-repo/semantics/acceptedVersio

    A PRODUÇÃO DE SENTIDOS SOBRE A SEXUALIDADE POR UMA JOVEM COM PARAPLEGIA CONGÊNITA

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    As mulheres e as pessoas com deficiência historicamente tiveram as suas vidas marcadas por preconceitos, que se refletem, inclusive, no campo da sexualidade. Nesse sentido, buscou-se problematizar a constituição da subjetividade de uma jovem com deficiência no que se refere aos sentidos construídos relativos à sexualidade, visto que a juventude é um processo de constituição do sujeito influenciado pelo meio no qual se desenvolve.Verificada a escassez de estudos que abordem conjuntamente essas questões, a presente pesquisa objetivou apreender os sentidos produzidos sobre a sexualidade por uma jovem com paraplegia congênita. Para tanto, foi utilizada a técnica do depoimento pessoal e a análise dos dados procedeu-se a partir da proposta dos núcleos de significação. Os resultados mostraram que a jovem participante não se enxerga como incapaz de manter relações amorosas, visto que a deficiência não representa um impedimento para a vivência de sua sexualidade.Palavras chaves: Pessoas com deficiência; Gênero, Juventude; Sentidos sobre a sexualidade. THE PRODUCTION OF SENSES ABOUT SEXUALITY BY A YOUNG LADY WITH PARAPLEGIA CONGENITAAbstract: Women and people with disabilities have historically had their lives marked by prejudices that are reflected even in the field of sexuality. Thus, we aimed to question the constitution of the subjectivity of a young disabled with regard to the built way related to sexuality, since youth is a process of constitution of the subject influenced by the environment in which it develops. It is noticed that there is a shortage of studies that jointly address these issues, so this research aimed at understanding the meanings produced about sexuality as a young lady with congenital paraplegia. To collect data the technique of personal testimony was used and the data analysis was carried out from the proposal of the "core meaning". The results showed that the young participant does not see herself as incapable of maintaining loving relationships, because she understands that disability is not an impediment to sexuality.Keywords: People with disabilities; Gender; Youth; The meanings of sexualit

    A PRODUÇÃO DE SENTIDOS SOBRE A SEXUALIDADE POR UMA JOVEM COM PARAPLEGIA CONGÊNITA

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    As mulheres e as pessoas com deficiência historicamente tiveram as suas vidas marcadas por preconceitos, que se refletem, inclusive, no campo da sexualidade. Nesse sentido, buscou-se problematizar a constituição da subjetividade de uma jovem com deficiência no que se refere aos sentidos construídos relativos à sexualidade, visto que a juventude é um processo de constituição do sujeito influenciado pelo meio no qual se desenvolve. Verificada a escassez de estudos que abordem conjuntamente essas questões, a presente pesquisa objetivou apreender os sentidos produzidos sobre a sexualidade por uma jovem com paraplegia congênita. Para tanto, foi utilizada a técnica do depoimento pessoal e a análise dos dados procedeu-se a partir da proposta dos núcleos de significação. Os resultados mostraram que a jovem participante não se enxerga como incapaz de manter relações amorosas, visto que a deficiência não representa um impedimento para a vivência de sua sexualidade. Palavras chaves: Pessoas com deficiência; Gênero, Juventude; Sentidos sobre a sexualidade.   THE PRODUCTION OF SENSES ABOUT SEXUALITY BY A YOUNG LADY WITH PARAPLEGIA CONGENITA   Abstract: Women and people with disabilities have historically had their lives marked by prejudices that are reflected even in the field of sexuality. Thus, we aimed to question the constitution of the subjectivity of a young disabled with regard to the built way related to sexuality, since youth is a process of constitution of the subject influenced by the environment in which it develops. It is noticed that there is a shortage of studies that jointly address these issues, so this research aimed at understanding the meanings produced about sexuality as a young lady with congenital paraplegia. To collect data the technique of personal testimony was used and the data analysis was carried out from the proposal of the "core meaning". The results showed that the young participant does not see herself as incapable of maintaining loving relationships, because she understands that disability is not an impediment to sexuality. Keywords: People with disabilities; Gender; Youth; The meanings of sexuality &nbsp

    Ileal intussusception due to a parasite egg : a case report

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    Ileal intussusception is the invagination of the small intestine within itself and accounts for 1% of cases of acute obstruction. However, physicians do not initially consider intussusception as a possible diagnosis of obstruction due to its rarity in adults. Herein, we report the case of a 22-year-old male who was admitted to the Emergency Department with continuous abdominal pain. Ultrasonography and computed tomography revealed an ileal intussusception. The patient underwent surgical removal of the segment of the small bowel. Unexpectedly, pathology revealed that the invagination occurred due to a parasite egg, with features suggestive of Schistosoma species. Schistosomiasis, although considered a parasitic disease in tropical countries, is not absent from Europe and though it is highly improbable, it may be responsible for cases of intussusception in adults. (C) 2014 Baishideng Publishing Group Inc. All rights reserved
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