156 research outputs found

    Portfolio Vol. VI N 1

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    Wyman, John. Mrs. Brannon\u27s Bathtub . Prose. 1. Holbrook, Harold R. Sonnet . Poem. 7. Hayne, Barbara. Prayer of A Youth . Poem. 7. Egger, Ellen. An Evening . Poem. 7. Cuninggim, Merrimon. Lambda Pi Beta Mu . Prose. 9. Willett, Thelma. White Rosebuds . Poem. 11. Willett, Thelma. Span of A Life in Mine . Poem. 11. Willett, Thelma. Seventeen . Poem. 11. Willett, Thelma. Ave Atque Vale . Poem. 11. Willett, Thelma. The Ashes of Letters . Poem. 11. Miller, Albert. ...To One I Have Known and Loved . Prose. 12. Wyman, John. Browning the Artist . Prose. 14. Brannon, Pat. Revolution . Poem. 18. Forsberg, Nancy. Unnamed. Poem. 18. Kearns, Carolyn. A Co-Ed\u27s Wish . Poem. 18. Goetz, Marilyn. Fate\u27s Fury . Prose. 19. Harvey, Richard. Man Who Ate the Cheesecake . Prose. 21. Spike, Robert. Mechanikos . Poem. 22. Stodghill, Patricia. Anodyne . Poem. 23. Ladd, Donald. Torch-Light . Poem. 23

    Portfolio Vol. VI N 2

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    Wyman, John. Mrs. Brannon\u27s Bathtub . Prose. 1. Holbrook, Harold R. Sonnet . Poem. 7. Hayne, Barbara. Prayer of A Youth . Poem. 7. Egger, Ellen. An Evening . Poem. 7. Cuninggim, Merrimon. Lambda Pi Beta Mu . Prose. 9. Willett, Thelma. White Rosebuds . Poem. 11. Willett, Thelma. Span of A Life in Mine . Poem. 11. Willett, Thelma. Seventeen . Poem. 11. Willett, Thelma. Ave Atque Vale . Poem. 11. Willett, Thelma. The Ashes of Letters . Poem. 11. Miller, Albert. ...To One I Have Known and Loved . Prose. 12. Wyman, John. Browning the Artist . Prose. 14. Brannon, Pat. Revolution . Poem. 18. Forsberg, Nancy. Unnamed. Poem. 18. Kearns, Carolyn. A Co-Ed\u27s Wish . Poem. 18. Goetz, Marilyn. Fate\u27s Fury . Prose. 19. Harvey, Richard. Man Who Ate the Cheesecake . Prose. 21. Spike, Robert. Mechanikos . Poem. 22. Stodghill, Patricia. Anodyne . Poem. 23. Ladd, Donald. Torch-Light . Poem. 23

    Next Steps from a School Gardening Partnership Conference (AGES: Academic Gardening to Enrich our Students): Expanding the Impact of School Gardens Through Higher Education, K-12 School and Community Coalitions

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    Research suggests that there are many benefits of school gardens for students, teachers and community. Not only can they help children eat more fruits and vegetables and be more physically active, they can help to create learning opportunities and increase teacher satisfaction. In Worcester, Massachusetts, a city with high poverty and food insecurity rates, a broad community coalition formed to brainstorm novel implementation models to improve the use and sustainability of school gardens. The group decided to foster new collaborations among higher education, K-12 schools and community organizations. The innovative idea was that higher education could meet their need for real-world application of various curricula, such as education, business, urban agriculture, marketing, horticulture, sustainable development, and engineering, through the implementation of school gardens. The resulting conference called AGES (Academic Gardening to Enrich our Students) united school teachers, professors, administration and community partners. The sessions featured information on: 1) successful models of higher education-K12 school garden partnerships, 2) building school gardening into the curriculum (psychosocial skills, STEM, environmental sciences, project-based learning, nutrition, healthy lifestyles), 3) research evidence on the benefits of school gardens, 4) strategies for building community through gardening, and 5) garden planning and maintenance. US Representative Jim McGovern was the keynote speaker, highlighting the importance of this collaborative work

    FIRE (facilitating implementation of research evidence) : a study protocol

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    Research evidence underpins best practice, but is not always used in healthcare. The Promoting Action on Research Implementation in Health Services (PARIHS) framework suggests that the nature of evidence, the context in which it is used, and whether those trying to use evidence are helped (or facilitated) affect the use of evidence. Urinary incontinence has a major effect on quality of life of older people, has a high prevalence, and is a key priority within European health and social care policy. Improving continence care has the potential to improve the quality of life for older people and reduce the costs associated with providing incontinence aids

    Task shifting and integration of HIV care into primary care in South Africa: The development and content of the streamlining tasks and roles to expand treatment and care for HIV (STRETCH) intervention

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    Background: Task shifting and the integration of human immunodeficiency virus (HIV) care into primary care services have been identified as possible strategies for improving access to antiretroviral treatment (ART). This paper describes the development and content of an intervention involving these two strategies, as part of the Streamlining Tasks and Roles to Expand Treatment and Care for HIV (STRETCH) pragmatic randomised controlled trial. Methods: Developing the intervention: The intervention was developed following discussions with senior management, clinicians, and clinic staff. These discussions revealed that the establishment of separate antiretroviral treatment services for HIV had resulted in problems in accessing care due to the large number of patients at ART clinics. The intervention developed therefore combined the shifting from doctors to nurses of prescriptions of antiretrovirals (ARVs) for uncomplicated patients and the stepwise integration of HIV care into primary care services. Results: Components of the intervention: The intervention consisted of regulatory changes, training, and guidelines to support nurse ART prescription, local management teams, an implementation toolkit, and a flexible, phased introduction. Nurse supervisors were equipped to train intervention clinic nurses in ART prescription using outreach education and an integrated primary care guideline. Management teams were set up and a STRETCH coordinator was appointed to oversee the implementation process. Discussion: Three important processes were used in developing and implementing this intervention: active participation of clinic staff and local and provincial management, educational outreach to train nurses in intervention sites, and an external facilitator to support all stages of the intervention rollout

    Effects of antiplatelet therapy on stroke risk by brain imaging features of intracerebral haemorrhage and cerebral small vessel diseases: subgroup analyses of the RESTART randomised, open-label trial

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    Background Findings from the RESTART trial suggest that starting antiplatelet therapy might reduce the risk of recurrent symptomatic intracerebral haemorrhage compared with avoiding antiplatelet therapy. Brain imaging features of intracerebral haemorrhage and cerebral small vessel diseases (such as cerebral microbleeds) are associated with greater risks of recurrent intracerebral haemorrhage. We did subgroup analyses of the RESTART trial to explore whether these brain imaging features modify the effects of antiplatelet therapy

    Pan-Cancer Analysis of lncRNA Regulation Supports Their Targeting of Cancer Genes in Each Tumor Context

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    Long noncoding RNAs (lncRNAs) are commonly dys-regulated in tumors, but only a handful are known toplay pathophysiological roles in cancer. We inferredlncRNAs that dysregulate cancer pathways, onco-genes, and tumor suppressors (cancer genes) bymodeling their effects on the activity of transcriptionfactors, RNA-binding proteins, and microRNAs in5,185 TCGA tumors and 1,019 ENCODE assays.Our predictions included hundreds of candidateonco- and tumor-suppressor lncRNAs (cancerlncRNAs) whose somatic alterations account for thedysregulation of dozens of cancer genes and path-ways in each of 14 tumor contexts. To demonstrateproof of concept, we showed that perturbations tar-geting OIP5-AS1 (an inferred tumor suppressor) andTUG1 and WT1-AS (inferred onco-lncRNAs) dysre-gulated cancer genes and altered proliferation ofbreast and gynecologic cancer cells. Our analysis in-dicates that, although most lncRNAs are dysregu-lated in a tumor-specific manner, some, includingOIP5-AS1, TUG1, NEAT1, MEG3, and TSIX, synergis-tically dysregulate cancer pathways in multiple tumorcontexts

    Pan-cancer Alterations of the MYC Oncogene and Its Proximal Network across the Cancer Genome Atlas

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    Although theMYConcogene has been implicated incancer, a systematic assessment of alterations ofMYC, related transcription factors, and co-regulatoryproteins, forming the proximal MYC network (PMN),across human cancers is lacking. Using computa-tional approaches, we define genomic and proteo-mic features associated with MYC and the PMNacross the 33 cancers of The Cancer Genome Atlas.Pan-cancer, 28% of all samples had at least one ofthe MYC paralogs amplified. In contrast, the MYCantagonists MGA and MNT were the most frequentlymutated or deleted members, proposing a roleas tumor suppressors.MYCalterations were mutu-ally exclusive withPIK3CA,PTEN,APC,orBRAFalterations, suggesting that MYC is a distinct onco-genic driver. Expression analysis revealed MYC-associated pathways in tumor subtypes, such asimmune response and growth factor signaling; chro-matin, translation, and DNA replication/repair wereconserved pan-cancer. This analysis reveals insightsinto MYC biology and is a reference for biomarkersand therapeutics for cancers with alterations ofMYC or the PMN
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