A beam-beam monitoring detector for the MPD experiment at NICA

The Multi-Purpose Detector (MPD) is to be installed at the Nuclotron Ion Collider fAcility (NICA) of the Joint Institute for Nuclear Research (JINR). Its main goal is to study the phase diagram of the strongly interacting matter produced in heavy-ion collisions. These studies, while providing insight into the physics of heavy-ion collisions, are relevant for improving our understanding of the evolution of the early Universe and the formation of neutron stars. In order to extend the MPD trigger capabilities, we propose to include a high granularity beam-beam monitoring detector (BE-BE) to provide a level-0 trigger signal with an expected time resolution of 30 ps. This new detector will improve the determination of the reaction plane by the MPD experiment, a key measurement for flow studies that provides physics insight into the early stages of the reaction. In this work, we use simulated Au+Au collisions at NICA energies to show the potential of such a detector to determine the event plane resolution, providing further redundancy to the detectors originally considered for this purpose namely, the Fast Forward Detector (FFD) and the Hadron Calorimeter (HCAL). We also show our results for the time resolution studies of two prototype cells carried out at the T10 beam line at the CERN PS complex.Comment: 16 pages, 12 figures. Updated to published version with added comments and correction

Biodiversidad de Bacillus thuringiensis patotipos II y IV y Bacillus sphaericus aislados de suelos agrícolas peruanos

Se aislaron 18 cepas nativas de Bacillus thuringiensis y 3 cepas de Bacillus sphaericus con potencial mosquitocida, de 175 muestras de aguas estancadas y suelos agrícolas de diferentes partes del país. Las observaciones microscópicas de colonias características, mostraron la presencia de cristales parasporales típicos de B thuringiensis. Los bioensayos realizados mostraron a las cepas BT-UNMSM-112 y BT-UNMSM-118 como las de mayor capacidad entomocida frente a los primeros estadios de Anopheles pseudopunctipennis y B. sphaericus - Bs-UNMSM 107 mostró la mayor efectividad frente a Culex spp. Se determinó los niveles de susceptibilidad, en el laboratorio, de esta especie a Bacillus thuringiensis var. Israelensis y Bacillus sphaericus, encontrándose una CL50 de 0.215 y 0.360 ìg /mL y CL90 0.236 y 0.428  ìg/ mL para B. thuringiensis BT-UNMSM 112 y BT-UNMSM 118 respectivamente y una CL50 de 0.87 ìg/mL y una CL90 de 0.95 ìg/mL para B. sphaericus Bs-UNMSM 107 frente a An. pseudopunctipennis. Para Culex spp se encontró 90 una CL50 de 0.562 y 0.920 ìg /mLy CL90 2.52 y 3.20 ìg/ mL para B. thuringiensis BT-UNMSM 112 y BT-UNMSM 118 respectivamente y una CL50 de 0.34 ìg/mL y una CL90 de 0.44 ìg/mL con B. sphaericus Bs-UNMSM-107

Exploración Visual

En el siguiente apartado se presentan imágenes visuales producto de procesos creativos que se adelantan en los cursos de Fotografía Artística, dibujo, posproducción de fotografía, diseño básico y dibujo digital. La selección de trabajos fue realizada por July Hernández, Viviana Aguillón, Olga Acero y Ricardo Hernández .  &nbsp

A922 Sequential measurement of 1 hour creatinine clearance (1-CRCL) in critically ill patients at risk of acute kidney injury (AKI)

Meeting abstrac

Molecular Characterization of Monocyte Subsets Reveals Specific and Distinctive Molecular Signatures Associated With Cardiovascular Disease in Rheumatoid Arthritis

Objectives: This study, developed within the Innovative Medicines Initiative Joint Undertaking project PRECISESADS framework, aimed at functionally characterize the monocyte subsets in RA patients, and analyze their involvement in the increased CV risk associated with RA.Methods: The frequencies of monocyte subpopulations in the peripheral blood of 140 RA patients and 145 healthy donors (HDs) included in the PRECISESADS study were determined by flow cytometry. A second cohort of 50 RA patients and 30 HDs was included, of which CD14+ and CD16+ monocyte subpopulations were isolated using immuno-magnetic selection. Their transcriptomic profiles (mRNA and microRNA), proinflammatory patterns and activated pathways were evaluated and related to clinical features and CV risk. Mechanistic in vitro analyses were further performed.Results: CD14++CD16+ intermediate monocytes were extended in both cohorts of RA patients. Their increased frequency was associated with the positivity for autoantibodies, disease duration, inflammation, endothelial dysfunction and the presence of atheroma plaques, as well as with the CV risk score. CD14+ and CD16+ monocyte subsets showed distinctive and specific mRNA and microRNA profiles, along with specific intracellular signaling activation, indicating different functionalities. Moreover, that specific molecular profiles were interrelated and associated to atherosclerosis development and increased CV risk in RA patients. In vitro, RA serum promoted differentiation of CD14+CD16− to CD14++CD16+ monocytes. Co-culture with RA-isolated monocyte subsets induced differential activation of endothelial cells.Conclusions: Our overall data suggest that the generation of inflammatory monocytes is associated to the autoimmune/inflammatory response that mediates RA. These monocyte subsets, -which display specific and distinctive molecular signatures- might promote endothelial dysfunction and in turn, the progression of atherosclerosis through a finely regulated process driving CVD development in RA

Mortality from gastrointestinal congenital anomalies at 264 hospitals in 74 low-income, middle-income, and high-income countries: a multicentre, international, prospective cohort study

Summary Background Congenital anomalies are the fifth leading cause of mortality in children younger than 5 years globally. Many gastrointestinal congenital anomalies are fatal without timely access to neonatal surgical care, but few studies have been done on these conditions in low-income and middle-income countries (LMICs). We compared outcomes of the seven most common gastrointestinal congenital anomalies in low-income, middle-income, and high-income countries globally, and identified factors associated with mortality. Methods We did a multicentre, international prospective cohort study of patients younger than 16 years, presenting to hospital for the first time with oesophageal atresia, congenital diaphragmatic hernia, intestinal atresia, gastroschisis, exomphalos, anorectal malformation, and Hirschsprung’s disease. Recruitment was of consecutive patients for a minimum of 1 month between October, 2018, and April, 2019. We collected data on patient demographics, clinical status, interventions, and outcomes using the REDCap platform. Patients were followed up for 30 days after primary intervention, or 30 days after admission if they did not receive an intervention. The primary outcome was all-cause, in-hospital mortality for all conditions combined and each condition individually, stratified by country income status. We did a complete case analysis. Findings We included 3849 patients with 3975 study conditions (560 with oesophageal atresia, 448 with congenital diaphragmatic hernia, 681 with intestinal atresia, 453 with gastroschisis, 325 with exomphalos, 991 with anorectal malformation, and 517 with Hirschsprung’s disease) from 264 hospitals (89 in high-income countries, 166 in middleincome countries, and nine in low-income countries) in 74 countries. Of the 3849 patients, 2231 (58·0%) were male. Median gestational age at birth was 38 weeks (IQR 36–39) and median bodyweight at presentation was 2·8 kg (2·3–3·3). Mortality among all patients was 37 (39·8%) of 93 in low-income countries, 583 (20·4%) of 2860 in middle-income countries, and 50 (5·6%) of 896 in high-income countries (p<0·0001 between all country income groups). Gastroschisis had the greatest difference in mortality between country income strata (nine [90·0%] of ten in lowincome countries, 97 [31·9%] of 304 in middle-income countries, and two [1·4%] of 139 in high-income countries; p≤0·0001 between all country income groups). Factors significantly associated with higher mortality for all patients combined included country income status (low-income vs high-income countries, risk ratio 2·78 [95% CI 1·88–4·11], p<0·0001; middle-income vs high-income countries, 2·11 [1·59–2·79], p<0·0001), sepsis at presentation (1·20 [1·04–1·40], p=0·016), higher American Society of Anesthesiologists (ASA) score at primary intervention (ASA 4–5 vs ASA 1–2, 1·82 [1·40–2·35], p<0·0001; ASA 3 vs ASA 1–2, 1·58, [1·30–1·92], p<0·0001]), surgical safety checklist not used (1·39 [1·02–1·90], p=0·035), and ventilation or parenteral nutrition unavailable when needed (ventilation 1·96, [1·41–2·71], p=0·0001; parenteral nutrition 1·35, [1·05–1·74], p=0·018). Administration of parenteral nutrition (0·61, [0·47–0·79], p=0·0002) and use of a peripherally inserted central catheter (0·65 [0·50–0·86], p=0·0024) or percutaneous central line (0·69 [0·48–1·00], p=0·049) were associated with lower mortality. Interpretation Unacceptable differences in mortality exist for gastrointestinal congenital anomalies between lowincome, middle-income, and high-income countries. Improving access to quality neonatal surgical care in LMICs will be vital to achieve Sustainable Development Goal 3.2 of ending preventable deaths in neonates and children younger than 5 years by 2030

OPTIMIZACIÓN DE PARÁMETROS FERMENTATIVOS PARA PRODUCCIÖN DE BIOMASA FORRAJERA CON LEVADURAS DESARROLLADAS EN CULTIVOS BATCH SOBRE SUERO LÁCTEO CRUDO Y DESPROTEINIZADO

This work was carried out with the purpose to optimize physical chemical parameters obtain a microbial biomass from Kluyveromyces marxianus NRRL –Y-1109 y Candida pseudotropicalis BT-UNMSM_6 . The yeasts were grown on sweet whey crude and deproteinized, supplemented with nitrogen and vitamins sources. The optimization of fermentation parameters was obtained applying a Taguchi´s factorial design. It was established as optimal conditions: An pH 4.5; Temperature 30 °C and an aeration rate of 1.475 VVM; Agitation speed 600 RPM, Lactose concentration 5 g/L; (NH4)2S04 6 g/L; Yeast extract 1.5 g/L . The average biomass yield obtained was 0.56 g/g lactose and 0.54 g/g Lactose for K. marxianus and C. pseudotropicalis respectively grown on sweet whey deproteinized diluted 50%, and Cellular yield 0.405 g/g with K. marxianus NRRL-Y-1109 and Yx/s 0.38 g/g with Candida pseudotropicalis grown on sweet whey crude. A lactose consumption of 98.25 &amp; 94.45% and a cellular concentration of 12.75 g/L &amp; 12.52 g/L respectively at the end of the fermentation.Se efectuó la optimización de parámetros de producción de biomasa de las levaduras Kluyveromyces marxianus NRRL –Y-1109 y Candida pseudotropicalis BT-UNMSM_6 sobre Suero lácteo crudo y desproteinizado suplementado con fuentes de nitrógeno y vitaminas. La optimización de parámetros se obtuvo aplicando un diseño estadístico factorial simplificada de Taguchi modificado. Se establecieron como condiciones óptimas para lograr el máximo rendimiento de biomasa: una temperatura de 30 °C, pH = 4,5; Agitación 600 RPM, un flujo de aireación de 1,475 volúmenes de aire por volumen de medio por minuto (VVM), Concentración de Lactosa 5 g/L; (NH4)2S04 6 g/L; Extracto de levadura 1.5 g/L. Se obtuvo un rendimiento promedio de: biomasa de 0,56 g/g lactosa, con K. marxianus NRRL-Y-1109 y un rendimiento de biomasa Yx/s 0.54 g/g lactosa para Candida pseudotropicalis en suero lácteo desproteinizado y diluido al 50% y un rendimiento de biomasa de 0,425 g/g , con K. marxianus NRRL-Y-1109 y un rendimiento Yx/s 0.38 g/g para Candida pseudotropicalis en suero lácteo crudo, un consumo de lactosa del 98.25% y 94.45%, una concentración celular 12,75 y 12.52 g/L, respectivamente, al final de la fermentación

Puntajes V COLUMNA

El Comité Editorial quiere brindar a los lectores de la RAAOT una actualización de las escalas de uso corriente. El empleo de tablas y escalas es una práctica muy extendida en la ortopedia y traumatología. La medición y la cuantificación de los aspectos clínicos, funcionales y radiográficos se convirtieron en una herramienta imprescindible para la toma de decisiones en diferentes aspectos de la actividad asistencial. Llevamos a cabo una revisión de las escalas más utilizadas, definimos su uso e incluimos bibliografía original y actualizada. Nivel de Evidencia:

Selección evaluación de microorganismos nativos con potencial antagonista de Rhizoctonia solani y Phythopthora infestans promotores del crecimiento de tuberculillos de papa Solanum tuberosum L. in vitro

World agricultural production of potatoes and Andean tubers has been seriously affected by pests and diseases, estimated losses of around 20 to 25 percent. For this reason farmers use synthetic fungicides that can cause resistance to pesticides and generate environmental pollution and toxicity; this problem forced to finding other effective and not harmful alternative methods to combat these pathogens. With respect to potatoes, the fungus Phytophthora infestans is responsible for rancha or late blight (Mont. De Bary) brings estimated at about three billion dollars in annual losses in developed countries, as well as being most responsible for substantial annual expenses by applying fungicides in farming. The objective of the present investigation was to design a biotechnological production process of bacterial biofertilizers from the selection of bacterial strains, in which they managed to isolate and recognition of 4 strains of Azotobacter sp., 2 strains of Azospirillum sp., 7 strains of Bacillus sp.,, 5 of Pseudomonas fluorescens and 2 of Bulkhoderia sp.; these with phosphorus solubilizing activity, nitrogen fixation and antagonist pathogenic fungi; where strains Bacillus sp; Ps. fluorescens-35; Ps. fluorescens-40; Ps. fluorescens-45; Ps. fluorescens -55 and Bulkhoderia cepacia-72, showed a higher activity against Rhizoctonia solani and medium antagonist activity in Phythophthora infestans, potato tuberculillo pathogens isolated from ground and roots of these Andean crops.La producción agrícola mundial de papas y tuberosas andinas se ha visto seriamente afectada por el ataque de plagas y enfermedades, estimándose las pérdidas alrededor del 20 al 25 por ciento. Por esta razón los agricultores utilizan fungicidas sintéticos que pueden originar resistencia a los plaguicidas, además de generar contaminación ambiental y toxicidad; esta problemática obliga a la búsqueda de otros mé- todos alternativos efectivos y no perjudiciales para combatir dichos patógenos. En lo que concierne a la papa, el hongo Phytophthora infestans responsable de la rancha o tizón tardío (Mont. De Bary) ocasiona pérdidas anuales estimadas en cerca de tres mil millones de dólares en los países desarrollados, además de ser la mayor responsable de cuantiosos gastos anuales por aplicación de fungicidas en el cultivo. El objetivo de la presente investigación fue diseñar un proceso biotecnológico de producción de biofertilizantes bacterianos a partir de la selección de cepas bacterianas, en el cual se lograron aislar y hacer reconocimiento de 4 cepas de Azotobacter sp., 2 cepas de Azospirillum sp., 7 cepas de Bacillus sp., 5 de Pseudomonas fluorescens y 2 de Bulkhoderia sp.; éstos con actividad solubilizadora de fósforo, fijación de nitrógeno y antagonista de hongos patógenos; donde las cepas Bacillus sp; Ps. fluorescens-35; Ps. fluorescens-40; Ps. fluorescens-45; Ps. fluorescens -55 y Bulkhoderia cepacia-72, presentaron una mayor actividad contra Rhizoctonia solani y una mediana actividad antagónica sobre Phythphthora infestans, patógenos de tuberculillo de papa aislados del suelo y raíces de estos cultivos andinos